Clinical trials: Immunity
Respiratory Syncytial Virus Infections
Evaluating the Safety and Immune Response to a Respiratory Syncytial Virus (RSV) Vaccine in Adults, RSV-Seropositive Children, and RSV-Seronegative Infants and Children
Human respiratory syncytial virus (RSV) is a common cause of upper respiratory tract illnesses as well as more severe lower respiratory illnesses, including bronchiolitis and pneumonia.
- Trial name
- NCT01459198
- Testing
- RSV MEDI ΔM2-2 vaccine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Influenza
Effect of Age and Prior Immunity to Response to Seasonal Influenza Vaccines in Children
A total of 88 children between 2 and 9 years of age will be randomized to receive a two dose schedule of either licensed live attenuated trivalent seasonal influenza vaccine (LAIV) or licensed inactivated seasonal influenza…
- Trial name
- NCT01246999
- Testing
- Live attenuated Influenza vaccine, Trivalent Influenza Vaccine, TIV followed by LAIV
- Where
- 2 sites in United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Immune Response to Oral Polio Vaccine
A Clinical Study Comparing Safety and Immunogenicity of bOPV of Bilthoven Biologicals
Bilthoven Biologicals has developed a new bivalent oral polio vaccine (bOPV) containing World Health Organization (WHO) approved Sabin strains of poliovirus type 1 and type 3.
- Trial name
- NCT02766816
- Testing
- Part 1 study - BBio bOPV, Part 2 study - BBio bOPV Lot 1, Part 2 study - BBio bOPV Lot 2
- Where
- Bangladesh
- Volunteers
- 1,120 people, healthy volunteers welcome
- Sponsor
- Bilthoven Biologicals
Coronary Artery Disease
Trained Immunity by Dual-pathway Inhibition in Coronary Artery Disease
Coronary artery disease (CAD) is a manifestation of systemic atherosclerosis for which single antiplatelet therapy (SAPT) is indicated if patients are stable.
- Trial name
- DUALCAD (NCT05210725)
- Testing
- Rivaroxaban 2.5 Mg Oral Tablet
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Radboud University Medical Center
Bronchiolitis
Studying Innate Immune Responses in Infants With Bronchiolitis
This study aims to establish whether impaired innate immune responses are associated with severity of Respiratory syncytial virus (RSV) infection.
- Trial name
- NCT01159795
- Where
- United Kingdom
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Transplant, Adaptive Immunity
CNTRP POSITIVE Study
Adequate control of immunosuppression is critical in preventing graft failure after solid organ transplantation (SOT) and in avoiding life-threatening viral and malignant complications.
- Conditions
- Transplant, Adaptive Immunity, EBV, Medication Adherence
- Trial name
- NCT02318030
- Where
- Canada
- Volunteers
- 600 people
- Sponsor
- The Hospital for Sick Children
Constipation - Functional
Breath Gases, Gut Flora, and Immunity in Children With Constipation
Constipation is a common problem in children that can affect their daily life, school performance, and social activities. Researchers have found that the bacteria living in our intestines (called "gut microbiome") may play an…
- Trial name
- NCT07797491
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
COVID, SARS-CoV-2
Antibody Detection in COVID-19 Cured Patients (SARS-CoV-2-CZ-Immunity)
The aim of the SARS-CoV-2-CZ-Immunity study is to determine the time profile of the presence of antibodies against SARS-CoV-2 in blood plasma by quantification of antibodies or performing a rapid test in COVID-19 cured patients.
- Trial name
- SARSCoV2CZImun (NCT04453280)
- Testing
- Quantitative analysis of anti-SARS-CoV-2-antibodies, SARS-CoV-2 diagnostic rapid test
- Where
- Czechia
- Volunteers
- 695 people
- Sponsor
- Institute of Health Information and Statistics of the Czech Republic
Localized Cancer
Neo-adjuvant Immunotherapy Master Trial for Localized Cancers
Most cancer treatments are developed without knowing whether the drug's targets are actually present in a patient's tumor or whether the patient is likely to benefit from the treatment.
- Trial name
- NEOREM (NCT07262489)
- Testing
- Each therapeutic NEOREM sub-protocol will mention the description of intervention
- Where
- France
- Volunteers
- 200 people
- Sponsor
- UNICANCER
Hepatitis A, Hepatitis A Virus
Immunity With Acute Hepatits A
Hepatitis A Virus (HAV) is a public health concern in Egypt, especially among children. Historically highly endemic, recent studies suggest a changing epidemiology.
