Clinical trials: Immune Dysfunction
DLBCL - Diffuse Large B Cell Lymphoma, Follicular Lymphoma (FL)
Long-term Study to Evaluate Safety and Persistence of GF-CART01
The goal of this observational study is to learn about the long-term safety of GF-CART01 after cell infusion up to 15 years.
- Conditions
- DLBCL - Diffuse Large B Cell Lymphoma, Follicular Lymphoma (FL), Primary Mediastinal Large B-Cell Lymphoma, High Grade B Cell Lymphoma
- Trial name
- NCT06985576
- Where
- Taiwan
- Volunteers
- 18 people
- Sponsor
- GenomeFrontier Therapeutics TW Co., Ltd.
Asthma, Asthma Attack
Genomics and Metagenomics of Asthma Severity
The Genomics and Metagenomics of Asthma Severity (GEMAS) study aims to assess the role of genomics, the microbiome, and the interaction between them in the development of asthma exacerbations in European patients with asthma.
- Trial name
- GEMAS (NCT04501926)
- Where
- 6 sites in Spain
- Volunteers
- 300 people
- Sponsor
- Maria Pino-Yanes
Peripheral T Cell Lymphoma
Chidamide Plus Chemotherapy in the Treatment of Peripheral T-cell Lymphoma
This is a single arm, prospective trial to evaluate the efficacy and safety of Chidamide in combination with previous chemotherapy in peripheral T cell lymphoma patients who did not achieve complete response after 3 cycles of…
- Trial name
- NCT02753543
- Testing
- Chidamide
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Ruijin Hospital
Moderate-to-Severe Atopic Dermatitis
Efficacy and Safety of Nemolizumab in Subjects With Moderate-to-Severe Atopic Dermatitis
The main purpose of the study was to assess the efficacy and safety of nemolizumab after a 16-week treatment period in adult and adolescent subjects with moderate-to-severe atopic dermatitis (AD) not adequately controlled with…
- Trial name
- NCT03985943
- Testing
- Nemolizumab
- Where
- 174 sites in United States, Australia and 12 more
- Volunteers
- 941 people
- Sponsor
- Galderma R&D
Dermatitis, Atopic
Wool Clothing for the Management of Childhood Atopic Dermatitis (DESSINE2)
The study is a sequentially recruited, cross-over-cohort, outpatient-based evaluation of the effectiveness of wool clothing, as compared to standard clothing, in reducing the severity of childhood atopic dermatitis (eczema) over…
- Trial name
- DESSINE2 (NCT04011215)
- Testing
- wool clothing, standard clothing
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Murdoch Childrens Research Institute
HIV Infections, Varicella-zoster Virus
The Immunogenicity of Varicella-zoster Virus Vaccine in HIV-infected Children
To study about the immunogenicity, safety and efficacy of varicella-zoster virus vaccine in HIV-infected children.
- Trial name
- NCT01138215
- Testing
- VZV vaccination
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- The HIV Netherlands Australia Thailand Research Collaboration
Infection, Human Immunodeficiency Virus
PENTA Fosamprenavir Study
Twice daily fosamprenavir, in combination with low dose ritonavir (FPV/RTV BID), is indicated for the treatment of HIV-infected adults, adolescents and children of 6 years of age and above for use in combination with other…
- Trial name
- NCT01077635
- Testing
- Exposure to licensed dose of FPV (+/- 20% of 18mg/kg BID + RTV)
- Volunteers
- 1 people
- Sponsor
- ViiV Healthcare
Asthma
Noninvasive Positive Airway Pressure in the Pediatric Emergency Department for the Treatment of Acute Asthma Exacerbations
Previous investigations and anecdotal experience have shown safety and utility of Noninvasive Positive Pressure Ventilation/Bilevel Positive Airway Pressure (NIPPV/BiPAP) for the treatment of asthma in children.
- Trial name
- RCT BiPAP (NCT01497691)
- Testing
- NIPPV (PALMtop PTV), Volumetric CO2 (NM3), USCOM
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
IgA Nephropathy
IgA Nephropathy Registration Initiative of High Quality (INSIGHT)
The investigators are registering all biopsy-proven primary IgA nephropathy (IgAN) patients at recruited hospitals and developing a IgAN database in China.
- Trial name
- NCT03001947
- Testing
- No intervention
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Sun Yat-sen University
Chronic Lymphocytic Leukemia, Acute Myeloid Leukemia
An Extension Study of Venetoclax for Subjects Who Have Completed a Prior Venetoclax Clinical Trial
The purpose of this extension study is to provide venetoclax and obtain long-term safety data for subjects who continue to tolerate and derive benefit from receiving venetoclax in ongoing studies.
- Conditions
- Chronic Lymphocytic Leukemia, Acute Myeloid Leukemia, Multiple Myeloma, Non-Hodgkin's Lymphoma
- Trial name
- NCT03844048
- Testing
- Venetoclax
- Where
- 56 sites in United States, Australia and 21 more
- Volunteers
- 165 people
- Sponsor
- AbbVie
Acute Lymphoblastic Leukemia, Adult B Acute Lymphoblastic Leukemia
Dexamethasone Compared With Prednisone During Induction Therapy and Methotrexate With or Without Leucovorin During Maintenance Therapy in Treating Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia
This randomized phase III trial is studying dexamethasone to see how well it works compared to prednisone during induction therapy.
