Clinical trials: Hearing Loss, Sensorineural
Bilateral Sensorineural Hearing Loss, Speech and Language Development Delay Due to Hearing Loss
Neural Prediction to Enhance Language
The language outcome of children receiving cochlear implantation to address bilateral sensorineural hearing loss is more variable than that of typical hearing children.
- Conditions
- Bilateral Sensorineural Hearing Loss, Speech and Language Development Delay Due to Hearing Loss, Social Communication
- Trial name
- NCT05962359
- Testing
- Parent-Implemented Communication Treatment
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Hearing Loss, Bilateral or Unilateral, Hearing Loss, Conductive
Sentio Systematic Evaluation
The study is designed as an international, multi-center, single-armed, non-interventional/observational study including subjects who has received or are planned to receive the Sentio system as part of normal clinical practice.
- Conditions
- Hearing Loss, Bilateral or Unilateral, Hearing Loss, Conductive, Hearing Loss, Mixed Conductive-Sensorineural, Single Sided Deafness
- Trial name
- SENSE (NCT07161154)
- Testing
- Transcutaneous bone conduction hearing system
- Volunteers
- 100 people
- Sponsor
- Oticon Medical
Hearing Loss, Sensorineural
CT and MRI for Pre-Operative Cochlear Imaging
This study investigates the role of the preoperative computed tomography (CT) and magnetic resonance imaging (MRI) before cochlear implants and their role in selecting suitable patients for surgery.
- Trial name
- NCT04131439
- Testing
- Computed Tomography and Magnetic resonance imaging
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Hearing Loss, Sensorineural, Hearing Loss, Bilateral
iotaSOFT Pediatric Study
Prospective, non-randomized, open-label study to evaluate the safety and efficacy of the iotaSOFT Insertion System when used to assist electrode array insertion during cochlear implant surgery in a pediatric population.
- Conditions
- Hearing Loss, Sensorineural, Hearing Loss, Bilateral, Hearing Loss, Unilateral
- Trial name
- NCT06106373
- Testing
- iotaSOFT Insertion System
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- iotaMotion, Inc.
Hearing Impairment, Sensorineural Hearing Loss, Bilateral
Hearing Aid Noise Reduction in Pediatric Users Pilot Study (Oticon Pilot Study)
The purpose of this study is to evaluate the efficacy of OpenSound Navigator (OSN), a hearing aid speech-enhancement algorithm developed by Oticon, as treatment for pediatric hearing aid users.
- Trial name
- NCT04469946
- Testing
- Oticon OpenSound Navigator speech enhancement algorithm
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Otoferlin Gene-mediated Hearing Loss
Long Term Follow-up Study of AAVAnc80-hOTOF Gene Therapy
This multi-center, observational, post-intervention long term follow-up (LTFU) study will monitor for safety and efficacy of AAVAnc80-hOTOF in individuals with sensorineural hearing loss due to otoferlin gene mutations who have…
- Trial name
- NCT06696456
- Where
- 5 sites in United States, Spain and 1 more
- Volunteers
- 30 people
- Sponsor
- Eli Lilly and Company
Eye Diseases Hereditary, Retinal Disease
Inherited Retinal Degenerative Disease Registry
The My Retina Tracker® Registry is sponsored by the Foundation Fighting Blindness and is for people affected by one of the rare inherited retinal degenerative diseases studied by the Foundation.
- Conditions
- Eye Diseases Hereditary, Retinal Disease, Achromatopsia, Bardet-Biedl Syndrome
- Trial name
- MRTR (NCT02435940)
- Where
- United States
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Foundation Fighting Blindness
Hearing Loss, Cochlear
Electrocochleography Function for Monitoring Residual Hearing
This trial is a pilot study to assess the feasibility of using Electrocochleography recorded from a cochlear implant intra-operatively in real time to monitor the progress of its insertion. Correlation between: 1.
- Trial name
- ECochG (NCT03848338)
- Testing
- Electrocochleography
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Hearing Loss, Sensorineural
Expanded Indications in the MED-EL Pediatric Cochlear Implant Population
The purpose of this investigation is to demonstrate the safety and effectiveness of MED-EL cochlear implants in children 7 months to 5 years, 11 months of age who fall outside the current FDA-approved candidacy criteria and, yet…
- Trial name
- NCT03900897
- Testing
- MED-EL SYNCHRONY PIN Cochlear Implant, Cochlear Implant
- Where
- 8 sites in United States
- Volunteers
- 247 people
- Sponsor
- Med-El Corporation
Sensorineural Hearing Loss, Hearing Disorder
Genetic Analysis of Hereditary Disorders of Hearing and Balance
This study will try to identify the genetic causes of hereditary hearing loss or balance disorders. People with a hearing or balance disorder that affects more than one family member may be eligible for this study.
