Clinical trials: Hypoxia Neonatal
Neonatal Acidemia and Hypoxia
Hypoxia Profiles Identified in Term Newborns With Cord pH <7.00
Severe neonatal acidosis is an identified risk factor for neonatal encephalopathies and severe neurological sequelae such as cerebral palsy.
- Trial name
- RCFHypA (NCT07333599)
- Where
- France
- Volunteers
- 400 people
- Sponsor
- University Hospital, Strasbourg, France
Hypoxic-Ischemic Encephalopathy
Neural Progenitor Cell and Paracrine Factors to Treat Hypoxic Ischemic Encephalopathy
The purpose of this study is to investigate the efficacy and safety of allogenic neural progenitor cell and paracrine factors of human mesenchymal stem cells for patients with moderate/severe Hypoxic-Ischemic Encephalopathy
- Trial name
- NCT02854579
- Testing
- neural progenitor cell, Paracrine factors, progenitor cell and paracrine factors
- Where
- 2 sites in China
- Volunteers
- 120 people
- Sponsor
- Navy General Hospital, Beijing
Hypoxic Ischemic Encephalopathy of Newborn, Neonatal Encephalopathy
Investigating Cerebral Oxygenation in the Newborn
The goal of this single centre observational study is to use near-infrared spectroscopy (NIRS) monitoring to investigate cerebral oxygenation in two groups of newborn infants who are at high risk of brain injury.
- Conditions
- Hypoxic Ischemic Encephalopathy of Newborn, Neonatal Encephalopathy, Premature Infant Disease
- Trial name
- ICON (NCT05588960)
- Testing
- Near-infrared spectroscopy monitoring (Masimo O3 Regional Oximeter with Neonatal Sensor)
- Where
- United Kingdom
- Volunteers
- 99 people
- Sponsor
- University of Edinburgh
Ischemic-Hypoxic Encephalopathy
Long Term Prognostic of Neonatal Hypoxic Ischemic Encephalopathy With Hypothermia Treatment
The primary objective is to evaluate neonatal characteristics, and biological and clinical investigations as predictive factors of death, or of severe and moderate neurodevelopmental disability at 3 years, in a large…
- Trial name
- LyTONEPAL (NCT02676063)
- Where
- 22 sites in France
- Volunteers
- 800 people
- Sponsor
- University Hospital, Grenoble
Perinatal Asphyxia
A Study of 2-Iminobiotin in Neonates With Perinatal Asphyxia
In case of insufficient oxygen supply to the brain of a newborn child (perinatal asphyxia), toxic compounds will be formed. These toxic compounds will damage the cells of the brain.
- Trial name
- NCT01626924
- Testing
- 2-Iminobiotin
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 6 people
- Sponsor
- Neurophyxia B.V.
Hypoxic Ischemic Encephalopathy of Newborn, Feeding Patterns
Continuous Versus Bolus Feeding in Neonates With Hypoxic Ischemic Encephalopathy
Therapeutic hypothermia (TH) is accepted worldwide as a standard of care for infants born at or beyond 36 weeks gestational age with moderate-to-severe hypoxic ischaemic encephalopathy (HIE).
- Trial name
- NCT06447155
- Testing
- Bolus feeding, Continuous feeding
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istanbul Training and Research Hospital
Hypoxic-ischemic Encephalopathy (HIE)
Therapeutic Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy in Vietnam
This study aims to evaluate the effectiveness of therapeutic hypothermia in neonates diagnosed with hypoxic-ischemic encephalopathy (HIE).
- Trial name
- HIE-TH Vietnam (NCT07555652)
- Testing
- Therapeutic Hypothermia
- Where
- Vietnam
- Volunteers
- 120 people
- Sponsor
- National Children's Hospital, Vietnam
Preterm Less Than 32wks With IVH, WMI/PVL, Late Preterm or Term (37-42wks) With Neonatal Encephalopathy Treated With Hypothermia for HIE
Cerebral/ Cortical Visual Impairment: Screening, Identification and Outcome Prediction in Neonates
Cerebral/Cortical Visual Impairment (CVI) is the leading cause of childhood visual impairment in the United States and other industrialized countries.
- Trial name
- CVI (NCT07275021)
- Testing
- Prospective Clinical and Neurodevelopmental Data Collection
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Brigham and Women's Hospital
Hypoxic-Ischemic Encephalopathy
PAEAN - Erythropoietin for Hypoxic Ischaemic Encephalopathy in Newborns
Double-blind, placebo controlled Phase III trial of erythropoietin for hypoxic ischaemic encephalopathy in infants receiving hypothermia.
- Trial name
- PAEAN (NCT03079167)
- Testing
- Epoetin Alfa, Normal saline
- Where
- 24 sites in Australia, New Zealand and 1 more
- Volunteers
- 313 people
- Sponsor
- University of Sydney
Hypoxic-Ischemic Encephalopathy
Systemic Hypothermia Improves Outcome of Hypoxic-Ischemic Encephalopathy
Perinatal asphyxia-induced brain injury is one of the most common causes of morbidity and mortality in term and preterm neonates.
