Clinical trials: Hyperoxia
Hyperoxemia, Oxygen Reserve Index
Oxygen Reserve Index and Prevention of Hyperoxemia
In patients under general anesthesia, the oxygen level (FiO2) used in inspiration is usually adjusted by monitoring the peripheral oxygen saturation level (SpO2).
- Conditions
- Hyperoxemia, Oxygen Reserve Index, Hyperoxia, Fraction of Inspired Oxygen
- Trial name
- NCT05505032
- Testing
- Oxygen, Masimo Root Radical 7
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Baskent University Ankara Hospital
Hyperoxia, Hypoxia
NICU Oxygen Control Study
Prematurely born infants in the hospital neonatal intensive care unit (NICU) will be included in the study. This clinical trial is a randomized crossover study to show that our automated oxygen control device performance is no…
- Trial name
- NCT04269161
- Testing
- Automatic control of inspired oxygen
- Where
- 2 sites in United States
- Volunteers
- 48 people
- Sponsor
- University of Missouri-Columbia
Hyperoxia
Hyperoxygenation in Anesthetized Children
This study is aiming at assessing the effect of inspired oxygen fraction during general anesthesia on children's lung mechanics and volume.
- Trial name
- OXPED (NCT02384616)
- Testing
- Oxygen
- Where
- Switzerland
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Walid HABRE
Premature Infant, Hypoxia
Measuring Oxygenation of Newborn Infants in Targeted Oxygen Ranges
The investigators aim to measure the effect of targeting premature babies to a slightly higher oxygen saturation target range (92-97%) than routinely used, for a brief period, to plan a future larger study of the effect of this…
- Conditions
- Premature Infant, Hypoxia, Hyperoxia
- Trial name
- MONITOR (NCT03360292)
- Testing
- Higher target range
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Edinburgh
Hyperoxia, Hypoxia
Computer-assisted Oxygen Therapy Weaning in Critically Ill Children
The study is designed to evaluate the feasibility, safety and clinical utility of using an adaptive model to wean oxygen by computer assistance.
- Trial name
- NCT03550469
- Testing
- Computer-assisted Oxygen Weaning
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Stanford University
Oxygen Toxicity, Oxidative Stress
Optimized Oxygen Delivery During General Anesthesia in Newborn Infants
An open randomized control trial investigating the delivery of two levels of inspired oxygen to newborn infants during general anesthesia.
- Trial name
- ANOXneo (NCT02698020)
- Testing
- Room-air
- Where
- Sweden
- Volunteers
- 35 people
- Sponsor
- Uppsala University
Premature Infant, Oxygen Therapy
Servo Controlled Oxygen Targeting Study
Most premature babies require oxygen therapy. There is uncertainty about what oxygen levels are the best. The oxygen levels in the blood are measured using a monitor called a saturation monitor and the oxygen the baby breathes is…
- Conditions
- Premature Infant, Oxygen Therapy, Hypoxia, Hyperoxia
- Trial name
- SCO2T (NCT04177992)
- Testing
- Servo control
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- University of Edinburgh
Psychosis, Schizophrenia
Normobaric Oxygen Therapy for Individuals With First-Episode Psychosis
Single-blind, randomized controlled trial of normobaric oxygen therapy among individuals with first-episode psychosis: Effects on symptomatology and cognition.
- Conditions
- Psychosis, Schizophrenia, First-episode Psychosis
- Trial name
- NCT04368039
- Testing
- Normobaric Oxygen
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Nicholas Breitborde
Infant, Newborn, Diseases, Mechanical Ventilation Complication
Optimising Neonatal Ventilation with Closed-loop Oxygen Control
Ventilated newborns frequently need supplemental oxygen but its use must be monitored carefully as both giving too much or too little oxygen can have harmful effects.
- Trial name
- NCT05657795
- Testing
- Closed-loop automated oxygen control (Oxygenie, SLE6000)
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- King's College Hospital NHS Trust
Traumatic Brain Injury
Comparison Between Different Types of Oxygen Treatment Following Traumatic Brain Injury
The purpose of this study is to study the effects of EARLY (no more than 24 four hours from injury) administration of extra amounts of oxygen on traumatic brain injury.