- Conditions
- Acute Lymphoblastic Leukemia, Adult B Acute Lymphoblastic Leukemia, Childhood B Acute Lymphoblastic Leukemia
- Trial name
- NCT00075725
- Testing
- Cyclophosphamide, Cytarabine, Daunorubicin Hydrochloride
- Where
- 234 sites in United States, Australia and 3 more
- Volunteers
- 3,154 people
- Sponsor
- Children's Oncology Group
Juvenile Idiopathic Arthritis, Inflammatory Bowel Diseases
Transition to Adulthood Through Coaching and Empowerment
Pediatric patients with Juvenile Idiopathic Arthritis or Inflammatory Bowel Disease who are preparing to transition into adult care face many unique challenges, and, to date, there is no comprehensive and implementable model of…
- Trial name
- TRACE (NCT05570617)
- Testing
- Transition Coach Intervention, Standard of Care- Youth Transition Roadmap
- Where
- Canada
- Volunteers
- 27 people
- Sponsor
- McMaster University
HIV Infections
Evaluating the Efficacy of Annual CHTC Retesting Among Male Couples at High Risk of HIV Infection
This randomized controlled trial evaluates the efficacy of couples HIV testing and counseling retesting. Eligible couples previously enrolled in NCT05000866 are invited to participate.
- Trial name
- 4Us Part B (NCT05833074)
- Testing
- Couples HIV testing and counseling, Individual HIV testing and counseling
- Where
- 2 sites in United States
- Volunteers
- 384 people
- Sponsor
- Hunter College of City University of New York
Limb Deficiencies, Pediatric ALL
Innovative Prosthetic Systems for Pediatric Limb Loss to Accommodate Growth
An immediate fit adjustable prosthetic system is being investigated for children. The age range being recruited is from 3 years up to 18 years old.
- Trial name
- NCT05230004
- Testing
- iFIT prosthesis
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Pennsylvania
Intellectual Disability, Mild, Muscular Strength
Effects of a Progressive Adapted Physical Education Program on Muscular Strength and Endurance in Adolescents With Mild Intellectual Disability
This randomized controlled trial investigated the effects of a 10-week progressive adapted physical education program on muscular strength and muscular endurance in adolescents with mild intellectual disability.
- Trial name
- PAPE-MID (NCT07599033)
- Testing
- Progressive Adapted Physical Education Program
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Inonu University
Asthma Exacerbation
Study of Preventive Treatment With Symbicort or Budicort Turbohaler in Childhood Asthma Return to School Epidemic
During the second week of September( week 38 of the year)there are recorded data of exacerbation of asthma all over the world, including Israel.
- Trial name
- NCT01179152
- Testing
- Budesonide turbuhaler, Budesonide+Formoterol turbuhaler
- Where
- Israel
- Volunteers
- 225 people
- Sponsor
- Meir Medical Center
Myasthenia Gravis, CIDP - Chronic Inflammatory Demyelinating Polyneuropathy
A Worldwide Pregnancy Safety Study to Assess Maternal, Fetal, and Infant Outcomes Following Exposure to Efgartigimod During Pregnancy and/or Breastfeeding.
This is a multi-country, prospective safety study of pregnant women exposed to efgartigimod or efgartigimod PH20 SC any time within 25 days prior to conception or any time during pregnancy.
- Trial name
- NCT06299748
- Testing
- Efgartigimod
- Where
- 4 sites in United States, Germany and 2 more
- Volunteers
- 279 people
- Sponsor
- argenx
Seasonal Allergic Rhinitis, Hay Fever
Study in Adult and Adolescent Subjects With Seasonal Allergic Rhinitis (SAR)
The purpose of the study is to assess the efficacy and safety of an investigational nasal aerosol compared with placebo nasal aerosol in the treatment of seasonal allergic rhinitis.
- Trial name
- NCT01024608
- Testing
- Beclomethasone dipropionate
- Where
- 4 sites in United States
- Volunteers
- 340 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Allergic Rhinitis Due to Cat Allergy
A Study to Examine the Efficacy and Safety of Anti-Fel d 1 Antibodies Injections in Cat-allergic Adolescent and Adult Patients With Allergic Rhinitis Who Live With a Cat
The primary objective of the study is to determine the efficacy of REGN1908-1909, as compared to placebo, to reduce allergic rhinitis/conjunctivitis symptoms and allergy rescue medication use during natural cat exposure.
- Trial name
- NCT04981717
- Testing
- REGN1908-1909
- Where
- 92 sites in United States, Belgium and 4 more
- Volunteers
- 446 people
- Sponsor
- Regeneron Pharmaceuticals
Autoimmune Diseases, Mental Disorders Diagnosed in Childhood
Treatment of Childhood Onset Psychiatric Disorders With Intravenous Immunoglobulin (IVIg)
Recent research studies of early onset-obsessive compulsive disorder (OCD) and Tourette's syndrome have questioned whether autoimmunity could play a role in the development of these conditions.
- Conditions
- Autoimmune Diseases, Mental Disorders Diagnosed in Childhood, Schizophrenia
- Trial name
- NCT00001768
- Testing
- Intravenous immunoglobulin
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Institute of Mental Health (NIMH)