Clinical trials: ICSI
Aneuploid Oocytes
The Eshre Study Into The Evaluation of Oocyte Euploidy by Microarray Analysis
A pragmatic, multicentre, randomized double-blind controlled trial with an intention-to-treat analysis, of the use of preimplantation genetic screening (PGS) for aneuploidy by means of microarray comparative genomic hybridization…
- Trial name
- ESTEEM (NCT01532284)
- Testing
- Polar Body Biopsy
- Where
- 8 sites in Belgium, Germany and 4 more
- Volunteers
- 396 people
- Sponsor
- European Society of Human Reproduction and Embryology
Invitro Fertilization
Embryoscope and Reproductive Outcome
cases with embyos cultured in the standard incubator and evaluated only by morphology are compared to cases with embryos continuously monitored by the embryoscope followed by embryo selection based on a multivariable model
- Trial name
- NCT02764255
- Volunteers
- 770 people
- Sponsor
- Ahmed Maged
Reproductive Techniques, Assisted
Early Follicular Phase vs Lutheal Phase Ovarian Stimulation in Bologna Criteria IVF/ICSI Cycles (LUTEAL Trial)
Exploratory, prospective, randomized, comparative, open trial with control group treated to assess the efficacy of follicular phase ovarian stimulation compared to lutheal phase ovarian stimulation in women with Bologna criteria…
- Trial name
- LUTEAL (NCT02625532)
- Testing
- Follicular phase, Luteal phase
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Instituto Bernabeu
Adenomyosis
Impact of Ultra-long Versus Long Down-regulation Protocol on IVF/ICSI in Adenomyosis
Adenomyosis is a benign condition defined as the invasion of ectopic endometrium into the myometrium, resulting in smooth muscle hyperplasia and endometrial inflammation, commonly associated with endometriosis and uterine…
- Trial name
- ADENOFIV (NCT03940807)
- Testing
- 11.25mg GnRH agonist, 0.1 mg GnRH agonist, 25 µg transdermal oestradiol
- Where
- 14 sites in France
- Sponsor
- University Hospital, Toulouse
Exposure to Toxins from Smoking, Female Infertility
Presence of Toxins from Smoking in the Follicular Fluid of Women Undergoing Intracytoplasmic Sperm Injection Treatment
Smoking is associated with many adverse health effects like circulatory disorders, pulmonary diseases or heart diseases. It was also shown that smoking correlates with a significantly higher risk for miscarriage, preterm birth or…
- Trial name
- NCT03414567
- Where
- Germany
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Infertility Treatment Center Dortmund
Fetal Cardiac Disorder
Fetal Cardiac Remodeling in Singleton Pregnancies Conceived by Assisted Reproductive Technology (Biopsied and Non-Biopsied ICSI) Versus Those Normally Conceived
The study aims to assess the presence of fetal cardiac remodeling and dysfunction in singleton pregnancies conceived by assisted reproductive technology (Biopsied and Non-Biopsied ICSI) as compared with those conceived…
- Trial name
- NCT05172336
- Where
- Egypt
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Wael Elbanna Clinic
Infertility, Female, IVF/ICSI
RCT to Assess the Clinical Benefit of the ERA Test in Infertile Women at Their First IVF/ICSI Cycle
Endometrial receptivity takes place in a self-limited period of time during the endometrial mid-secretory stage. This period, named as window of implantation (WOI), is modulated by molecular changes allowing embryo implantation…
- Trial name
- NCT04687670
- Testing
- ERA
- Where
- 3 sites in China
- Volunteers
- 714 people
- Sponsor
- Peking University Third Hospital
Polycystic Ovarian Syndrome
Follicular Synchronization in PCOS Patients Undergoing ICSI
The use of GnRH antagonist protocol nowadays is the slandered protocol of controlled ovarian stimulation in patients with poly cystic ovarian syndrome (PCOS) because it decreases the incidence of OHSS(1, 2).
- Trial name
- NCT04069117
- Testing
- letrozole 2.5mg (Femara; Novartis Pharma Services, Basel, Switzerland)
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Mansoura University Hospital
IVF
Prolonged Protocol of Early Follicular or Mid Luteal Phase
Due to the injection of gonadotropin releasing hormone agonist (GnRH-a) before controlled ovarian hyperstimulation (COH), the scheme of prolonged early follicular period protocol has obvious advantages in achieving ideal egg…
- Trial name
- NCT04522479
- Testing
- Change the injection time of long acting GnRH-a
- Where
- China
- Volunteers
- 1,150 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Infertility, Reproductive Issues
Impact of a Predetermined Day 5 ET vs. a Predetermined Day 6 ET on Clinical Pregnancy Rate After ICSI Treatment
The aim of this prospective multicenter study is to investigate the influence of a predetermined embryo transfer on day 6 compared to a predetermined embryo transfer on day 5.
