Clinical trials: Highly Sensitive
Peanut Allergy
High Threshold Peanut Challenge Study
This protocol is designed to better characterize a sub-population of peanut sensitized individuals who may be non-allergic, despite significant sensitization, or who may be allergic, but at high threshold doses.
- Trial name
- PAID-UP (NCT02698033)
- Testing
- Peanut flour, Toasted oat flour
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Peanut Allergy
High and Low Dose Oral Peanut Immunotherapy - Comparison of Efficacy and Safety
In this trial the investigators aim to assess the effectiveness and safety of oral immunotherapy with peanut protein in high and low dose (300mg versus 150mg) in children with peanuts allergy.
- Trial name
- NCT04415593
- Testing
- High dose of peanuts, Low dose of peanuts
- Where
- Poland
- Volunteers
- 44 people
- Sponsor
- Medical University of Warsaw
Asthma
Asthma Express: Bridging the Emergency to Primary Care in Underserved Children
Asthma is the number one cause of pediatric emergency department (ED) visits in young minority children and is responsible for high healthcare costs.
- Trial name
- NCT01981564
- Testing
- Asthma Express Intervention, Standard Asthma Education Control Group
- Where
- United States
- Volunteers
- 222 people
- Sponsor
- Johns Hopkins University
Malaria,Falciparum, Malaria in Pregnancy
Improving Neonatal Health Through Rapid Malaria Testing in Early Pregnancy With High-Sensitivity Diagnostics
The purpose of the INTREPiD study is to compare 1st trimester screening for malaria parasites with a high-sensitivity malaria rapid diagnostic test followed by treatment of test-positive women with artemether-lumefantrine (AL)…
- Conditions
- Malaria,Falciparum, Malaria in Pregnancy, Malaria in Childbirth, Pregnancy
- Trial name
- INTREPiD (NCT05757167)
- Testing
- Malaria High-Sensitivity Rapid Diagnostic Test (HS-RDT), Artemether-lumefantrine (AL)
- Where
- 2 sites in Democratic Republic of the Congo, Kenya
- Volunteers
- 2,174 people
- Sponsor
- Duke University
Asthma
Efficacy of Dupilumab Added to Medium Dose Inhaled Corticosteroid/Long-acting Beta-agonist (ICS/LABA) in Comparison to ICS Dose Escalation to High Dose ICS/LABA in Adolescent and Adult Patients With Uncontrolled Asthma
This study is researching a drug called dupilumab. The study is focused on patients who have uncontrolled asthma. Asthma is a condition where the airways narrow and swell, making it difficult to breathe.
- Trial name
- AIM4:Next Step (NCT06572228)
- Testing
- dupilumab, ICS/LABA
- Where
- 77 sites in United States, Canada and 4 more
- Volunteers
- 120 people
- Sponsor
- Regeneron Pharmaceuticals
Asthma
Vitamin D and Severe Asthma Exacerbations
This study of vitamin D is designed to assess both the safety and efficacy of potential doses (2,000 IU/day and 4,000 IU/day) in raising a vitamin D level to a normal range in a short period of time (e.g.
- Trial name
- SAVED-P (NCT01921894)
- Testing
- Cholecalciferol
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Pittsburgh
Asthma
Comparison of Nebulizers in ED in Pediatric Asthma Patients
The primary objective will be, in an open-label randomized trial, a comparison of emergency department (ED) length of stay (LOS) between children experiencing acute asthma treated with two different nebulizers.
- Trial name
- NCT01951378
- Testing
- Hudson RCI® nebulizer, NebuTech® HDN® nebulizer, Albuterol
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Seton Healthcare Family
Asthma
Improving Asthma Outcomes in an Urban Pediatric Population
Little is known about how ED-based programs can help to reduce pediatric ED visits for asthma. The current study evaluated a novel intervention in which the ED itself became the site of highly individualized, comprehensive…
- Trial name
- NCT00140439
- Testing
- Emergency Department based asthma follow-up clinic
- Where
- United States
- Volunteers
- 488 people
- Sponsor
- Stephen J. Teach, MD, MPH
Acute Coronary Syndrome, Myocardial Infarction
High-Sensitivity Cardiac Troponin On Presentation to Rule Out Myocardial Infarction
Patients with suspected acute coronary syndrome account for a tenth of all presentations to the Emergency Department and up to 40 per cent of unplanned hospital admissions.
- Trial name
- HiSTORIC (NCT03005158)
- Testing
- Validation Phase, Randomization Phase, Implementation Phase
- Volunteers
- 31,492 people
- Sponsor
- University of Edinburgh
Asthma, Airway Hyperresponsiveness
Bronchospasm Associated With High Nitric Oxide
Intraoperative bronchospasm challenges anesthesia's safety. This study aims to investigate high concentration of exhaled nitric oxide as a marker of intraoperative bronchospasm.
- Trial name
- NCT00666510
- Where
- Brazil
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Food Allergy
High and Low Dose Oral Sesame Immunotherapy - Comparison of Efficacy and Safety
In this trial the investigators aim to assess the effectiveness and safety of oral immunotherapy with sesame protein in high and low dose (300mg versus 1200mg) in children with sesame allergy.
