Clinical trials: Hypertensive Disorders
Essential Hypertension
Series of N-of-1 Crossover Trials of Antihypertensive Therapy in Adolescents With Essential Hypertension
Children are increasingly being diagnosed with essential hypertension and the absence of comparative effectiveness research in antihypertensive therapies has contributed to considerable differences in prescribing practices among…
- Trial name
- NCT02412761
- Testing
- Lisinopril, Amlodipine, Hydrochlorothiazide
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- The University of Texas Health Science Center, Houston
Preterm Labor, Small for Gestational Age at Delivery
Calcium Aspirin Multiple Micronutrients (CAMMS) to Reduce Preterm Birth
This trial will evaluate the impact of an integrated intervention of daily maternal calcium, aspirin, and multiple micronutrients (CAMMS) compared to iron-folic acid (IFA) during pregnancy on preterm birth and other adverse birth…
- Conditions
- Preterm Labor, Small for Gestational Age at Delivery, Hypertensive Disorder of Pregnancy, Low Birth Weight
- Trial name
- CAMMS (NCT05612984)
- Testing
- Calcium aspirin multiple micronutrients, Iron-folic Acid
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Hypertension in Pregnancy
Hypertensive Disorders of Pregnancy - the Neonatal Burden of Disease
Around one in ten women have high blood pressure in pregnancy. This is potentially serious, with risks to the woman and her baby.
- Trial name
- NCT05015049
- Where
- United Kingdom
- Volunteers
- 823,957 people
- Sponsor
- Imperial College London
Preeclampsia
Antenatal Platelet Response On Aspirin and Correlation With HDP (Hypertensive Disorders of Pregnancy)
This proposal has three aims to characterize the relationship between aspirin therapy, platelet function response, and prevention of hypertensive disorders of pregnancy (HDP) through a prospective, cohort study using…
- Trial name
- APROACH (NCT04295850)
- Testing
- Aspirin 81 mg
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Thomas Jefferson University
Hypertension
Dose Response of Valsartan on Sitting Systolic Blood Pressure in Children 6 Months - 5 Years of Age With High Blood Pressure
The purpose of this study is to evaluate the safety and efficacy of three doses of valsartan (0.25, 1.0, and 4.0 mg/kg) on mean sitting systolic blood pressure (MSSBP) and mean sitting diastolic blood pressure (MSDBP) in 6 months…
- Trial name
- NCT00435162
- Testing
- Valsartan 0.25 mg/kg, Valsartan 1.0 mg/kg, Valsartan 4.0 mg/kg
- Where
- 11 sites in United States, Belgium and 9 more
- Volunteers
- 74 people
- Sponsor
- Novartis Pharmaceuticals
Hypertensive Disorders of Pregnancy, Preeclampsia
Effectiveness of Two Aspirin Doses for Prevention of Hypertensive Disorders of Pregnancy: ASPIRIN TRIAL
The overall goal of this large, pragmatic, comparative effectiveness trial is to test the hypothesis that among at-risk individuals, 162 mg/day aspirin is superior to 81 mg/day in preventing Hypertensive disorders of pregnancy…
- Conditions
- Hypertensive Disorders of Pregnancy, Preeclampsia, Gestational Hypertension
- Trial name
- ASPIRIN (NCT06468202)
- Testing
- Aspirin 81 mg, Aspirin 162 mg
- Where
- 20 sites in United States
- Volunteers
- 10,742 people
- Sponsor
- Ohio State University
Pregnancy-Associated Hypertension, Gestational Hypertension
Community Health Worker Support to Lower Blood Pressure After a Pregnancy With High Blood Pressure
High blood pressure during or after pregnancy (such as preeclampsia, gestational hypertension, eclampsia, or Hemolysis, Elevated Liver enzymes, and Low Platelet (HELLP) syndrome) raises a mother's risk of heart disease later in…
- Conditions
- Pregnancy-Associated Hypertension, Gestational Hypertension, Preeclampsia, Eclampsia
- Trial name
- AW2H (NCT07778966)
- Testing
- Alabama Womb to Heart Solution (AW2H) Community Health Worker (CHW) Program, Usual postpartum care with self-measured blood pressure education and home blood pressure monitor
- Where
- United States
- Volunteers
- 174 people
- Sponsor
- University of Alabama at Birmingham
Neuroimaging, Cognitive Dysfunction
Long-term Consequences of Neuroimaging and Perceived Cognitive Dysfunction in oPRES
The purpose of this study is to explore the long-term consequences of neuroimaging and perceived cognitive dysfunction in obstetrics posterior reversible encephalopathy syndrome.
