Clinical trials: Gut-brain Axis
Epilepsy
Fecal Microbiota Transplantation for Epilepsy
Increasing evidences showed the microbiota effects on neuropsychiatric disorders. This clinical trial aims to evaluate the efficacy and safety of fecal microbiota transplantation for epilepsy.
- Trial name
- NCT02889627
- Testing
- Fecal microbiota suspension
- Where
- China
- Volunteers
- 50 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Tourette Syndrome
Washed Microbiota Transplantation for Tourette's Syndrome
This study aimed to evaluate the efficacy of washed microbiota transplantation in the treatment of Tourette's syndrome (TS).
- Trial name
- WMT (NCT03764748)
- Testing
- Washed Microbiota Transplantation
- Where
- 2 sites in China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Second Hospital of Nanjing Medical University
Autism Spectrum Disorder
Exploring the Gut-Brain-Behavior Axis With Biomarkers, Probiotic Efficacy, and Artificial Intelligence Algorithms
With an increased prevalence of autism spectrum disorder (ASD) worldwide and in Taiwan, ASD demands urgent attention due to its lasting impact, unclear causes, and limited diagnostic and treatment options.
- Trial name
- NCT06677840
- Where
- Taiwan
- Volunteers
- 110 people
- Sponsor
- National Taiwan University Hospital
Autism Spectrum Disorder
Gut to Brain Interaction in Autism. Role of Probiotics on Clinical, Biochemical and Neurophysiological Parameters
The purpose of this study is to assess the effects of a 6-months supplementation with probiotic Vivomixx® on inflammatory and gastrointestinal (GI) biomarkers, gastrointestinal disturbances, behavioral and developmental profiles…
- Trial name
- NCT02708901
- Testing
- Vivomixx®
- Where
- Italy
- Volunteers
- 85 people
- Sponsor
- IRCCS Fondazione Stella Maris
ADHD, ADHD - Attention Deficit Disorder With Hyperactivity
A Clinical Trial Evaluating Fecal Microbiota Transplantation (FMT) in Adolescents With ADHD
The primary goals of this phase 2 clinical trial are to determine the feasibility, safety, and tolerability of oral Fecal Microbiota Transplantation (FMT) in adolescents (aged 13-17) with Attention-Deficit/Hyperactivity Disorder…
- Conditions
- ADHD, ADHD - Attention Deficit Disorder With Hyperactivity, ADHD - Combined Type
- Trial name
- FMT-ADHD-2026 (NCT07756255)
- Testing
- Fecal Microbiota Transplant (FMT), Nitazoxanide 500mg BID, Vancomycin 250mg BID
- Where
- Canada
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Crohn Disease
Effect of Acupuncture on the Microbiota-gut-brain Axis in Crohn's Disease
Multidisciplinary techniques such as multimodal neuroimaging, microbiology, and bioinformatics were applied to study the differences in correlation characteristics between gut microbes, functional brain networks, and peripheral…
- Trial name
- NCT06364722
- Testing
- Acupuncture treatment
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Shanghai Institute of Acupuncture, Moxibustion and Meridian
Attention-deficit/Hyperactivity Disorder
Washed Microbiota Transplantation for Attention-deficit/Hyperactivity Disorder
Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder characterized by inattention and hyperactivity-impulsivity.
- Trial name
- WMT for ADHD (NCT06376331)
- Testing
- washed microbiota transplantation
- Where
- 2 sites in China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The Second Hospital of Nanjing Medical University
Pediatric Migraine
The Efficacy of Beneficial Intestinal Microbiota in the Treatment of Migraine and Its Mechanism: Basic and Clinical Studies
pediatric migraine
- Trial name
- NCT07092241
- Testing
- microbiota
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Microbiome, Neurodevelopment Outcome
The Premature Gut Microbiome and the Influence on Neonatal Immunity, Brain Development and White Matter Injury
Recent advances in neonatal intensive care have dramatically increased the survival rate of extremely premature infants but the number of survivors with severe morbidity and lifelong neurodevelopmental impairment remains high.
