Clinical trials: Immune System Function
Complication of Prematurity, Immunologic Deficiency Syndromes
Novel Mechanisms and Approaches to Treat Neonatal Sepsis
Mortality related to neonatal sepsis exceeds 1 million deaths worldwide; the highest risk of mortality is in preterm neonates, especially low birth weight (LBW), and very low birth weight (VLBW) neonates.
- Trial name
- NCT02554630
- Testing
- Adjuvant, Blood Collection
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University of Florida
Neurocognitive Impairment, Acute Lymphoblastic Leukemia
Risk of Psychopathology and Neurocognitive Impairment in Leukemia Survivors
1. This study will evaluate the association between changes in basic cognitive and behavioral functioning by the end of chemotherapy treatment, and the later development of higher order executive functions in pediatric acute…
- Trial name
- NCT01014195
- Testing
- Neurocognitive and behavioral evaluation
- Where
- United States
- Volunteers
- 237 people
- Sponsor
- St. Jude Children's Research Hospital
Inflammatory Bowel Disease
Immune Function in Offsprings of Females With Inflammatory Bowel Disease
1. To evaluate the immune response to vaccines in infants of IBD patients treated with anti-TNF medications during pregnancy compared to infants of IBD mother not treated with anti-TNF medications. 2.
- Trial name
- NCT02079441
- Where
- Israel
- Volunteers
- 24 people
- Sponsor
- Sheba Medical Center
Spinal Cord Injuries, Cerebral Palsy
LEAP a New Overground Body Weight Support Robot: Usability Trial
People with central nervous system disorders such as spinal cord injury, stroke, cerebral palsy, Parkinson's disease, multiple sclerosis, etc… often have impaired lower extremity function that limits activities of daily life and…
- Conditions
- Spinal Cord Injuries, Cerebral Palsy, Parkinson Disease, Multiple Sclerosis
- Trial name
- LEAP (NCT03458169)
- Testing
- Therapist LEAP session feedback, Participant LEAP session feedback, LEAP risk control validation
- Where
- Switzerland
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Clinique Romande de Readaptation
Type 1 Diabetes
Vitamin D and Residual Beta-Cell Function in Type 1 Diabetes
This project is designed to study the role of vitamin D supplementation on the honeymoon phase of type 1 diabetes in children who are on standardized insulin treatment.
- Trial name
- PCR (NCT03046927)
- Testing
- Ergocalciferol
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Benjamin U. Nwosu, MD
Asthma
Study of Dose-response to Bronchodilator and Dose-finding in Child 2.5 to 6 Years - Study Golden
In older children and adults, bronchodilator (BD) dose-effect relationship is part of the characteristics of asthma disease. There are no data on BD dose-response relationship in wheezy preschool children whose disease…
- Trial name
- DORESI (NCT01470755)
- Testing
- salbutamol, Salbutamol - dose2, Salbutamol -dose3
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Bronchiolitis, Asthma
Acute Bronchiolitis in Infants and Allergic Asthma
Predicting the risk of allergenic sensitizations and asthma development in the first year of life is difficult. Investigator decided to follow prospectively two cohorts of infants with acute bronchiolitis, hospitalized or treated…
- Conditions
- Acute Bronchiolitis, Asthma, Allergy
- Trial name
- NCT03915197
- Testing
- Pneumological evaluation
- Where
- France
- Volunteers
- 320 people
- Sponsor
- University Hospital, Clermont-Ferrand
Asthma, Allergic Rhinitis
PF and FeNO and Clinical Characteristics in Children Being Diagnosed Due to Suspicion of Allergic Diseases
The aim of this study is to assess the influence of kind of allergic disease, allergic profile, allergen exposure, treatment method on lung function parameters, fractional exhaled nitric oxide level in children suspected and…
- Conditions
- Asthma, Allergic Rhinitis, Atopic Dermatitis, Urticaria
- Trial name
- NCT01805635
- Testing
- No intervention
- Where
- Poland
- Volunteers
- 5,500 people, healthy volunteers welcome
- Sponsor
- Medical University of Lodz
Type 1 Diabetes Mellitus
Mesenchymal Stem Cells in Patients With Type 1 Diabetes Mellitus
In this prospective, dual-center, open trial, patients with recent onset type 1 diabetes will receive one dose of allogenic Adipose tissue-derived stromal/stem cells (1x106 cells/kg) and oral cholecalciferol 2000UI/day for 24…
- Trial name
- NCT03920397
- Testing
- Infusion of adipose tissue-derived stem/stromal cells and oral Cholecalciferol supplementation
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Type 1 Diabetes (T1D)
Cognitive Function and Mental Health in Children and Youth With Type 1 Diabetes (T1D)
The Hirabai Cowasji Jehangir Medical Research Institute (HCJMRI), Pune, a Center of Excellence in type 1 diabetes (T1D), has extensive experience in studying prospective cohorts with high follow-up rates.
