Clinical trials: Head Neck Cancer
Facial Neoplasms
A Comparison of Accuracy Between Different Facial Scanning Techniques
Conventional alginate impressions are still a burden to both the patient and the operator especially in extraoral maxillofacial rehabilitations cases.
- Trial name
- NCT07557212
- Testing
- portable scanning, stationery scanning, mobile app scanning
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Dysphagia, Esophageal, Dysphagia, Oral Phase
Post-thyroidectomy Dysphagia: An International Multicentric CONSORT - Compatible RCT
The most common and feared complications of total thyroidectomy are vocal cord paralyses and hypocalcemia. However, post-thyroidectomy dysphagia is not uncommon and has important consequences on the quality of life (QoL).
- Conditions
- Dysphagia, Esophageal, Dysphagia, Oral Phase, Dysphagia Comes and Goes, Thyroiditis
- Trial name
- Dysphagia-TT (NCT04410601)
- Testing
- Total thyroidectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 500 people
- Sponsor
- Umraniye Education and Research Hospital
Nasopharyngeal Carcinoma
Phase IV Clinical Trial of Nimotuzumab in the Treatment of Nasopharyngeal Carcinoma
This clinical study is designed as an open, single group, multi-center, phase 4 clinical study to assess the safety of Nimotuzumab in the treatment of nasopharyngeal carcinoma and to provide a more reasonable basis for clinical…
- Trial name
- NCT02293356
- Testing
- Nimotuzumab Injection
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Biotech Pharmaceutical Co., Ltd.
Esophageal Squamous Cell Carcinoma, Immunotherapy
Trajectory Analysis of NLR and Its Association With Efficacy of Immunochemotherapy in ESCC.
Conduct a retrospective and prospective study to confirm the association between blood cells counts and the efficacy and safety in immunochemotherapy in patients with advanced esophageal cancer.
- Conditions
- Esophageal Squamous Cell Carcinoma, Immunotherapy, Chemotherapy
- Trial name
- NCT06125262
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Guangdong Provincial People's Hospital
Eyelid Tumor
Mohs Surgery Combind With Cryotherapy for Eyelid Malignant Tumors.
This study aim to investigate whether the prognosis of eyelid malignant tumor is better treated with Mohs surgery combind with cryotherapy than Mohs surgery only.
- Trial name
- NCT05072327
- Testing
- Mohs surgery, cryotherapy
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Sun Yat-sen University
Esophageal Neoplasms
Irreversible Electroporation(IRE) For Unresectable Esophageal Neoplasms
The purpose of this study is to evaluate the safety and efficacy of irreversible electroporation (IRE) for unresectable Esophageal Neoplasms.
- Trial name
- IRE (NCT02430701)
- Testing
- Irreversible electroporation (IRE), NanoKnife
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fuda Cancer Hospital, Guangzhou
Esophageal Cancer
Defining the Radiotherapy Dose and Volume Parameters Affecting Postoperative Complications in Esophageal Cancer Patients
The purpose of this study is to identify features of the cumulative dose-volume histogram (DVH) for patients treated with trimodality therapy in oesophageal cancer and correlate these with postoperative complications.
- Trial name
- NCT02323776
- Testing
- Trimodality protocol
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- Maastricht Radiation Oncology
HNSCC
Immune Modulation by Abemaciclib in Head and Neck Squamous Cell Carcinoma (HNSCC). (AIM Trial)
This is a Phase II single-arm window trial to assess the clinical and biological effects of neoadjuvant abemaciclib in patients with HPV-negative head and neck squamous cell carcinoma (HNSCC).
- Trial name
- NCT04169074
- Testing
- Abemaciclib
- Where
- 2 sites in United States
- Volunteers
- 7 people
- Sponsor
- University of Arizona
Premalignant Lesion, Oral Cancer
Diagnostic Accuracy of Mobile Phone Imaging Compared to Conventional Clinical Examination for Oral Cancer Screening
The aim of study is to evaluate the sensitivity and specificity of using mobile phone photographs versus conventional clinical examination as a screening tool for early detection of oral cancer.
- Trial name
- NCT06060288
- Testing
- Diagnosis by mobile phone imaging
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Cairo University
Radiation-induced Mucositis of Oral Mucous Membranes
Assessing the Preventing and Therapeutic Effect of Propolis in Radiotherapy Induced Mucositis of Head and Neck Cancers
The purpose of this study is to determine whether propolis is effective in the treatment and prevention of radiotherapy induced oral mucositis.
- Trial name
- NCT01375088
- Testing
- propolis
- Where
- Iran
- Volunteers
- 20 people
- Sponsor
- Mashhad University of Medical Sciences
Nasopharyngeal Carcinoma
A Phase III Study of Radiotherapy With or Without Adjuvant C/T in Advanced Stage Nasopharyngeal Carcinoma Patients
To investigate the efficacy of adjuvant PFL chemotherapy after radiotherapy vs radiotherapy alone in AJC stage IV nasopharyngeal carcinoma patients.
- Trial name
- NCT00201344
- Testing
- Cisplatin,5-FU,Leucovorin
- Where
- Taiwan
- Volunteers
- 320 people
- Sponsor
- National Health Research Institutes, Taiwan
Thyroid Goiter, Thyroid Carcinoma
Parathyroid Reimplantation in Forearm Subcutaneous Tissue During Thyroidectomy: a Simple Way to Avoid Ipoparathyroidism and Evaluate Graft Function
The purpose of this study is to evaluate safety and effectiveness of normal parathyroid tissue reimplantation in forearm subcutaneous tissue in case of accidental removal of parathyroid gland during thyroid surgery.
