Clinical trials: Headache Disorders
Migraine
Efficacy and Safety of Erenumab in Pediatric Participants With Episodic Migraine
This study will evaluate the efficacy and safety of erenumab in migraine prevention in children (6 to <12 years) and adolescents (12 to <18 years) with episodic migraine.
- Trial name
- OASIS(EM) (NCT03836040)
- Testing
- Erenumab Dose 1, Erenumab Dose 2, Erenumab Dose 3
- Where
- 11 sites in United States, Belgium and 2 more
- Volunteers
- 457 people
- Sponsor
- Amgen
Migraine
Omega-3 Supplementation for Pediatric Migraine
The purpose of the study is to assess the biochemical and clinical effects of omega-3 polyunsaturated fatty acid (PUFA) supplementation in youth suffering from migraine, including its effects on migraine disability, psychological…
- Trial name
- NCT06899074
- Testing
- Omega 3 Polyunsaturated Fats
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of North Carolina, Chapel Hill
Cervicogenic Headache
The Effect of Myofascial Release in Patients With Cervicogenic Headache
Cervicogenic headache (CeH) is a secondary and often unilateral that is known by referring pain from soft or hard cervical structures to occipital, temporal, frontal and sometimes pre-orbital regions.
- Trial name
- RCT (NCT03113357)
- Testing
- Myofascial release technique, conventional exercise therapy
- Where
- Iran
- Volunteers
- 34 people
- Sponsor
- University of Social Welfare and Rehabilitation Science
Migraine Disorders, Migraine Variant
Vestibular System in Migrainous Vertigo Patients
Do migrainous vertigo patients have more pathology in their vestibular system than migraine patients without vertigo? The aim of this study is to compare the vestibular system of migraine patients with and without vertigo in the…
- Conditions
- Migraine Disorders, Migraine Variant, Episodic Recurrent Vertigo
- Trial name
- NCT00901953
- Where
- Norway
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Bergen
Migraine
Fremanezumab Managed Access Program for Pediatric Patients
This is a Managed Access Program (MAP) based on a licensed physician's unsolicited request on a compassionate basis. Specifically, this MAP is for male and female pediatric patients 6 to 17 years with a diagnosis of either…
- Trial name
- NCT03539393
- Testing
- Fremanezumab
- Sponsor
- Teva Branded Pharmaceutical Products R&D LLC
Chronic Headache
The Turkish Fear of Pain Questionnaire
Children's chronic pain is a significant condition that affects roughly 25% of children, with approximately 3% of them requiring intense pain therapy.
- Trial name
- NCT05414513
- Where
- Turkey (Türkiye)
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Migraine, Pediatric Migraine
PEDİATRİC MİGRAİNE PATİENTS İN FİNDİNGS
Migraine is a common neurological disease in the pediatric population. However, studies investigating the clinical symptoms associated with the different phases of migraine attacks (prodrome, aura, postdrome), particularly in…
- Trial name
- NCT07593287
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Mersin University
Migraine Headache
Clinical Study Examining Use of an Over-the-Counter Supplement for the Prevention of Menstrually-Associated Migraine Headache
The purpose of this trial is to study the use of soy isoflavones in the prevention of menstrually-associated migraines. Additionally, this trial may provide insight into the menstrual cycle and menstrually-related headaches in…
- Trial name
- NCT00203255
- Testing
- Soy Isoflavones
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Thomas Jefferson University
Headache Disorders, Primary
The Effects of Connective Tissue Massage and Lifestyle Modifications in Adolescents Tension Type Headache
The purpose of this study is to investigate the effects of connective tissue massage and lifestyle modifications in adolescents tension type headache, pain severity, pain duration, pain frequency and quality of life and pressure…
- Trial name
- NCT02549300
- Testing
- Connective tissue massage
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Hacettepe University
Migraine
AMG 334 20160172 Pediatric Migraine PK Study.
AMG 334 20160172 Pediatric Migraine PK Study.
- Trial name
- NCT03499119
- Testing
- AMG 334 Dose 1, AMG 334 Dose 2, AMG 334 Dose 3
- Where
- 14 sites in United States
- Volunteers
- 53 people
- Sponsor
- Amgen
Chronic Migraine Without Aura, Intractable, Migraine With Typical Aura
Treatment of Chronic Migraine Headaches.
The purpose of the study is assessment of the safety and efficacy of the De-Novo therapy in the treatment of craniofacial neuralgia and migraine headaches.This is an open-label study of simultaneous administration of combination…
- Conditions
- Chronic Migraine Without Aura, Intractable, Migraine With Typical Aura, Migraine Disorders
- Trial name
- Migraine (NCT03220113)
- Testing
- Dexamethasone, Lidocaine, Thiamine cohort
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Corona Doctors Medical Clinics, Inc.