- Trial name
- DMBCOG (NCT07164768)
- Where
- India
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Hirabai Cowasji Jehangir Medical Research Institute
Diabetes Mellitus, Type 1
Influence of Vitamin D on Vascular Function in Adolescents and Young Adults With Type 1 Diabetes
The purpose of this study is to study the role of low vitamin D levels on the health of blood vessels or vascular function in adolescents and young adults with type 1 diabetes.
- Trial name
- NCT01103817
- Testing
- Vitamin D
- Where
- Canada
- Volunteers
- 33 people
- Sponsor
- The Hospital for Sick Children
Juvenile Idiopathic Arthritis
Effect of Whole Body Vibration Therapy in Children With Juvenile Idiopathic Arthritis
Juvenile idiopathic arthritis (JIA) is one of the most common chronic illnesses in children, with recent data suggesting that 1 to 4 in 1000 Canadian children and youth cope with the condition.
- Trial name
- WBV-JIA (NCT00836394)
- Testing
- Galileo (whole body vibration (WBV) therapy)
- Where
- Canada
- Sponsor
- Children's Hospital of Eastern Ontario
Type 1 Diabetes Mellitus
Effects of Vitamin C and E on Endothelial Function in Adolescent Diabetes
The endothelium is the lining of the blood vessels that helps prevent damage to the vessels. The endothelium does not function as well as it should in adolescents with type 1 diabetes. This causes future diabetes complications.
- Trial name
- NCT02019186
- Testing
- Vitamin C, Vitamin E
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Nationwide Children's Hospital
Biliary Atresia
Evaluation of Immune Function in Biliary Atresia Children With Prolonged Jaundice
Null hypothesis of this study: Biliary atresia patients with cholestatic jaundice do not have systemic immunity defect.
- Trial name
- NCT00155194
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Intellectual Disability, Mild
Biofeedback Training's Impact on Cognitive and Motor Skills in Kids With Intellectual Disabilities
The expected outcome of the study is to confirm or reject the hypothesis that traditional rehabilitation in combined with biofeedback training produces better results in improving motor and cognitive functions, relative to…
- Trial name
- NCT06120686
- Testing
- Biofeedback method, Conventional therapy program
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Aleksandra Kiper
Asthma
Effect of Inhaled Mometasone/Formoterol Versus Inhaled Fluticasone/Salmeterol in Asthma Patients
The purpose of this study is to investigate the effectiveness of inhaled mometasone/formoterol versus inhaled fluticasone/salmeterol on peripheral airway function in treatment of asthma.
- Trial name
- NCT02415179
- Testing
- Inhaled Mometasone/formoterol, Inhaled Fluticasone/Salmeterol
- Where
- Thailand
- Volunteers
- 52 people
- Sponsor
- Mahidol University
Acute Lymphoblastic Leukemia
Adaptive Variable-Resistance Training in Pediatric Survivors of Acute Lymphoblastic Leukemia
This study was designed to investigate the effect of eight weeks of adaptive variable-resistance training (Adaptive-VRT) on chemotherapy-induced sarcopenia, fatigue, and functional restrictions in a convenience sample of…
- Trial name
- NCT06338020
- Testing
- Adaptive variable-resistance training, Standard physical therapy
- Where
- Saudi Arabia
- Volunteers
- 62 people
- Sponsor
- Cairo University
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Type 1 Diabetes, Adherence, Patient
Diabetes Journey: An Adolescent Adherence Barriers Intervention
The purpose of this study is to examine the feasibility, acceptability, and preliminary efficacy of a web-based intervention addressing adherence barriers in adolescents with T1D.
- Trial name
- NCT04404556
- Testing
- Diabetes Journey, Enhanced Standard of Care
- Where
- 2 sites in United States
- Volunteers
- 195 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Transfusion Reactions
Mild Pulmonary Function Changes With Transfusion
The purpose of the study is to determine whether transfusion is associated with mild pulmonary changes.
- Trial name
- NCT00681954
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- University of California, San Francisco