- Conditions
- Thyroid Goiter, Thyroid Carcinoma, Multinodular Goiter, Graves Diseases
- Trial name
- NCT02194920
- Testing
- Thyroidectomy and parathyroid reimplantation in forearm subcutaneous tissue
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Roma La Sapienza
Lung Cancer, Breast Cancer
Plasma Metabolic Biomarkers for Multi-Cancer Diagnosis
The aim of this observational study is to comprehensively analyze the metabolites in plasma samples from multi-cancer patients using advanced mass spectrometry detection technology, in conjunction with metabolomics approaches.
- Conditions
- Lung Cancer, Breast Cancer, Colorectal Cancer, Thyroid Cancer
- Trial name
- NCT06363123
- Where
- 4 sites in China
- Volunteers
- 2,700 people, healthy volunteers welcome
- Sponsor
- Beijing Friendship Hospital
Neoplasms (Cancer / Tumors), Colorectal Neoplasms
A Preregistered Multi-Cohort Evaluation of the FATHOM AI System for Molecular Testing Prioritization to Support Clinical Trial Enrollment
Many clinical trials evaluating cancer treatments require patients to undergo testing for specific molecular markers as part of eligibility screening, typically using immunohistochemistry or sequencing.
- Conditions
- Neoplasms (Cancer / Tumors), Colorectal Neoplasms, Lung Neoplasms, Endometrial Neoplasms
- Trial name
- FATHOM (NCT07814872)
- Where
- United States
- Volunteers
- 30,000 people
- Sponsor
- Harvard Medical School (HMS and HSDM)
Laryngectomy
Effect of Zinc and Probiotics Supplementation on Laryngeal Cancer Patients Undergoing Laryngectomy Surgery to Improve Prognosis and Better Wound Healing
using zinc and probiotics supplementation for providing better prognosis for laryngeal cancer patients under going total or partial laryngectomy.
- Trial name
- NCT06674564
- Testing
- Zinc Acetate 50 Mg Oral Capsule, Probiotic
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Ain Shams University
Oral Cavity Carcinoma
Behavior Changing Intervention for Smokeless Tobacco and Betel Quid Use in Adolescents
Smokeless tobacco (SLT) is a known risk factor for Oral, Pharyngeal and Esophageal carcinoma. Three-quarters global SLT consumption is among the South Asian Population.
- Trial name
- NCT03488095
- Testing
- BCI for SLT and BQ Use in Adolescents: A CRT
- Where
- Pakistan
- Volunteers
- 2,200 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Primary Hyperparathyroidism Due to Adenoma
Intraoperative Identification of Parathyroid Adenomas Using PTeye™ and FLUOBEAM® LX: a Prospective Cohort Study
The goal of this observational study is to evaluate the efficacy of PTeyeTM device to confirm a parathyroid adenoma on a visually suspected tissue in comparison with the FLUOBEAM®LX device.
- Trial name
- PTeye (NCT06788223)
- Testing
- Parathyroidectomy
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- Aristotle University Of Thessaloniki
Hurthle Cell Thyroid Cancer, Tall Cell Variant Thyroid Cancer
Studies on Tumors of the Thyroid
Participants in this study will be patients diagnosed with or suspected to have a thyroid nodule or thyroid cancer. The main purpose of this study is to further understand the methods for the diagnosis and treatment of thyroid…
- Conditions
- Hurthle Cell Thyroid Cancer, Tall Cell Variant Thyroid Cancer, Follicular Thyroid Cancer, Thyroid Cancer
- Trial name
- NCT00001160
- Testing
- 68-Gallium Dotatate
- Where
- United States
- Volunteers
- 2,500 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Esophageal Cancer
Clinical Value and Efficacy Index of Lymphadenectomy for Thoracic Escc
The goal of this observational study is to to clarify the focus of lymph node dissection during esophagectomy.. The main question[s] it aims to answer is: provide a basis for accurate staging and the relationship between OS and…
- Trial name
- NCT05604664
- Where
- China
- Volunteers
- 1,727 people
- Sponsor
- Yongtao Han
Head and Neck Squamous Cell Carcinoma (HNSCC) - Recurrent/Metastatic (R/M), Nasopharyngeal Carcinoma
Phase I Study of Becotatug Vedotin for Safety and Efficacy in EGFR-Positive Pediatric Relapsed/Refractory or Metastatic Solid Tumors
There is a significant unmet medical need for effective therapies for pediatric relapsed/refractory solid tumors. EGFR is highly and stably expressed in multiple pediatric solid tumor subtypes, and adult Phase I data of Becotatug…
- Conditions
- Head and Neck Squamous Cell Carcinoma (HNSCC) - Recurrent/Metastatic (R/M), Nasopharyngeal Carcinoma, Lymphoepithelial Carcinoma, Rhabdomyosarcoma
- Trial name
- MRG003 (NCT07584499)
- Testing
- Becotatug Vedotin
- Where
- China
- Volunteers
- 51 people
- Sponsor
- Sun Yat-sen University