Clinical trials: ICSI
Pentoxifylline Allergy
Beneficial Effect of Adding Pentoxifylline to Processed Semen Samples on ICSI Outcome in Infertile Males
To evaluate the effect of pentoxifylline used in preparation of semen samples that will be used for ICSI in infertile men complaining of mild and moderate asthenozoospermia (i.e.
- Trial name
- NCT01793272
- Testing
- effect of pentoxifylline on ICSI outcome
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Adam International Hospital
Conventional IVF, ICSI
Child Follow-up in Women Treated With Conventional IVF or ICSI
To compare the physical, mental and motor development of babies born from pregnancy using ICSI technique and and conventional IVF in non-male factor infertile couples.
- Trial name
- NCT04866524
- Testing
- Developmental score according to The Ages & Stages Questionnaires®, Third Edition - ASQ®-3, Physical development and General Health, Developmental Red flags
- Where
- Vietnam
- Volunteers
- 322 people
- Sponsor
- Mỹ Đức Hospital
Embryo Hypoxia
The Effect of Low Oxygen Tension on the Early Development of Human Embryo in IVF/ICSI
To investigate the effect of low oxygen tension during in vitro culture in terms of embryo quality and outcomes of pregnancy in vitro fertilization/ Intracytoplasmic sperm injection
- Trial name
- NCT01983696
- Testing
- 5% oxygen concentration
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanxi Provincial Maternity and Children's Hospital
Ovarian Stimulation
Lutropin Alfa in Women at Risk of Poor Response
Evaluate the effectiveness of adding lutropin alfa (recombinant human luteinizing hormone [r-hLH]) in the middle of the follicular phase compared to no addition, in infertile women at risk of poor response stimulated with…
- Trial name
- NCT01112358
- Testing
- r-FSH, r-hLH, Analogous GnRH antagonist
- Where
- Spain
- Volunteers
- 58 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Polycystic Ovarian Syndrome
Letrozole Combined With Gonadotropins (Gn) for Ovarian Stimulation Undergoing in Vitro Fertilization/Intracytoplasmic Sperm Injection (IVF/ICSI) in Patients With Polycystic Ovary Syndrome (PCOS)
The purpose of this study is to determine whether letrozole combined with gonadotropins are effective in the ovarian hyperstimulating for IVF/ICSI in patients with PCOS.
- Trial name
- NCT00894608
- Testing
- letrozole + gonadotropins, GnRHa + gonadotropins
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Yunyang Medical College
Infertility, Intracytoplasmic Sperm Injection
Health of Children Born From ICSI With AOA (AOA-BABIES)
The investigators follow up on the development of children born from ICSI-AOA using the Developmental Red Flags and Ages \& Stages Third Edition (ASQ-3) Questionnaires to give strong evidence about the safety of AOA in assisted…
- Trial name
- NCT05578118
- Where
- Vietnam
- Volunteers
- 63 people
- Sponsor
- Mỹ Đức Hospital
IVF, Frozen Embryo Transfer
Lipiodol Prior to FET (LIFE)
Lipiodol® flushing is an effective fertility treatment for women with unexplained infertility. It is speculated that the treatment effect could work through a direct effect of Lipiodol® on the endometrium.
- Conditions
- IVF, Frozen Embryo Transfer, Hysterosalpingography
- Trial name
- LIFE (NCT06563908)
- Testing
- Lipiodol® uterine treatment prior to IVF/ICSI
- Volunteers
- 784 people
- Sponsor
- Mỹ Đức Hospital
Reduced Sperm Motility, IVF
Sperm Selection and Embryo Development: Comparison of the Density Gradient Centrifugation and Microfluidic Chip Sperm Preparation Methods Sperm Selection and Embryo Development: Comparison of the Density Gradient Centrifugation and Microfluidic Chip Sperm Preparation Methods
Purpose: To compare the effects of the density gradient centrifugation and microfluidic chip sperm preparation methods on embryo development in a study population with astheno-teratozoospermia.
- Conditions
- Reduced Sperm Motility, IVF, ICSI, Astheno Teratozoospermia
- Trial name
- NCT04962074
- Testing
- Microfluidic sperm sorting chip, Density gradient
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people
- Sponsor
- Maltepe University
IVF, Infertility
Evaluating Piezo-ICSI. - The EPI Study.
Intracytoplasmic sperm injection (ICSI) has successfully been used to treat both severe male infertility and fertilization failure since its introduction in the early 1990´s.
- Trial name
- NCT04669652
- Testing
- Piezo-ICSI
- Where
- 2 sites in United Kingdom
- Volunteers
- 265 people
- Sponsor
- Vitrolife
Infertility, Female, Reproductive Techniques, Assisted
SISTER: Sibling Oocyte Insemination With Frozen Sperm From Third Party Donors: Evaluation of Reproductive Techniques
The goal of this clinical trial is to learn whether two different methods of helping eggs and sperm join-intracytoplasmic sperm injection (ICSI) and conventional in vitro fertilization (IVF)-lead to better embryo development when…
- Conditions
- Infertility, Female, Reproductive Techniques, Assisted, Fertilization in Vitro
- Trial name
- SISTER (NCT07175571)
- Testing
- Intracytoplasmic Sperm Injection (ICSI), Conventional Insemination (IVF)
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Shady Grove Fertility Reproductive Science Center
Male Infertility, Female Infertility
IMSI in Couples With Previous Implantation Failures
There is a lack of clarity regarding the justification to instruct the couple to shift from intracytoplasmic sperm injection (ICSI) to intracytoplasmic morphologically selected sperm injection (IMSI).