- Trial name
- NCT06447077
- Where
- Germany
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- Infertility Treatment Center Dortmund
In Vitro Fertilization
A Trial of Single Dose Corifollitropin Alfa's Ability to Induce Multiple Follicular Growth During the First Week of Controlled Ovarian Stimulation for IVF or ICSI (38833)(P05788)
To evaluate the induction of multiple follicular growth after single dose administration of 100 μg or 150 μg Org 36286 in a long protocol of GnRH agonist.
- Trial name
- Realize (NCT00702351)
- Testing
- Org 36286 (corifollitropin alfa)
- Volunteers
- 50 people
- Sponsor
- Organon and Co
Stimulation in the Ovary, IVF Outcome
Comparing IVF/ICSI Cycle Outcomes of Post Ovulation Ovarian Stimulation Protocol With Elonva Without GnRH Antagonist to Follicular Phase Day 2 Stimulation Fixed Day 5 Antagonist Protocol
There are several approaches to the timing of antagonist administration in IVF/ICSI cycles. The primary goal is indeed to prevent premature ovulation, which could jeopardize the success of the cycle There is an emerging concept…
- Trial name
- NCT06879002
- Testing
- Ovarian stimulation with menstruation or after ovulation
- Where
- 2 sites in United Arab Emirates
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
IVF, PCO
Progesterone Primed Protocol Versus GnRH Antagonist in With PCO Undergoing ICSI
To compare the effectiveness and safety of Progesterone Primed Ovarian Stimulation protocol (PPOS) using Dydrogestrone vs GnRH Antagonist Protocol in patients with expected high ovarian response undergoing ICSI cycle
- Trial name
- NCT05951400
- Testing
- Dydrogesterone Tablets, Cetrorelix
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Beni-Suef University
Recurrent Implantation Failure
Platelet Rich Plasma and Recurrent Implantation Failure
This study is a randomized controlled clinical trial to compare the pregnancy outcomes of infertile women with recurrent implantation failure.
- Trial name
- NCT03996837
- Testing
- Intra uterine infusion of platelet rich plasma
- Where
- Iran
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Royan Institute
Endometriosis
Anti-TNFα Therapy for Improving Pregnancy Rates in Endometriosis Patients With Failed ICSI
This prospective study targets infertile women with endometriosis (EM) who have experienced a previously failed Intracytoplasmic Sperm Injection (ICSI) trial.
- Trial name
- NCT07509411
- Testing
- TNF-α Inhibitor, Frozen Blastocyst Transfer (FBT)
- Where
- Egypt
- Volunteers
- 145 people
- Sponsor
- Benha University
Infertility
EGG Sensor for Oocyte Characterization
While intracytoplasmic sperm injection (ICSI) has made significant progress in the treatment of male infertility, the cumulative delivery rate is less than 30%, and birth is sometimes only achieved after several transfers.
- Trial name
- EGG_SENSOR (NCT06497998)
- Testing
- Mechanical characterization
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Polycystic Ovarian Syndrome
Letrozole Combined With Gonadotropins (Gn) for Ovarian Stimulation Undergoing in Vitro Fertilization/Intracytoplasmic Sperm Injection (IVF/ICSI) in Patients With Polycystic Ovary Syndrome (PCOS)
The purpose of this study is to determine whether letrozole combined with gonadotropins are effective in the ovarian hyperstimulating for IVF/ICSI in patients with PCOS.
- Trial name
- NCT00894608
- Testing
- letrozole + gonadotropins, GnRHa + gonadotropins
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Yunyang Medical College
Infertility
Luteal Phase Support With Daily Administration of Gonadotropin-releasing Hormone Agonist Compared to Progesterone/Estradiol in IVF/ICSI Cycles With Ovulation Triggering With GnRH-a
Purpose: To determine the efficacy and safety of daily injections of gonadotropin-releasing hormone agonist in comparison with the standard strategy of supporting the luteal phase in protocols with gonadotropin-releasing hormone…
- Trial name
- NCT05143723
- Testing
- Gonadotropin-releasing hormone agonist
- Where
- Russia
- Volunteers
- 102 people
- Sponsor
- Kuban State Medical University
ICS
Melatonin Therapy for Improving ICSI Outcomes in Women With Diminished Ovarian Reserve
Diminished ovarian reserve (DOR) is a major challenge in female fertility, often leading to poor oocyte quality and low pregnancy rates during assisted reproduction.
- Trial name
- NCT07318974
- Testing
- Melatonin capsule
- Where
- Egypt
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Benha University
Female Infertility
Intracytoplasmic Morphologically Selected Sperm Injection and Advanced Maternal Age
The objective of this study was to evaluate the advanced maternal age as a rationale for performing intracytoplasmic morphologically selected sperm injection (IMSI).
- Trial name
- IMSIAMA (NCT01620346)
- Testing
- Intracytoplasmic sperm injection (ICSI), Intracytoplasmic morphologically selected sperm injection
- Where
- Brazil
- Volunteers
- 66 people
- Sponsor
- Sapientiae Institute