- Conditions
- Sensorineural Hearing Loss, Hearing Disorder, Vestibular Disease
- Trial name
- NCT00023049
- Where
- 2 sites in United States, Nigeria
- Volunteers
- 335 people
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Sensorineural Hearing Loss
Sensorineural Hearing Loss Imprint
this study will investigate the consequences of sensorineural hearing loss on manual dexterity and coordination skills in Children.
- Trial name
- NCT07023250
- Testing
- manual dexterity and coordination skills
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Cairo University
Hearing Impairment, Hearing Loss, Sensorineural
Hearing Aid Noise Reduction in Pediatric Users (Oticon Study)
The purpose of this study is to evaluate the efficacy of OpenSound Navigator (OSN), a hearing aid speech-enhancement algorithm developed by Oticon, as treatment for pediatric hearing aid users.
- Trial name
- OtiS (NCT03771287)
- Testing
- Oticon OpenSound Navigator speech enhancement algorithm, Oticon omni-directional microphone algorithm
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Sudden Hearing Loss
Trans-round Window Membrane Intracochlear Steroid
Safety and efficacy of intracochlear injection of glucocorticoid through the round window membrane in patients with profound or complete sudden sensorineural hearing loss
- Trial name
- NCT07540728
- Testing
- Experimental: Group A: intracochlear triamcinolone acetonide injection, intracochlear injection of dexamethasone, intratympanic dexamethasone injection
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Sensorineural Hearing Loss
Role of Diffusion Tensor-magnetic Resonance Imaging in Investigating Sensorineural Hearing Loss
DTI and auditory tractography can be incorporated into the diagnostic toolkit for patients who are scheduled to undergo cochlear implantation and whose standard assessments have been unable to determine the functional integrity…
- Trial name
- NCT06434129
- Testing
- DTI
- Where
- Egypt
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Assiut University
Cochlear Implant Users, Cochlear Hearing Loss
Effects of Binaural Hearing on Listening Effort and Cognitive Development in Mandarin-speaking Children With Cochlear Implants
The goal of this observational study is to learn how listening effort affects brain development and daily life in school-aged children (ages 6-18) who use cochlear implants (CIs), which are electronic devices surgically placed in…
- Trial name
- NCT07509788
- Where
- China
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Xiong hao
Effectiveness of Application Education Intervention, Noise Induced Hearing Loss
Prevention of Noise-Induced Hearing Loss in Primary Education
The goal of this randomized controlled trial is to evaluate the effectiveness of the educational program the HoorToren in promoting recreational safe listening behavior among Dutch primary school children in group 7 (aged 10-11…
- Conditions
- Effectiveness of Application Education Intervention, Noise Induced Hearing Loss, Behavior Change Interventions, Primary School Children
- Trial name
- NCT07513077
- Testing
- HoorToren educational package
- Where
- Netherlands
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Hearing Loss, Sensorineural, Hearing Loss, Bilateral
Iowa/Nucleus 10/10 mm and Nucleus Freedom Feasibility Study
The purpose of this study is to evaluate whether the Iowa/Nucleus 10/10 mm in one ear, in conjunction with a Nucleus Freedom implant in the other ear can provide useful binaural hearing in pediatric subjects who have bilateral…
- Trial name
- NCT00594061
- Testing
- Iowa/Nucleus 10/10 mm and Freedom Cochlear Implantation
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Bruce J Gantz
Retinitis Pigmentosa, Usher Syndrome Type 2
Study to Evaluate the Efficacy Safety and Tolerability of Ultevursen in Subjects With RP Due to Mutations in Exon 13 of the USH2A Gene (Sirius)
The purpose of this study is to evaluate the efficacy safety and tolerability of ultevursen administered via intravitreal injection (IVT) in subjects with Retinitis Pigmentosa (RP) due to mutations in exon 13 of the USH2A gene.
- Conditions
- Retinitis Pigmentosa, Usher Syndrome Type 2, Deaf Blind, Retinal Disease
- Trial name
- NCT05158296
- Testing
- Ultevursen
- Where
- 15 sites in United States, Germany and 2 more
- Volunteers
- 7 people
- Sponsor
- Laboratoires Thea
Neurofibromatosis Type 2, Severe Profound Sensorineural Hearing Loss
Compassionate Use Arm - ABI541 ABI for 10 NF2 Patients
The Nucleus 24 Auditory Brainstem Implant (ABI) is the only FDA approved device for restoration of meaningful hearing in Neurofibromatosis Type 2 (NF2) patients.
- Trial name
- NCT02589912
- Testing
- Nucleus Profile ABI541 Auditory Brainstem Implant
- Where
- United States
- Sponsor
- Massachusetts Eye and Ear Infirmary