- Trial name
- Hepatitis A (NCT06942962)
- Volunteers
- 50 people
- Sponsor
- Assiut University
Varicella
An Immunity Persistence Study of Booster Dose of Live Attenuated Varicella Vaccine
This an open-label phase Ⅳ clinical trial of live attenuated varicella vaccine manufactured by Sinovac (Dalian) Vaccine Technology Co., Ltd.The purpose of this study is to evaluate the immunity persistence of live attenuated…
- Trial name
- NCT06484686
- Testing
- Live Attenuated Varicella Vaccine
- Where
- China
- Volunteers
- 414 people, healthy volunteers welcome
- Sponsor
- Sinovac (Dalian) Vaccine Technology Co., Ltd.
Inborn Errors of Immunity
Evaluation Of Non Infectious Presentation of Inborn Errors Of Immunity
Inborn errors of immunity (IEI) are a wide number of conditions featured by impaired immune response, and their classification is in a continuous update, with the discovery of new clinical entities .
- Trial name
- NCT05870410
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Sohag University
Innate Immune Response
Predictors of Poor Immune Response to Rotavirus Vaccine in Infants
This will be a randomized study with the primary objective of assessing the impact of withholding versus encouraging breastfeeding on the immunogenicity of Rotarix® in infants.
- Trial name
- PPIR (NCT01700127)
- Testing
- Breastfeeding
- Where
- India
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Society for Applied Studies
Ebola Virus Disease
PREVAIL VI: Identification of Host Genetic Factors Underlying Ebola Virus Disease Risk, Mortality, Long-term Sequelae, Viral RNA Persistence, Humoral Immunity, and Ebola Vaccine Response
Background: Genes are instructions that tell the body how to work and grow. They can affect how the body responds to infection. Researchers want to learn more about genes that affect how the body responds to the Ebola virus.
- Trial name
- NCT03098862
- Where
- 4 sites in Liberia
- Volunteers
- 4,830 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Exposure, HIV Infection
Early Versus Delayed BCG Vaccination of HIV-exposed Infants
In sub-Saharan Africa (SSA), more than 300,000 babies with HIV die each year. HIV-infected children develop AIDS and die faster in SSA than those in developed countries.
- Trial name
- NCT02062580
- Testing
- BCG
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- University of Cape Town
Down Syndrome With and Without Auto Immune Abnormalities
Pilot Study of Auto-immune Abnormalities Associated With Down Syndrome
The purpose of the study is to identify biological data linked to auto immune abnormalities associated with Down Syndrome.
- Trial name
- IMMUTRI (NCT01041469)
- Where
- 2 sites in France
- Volunteers
- 72 people
- Sponsor
- Institut Jerome Lejeune
Influenza
Influenza Immunity in Children
This study evaluates how different methods of early exposure to influenza (natural infection, live attenuated influenza vaccination, inactivated influenza vaccination) initially stimulate immunity and poise the immune system to…
- Trial name
- NCT02559505
- Testing
- Seasonal IIV 0.25 mL dose, Natural influenza infection, Seasonal IIV 0.5 mL dose
- Where
- United States
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Prebiotics
Effect of a Kefir Beverage on Immunity and Lipid Profile
This is an exploratory cluster randomized controlled trial to evaluate the effect of a kefir beverage, enriched with prebiotics components, on immunity, lipid profile and adiposity in a population-based study, using the family as…
- Trial name
- NCT03312660
- Testing
- Prebiotic group
- Where
- Spain
- Volunteers
- 158 people
- Sponsor
- Hospital Clinico Universitario de Santiago
COVID, SARS-CoV 2
COVID-19: Herd Immunity Study in the Czech Republic
The aim of the SARS-CoV-2-CZ-Preval study is to quantify the prevalence of individuals with a history of SARS-CoV-2 coronavirus infection in the Czech population, except for those diagnosed with COVID-19 by methods based on…
- Trial name
- SARSCoV2CZPrev (NCT04401085)
- Testing
- SARS-CoV-2 diagnostic rapid test, Quantitative analysis of SARS-CoV-2 antibodies
- Where
- Czechia
- Volunteers
- 27,000 people, healthy volunteers welcome
- Sponsor
- Institute of Health Information and Statistics of the Czech Republic
Coronavirus Disease 2019
Long-term COVID-19 Immune Response in a Vulnerable Neighbourhood in Argentina
Between June 10t h and July 1st, a cross-sectional design study in an Argentina slum, showed a prevalence based on immunoglobuling G-class (IgG) antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) of…
- Trial name
- NCT04673279
- Testing
- serology
- Where
- Argentina
- Volunteers
- 189 people
- Sponsor
- Hospital Italiano de Buenos Aires