- Trial name
- Sesame (NCT05158413)
- Testing
- High dose, Low dose
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Medical University of Warsaw
Thalassemia
Adiponectin, IL-6 and hsC-RP in Relation to Carotid Intima-media Thickness in B-thalassemia Patients
Every year, 100,000 neonates are born with hemoglobinopathies around the world. Thalassemia is the most common heterogeneous disease of the human being .
- Trial name
- NCT03170245
- Testing
- Interleukin-6, HsC-RP, Adiponectin level
- Where
- Egypt
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Assiut University
Immunity
A Clinical Study to Investigate the Effect of a Partially Hydrolysed Infant Formula With Added Synbiotics on the Development of Allergic Manifestations in Infants at High Risk of Developing Allergy
With the rising prevalence of allergic diseases and the subsequent risk of developing other immune-related disorders, primary prevention of allergy has become a major priority.
- Trial name
- MAESTRO (NCT03062995)
- Testing
- Infant Formula with added synbiotics, Standard Infant formula
- Volunteers
- healthy volunteers welcome
- Sponsor
- Nutricia Research
Gestational Diabetes Mellitus in Pregnancy
Can Albumin/C-reactive Protein Ratio be Utilized for Predicting Gestational Diabetes Diagnosis or the Adverse Outcomes
This study provides a comprehensive evaluation of the potential utility of the albumin/high-sensitivity C-reactive protein (hsCRP) ratio in diagnosing gestational diabetes mellitus (GDM) and predicting adverse pregnancy outcomes.
- Trial name
- Alb/hsCRP (NCT06761053)
- Testing
- Intervention/Exposure for the GDM Group (Experimental Arm), Intervention/Exposure for the Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Mustafa Kemalpasa Government Hospital
Asthma, Airway Inflammation
Asthma Study Comparing Anti-Inflammatory Effects of 3 Doses of Mometasone Furoate/Formoterol Fumarate and Medium Dose Mometasone Furoate (Study P05122 AM1)(COMPLETED)
This is a 2-week double-blind, placebo-controlled, parallel group study comparing the anti-inflammatory effects of low, medium, and high dose mometasone furoate/formoterol fumarate (MF/F) metered dose inhaler (MDI) formulation…
- Trial name
- NCT00635882
- Testing
- mometasone furoate/formoterol 100/10 mcg, mometasone furoate/formoterol 200/10 mcg, mometasone furoate/formoterol 400/10 mcg
- Volunteers
- 93 people
- Sponsor
- Organon and Co
Asthma
Effects of Mometasone Furoate/Formoterol Combination Versus Mometasone Furoate Alone in Persistent Asthmatics (Study P04431AM2)(COMPLETED)
This is a randomized, multicenter, double blind, parallel-group study evaluating the efficacy of mometasone furoate/formoterol fumarate (MF/F) metered dose inhaler (MDI) 400/10 mcg twice daily (BID) compared with MF MDI 400 mcg…
- Trial name
- NCT00381485
- Testing
- Mometasone furoate/formoterol (MF/F) combination, Mometasone furoate MDI (MF MDI)
- Volunteers
- 834 people
- Sponsor
- Organon and Co
Asthma
Preventing Asthma in High Risk Kids
This trial is a randomized, double-blind, placebo controlled trial designed to test whether two years treatment of preschool children aged 2-3 years of age at high risk for asthma with omalizumab (anti-IgE) for two years will…
- Trial name
- PARK (NCT02570984)
- Testing
- Omalizumab
- Where
- 13 sites in United States
- Volunteers
- 200 people
- Sponsor
- Boston Children's Hospital
Peripheral Arterial Disease, Myocardial Injury
Cardiovascular Risk in Peripheral Artery Disease Patients Undergoing Endovascular Revascularisation
This study will investigate heart-related complications in patients with peripheral arterial disease (PAD) undergoing endovascular revascularization procedures to improve blood flow in the legs.
- Conditions
- Peripheral Arterial Disease, Myocardial Injury, Troponin, NT-proBNP
- Trial name
- RISK (NCT07599540)
- Where
- Slovenia
- Volunteers
- 500 people
- Sponsor
- University Medical Centre Ljubljana
Systemic Lupus Erythematosus
Highly Sensitive Serum Cardiac Troponin T and Cardiovascular Events in Patients With Systemic Lupus Erythematosus
Identification of biological markers able to better stratify cardiovascular risks in systemic lupus erythematosus patients is needed.
- Trial name
- TROPOPLUS (NCT04580108)
- Where
- France
- Volunteers
- 446 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Obesity
Adipokines in Obese Adolescents With Insulin Resistance
The purpose of this study is to compare serum concentrations of inflammatory cytokines, interleukin 6 (IL-6), High-sensitivity C-reactive protein (hs-CRP), adiponectin, and tumour necrosis factor alpha (TNFα), before and after…
- Trial name
- NCT01410604
- Testing
- Metformin
- Where
- 2 sites in Mexico
- Volunteers
- 31 people
- Sponsor
- Hospital Regional de Alta Especialidad del Bajio