Clinical trials: Immune Function
Guillain-Barre Syndrome
Effects of Proprioceptive Neuromuscular Training on Sensory and Motor Function in Guillain Barre Syndrome
This study aims to determine the effects of Proprioceptive Neuromuscular Training on Sensory versus Motor Function in patients presenting with Guillain Barre Syndrome.
- Trial name
- NCT05491096
- Testing
- Proprioceptive Neuromuscular Training, Conventional Physical Therapy
- Where
- Pakistan
- Volunteers
- 26 people
- Sponsor
- Riphah International University
Asthma
Mechanism(s) of Airflow Limitation During Exacerbation of Asthma
The purpose of this study is to evaluate the site and mechanisms responsible for expiratory airflow limitation in chronic, treated, non-smoking, stable asthmatics with moderate to severe persistent expiratory airflow obstruction.
- Trial name
- NCT01225913
- Testing
- fluticasone/salmeterol in all asthmatics, budesonide/formoterol or fluticasone/salmeterol in all asthmatics
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Gelb, Arthur F., M.D.
Asthma, Wheezing
Lung Function and Structure in Healthy Infants and Infants With Recurrent Wheezing
Infants will be enrolled into this study in one of three groups. First, there will be a group of full term infants with no history of wheezing.
- Conditions
- Asthma, Wheezing, Infant
- Trial name
- NCT00507676
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Indiana University
Type 1 Diabetes
Combination Therapy With Sitagliptin and Lansoprazole to Restore Pancreatic Beta Cell Function in Recent-Onset Type 1 Diabetes
Sanford Research/USD proposes to study the combination therapy of oral administration of sitagliptin and lansoprazole versus placebo for the preservation of pancreatic beta cells still present in patients with recent-onset…
- Trial name
- REPAIR-T1D (NCT01155284)
- Testing
- Sitagliptin and Lansoprazole
- Where
- 3 sites in United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Sanford Health
Asthma
The Correlations of FeNO, Blood Eosinophils and Lung Function in Well-controlled Asthma
In Asthma, the levels of exhaled FeNO is correlated to sputum eosinophils particularly in the patient with poor controlled asthma or severe asthma.
- Trial name
- NCT04454385
- Testing
- Patients with well controlled asthma
- Where
- Thailand
- Volunteers
- 84 people
- Sponsor
- Hat Yai Medical Education Center
Thyrotoxicosis
Thiamine Supplement in Patients With Severe Hyperthyroidism
Thyrotoxicosis is a hypermetabolic state in which there is increased utilization of thiamine. Thiamine deficiency has been observed in association with hyperthyroidism.
- Trial name
- NCT02767245
- Testing
- Thiamine
- Where
- Thailand
- Volunteers
- 12 people
- Sponsor
- Ramathibodi Hospital
Asthma
Effects of Noninvasive Ventilation Compared to Salbutamol
Asthma is a chronic inflammatory disease characterized by recurrent and reversible episodes of airway obstruction. Drug treatment usually includes inhaled corticosteroids and bronchial dilators, which often do not have adequate…
- Trial name
- NCT03430505
- Testing
- Bilevel, Albuterol
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Nove de Julho
Type 1 Diabetes
The Effect of Gluten-free Diet on New Onset Type 1 Diabetes (T1D)
The primary aim of this pilot study is to test whether gluten-free diet (GFD) instituted in children shortly after onset of Type 1 Diabetes (T1D) can decelerate the decline in beta cell function as compared to age matched…
- Trial name
- NCT02867436
- Testing
- Gluten-free diet
- Where
- 2 sites in Czechia
- Volunteers
- 45 people
- Sponsor
- University Hospital, Motol
Glomerulonephritis, Lupus Nephritis
Cyclophosphamide and Fludarabine to Treat Lupus Nephritis
This study will test the safety and effectiveness of combination therapy with cyclophosphamide (Cytoxan) and fludarabine in treating lupus nephritis (kidney inflammation).
- Conditions
- Glomerulonephritis, Lupus Nephritis, Systemic Lupus Erythematosus
- Trial name
- NCT00001676
- Testing
- SQ Fludarabine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Chediak Higashi Syndrome, Chronic Granulomatous Disease
Learning and Behavior Problems in Children With Chronic Granulomatous Disease and Related Disorders
This study will try to determine what causes learning, behavioral and emotional problems in children with chronic granulomatous disease (GCD) and other phagocyte disorders.