- Trial name
- NCT00170352
- Testing
- Hyperbaric Oxygen Treatment (HBOT), Enhanced Oxygen Treatment (Enhanced FiO2)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Hennepin Healthcare Research Institute
Response to Hyperoxia
Neonatal Cerebral Oxygenation After Exposure to Oxygen Evaluated With the INVOS Oximeter
Due to the increased risk of brain damage, continuous monitoring of the cerebral oxygenation is interesting. The investigators will evaluate the capability of the INVOS Oximeter to detect induced changes in the cerebral regional…
- Trial name
- NCT01690650
- Testing
- Oxygen
- Where
- Denmark
- Volunteers
- 33 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Chronic Obstructive Pulmonary Disease
Helium-Hyperoxia and 6MWT Distance in COPD
We assessed the effect of altering inspired gas on the 6MWT distance in COPD. We hypothesized that HeO2 would improve walking distance and reduce shortness of breath compared to both RA and O2, and potentially improve quality of…
- Trial name
- NCT00394225
- Testing
- Oxygen, Helium
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- University of Saskatchewan
Oxygen Toxicity, Hyperoxia
Hyperbaric Oxygen Therapy Effects on Pulmonary Functions
Prospective analysis included patients, 18 years or older, scheduled for 60 daily HBOT sessions between 2016-2018. Each session was 90 min of 100% oxygen at 2 ATA with 5 minutes air breaks every 20 min, five days per week.
- Trial name
- PulmHBOT (NCT03754985)
- Testing
- Hyperbaric oxygen therapy
- Where
- Israel
- Volunteers
- 105 people
- Sponsor
- Assaf-Harofeh Medical Center
Respiratory Distress Syndrome, Hyperoxia
Clinical Evaluation of a Closed Loop Oxygen Controller for Neonatal Respiratory Care
Nearly forty years ago Berran and coworkers tested an analog oxygen controller to maintain incubator oxygen levels for infants suffering neonatal respiratory disease in order to prevent hyperoxia.
- Conditions
- Respiratory Distress Syndrome, Hyperoxia, Prematurity
- Trial name
- NCT00887731
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Utah
Pulmonary Disease, Chronic Obstructive
Breathing Helium-Hyperoxia During Exercise in Patients With Chronic Obstructive Pulmonary Disease
Regular exercise can help patients with the lung disease, chronic obstructive pulmonary disease (COPD). But COPD patients have a hard time with training because of their breathing.
- Trial name
- NCT01283685
- Testing
- breathing helium-hyperoxia, breathing supplemental oxygen
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- West Park Healthcare Centre
Bronchopulmonary Dysplasia, Retinopathy of Prematurity
Genes Associated With Bronchopulmonary Dysplasia and Retinopathy of Prematurity
Background: Some premature babies develop bronchopulmonary dysplasia (BPD) and retinopathy of prematurity (ROP). BPD and ROP are long-term chronic diseases of the lungs and eyes, respectively.
- Conditions
- Bronchopulmonary Dysplasia, Retinopathy of Prematurity, Prematurity, Pulmonary Disease
- Trial name
- NCT01780155
- Where
- 8 sites in United States, Argentina
- Volunteers
- 1,068 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Infant Respiratory Distress Syndrome, Ventilator Lung; Newborn
Closed-loop Automatic Oxygen Control (CLAC-4) in Preterm Infants
Two-center, randomised controlled, cross-over clinical trial in preterm infants born at gestational age below 34+1/7 weeks receiving supplemental oxygen and respiratory support (Continous positive airway pressure (CPAP) or…
- Trial name
- CLAC-4 (NCT03163108)
- Testing
- Closed-loop automatic oxygen control (CLAC) fast in addition to RMC, Closed-loop automatic oxygen control (CLAC) slow in addition to RMC
- Where
- 2 sites in Germany
- Volunteers
- 19 people
- Sponsor
- University Hospital Tuebingen
Premature Infant, Respiratory Insufficiency
Comparison of Oxygen Controllers in Preterm InfanTs
Premature infants often receive respiratory support and supplemental oxygen for a prolonged period of time during their admission in the NICU.
- Conditions
- Premature Infant, Respiratory Insufficiency, Hypoxia, Hyperoxia
- Trial name
- COCkPIT (NCT03877198)
- Testing
- Automated oxygen control by the CLiO2 algorithm, Automated oxygen control by the Oxygenie algorithm
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Leiden University Medical Center
COPD
CO2-Patterns During Hyperoxia and Physical Exercise in COPD
The aim of the study is to investigate a possible correlation between the change in PCO2 during a hyperoxia-test and the change in PCO2 during walking in people with COPD
- Trial name
- NCT04955561
- Testing
- Oxygen therapy, Medical Air, 10L/min O2
- Where
- Germany
- Volunteers
- 55 people
- Sponsor
- Schön Klinik Berchtesgadener Land
Anesthesia
Perioperative UtiLisation of SupplEmental Oxygen
The World Health Organisation recommends that all patients having a general anaesthetic for surgery should be given 80% oxygen as this might reduce their risk of getting an infection after their operation.
- Trial name
- PULSE Ox (NCT03552627)
- Testing
- Oxygen
- Where
- United Kingdom
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University Hospital Southampton NHS Foundation Trust