- Trial name
- NCT00817401
- Testing
- hypothermia
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zhengzhou University
Pulmonary Hypertension Due to Lung Diseases and Hypoxia, Pulmonary Hypertension
Glucocorticoids and Pulmonary Hypertension
Pediatric idiopathic pulmonary hypertension has significant morbidity and mortality. An ever expanding body of knowledge indicates the important contribution of inflammation to pathogenesis and successful treatment with…
- Conditions
- Pulmonary Hypertension Due to Lung Diseases and Hypoxia, Pulmonary Hypertension, Bronchopulmonary Dysplasia
- Trial name
- NCT04499196
- Testing
- GlucoCorticoid
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Washington University School of Medicine
Hypoxic-Ischemic Encephalopathy, Brain Ischemia Hypoxia
CEUS Evaluation of Hypoxic Ischemic Injury
Neonates presenting with neurologic symptoms require rapid, non-invasive imaging with high spatial resolution and tissue contrast.
- Trial name
- NCT03549520
- Testing
- Sulfur hexafluoride lipid-type A microspheres
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Children's Hospital of Philadelphia
Asphyxia Neonatorum, Fetal Hypoxia
Sustained Cord Circulation at Emergency Cesarean Section
The goal of this clinical trial is to evaluate if sustained cord circulation during resuscitation improves outcomes for term neonates born by emergency Cesarean section.
- Trial name
- SUCCECS (NCT06540222)
- Testing
- Sustained cord (≥ 180 seconds) resuscitation, Routine (< 60 seconds) cord clamping
- Where
- 12 sites in Sweden
- Volunteers
- 2,200 people
- Sponsor
- Region Skane
Hypoxic-Ischemic Encephalopathy
The Effects of Minimal Enteral Nutrition on Mesenteric Blood Flow and Oxygenation in Neonates With HIE
The goal of this clinical trial is to evaluate the effects of minimal enteral nutrition (MEN) on mesenteric blood flow and oxygenation with Doppler USG and Near Infrared Spectroscopy (NIRS) during therapeutic hypo¬thermia (TH) in…
- Trial name
- NCT06344286
- Testing
- Minimal enteral nutrition, Distilled water
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istanbul Training and Research Hospital
Neurologic Manifestations, Premature Birth
The Neu-Prem Trial: Neuromonitoring of Preterm Newborn Brain During Birth Resuscitation
The purpose of this study is to characterize the normal brain function of premature infants (23 to 31+6 weeks GA) during birth transition and through the first 72 hours of life.
- Conditions
- Neurologic Manifestations, Premature Birth, Hypoxia-Ischemia, Brain
- Trial name
- Neu-Prem (NCT02605733)
- Testing
- EEG, NIRS
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Sharp HealthCare
Hypoxic Ischemic Encephalopathy
Darbe Administration in Newborns Undergoing Cooling for Encephalopathy
Selective head cooling or whole body hypothermia has become the standard of care for neonatal hypoxia-ischemia encephalopathy (HIE).
- Trial name
- DANCE (NCT01471015)
- Testing
- Darbepoetin alfa
- Where
- 7 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of Utah
Persistent Pulmonary Hypertension of Newborn
Nebulized Magnesium Sulfate and Sildenafil for Persistent Pulmonary Hypertension of Newborn
The aim of this study is to evaluate the effectiveness of nebulized magnesium sulfate combined with sildenafil citrate, compared with sildenafil citrate alone, in treating neonates with severe persistent pulmonary hypertension on…
- Trial name
- NCT04898114
- Testing
- Magnesium sulfate, Sildenafil Citrate, Isotonic saline
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Sohag University
Congenital Heart Defects, Brain Ischemia
Hypothermia Therapy in Pediatric Cardiac Intensive Care Unit for Suspected for Brain Injury
Cardiac pathology is a major risk for brain injury and neurodevelopmental deficit. The most common cause of cardiac pathology is congenital heart defects (CHD) about 4-8/1000 live births a year.
- Conditions
- Congenital Heart Defects, Brain Ischemia, Hypoxia Brain, Child
- Trial name
- Coolheart (NCT02395276)
- Testing
- Whole body hypothermia
- Volunteers
- 75 people
- Sponsor
- Sheba Medical Center
Cerebral Hypoxia
Neonatal Brain Oxygenation Study
Implementing target ranges for regional cerebral saturations in extremely preterm infants in the first week of life may improve neurodevelopmental outcomes at 22-26 months corrected age compared to those without targeted cerebral…
- Trial name
- BOX (NCT04439968)
- Testing
- Clinical algorithm
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Stanford University
Neurodevelopmental Disorders, Neurodevelopmental Disorders (NDD)
Intensive Multimodal Neurorehabilitation Targeting Neuroplasticity in Pediatric Neurodevelopmental and Chromosomal Disorders
This observational study evaluates functional and developmental outcomes in pediatric participants undergoing a two week intensive multimodal neurorehabilitation program.
- Conditions
- Neurodevelopmental Disorders, Neurodevelopmental Disorders (NDD), Neurodevelopmental Disorders and Developmental Abnormalities, Developmental Delay (Disorder)
- Trial name
- GEN-HOPE (NCT07493096)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Healing Hope International