- Conditions
- Chediak Higashi Syndrome, Chronic Granulomatous Disease, Job's Syndrome, Leukocyte Disorder
- Trial name
- NCT00005933
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Diabetes Mellitus, Type 1, Diabetes Mellitus
Urine Extracellular Vesicles: Non-invasive Biomarkers of Β-cell Function and Novel Therapeutic Agents in Diabetes
Diabetes mellitus is a common chronic disease with a huge socioeconomic burden worldwide. Type 1 Diabetes(T1D) accounts for nearly 95% of diabetes in pediatric age and a lifelong dependence on exogenous insulin.
- Trial name
- EvsBioDiabetes (NCT06832215)
- Testing
- Blood and urine samples collection
- Where
- Portugal
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Unidade Local de Saúde de Coimbra, EPE
Glomerulopathy, C3G
Pilot STUDY to Monitor Ex-vivo the Biological Effects of the C3 Inhibitor, PEGCETACOPLAN, on Activation of Complement in Fluid Phase and on Podocytes in Patients With C3G and Primary IC-MPGN
This is a prospective, multicenter, non-interventional, observational pharmacological real-world study to characterize longitudinal changes in ex vivo biomarkers of complement activation in patients with C3G and primary IC-MPGN…
- Conditions
- Glomerulopathy, C3G, Membranoproliferative Glomerulonephritis (MPGN)
- Trial name
- COMPASS (NCT07904338)
- Testing
- Blood sample
- Where
- Italy
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Mario Negri Institute for Pharmacological Research
Type 1 Diabetes Mellitus, Coronary Artery Disease
Isometric Handgrip Exercise -MRI in Children and Adolescents
This project aims to assess coronary vessel response to isometric handgrip exercise (IHE) during magnetic resonance imaging (MRI) in children with T1D children and healthy controls.
- Trial name
- NCT03506711
- Testing
- Isometric Handgrip Exercise during magnetic resonance imaging
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Lausanne Hospitals
Asthma
Effects of Montelukast in Children With Asthma
Leukotriene receptor antagonists (LTRAs) reduce fractional exhaled nitric oxide (FENO) concentrations in children with asthma, but the effect of LTRA withdrawal on FENO and lung function is unknown.
- Trial name
- NCT00675285
- Testing
- montelukast sodium
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- Catholic University of the Sacred Heart
Asthma
Asthma (and Dietary) Inflammation Reduction
The purpose of this study is to evaluate the effects of a diet that is low in glycemic load and abundant in fiber, fruits, vegetables, legumes and omega-3 fatty acids ("anti-inflammatory diet") on pulmonary function in pediatric…
- Trial name
- AIR (NCT01996891)
- Testing
- Anti-Inflammatory Diet
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Boston Children's Hospital
Acute Leukemia
Evaluation of Brain Changes in ALL Patients on Therapy
The study is aimed at assessing changes in the brain of patients from 6 to 18 years old with a diagnosis of acute lymphoblastic leukemia during chemotherapy.
- Trial name
- NCT04767152
- Testing
- MRI
- Where
- Russia
- Volunteers
- 110 people
- Sponsor
- Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Heart Rate Variability (ANS Function)
Autonomic Nervous System and Sickle Cell Disease
Sickle cell disease (SCD) children and adults with asthma have an increased rate of vaso-occlusive crisis, acute chest syndrome episodes, and premature mortality when compared to those without asthma.
- Trial name
- DrepaSympa (NCT04062409)
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Asthma
Aerobic Exercise in Children With Moderate and Severe Asthma
Regular aerobic physical activity in short-term moderate asthma and severe: Reduce the levels of inflammatory mediators Improves functional capacity Improves Quality of Life Improved lung function Reduces the sensation of dyspnea…
- Trial name
- AECA (NCT01920529)
- Testing
- aerobic exercise
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Instituto Materno Infantil Prof. Fernando Figueira
Ventricular Dysfunction, Asthma in Children
Evaluation of Cardiac Biomarkers and Ventricular Function in Asthmatic Children
Evaluation of cardiac biomarkers and the left and right ventricular systolic and diastolic function in asthmatic children in Assuit university hospital
- Trial name
- NCT05985720
- Volunteers
- 50 people
- Sponsor
- Assiut University
Healthy, Healthy Nutrition
The BEGIN Study Bifidobacterium Infantis to Newborns: Effects of Modulating the Gut Microbial Composition on Growth, Immune Function and Inflammatory Conditions - a Randomized Placebo-controlled Double-blinded Intervention Trial
The goal of The BEGIN Study, a randomized controlled double-blinded intervention trial, is to learn if probiotics, with Bifidobacterium longum subspecies infantis Bifin02 (B.
- Trial name
- BEGIN (NCT06452199)
- Testing
- B. infantis
- Where
- 2 sites in Denmark
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Aarhus