Clinical trials: Immune Function
Asthma
Lung Function of Asthmatic Children by Nebulized MgSO4
Asthma is a common chronic respiratory illness which results in frequent wheezing, cough,reduced quality of life. Standard treatment for asthma attack includes oxygen therapy, β2-agonists (e.g.
- Trial name
- NCT01799109
- Testing
- Magnesium Sulfate & albuterol, albuterol, magnesium
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Chongqing Medical University
Rheumatoid Arthritis
Activity Limitations in Rheumatoid Arthritis
Objective: To evaluate what factors contribute to activity limitations in subjects with rheumatoid arthritis considering the International Classification of Functioning, Disability and Health model.
- Trial name
- NCT02730286
- Testing
- observational study
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Federal University of Minas Gerais
Common Variable Immunodeficiency (CVID), Primary Immune Regulatory Disorder
Hematopoietic Stem Cell Transplantation (HSCT) for Common Variable Immunodeficiency (CVID) and Other Autoimmune Manifestations of Primary Immune Regulatory Disorders (PIRD)
This is a research protocol that will examine Hematopoietic Stem Cell Transplantation (HSCT) using a reduced conditioning regimen (RIC) with total body Irradiation (TBI) in those diagnosed with Common Variable Immunodeficiency…
- Conditions
- Common Variable Immunodeficiency (CVID), Primary Immune Regulatory Disorder, Immune Dysregulation, DiGeorge Syndrome
- Trial name
- CVID/PIRD (NCT07284641)
- Testing
- Hematopoietic stem cell transplant (HSCT)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Paul Szabolcs
Hepatitis B Virus Infection, Children
Entecavir With or Without Pegylated Interferon α-2b in Children Aged 3-6 Years With Immune-Active Chronic Hepatitis B
This study aims to evaluate the efficacy and safety of entecavir monotherapy versus sequential entecavir plus pegylated interferon α-2b in achieving functional cure in immune-active, HBeAg-positive children aged 3-6 years with…
- Conditions
- Hepatitis B Virus Infection, Children, Chronic Hepatitis B
- Trial name
- NCT07345611
- Testing
- Entecavir, Entecavir + Pegylated interferon α-2b
- Volunteers
- 60 people
- Sponsor
- Qing-Lei Zeng
Acinetobacter Baumannii Infection
Effects of Immune Function on Prognositic Outcome in Critical Ill Patients With Acinetobacter Baumannii Infection
The purpose of the present study is to evaluate the effects of immune function on prognositic outcome in critical ill patients with Acinetobacter baumannii infection.
- Trial name
- NCT02886637
- Testing
- None intervention
- Volunteers
- 40 people
- Sponsor
- Southeast University, China
Liver Transplant; Complications
Immune Function Following Liver Transplantation
Post-operative care following liver transplantation is characterized by a high incidence of infective and immunological complications.
- Trial name
- SEPTIFOIE (NCT04302246)
- Testing
- Biological testing on sequential blood sample
- Volunteers
- 61 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Asthma in Children
Video Game-Based and Conventional Breathing Exercises on Pulmonary and Extrapulmonary Features in Children with Asthma
Conventional breathing exercises are recommended as a support to drug therapy, which is the primary treatment modality for symptom management in asthma patients.
- Trial name
- NCT06546566
- Testing
- Video Game-Based Breathing Exercises, Conventional Breathing Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Atlas University
Type 1 Diabetes, Cardiovascular Risk Factor
Determinants of Cardiovascular Disease Risk Factors Among Youth With Type 1 Diabetes
Type 1 diabetes mellitus (T1D) is the most common form of diabetes among children and youth, and it is increasing around the world, particularly among children under 5 years.
- Trial name
- CARDEA (NCT04304729)
- Where
- Canada
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- St. Justine's Hospital
Asthma, Dyspnea; Asthmatic
Asthma Diagnosis Verified by Lung Function
Guidelines suggests that asthma should not be treated prior to a reversibility test and/or an assessment with peak expiratory flow (PEF) unless there is a clinical urgency for the patient to be treated.
- Conditions
- Asthma, Dyspnea; Asthmatic, Diagnoses Disease
- Trial name
- ADVERT (NCT04652141)
- Testing
- AsthmaTuner
- Where
- Sweden
- Volunteers
- 146 people
- Sponsor
- Björn Nordlund
Atopic Dermatitis
VANOS Cream and Skin Barrier Function
The purpose of this study is to determine the effect of short-term therapy using "VANOS Cream," a super-potent topical steroid cream on skin barrier function in patients with atopic dermatitis.