Chronic Pain Syndrome, Chronic Daily Headache
Offset Analgesia as a Measure of Central Sensitization in Children
Pediatric chronic pain disorders are common and consequential in Western societies, occurring in 25-80% of population-based samples with a median prevalence of 11-38% and significant pain-related disability in 3-5% of these…
- Conditions
- Chronic Pain Syndrome, Chronic Daily Headache, Functional Abdominal Pain Syndrome, Musculoskeletal Pain Disorder
- Trial name
- NCT03445403
- Testing
- Offset analgesia
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
COVID-19, Long COVID
Effectiveness of Transcranial Direct Current in Patients With Persistent COVID-19 With Headaches and Chronic Pain.
This study aims to verify the efficacy/effectiveness of treatment with transcranial direct current stimulation (TDCS) in patients with Long Covid who experience headaches, migraines, and chronic pain, such as arthralgia and…
- Conditions
- COVID-19, Long COVID, Long Covid19, SARS CoV 2 Infection
- Trial name
- NCT05780450
- Testing
- Transcranial Direct Current Therapy (tDCS)
- Where
- 2 sites in Spain
- Volunteers
- 87 people
- Sponsor
- Fundación Universidad Católica de Valencia San Vicente Mártir
Migraine
Study to Assess Adverse Events and Disease Activity of Oral Ubrogepant Tablets for the Acute Treatment of Migraine in Children and Adolescents (Ages 6-17)
Migraine is a common neurological disorder typically characterized by attacks of throbbing, moderate to severe headache, often associated with nausea, vomiting, and sensitivity to light and sound.
- Trial name
- Ubro Peds (NCT05125302)
- Testing
- Ubrogepant
- Where
- 129 sites in United States, Puerto Rico
- Volunteers
- 1,059 people
- Sponsor
- AbbVie
Pediatric Migraine, Migraine Disorders, Brain
Comorbidity-Based Propranolol Use in Pediatric Migraine
This observational retrospective cohort study aims to identify clinical and biochemical predictors of response to propranolol prophylaxis in pediatric migraine.
- Conditions
- Pediatric Migraine, Migraine Disorders, Brain, Vitamin D Deficiency
- Trial name
- NCT07103031
- Testing
- Behavioral therapy, Propranolol
- Where
- Turkey (Türkiye)
- Volunteers
- 488 people
- Sponsor
- Kayseri University
Migraine
Acute Treatment of Migraine in Pre-Adolescents: Real-World Analysis of Remote Electrical Neuromodulation (REN)
Migraine is a prevalent neurological disorder that severely impacts both children and adolescents, causing significant disability.
- Trial name
- NCT06138756
- Testing
- Nerivio
- Where
- 2 sites in United States, Israel
- Volunteers
- 293 people
- Sponsor
- Theranica
Migraine, Headache
The Role of CGRPand Nociceptin in Migraine
The release of the neuropeptide calcitonin gene-related peptide (CGRP) is thought to play a causative role in migraine. Nociceptin immunoreactivity and ORL-1 mRNA have been detected in human trigeminal ganglia where it was…
- Trial name
- NCT00155129
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Migraine
High School Start Time and Teen Migraine Frequency
Migraine is common in adolescents and can cause missed school and disability. The American Academy of Pediatrics (AAP) recommends that high schools start no earlier than 8:30 AM in order to accommodate the physiologic needs of…
- Trial name
- NCT03766412
- Testing
- High School start time
- Where
- United States
- Volunteers
- 256 people
- Sponsor
- University of California, San Francisco
Migraine, Pain
Nitrous Oxide for Acute Migraine Pain in the Emergency Room (ED)
BACKGROUND Migraine headaches account for 8-18% of all headaches seen in pediatric emergency rooms. Standard treatment includes IV pain medications, anti-emetics, and IV fluids.
- Trial name
- NCT01287052
- Testing
- Nitrous Oxide
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Migraine
A Controlled Trial to Investigate the Efficacy and Safety of Frovatriptan to Prevent Menstrual Migraine
Although the predictability of an MRM headache attack lends itself to preventative treatment, there are currently no drugs specifically indicated for the prevention of MM.
- Trial name
- NCT00475514
- Testing
- Frovatriptan 2.5mg QD, Frovatriptan 2.5 mg BID
- Volunteers
- 500 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company