Clinical trials: Heart Defects
CT Coronary Angiography, Arterial Switch Operation
CT Coronary Angiography After Arterial Switch Operation
The purpose of this study is to find a non-invasive alternative (with using ECG gated 64-slice CT angiography) to invasive coronary angiography for detecting coronary lesions in patients who had undergone arterial switch…
- Trial name
- SCANTGV (NCT01153776)
- Testing
- 64-slice CT angiography
- Where
- France
- Volunteers
- 42 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Primary Ciliary Dyskinesia, Kartagener Syndrome
Longitudinal Characterization of Respiratory Tract Exacerbations and Treatment Responses in Primary Ciliary Dyskinesia
The overall objective of this longitudinal, observational study is to provide information needed to inform the design of future interventional trials of respiratory exacerbation prevention and treatment in children and adults…
- Trial name
- NCT05161858
- Where
- 7 sites in United States, Canada
- Volunteers
- 105 people
- Sponsor
- University of North Carolina, Chapel Hill
Caridovascular Disease, Congenital Heart Disease
Real-time MRI Right Heart Catheterization Using Passive Catheters
Background: Currently, heart catheterization procedures are guided by X-rays. Researchers are developing new techniques to perform heart catheterization without the use of X-rays by investigating possible uses of magnetic…
- Conditions
- Caridovascular Disease, Congenital Heart Disease, Pulmonary Hypertension
- Trial name
- NCT01287026
- Testing
- Cardiac Real-time MRI RHC (Right Heart Catheterization)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Hypoplastic Left Heart Syndrome, Single Ventricle
Transcoronary Infusion of Cardiac Progenitor Cells in Patients With Single Ventricle Physiology
Hypoplastic left heart syndrome (HLHS) and related anomalies involved a single ventricle are characterized by hypoplasia of the left heart and the aorta with compromised systemic cardiac output.
- Conditions
- Hypoplastic Left Heart Syndrome, Single Ventricle, Heart Failure
- Trial name
- TICAP (NCT01273857)
- Testing
- Autologous cardiac progenitor cell transplantation, staged shunt procedure
- Where
- Japan
- Volunteers
- 14 people
- Sponsor
- Okayama University
Hypoplastic Left Heart Syndrome
Cerebral Anatomy, Hemodynamics and Metabolism
Single ventricle lesions are the leading cause of illness and death from congenital heart disease. The modified Fontan Operation is the corrective surgery for these lesions.
- Trial name
- NCT02919956
- Testing
- Magnetic Resonance Imaging, Neurodevelopmental Testing
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Patent Ductus Arteriosus
Serum Level Measurement of Oral Paracetamol and Oral Ibuprofen for Patent Ductus Arteriosus Treatment in Preterm Infants
The purpose of this study is to determine oral paracetamol and ibuprofen efficacy and safety in relation to serum levels in closure of patent ductus arteriosus in preterm infants.
- Trial name
- NCT01544972
- Testing
- Oral paracetamol, Oral ibuprofen
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
Congenital Heart Diseases
The Protective Effects of Sevoflurane in Pediatric Cardiac Surgery
During repair of a congenital heart defect the child is exposed to myocardial hypoxia. Recent studies have suggested that the paediatric myocardium is more sensitive to hypoxia and cardioplegic arrest than the adult.
- Trial name
- NCT01450956
- Testing
- Sevoflurane, Control
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Xijing Hospital
Wolff-Parkinson-White Syndrome
Accessory Pathway Antegrade Effective Refractory Period Among WPW Patients: the Risk in Relation to the Location
To correlate the antegrade effective refractory period of the accessory pathway with its anatomical location in the heart. To investigate whether the accessory pathway location can predict the high risk nature of the accessory…
- Trial name
- NCT04106622
- Testing
- electrophysiological study
- Volunteers
- 35 people
- Sponsor
- Assiut University
Marfan Syndrome
Atenolol Versus Losartan in the Prevention of Progressive Dilation of the Aorta in Marfan Syndrome
The purpose of this study is to evaluate the efficacy of Losartan versus Atenolol in the progression of aortic dilatation in patients with Marfan syndrome.
- Trial name
- LO-AT-MARFAN01 (NCT01145612)
- Testing
- Losartan, Atenolol
- Where
- 2 sites in Spain
- Volunteers
- 140 people
- Sponsor
- Forteza, Albert, M.D.
Respiratory Distress Syndrome in Premature Infant, Patent Ductus Arteriosus After Premature Birth
Combined Lung Ultrasounds and Transthoracic Electrical Bioimpedance in Preterm Infants With Respiratory Distress.
Respiratory distress syndrome (RDS) is among the most common complications of preterm birth, and typically becomes manifested soon after birth.