- Conditions
- Microbiome, Neurodevelopment Outcome, Immunology
- Trial name
- PreMiBraIn (NCT03213275)
- Testing
- Microbiome Sequencing, Neurophysiologic Assessment, Immunological test
- Where
- Austria
- Volunteers
- 60 people
- Sponsor
- Medical University of Vienna
Obsessive-Compulsive Disorder, Tic Disorder
Pathogenesis of Pediatric Obsessive-compulsive Disorder: Based on the Microbiota-gut-brain Axis
This study aims to investigate the characteristics of the microbiota-gut-brain axis in pediatric patients with obsessive-compulsive disorder (OCD) through performing an integrated analysis of gut microbiota, serum metabolomics…
- Trial name
- NCT06754319
- Where
- China
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Functional Nausea
Comparison of the Therapeutic Effect of Acupressure Therapy and Iberogast ® (STW-5) in Children With Functional Nausea
Functional gastrointestinal disorders are common disorders that are characterized by persistent and recurring GI symptoms. These occur as a result of abnormal functioning of the GI tract and are not caused by structural or…
- Trial name
- NCT02660970
- Testing
- Acupressure, Iberogast
- Where
- Switzerland
- Volunteers
- 56 people
- Sponsor
- University Hospital, Basel, Switzerland
Functional Abdominal Pain Syndrome
The Effects of Probiotics, Lactobacillus GG, in the Treatment of Abdominal Pain in Children With Functional Abdominal Pain Disorders
Recurrent or chronic abdominal pain is one of the common gastrointestinal problems in children. While most children do not have organic origins (so called functional abdominal pain disorders; FAPDs), the symptoms can nevertheless…
- Trial name
- NCT06310733
- Testing
- LGG
- Where
- Thailand
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Prince of Songkla University
Meconium Obstruction of Prematurity
Saline Enema Administration in Meconium Obstruction of Prematurity and Impact on the Resolution, Feeds, Microbiome, and Gut-brain Axis.
The goal of this clinical trial is to study the effect of twice-daily saline enema (SE) in the treatment obstruction of prematurity (MOP) in infants with the birth weight ≤1.25kg.
- Trial name
- NCT06048614
- Testing
- Saline Enema (SE), Glycerin Suppository
- Where
- 2 sites in Singapore
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Anorexia Nervosa
The Fecal Microbiome Transplant (FMT) Study for Anorexia Nervosa
Anorexia Nervosa (AN) is a severe, debilitating and potentially life threatening illness that is difficult to treat. A cardinal symptom of AN is the mistaken belief on the part of the individuals that they are overweight and must…
- Trial name
- NCT07143981
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Epilepsy, Microbiota
EPIGUT: EPILEPSY AND GASTROINTESTINAL MICROBIOTA: UNDERSTANDING THERAPY RESPONSE
The goal of this observational study is to learn how the bacteria in the gut and mouth (called the microbiota) are linked to different types of epilepsy and how they may affect how well seizure medicines work.
- Conditions
- Epilepsy, Microbiota, Proteomics, Metabolomics
- Trial name
- EpiGUT (NCT07253701)
- Where
- 6 sites in Sweden
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Preterm, Neurodevelopmental Disorders
Dietary Pattern Intervention for Neurodevelopment in Preterm Infants
The purpose of this randomized controlled trial is to evaluate the effect of a structured, high-prebiotic dietary pattern on the neurodevelopmental outcomes of preterm infants.
- Conditions
- Preterm, Neurodevelopmental Disorders, Dysbiosis
- Trial name
- NCT07702734
- Testing
- Structured High-Prebiotic Dietary Pattern
- Where
- China
- Volunteers
- 116 people
- Sponsor
- Fudan University
Gut Microbiota, Epilepsy
MiCrobiota-gut-brain Axis in Resistant Epilepsy
Epilepsy is one of the most common neurological chronic conditions with a serious burden on patients, their caregivers, and society. Drug-resistant epilepsy (DRE) heightens this burden. New approaches are thus a priority.
- Conditions
- Gut Microbiota, Epilepsy, Drug-Resistant Epilepsy
- Trial name
- CARE (NCT07010445)
- Testing
- Naïve: epilepsy first diagnosis,, DRE-surgery: resective surgery;, anti-epileptic drugs;
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Niguarda Hospital
Crohn Disease, Inflammatory Bowel Diseases
Effect of Acupuncture on Patients With Crohn's Disease in Remission
To observe the therapeutic effect of acupuncture on Crohn's disease in remission and its influence of brain functional activity
- Trial name
- NCT04211129
- Testing
- acupuncture
- Where
- 2 sites in China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shanghai Institute of Acupuncture, Moxibustion and Meridian