- Trial name
- NCT00819507
- Testing
- Fluocinonide
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Oregon Health and Science University
Sjogren's Syndrome, Xerostomia
Pilot Study of Thalidomide to Treat Sjogren's Syndrome
This study will evaluate the safety and effectiveness of thalidomide in treating Sjogren's syndrome. In this autoimmune disease, the immune system attacks the body's tear glands and salivary glands, causing dry mouth and dry…
- Trial name
- NCT00001599
- Testing
- Thalidomide
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Asthma, Asthma in Children
Comparison of Mesh Nebulizer and Compressor Nebulizer With Pulmonary Function Test in Pediatric Asthma Attacks
Asthma is a worldwide health problem and is one of the most common chronic diseases of childhood in most countries. Symptoms begin before the age of 5 years in 80% of children with asthma, but the diagnosis is not always easy.
- Trial name
- NCT06211998
- Testing
- Group 1, Group 2
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Berker Okay
Critical Ill Patients in SICU
Omegaven (w-3 Fish Oil) Supplemented Parenteral Nutrition in Subjects of SICU.
1. A prospective, controlled, randomized, study evaluating the clinical efficacy, including nutritional status, immune function and safety of Omegaven (ω-3 fish oil) supplemented parenteral nutrition in subjects of SICU. 2.
- Trial name
- NCT00172198
- Testing
- Omegaven 10%
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Candle Burning, Cooking
Acute Health Effects Due to Ultrafine Particles From Candles and Cooking
People spend up to 90% of their life indoor, and the way we live and behave in our homes has substantial effects on our health and well-being.
- Conditions
- Candle Burning, Cooking, Lung Function Decreased, DNA Damage
- Trial name
- Ultrafine (NCT04315740)
- Testing
- Particles from candles, Particles from cooking, Clean Air
- Where
- Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Muscle Damage, Inflammation
Protein and Recovery From Exercise-induced Muscle Damage
Intense, eccentric resistance exercise causes muscle damage, soreness, inflammation, and a loss of muscle function. Protein-amino acid supplementation before, during, and following damaging resistance exercise may reduce muscle…
- Trial name
- NCT02034721
- Testing
- Protein supplement
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Appalachian State University
Abdominal Pain, Functional Abdominal Pain
Epidemiological Analysis for Hereditary Angioedema Disease
An international, multicenter, epidemiological, observational study investigating the prevalence of Hereditary Angioedema (HAE) disease among participants with recurrent episodes of abdominal pain of no obvious etiology.
- Trial name
- EHA (NCT03558009)
- Where
- 35 sites in Germany, Italy and 4 more
- Volunteers
- 2,318 people
- Sponsor
- CENTOGENE GmbH Rostock
Infant, Very Low Birth Weight
Human Milk Fortifier and Cytokine Profile
This is a research study investigating if adding human milk fortifier to a preterm babies breast milk feedings affects the baby's immune system.
- Trial name
- NCT00601081
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Christiana Care Health Services
Pulmonary Function Tests
Iron Status and Lung Function in Pediatric Asthma
Iron has a variable role regarding asthma and respiratory function. In addition, iron deficiency may affect spirometry results in asthmatic children.
- Trial name
- NCT05277610
- Testing
- iron studies
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Asthma in Children, Lung Function Decreased
Lung Function Variability in Children and Adolescents
Long-term variability analysis of peak expiratory flow (PEF) and forced expiratory volume in 1 s (FEV1) has been successfully used in research to predict the exacerbation of the disease in adult individuals with asthma.
- Trial name
- LUV (NCT04163146)
- Testing
- Measurements of PEF and FEV1
- Where
- Greece
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Patras
Asthma in Children
Proof-of-concept of the Measurement of Lung Function Using the Relaxed Expiratory Occlusion Monitor (REOM)
(i) To validate the inversed occlusion technique by comparing the results of resistance obtained on the relaxed expiratory occlusion monitor (REOM) with the resistance obtained with respiratory oscillometry (OSC) measurements on…
- Trial name
- NCT04903145
- Testing
- REOM
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- Thorasys Thoracic Medical Systems Inc.