Clinical trials: Heart Defects
Heart Disease Congenital
The Swiss Registry for Heart Diseases in Children Living in Switzerland. SPHC
The Swiss Pediatric Heart Cohort aims to collect representative longitudinal data on all children diagnosed with a clinically relevant heart disease in Switzerland.
- Trial name
- SPHC (NCT04442685)
- Where
- Switzerland
- Volunteers
- 590 people
- Sponsor
- University Children's Hospital, Zurich
Congenital Heart Disease, Fetal Cardiac Disorder
Fetal Cardiac Magnetic Resonance in Detection of CHD
The aim of this clinical prospective study is to investigate the value of fetal cardiac magnetic resonance imaging using a new Doppler ultrasound based gating method for the detection of congenital heart desease.
- Conditions
- Congenital Heart Disease, Fetal Cardiac Disorder, Heart Defect, Congenital
- Trial name
- NCT05066399
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bonn
Patent Foramen Ovale, PFO
Lifetech Cera™ PFO Occluder Post-Market Clinical Follow-Up
The objective of this post-market registry is to assess the clinical use of the Lifetech Cera™ PFO Occluder in a real-world and on-label fashion.
- Trial name
- NCT05893758
- Testing
- The Cera™ PFO Occluder
- Where
- 5 sites in Poland
- Volunteers
- 94 people
- Sponsor
- Lifetech Scientific (Shenzhen) Co., Ltd.
Heart Defects, Congenital
Physical Activity in Fontan Patients
The purpose of this study is to determine which is the most effective intervention for increasing lifestyle physical activity in Fontan patients: an education (stage of change) intervention or a physical activity (mastery…
- Trial name
- NCT00363363
- Testing
- Physical Activity, Education
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- The Hospital for Sick Children
Atrial Septal Defect
Safety and Efficacy Study of Transcatheter Closure of Ostium Secundum ASDs
Evaluate the safety and efficacy of the GORE® CARDIOFORM ASD Occluder in the percutaneous closure of ostium secundum atrial septal defects (ASDs)
- Trial name
- ASSURED (NCT02985684)
- Testing
- GORE® CARDIOFORM ASD Occluder
- Where
- 22 sites in United States
- Volunteers
- 125 people
- Sponsor
- W.L.Gore & Associates
Apnea of Prematurity, Preterm Birth
Hemodynamic Responses to Cardio-respiratory Events in Preterm Infants
Intermittent episodes of hypoxemia and/or bradycardia, also defined as cardio-respiratory events (CRE) are very frequent in preterm infants and may result in transient hypoxia and hypoperfusion of target organs, with possible…
- Conditions
- Apnea of Prematurity, Preterm Birth, Patent Ductus Arteriosus, Hypoxia, Brain
- Trial name
- NCT04184245
- Where
- Italy
- Volunteers
- 42 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Heart Disease Congenital, Neurodevelopmental Disorder
Characterization and Support of Neurodevelopmental Disorders Associated With Congenital Cardiac malfoRmations - Neonatal
Congenital heart defects (CHD), as the leading cause of birth defects, affect 12 million people globally and approximately 41,000 newborns each year in Europe.
- Trial name
- CATAMARAN - NN (NCT06690151)
- Testing
- Neurodevelopmental assessment (Bayley-IV), Biological sampling, ELFE dietary questionnaire
- Where
- 8 sites in France
- Volunteers
- 450 people
- Sponsor
- Nantes University Hospital
Idiopathic Pulmonary Arterial Hypertension, Cardiomyopathy
Comparison of Inhaled Nitric Oxide and Oxygen in Participants Reactivity During Acute Pulmonary Vasodilator Testing
The primary purpose of this study is to compare the number of participants with reversible pulmonary hypertension (vasoreactivity) due to nitric oxide for inhalation and oxygen as compared to 100% oxygen.
- Trial name
- NCT00626028
- Testing
- Nitric Oxide for inhalation, Oxygen, Nitric Oxide plus Oxygen
- Where
- 18 sites in United States, France and 3 more
- Volunteers
- 136 people
- Sponsor
- Mallinckrodt
Atrial Septal Defect
Safety and Efficacy of the AbsnowTM II Absorbable Atrial Septal Defect Closure System for Atrial Septal Defect Closure Therapy
A prospective, multicenter, randomized controlled, non-inferiority clinical trial to evaluate the safety and efficacy of the AbsnowTM II absorbable atrial septal defect occluder system for atrial septal defect closure therapy.
- Trial name
- NCT07529028
- Testing
- Absnow II Absorbable Atrial Septal Defect Occluder System, Cera Atrial Septal Defect Occluder
- Volunteers
- 236 people
- Sponsor
- Lifetech Scientific (Shenzhen) Co., Ltd.