- Conditions
- Respiratory Distress Syndrome in Premature Infant, Patent Ductus Arteriosus After Premature Birth, Perinatal Morbidity
- Trial name
- NCT04359134
- Where
- 2 sites in Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Bicuspid Aortic Valve
A Multicentre Retrospective Study on Bicuspid Aortic Valve
Bicuspid Aortic Valve (BAV) is a common congenital heart disease with an incidence ranging from 0.16% in Asians to 2% in Westerners.
- Trial name
- NCT05818722
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Congenital Heart Disease (CHD)
Feasibility of a Virtual Mental Health Intervention for Children with Congenital Heart Disease
Children with congenital heart disease are at much higher risk for behavioral and emotional difficulties in early childhood and beyond 1.
- Trial name
- NCT06659302
- Testing
- I-inTERACT North Step 1, I-inTERACT North step 2, I-inTERACT North
- Volunteers
- 20 people
- Sponsor
- University of Calgary
Aortic Coarctation
Comparison Between Serratus Anterior Plane Block and Erector Spinae Plane Block in Coarctectomy
Pain is considered to be subjective, however, in children, it is believed to be felt rather than expressed because they often depend on the caregiver for their safety and well-being.
- Trial name
- NCT06567275
- Testing
- Erector Spinae Plane Block, Serratus Anterior Plane Block
- Where
- Egypt
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pulmonary Arterial Hypertension
Clinical Study to Assess the Long-term Safety, Tolerability, and Efficacy of Macitentan in Subjects With Eisenmenger Syndrome
Long-term study to evaluate if macitentan is safe, tolerable and efficient enough to be used for treatment of Eisenmenger syndrome.
- Trial name
- MAESTRO-OL (NCT01739400)
- Testing
- Macitentan 10 mg tablet, once daily.
- Where
- 51 sites in United States, Austria and 17 more
- Volunteers
- 217 people
- Sponsor
- Actelion
Congenital Heart Disease
Parenting After Infant Congenital Heart Defect Diagnosis
The purpose of this research study is to learn about parents' experiences following diagnosis of a fetal/neonatal Congenital Heart Defect (CHD).
- Trial name
- NCT01503307
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- Medical College of Wisconsin
Congenital Heart Disease, Psychological Intervention
Psychological Functioning of Children and Adolescents With CHD andTheir Parents, An Intervention Based Study
Almost 1% of infants are born with Congenital Heart Disease (CHD), an umbrella term referring to a range of anomalies in the heart's structure that are present at birth.
- Conditions
- Congenital Heart Disease, Psychological Intervention, Parenting, Quality of Life
- Trial name
- CHDPIM (NCT05109806)
- Testing
- problem prevention therapy with CHD
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Government College University Faisalabad
Atrial Septal Defect (ASD), Dexmedetomidine
Effect of Dexmedetomidine Supplementation to General Anaesthesia in Paediatric Transcatheter Closure of Atrial Septal Defect
The aim of this randomized trial is to determine efficacy of dexmedetomidine in improving quality of recovery in pediatric patients undergoing interventional catheter closure of ASD while maintaining the hemodynamic parameters.
- Conditions
- Atrial Septal Defect (ASD), Dexmedetomidine, Delirium - Postoperative, Stress Response
- Trial name
- NCT06631534
- Testing
- Dexmedetomidine
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Alexandria University
Hypoplastic Left Heart Syndrome
Family Adaptation Study Following the Diagnosis of Hypoplastic Left Heart Syndrome in a Newborn
Survival for one of the most complex forms of congenital heart disease, hypoplastic left heart syndrome (HLHS), has improved dramatically.
- Trial name
- NCT00734643
- Where
- United States
- Volunteers
- 213 people
- Sponsor
- Medical College of Wisconsin
Tetralogy of Fallot, Hypoplastic Left Heart Syndrome
Impact of NAVA Ventilation on Brain Oxygenation and Perfusion in Children With Congenital Heart Disease
Positive intra-thoracic pressures induced by mechanical ventilation can negatively impact right heart hemodynamics by restricting systemic venous return and increasing right ventricular afterload.
- Conditions
- Tetralogy of Fallot, Hypoplastic Left Heart Syndrome, Univentricular Heart, Heart Defects, Congenital
- Trial name
- NCT04581668
- Testing
- Two ventilation periods with two different modes: conventional ventilation followed by NAVA.
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- St. Justine's Hospital
Congenital Heart Disease, Child Development
A Parent-child Yoga Intervention for Reducing Attention Deficits in Children with Congenital Heart Disease: a Feasibility Study
The proposed study aims to determine the feasibility of the procedures for a future full randomized controlled trial (RCT), which will test the efficacy of a parent-child yoga intervention in reducing attention deficits in…
- Conditions
- Congenital Heart Disease, Child Development, Neurodevelopmental Disorders, Parents
- Trial name
- NCT05997680
- Testing
- Parent-child yoga
- Where
- 2 sites in Canada
- Volunteers
- 24 people
- Sponsor
- Anne Gallagher
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