Clinical trials: Highly Sensitive
Coronary Artery Disease, Percutaneous Coronary Intervention
Different Doses of Colchicine on hsCRP
Colchicine reduced atherothrombotic cardiovascular events in the COLCOT and LoDoCo2 studies. US Food and Drug Administration approved colchicine as the first anti-inflammatory drug for cardiovascular diseases on June, 2023.
- Trial name
- NCT06078904
- Testing
- Colchicine 0.5 MG, Colchicine 0.375 MG, Colchicine 0.25 MG
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Taste Sensitivity, Umami Taste Perception
Umami Taste Intensity and ad Libitum Meal Intake
Background Sweet and salty tastes can influence food intake {Sørensen, 2003 #40}. Increased intensity of these tastes has been shown to decrease food intake and increase satiation compared to the less intense taste, independent…
- Conditions
- Taste Sensitivity, Umami Taste Perception, Food Intake Regulation, Hedonic Function
- Trial name
- RiceSort (NCT07059117)
- Testing
- Hedonic mapping, Ad libitum risotto test meal
- Where
- Netherlands
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Non-ST-elevation Myocardial Infarction (NSTEMI)
Hs-cTnI Diagnosis of NSTE-ACS Patients in China
This study is to validate 1-hour and 3-hours diagnostic strategy using Architect high-sensitivity cardiac troponin I (hs-cTnI) in Chinese patients with suspected Non-ST-elevation Myocardial Infarction (NSTEMI).
- Trial name
- HEADLINES (NCT03734796)
- Where
- China
- Volunteers
- 2,400 people
- Sponsor
- China National Center for Cardiovascular Diseases
Obesity, Insulin Resistance
Effects of Exercise Training Intensity on Fitness and Insulin Sensitivity in African Americans
African Americans are at a substantially greater type 2 diabetes risk compared to Caucasians; however, very little data are available on the effects of exercise training on type 2 diabetes risk factors in at risk African…
- Conditions
- Obesity, Insulin Resistance, Sedentary Lifestyle
- Trial name
- HI-PACE (NCT02892331)
- Testing
- Moderate intensity exercise training (MOD-INT), High Intensity exercise training (HI-INT)
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- East Carolina University
Breast Cancer
SAHARA-04 : Adaptive Radiotherapy in Hypersensitive Patients and High Locoregional Risk Breast Cancer With ETHOS Technology
Prospective, open-label, bi-center study, assessing the clinical outcomes of adaptive breast radiotherapy with ETHOS in hypersensitive patients.
- Trial name
- SAHARA-04 (NCT06053086)
- Testing
- Treatment ETHOS radiotherapy, Conventional IMRT
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
End-stage Renal Disease
Study of High Sensitive Troponin-I Level in End-stage Renal Disease Patients Receiving Hemodialysis
This study objective is to compare the high sensitive troponin-I level in end-stage renal disease patients received hemodialysis without acute cardiovascular event with healthy population.
- Trial name
- NCT02572466
- Testing
- Hemodialysis
- Where
- Thailand
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Schizophrenia, Cognitive Dysfunction
Supportive Psychotherapy as Adjunct to Risperidone for Cognitive Function and Inflammation in Schizophrenia
This study examined whether adding structured supportive psychotherapy to risperidone treatment is more effective than risperidone alone in improving cognitive function and reducing inflammation in patients with schizophrenia.
- Conditions
- Schizophrenia, Cognitive Dysfunction, Inflamation
- Trial name
- SUPPORT-SCZ (NCT07477301)
- Testing
- Structured Supportive Psychotherapy, Risperidone 2 mg
- Where
- Indonesia
- Volunteers
- 46 people
- Sponsor
- Hasanuddin University
Acute Coronary Syndrome Without ST Elevation on Electrocardiogram
Calibration Study PREDICT - Prehospital Triage for Suspected Acute Coronary Syndrome Without ST-segment Elevation
The PREDICT calibration study is a prospective, non-interventional trial aiming to adapt and calibrate the ACS-Pathfinder algorithm for prehospital triage of patients with suspected non-ST-elevation acute coronary syndrome…
- Trial name
- PREDICT (NCT07419139)
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- Leipzig Heart Science gGmbH
Atherosclerosis, Diabetes Mellitus
Effects of Worksite Wellness Interventions on Vascular Function, Insulin Sensitivity and High-Density Lipoprotein in Overweight or Obese Women
Employees in developed societies are becoming increasingly sedentary at work and at home due to technological advances. Physical inactivity coupled with excess intake of calorie-rich foods are responsible for the epidemic of…
- Conditions
- Atherosclerosis, Diabetes Mellitus, Obesity, Dyslipidemia
- Trial name
- NCT00666172
- Testing
- Exercise, Weight Loss
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Acute Myocardial Infarction
Hemorrhagic Myocardial Infarction Detection by Post-reperfusion Troponin Kinetics
Pilot trial to determine diagnostic efficacy of post-reperfusion troponin kinetics in detection of hemorrhagic myocardial infarction
- Trial name
- MIRON-TROP (NCT05872308)