Congenital Heart Disease
Calprotectin and Gut Disease Study
Necrotising enterocolitis (NEC) is a serious gut disease that can develop in infants born with cardiac defects. It causes inflammation and injury to the gut mucosa and may be life-threatening.1 The aetiology of NEC in cardiac…
- Trial name
- SAFE NEC (NCT07112794)
- Volunteers
- 300 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Tetralogy of Fallot
Assessment of Right Ventricular Volume in Tetralogy of Fallott (TOF) Patients
Assessment of Right Ventricular Volume using the VentriPoint Medical system in patients with Tetralogy of Fallot following repair; a comparison study to cMRI.
- Trial name
- VMS TOF (NCT01419756)
- Testing
- VentriPoint Medical System
- Where
- 6 sites in United States, Canada
- Volunteers
- 109 people
- Sponsor
- VentriPoint Diagnostics Ltd.
Anesthesia; Hypothermia, Congenital Heart Disease
Evaluation of a Novel Patient Warming System During MRI
Patients under deep sedation and general anesthesia lose heat to their surrounding environment. Hypothermia after anesthesia is associated with worse patient outcomes, including increased number of infections and cardiovascular…
- Trial name
- NCT03150953
- Testing
- MRI-safe bore covering
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Andrew Matisoff
Congenital Heart Disease, Brain Injuries
Autologous Umbilical Cord Blood Treatment of Neonate With CHD
The aim of the study is to evaluate the feasibility and safety and efficacy of collecting and infusing autologous umbilical cord blood (UCB) in newborn infants with hypoplastic left heart syndrome (HLHS) and transposition of…
- Conditions
- Congenital Heart Disease, Brain Injuries, Low Cardiac Output Syndrome, Neonatal Disorder
- Trial name
- NCT03558269
- Testing
- Autlogous UCB infusion
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Sheba Medical Center
Primary Ciliary Dyskinesia, Kartagener Syndrome
Diagnosis of Primary Ciliary Dyskinesia
Primary ciliary dyskinesia is an inherited respiratory disease caused by various functional and ultrastructural abnormalities of respiratory cilia.
- Trial name
- DCP (NCT00783887)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 125 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Congenital Heart Disease (CHD), Postoperative Respiratory Dysfunction
Effect of Coughing Exercises Versus Incentive Spirometry on Respiratory Function and Recovery in Children After Cardiac Surgery.
This study examines the effects of coughing exercises and incentive spirometry (IS) on lung function and recovery in children who undergo heart surgery.
- Conditions
- Congenital Heart Disease (CHD), Postoperative Respiratory Dysfunction, Postoperative Recovery After Cardiac Surgery
- Trial name
- CEXIS (NCT07405333)
- Testing
- Coughing Exercises, Incentive Spirometry, Standard Postoperative Care
- Where
- 4 sites in Iraq
- Volunteers
- 99 people
- Sponsor
- University of Baghdad
Double Outlet Right Ventricle
Surgical Planning for Reconstruction of Complex Heart Defects
The purpose of this study is to utilize cardiac imaging data acquired as part of the standard of care for these patients, such as MRI, 3D echo, and CT, and existing 3D reconstruction protocols to assess the feasibility of using…
- Trial name
- NCT00972608
- Testing
- Anatomic Reconstruction and Surgical Planning
- Where
- 2 sites in United States
- Volunteers
- 66 people
- Sponsor
- Emory University
Cardiovascular Diseases, Defect, Congenital Heart
Family Study of Congenital Cardiovascular Malformations
To determine genetic mechanisms responsible for congenital cardiovascular malformations.
- Conditions
- Cardiovascular Diseases, Defect, Congenital Heart, Heart Diseases
- Trial name
- NCT00005258
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Patent Ductus Arteriosus After Premature Birth
Hemodynamically Important Patent Ductus Arteriosus in Newborns Under 32 Weeks
To define the characteristics of hemodynamically significant PDA by echocardiography, to investigate the systemic effects of the ductus with cerebral and renal Doppler flow studies, and to determine the oxygen consumption in the…
- Trial name
- NCT05686343
- Testing
- Echocardiography, Doppler ultrasonography, Near-infrared spectroscopy
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Ankara University
Cardiovascular Diseases, Heart Diseases
Epidemiology of Long QTand Asian Sudden Death in Sleep
To conduct a cross-sectional epidemiologic study of the determinants of prolonged heart rate corrected QT interval (QTc) among 300 men and 300 woman in the population with the highest known risk of SUDS: Southeast Asian refugees…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Arrhythmia, Death, Sudden, Cardiac
- Trial name
- NCT00005367
- Sponsor
- Utah State University
Congenital Heart Disease
Value of MRI in Congenital Heart Disease
Congenital heart disease (CHD) is the most prevalent congenital anomaly and a major cause of infant morbidity and mortality. It encompasses various cardiac chamber anomalies.
- Trial name
- NCT06752187
- Volunteers
- 55 people
- Sponsor
- Assiut University
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