- Trial name
- NCT02107521
- Testing
- Intracytoplasmic morphologically selected sperm injection, Intracytoplasmic sperm injection
- Where
- Brazil
- Volunteers
- 25 people
- Sponsor
- Sapientiae Institute
STERILITY
Assessment of the Effectiveness and Tolerability of Ovarian Hyperstimulation
The aim of the study is to assess the effectiveness of 5 mixed protocols of ovarian hyperstimulation with urinary gonadotrophins to achieve clinical pregnancy in females undergoing assisted reproductive techniques (IVF/ICSI)…
- Trial name
- DESCARTES (NCT01331720)
- Testing
- hMG-HP
- Where
- 14 sites in Spain
- Volunteers
- 279 people
- Sponsor
- Ferring Pharmaceuticals
Infertility
Half-Dose Depot Triptorelin Versus Reduced-Dose Daily Buserelin
The purpose of this study is to determine whether half-dose depot triptorelin are as effective as reduced-dose daily buserelin in the controlled ovarian stimulation for intracytoplasmic sperm injection and embryo transfer
- Trial name
- NCT00461916
- Testing
- Half-Dose Depot Triptorelin, Reduced-Dose Daily Buserelin
- Where
- Iran
- Volunteers
- 182 people
- Sponsor
- Tehran University of Medical Sciences
Pregnancy
Motile Sperm Organelle Morphology Examination (MSOME) Influence on Intracytoplasmic Sperm Injection (ICSI) Outcomes in Infertile Couples
A new technique based on the motile sperm organelle morphology examination (MSOME) at a magnification of at least ×6000 has been developed.
- Trial name
- NCT01731639
- Testing
- MSOME
- Where
- Brazil
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Sapientiae Institute
Singeleton Conceived Fresh and Frozen Embryo Transfer (ICSI/IVF), Naturally Conceived
NEURODEVELOPMENTAL OUTCOMES OF SINGLETON CONCEIVED FROM FRESH AND FROZEN EMBRYO TRANSFER COMPARED WITH NATURALLY CONCEIVED
This study aimed to: detect difference in neurobehavior, maturity, Apgar score and birth weight of singleton conceived from fresh and frozen embryo transfer and naturally conceived.
- Trial name
- NCT04772872
- Testing
- Assessment by Brazelton neonatal behavior for group A,Band C
- Where
- Egypt
- Volunteers
- 186 people
- Sponsor
- Cairo University
Infertility
Ovarian Stimulation Using Recombinant Follicle-stimulating Hormone (FSH) and Gonadotrophin Releasing Hormone (GnRH) Agonist in Alternate Days
The present prospective study was designed to compare the effects of administering a daily dose of gonadotrophin releasing hormone (GnRH) antagonist vs.
- Trial name
- Gonapeptyl (NCT01468441)
- Testing
- Triptorelin, Cetrorelix
- Where
- Brazil
- Volunteers
- 96 people
- Sponsor
- Fertility - Assisted Fertilization Center
Infertility, Female, IVF
RCT to Assess the Impact of Microbiome Status in Infertile IVF Patients at Their First IVF/ICSI Cycle
Although the endometrium has been traditionally considered free of bacteria, recent studies have documented the presence of an endometrial microbiome.
- Trial name
- NCT04686357
- Testing
- EMMA/ALICE
- Volunteers
- 1,018 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Infertility, Female, IVF/ICSI
RCT to Assess the Clinical Benefit of the ERA Test in Infertile Women at Their First IVF/ICSI Cycle
Endometrial receptivity takes place in a self-limited period of time during the endometrial mid-secretory stage. This period, named as window of implantation (WOI), is modulated by molecular changes allowing embryo implantation…
- Trial name
- NCT04687670
- Testing
- ERA
- Where
- 3 sites in China
- Volunteers
- 714 people
- Sponsor
- Peking University Third Hospital
Child Development, Endometrial Preparation
Development of IVF/ICSI Children Born From Different Endometrial Preparation Protocols
The efficacy and safety of endometrial preparation regimens remain controversial. In the most recent meta-analysis, using natural and modified natural cycle protocol to prepare the endometrium in frozen embryo transfer resulted…
- Trial name
- MONARTBABIES (NCT05502770)
- Testing
- Developmental score according to The Ages & Stages Questionnaires®, Third Edition - ASQ®-3, Physical development and General Health, Developmental Red flags
- Where
- Vietnam
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Mỹ Đức Hospital
Unexplained Infertility
The Effect of LMWH on ICSI in Patients With Unexplained Infertility and Negative Immunological Markers
The purpose of this study is to assess the efficacy of LMWH treatment in women with unexplained infertility and negative immunological markers undergoing ICSI.
- Trial name
- NCT02861105
- Testing
- LMWH, 0.9% saline solution
- Volunteers
- 716 people
- Sponsor
- Ain Shams University