- Where
- 2 sites in United States, India
- Volunteers
- 227 people
- Sponsor
- Rohan Dharmakumar
Chest Pain, Coronary Artery Disease
Trial of Cardiac CT in Acute Chest Patients With Intermediate Level Initial High-sensitivity Cardiac Troponin
Patients who present to the emergency department (ED) with acute chest pain (ACP) possibly due to Coronary artery disease (CAD), with a normal heart tracing (ECG), need to have further troponin blood tests to confirm or exclude a…
- Conditions
- Chest Pain, Coronary Artery Disease, Acute Coronary Syndrome, Ischemic Heart Disease
- Trial name
- PROTECCT (NCT03583320)
- Testing
- Cardiac CT angiogram
- Where
- United Kingdom
- Volunteers
- 250 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Aging
Protein Quantity and Quality in Older Subjects
After the age of ~50, humans start to lose muscle mass at a rate of about 1-3% per year. However, the loss of muscle mass beyond a certain point can make it increasingly difficult to perform activities of daily living such as…
- Trial name
- NCT05301179
- Testing
- Protein quantity and quality
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- McMaster University
Lung Cancer
Almonertinib as First-line Treatment in Patients With EGFR Mutations Positive in Advanced NSCLC With Brain Metastases
This is a prospective, open-label, multi-center, single-arm clinical trial
- Trial name
- ACHIEVE (NCT04808752)
- Testing
- Almonertinib
- Where
- China
- Volunteers
- 63 people
- Sponsor
- Zhejiang Cancer Hospital
Asthma (Diagnosis), Pulmonary Function
Effect of Linvemastat in Patients With Partially Controlled Asthma (syMMPonia)
This study explores a potential new treatment for adults with moderate-to-severe asthma using a drug called linvemastat, which targets an enzyme linked to lung inflammation.
- Conditions
- Asthma (Diagnosis), Pulmonary Function, Moderate-to-Severe Asthma
- Trial name
- syMMPonia (NCT07191535)
- Testing
- linvemastat
- Volunteers
- 135 people
- Sponsor
- Foresee Pharmaceuticals Co., Ltd.
Adult Medulloblastoma, Childhood Medulloblastoma
Comparative Study of Sensitivity of Ga-DOTATOC PET vs Octreoscan SPECT + CT
This clinical trial studies gallium Ga 68-edotreotide positron emission tomography (PET)/computed tomography (CT) compared with indium In 111 pentetreotide plus contrast-enhanced CT (or MRI) in diagnosing patients with…
- Conditions
- Adult Medulloblastoma, Childhood Medulloblastoma, Neuroblastoma, Neuroendocrine Tumor
- Trial name
- NCT01869725
- Testing
- gallium Ga 68-edotreotide, positron emission tomography/computed tomography, indium In 111 pentetreotide
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Sue O'Dorisio
Anxiety Disorders, Anxiety
Personalized Feedback for Smokers With Elevated Anxiety Sensitivity
This project will develop and refine a computer-delivered integrated Personalized Feedback Intervention (PFI) that directly addresses smoking and anxiety sensitivity (AS).
- Conditions
- Anxiety Disorders, Anxiety, Tobacco Dependence, Smoking, Cigarette
- Trial name
- NCT03382093
- Testing
- Personalized Feedback Intervention, Smoking Information Control
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University of Houston
Bone Lesion
Artificial Intelligence and Bone Tomoscintigraphies Achieved With CZT Camera
This study aimed to determine whether the whole-body bone Single Photon Emission Computed Tomography (SPECT) recording times of around 10 minutes, routinely provided by a high-sensitivity 360 degrees cadmium and zinc telluride…
- Trial name
- IATOS (NCT06281015)
- Testing
- Whole-body bone single photon emission tomography (SPECT) for detection or follow-up of bone metastasis
- Where
- France
- Volunteers
- 19 people
- Sponsor
- Central Hospital, Nancy, France
Periodontal Inflammation
Saliva Levels of S100A12, CRP, Fetuin-A in Periodontal Disease Patients
Hs-CRP, Fetuin-A and S100A12 are acute phase proteins associated with many systemic diseases and conditions. The aim of this study was to determine the clinical parameters and salivary Hs-CRP, Fetuin-A and S100A12 levels before…
- Trial name
- NCT03345745
- Testing
- salivary samples
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Ordu University
Hay Fever
Evaluation of High Speed Laser Doppler Imaging Technology
Skin prick tests (SPT) are commonly used in daily allergological practice to assess skin reactivity to allergens. Multiple factors can contribute to non-optimal results of conventional wheal and flare measurement (CWFM) of SPT…
- Trial name
- HSL-DI (NCT02619331)
- Testing
- Allergy test reading
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Two-Dimensional Echocardiography
The Cardiopathic Features and Analysis of Risk Factors in the Elderly Diabetic
Objectives: To investigate the cardiac condition of the diabetic patients in our hospital in order to seek for the new diagnostic method of warning its cardiovascular complications in early times.
- Trial name
- NCT00940082
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Third Military Medical University