- Conditions
- Neuroimaging, Cognitive Dysfunction, Posterior Reversible Encephalopathy Syndrome
- Trial name
- NCT05140850
- Testing
- neuroimaging examination,neuro-cognitive test,blood pressure,blood sample
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Dunjin Chen
Hypertensive Intracerebral Hemorrhage
Acute Hypertensive Cerebral Hemmorrhage Surgery
The Neuroendoscopic, Trans-occipital Approach Evacuation of Acute Hypertensive Cerebral Hemmorrhage Combined Low-drainage Surgery: a Multi-center Clinical Trial
- Trial name
- NET-OCEAN (NCT04957849)
- Testing
- The Neuroendoscopic, Trans-occipital Approach Evacuation of Acute Hypertensive Cerebral Hemmorrhage Combined Low-drainage Surgery, Endoscopic Evacuation of Acute Hypertensive Intracerebral Hemorrhage via Trans-frontal keyhole approach
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Shanghai Changzheng Hospital
Hypertensive Disorder of Pregnancy
Thriving Hearts: Healing-Centered, Integrated, Community Maternity Care
The overarching goal of Thriving Hearts is to implement a multi-level program through Local Health Departments (LHDs) that cultivates conditions for mothers and birthing people to not only survive pregnancy, but to thrive.
- Trial name
- NCT06744231
- Testing
- Usual Care, Thriving Hearts
- Where
- United States
- Volunteers
- 17,500 people
- Sponsor
- University of North Carolina, Chapel Hill
Hypertension
Atacand Dose Ranging in Hypertensive Pediatric Subjects 1 Year to Less Than 6 Years of Age
This is a dose ranging study of candesartan cilexetil in hypertensive pediatric subjects ages 1 to less than 6 years of age. It employs a double blind, randomized, dose ranging design intended for conduct as a multicenter trial.
- Trial name
- NCT00244621
- Testing
- candesartan cilexetil (Atacand)
- Where
- 38 sites in United States, Belgium and 8 more
- Volunteers
- 95 people
- Sponsor
- AstraZeneca
Essential Hypertension
A Phase III Clinical Study of Valsartan Oral Solution for the Treatment of Hypertension in Children and Adolescents
This study was an randomized, double-Blind, placebo-controlled, multicenter Phase II/III study.
- Trial name
- NCT06863987
- Testing
- Valsartan Oral Solution
- Where
- China
- Volunteers
- 342 people
- Sponsor
- Shandong New Time Pharmaceutical Co., LTD
Preeclampsia, Eclampsia
The Preeclampsia Registry
The purpose of The Preeclampsia Registry is to collect and store medical and other information from women who have been medically diagnosed with preeclampsia or a related hypertensive (high blood pressure) disorder of pregnancy…
- Conditions
- Preeclampsia, Eclampsia, HELLP Syndrome, Toxemia
- Trial name
- TPR (NCT06377878)
- Where
- United States
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Preeclampsia Foundation
Hypertension;Nephropathy
Whole Exome Sequencing in CKD Hypertension
The prevalence of hypertension in patients with CKD in China is high but the control rate is low. Compared with the single blood pressure measurement method of the blood pressure of the office, ambulatory blood pressure…
- Trial name
- WESCH (NCT03718585)
- Testing
- whole exome sequencing analysis
- Where
- China
- Volunteers
- 4,000 people
- Sponsor
- Fifth Affiliated Hospital, Sun Yat-Sen University
Hypertension
Improving Outcomes for Hypertensive Children
Approximately 200 children age 6 - <18 years receiving medications for essential hypertension (HTN) will be recruited from the Pediatric Hypertension Clinic at the time of a routine clinic visit.
- Trial name
- NCT01485783
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- Arkansas Children's Hospital Research Institute
Basal Ganglionic Hemorrhage
Prognostic Factors for Surgical Management of Large Hypertensive Basal Ganglionic Haemorrhage
The aim of this study is to present current and comprehensive recommendations for surgical treatment of this hematoma and to determine the factors that may improve the survival rate
- Trial name
- NCT06309940
- Testing
- Prognostic factors of surgical evacuation of basal ganglionic haemorrhage
- Volunteers
- 25 people
- Sponsor
- Assiut University
Pre-Eclampsia, Eclampsia
Catestatin and Hypertension in Pregnancy
Catestatin is a kind of protein involved with cardiovascular disease. Accumulated evidence shows that Catestatin may be a predictor of primary hypertension, but whether it plays the same role in pregnant hypertensive disorders…
- Conditions
- Pre-Eclampsia, Eclampsia, Hypertension, Pregnancy-Induced, Hypertension in Pregnancy
- Trial name
- NCT03200743
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Yuchen Pan
Pulmonary Hypertension
Phase III Randomized Study of UT-15 in Patients With Primary Pulmonary Hypertension
OBJECTIVES: I. Determine the safety and efficacy of UT-15 in patients with severe symptomatic primary pulmonary hypertension.
- Trial name
- NCT00004497
- Testing
- UT-15
- Where
- 7 sites in United States
- Sponsor
- United Therapeutics