Clinical trials: Implant Therapy
Eye Disease, Inflammation
Cyclosporin Implant to Treat Uveitis
This study will evaluate the safety and effectiveness of a sustained-release cyclosporin implant to treat uveitis, a sight-threatening eye inflammation caused by an immune system abnormality.
- Conditions
- Eye Disease, Inflammation, Uveitis
- Trial name
- NCT00001737
- Testing
- Cyclosporin A Implant
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Eye Institute (NEI)
Improvement of Treatment Satisfaction
Treatment Satisfaction in Implantable Cardioverter Defibrillator Recipients
Remote monitoring of implantable cardioverter defibrillators (ICD) is a promising new development in ICD therapy and has been shown to be technically feasible and safe.While data on safety and feasibility of remote monitoring are…
- Trial name
- SAN REMO 2 (NCT01230073)
- Testing
- Home-Monitoring, Follow-up by Home-Monitoring
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Cervical Disc Disease, Cervical Disc Herniation
Dynamic Cervical Implant in Treatment of Cervical Disc Disease
Evaluation of outcome of DCI in treatment of cervical disc disease to patients admitted to neurosurgery department, Asyut University Hospitals.
- Conditions
- Cervical Disc Disease, Cervical Disc Herniation, Cervical Disc Degeneration
- Trial name
- DCI (NCT04627454)
- Testing
- Discectomy and insertion of dynamic cervical implant in cervical disc herniation
- Volunteers
- 20 people
- Sponsor
- Assiut University
Angina Pectoris, Coronary Artery Disease
Chronic Total Coronary Occlusion Treatment Results 6 Years After Bioresorbable Scaffold Implantation
Aim of the study is to evaluate chronic total coronary occlusion treatment results 6 years after bioresorbable scaffold implantation by quantitative coronary analysis, intravascular ultrasound and optical coherence tomography.
- Conditions
- Angina Pectoris, Coronary Artery Disease, Occlusion, Coronary
- Trial name
- CTO_BVS (NCT06164977)
- Testing
- Percutaneous coronary intervention.
- Where
- Latvia
- Volunteers
- 34 people
- Sponsor
- Pauls Stradins Clinical University Hospital
Dysfunction of the Prosthetic Conduct, Lesions of the Right Ventricular Outflow Tract
Medico-economic Evaluation of a Non-chirurgical Pulmonary Valve Replacement (REVALV)
This prospective interventional study is designed to evaluate the cost/advantage ratio in the treatment of lesions of the right ventricular outflow tract using transcatheter pulmonary valved stent (Melody).
- Trial name
- REVALV (NCT01250327)
- Testing
- Melody, bare stent, Surgery
- Where
- France
- Volunteers
- 93 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Non-infectious Uveitis
Safety and Efficacy of Fluocinolone Acetonide Intravitreal Implant vs Standardized Therapy
This is a 3 year,superiority, multicenter, open-label, randomised controlled safety and efficacy study. The aim of this study is to evaluate the effect of an intravitreal fluocinolone acetonide (0.59 mg) implant compared to…
- Trial name
- NCT00468871
- Testing
- fluocinolone acetonide intravitreal implant, corticosteroids and immunosuppressants
- Volunteers
- 140 people
- Sponsor
- Bausch & Lomb Incorporated
Death, Sudden, Cardiac, Ventricular Fibrillation
Failure of Chronically Implanted Defibrillator Leads -Incidence and Management
Comparison of two different approaches to address the problem of malfunctioning ICD-leads. These leads consist of two parts. One that is used for detection of arrhythmias(and pacing if required) (Pace/Sense) and a second part…
- Trial name
- NCT00614718
- Where
- 3 sites in Germany, Switzerland
- Volunteers
- 1,317 people
- Sponsor
- University Hospital, Basel, Switzerland
Symptomatic Cartilage Defects of the Femoral Condyle
Comparison of BioCart™II With Microfracture for Treatment of Cartilage Defects of the Femoral Condyle
BioCart™II is a novel scaffold seeded with autologous chondrocytes to be used to repair cartilage lesions of the knee. This study is designed to compare the efficacy and safety of BioCart™II treatment compared to microfracture…
- Trial name
- NCT00729716
- Testing
- BioCart™II, Microfracture
- Where
- 8 sites in United States, Israel
- Volunteers
- 40 people
- Sponsor
- ProChon Biotech Ltd
Pain Management
Evaluation of Paro, a Therapeutic Assistance Robot in Analgesic Management During the Placement of a Peripheral Intravenous Line in Infants and Children.
Peripheral intravenous catheterization is one of the most frequently performed procedures in pediatric emergency departments and hospital units.
- Trial name
- PARO (NCT07299006)
- Testing
- Experimental group: Standard multimodal pain management strategy supplemented with the PARO therapeutic robot., Non-pharmacological and standard pharmacological interventions.
- Where
- 5 sites in France
- Volunteers
- 120 people
- Sponsor
- Fondation Lenval
Type 1 Diabetes
Medtronic MiniMed Implantable Insulin Pump
This research is being done to find out whether subjects previously treated with the implantable insulin pump (IIP) therapy, and now taking insulin by injection, will benefit from re-implantation of IIP.
- Trial name
- NCT00298740
- Testing
- Aventis U-400 Insulin
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Johns Hopkins University
MPS I
Ascending Dose Study of Genome Editing by the Zinc Finger Nuclease (ZFN) Therapeutic SB-318 in Subjects With MPS I
The purpose of the study is to evaluate the safety, tolerability of ascending doses of SB-318. SB-318 is an intravenously delivered Zinc Finger Nuclease (ZFN) Therapeutic for genome editing.
- Trial name
- NCT02702115
- Testing
- SB-318
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Sangamo Therapeutics
Mucopolysaccharidosis II, MPS II
Ascending Dose Study of Genome Editing by the Zinc Finger Nuclease (ZFN) Therapeutic SB-913 in Subjects With MPS II
The purpose of the study is to evaluate the safety, tolerability and effect on leukocyte and plasma Iduronate 2-Sulfatase (IDS) enzyme activity of ascending doses of SB-913.
- Trial name
- NCT03041324
- Testing
- SB-913
- Where
- 5 sites in United States
- Volunteers
- 9 people
- Sponsor
- Sangamo Therapeutics
Cochlear Implantation
Follow-up of Cochlear Implanted Children at 3 Years : Comparison of Electrophysiological and Speech-language Results
The objective of the study is to compare the responses recorded with automated cortical auditory evoked potentials, of children who had one or two cochlear implants for 3 years, and the results of the speech therapy assessment.
- Trial name
- ImplantHear3 (NCT04192968)
- Testing
- Cortical auditory evoked potentials, Additional exams
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Coronary Artery Perforation
Covered Stents in Treatment of Coronary Artery Perforation
Covered stents have been mainly used for treatment of potentially life-threatening coronary artery perforation and coronary artery aneurysm.
- Trial name
- CRACK (NCT04630314)
- Testing
- Percutaneus Coronary Intervention
- Where
- 6 sites in Poland
- Volunteers
- 119 people
- Sponsor
- Medical University of Silesia
Pain
Musical Intervention During IV-line Placement in Neonates
The goal of this clinical trial is to test the effect of music in reducing the pain felt by newborn children during an intravenous line procedure. An intravenous line is a small tube brought into a vein by using a needle.
- Trial name
- NCT05926921
- Testing
- music
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Spaarne Gasthuis
Time, Patient Preference
DryShield vs Cotton Roll Isolation During Sealants Placement: Efficiency and Patient Preference
The goals of this study are to determine if 1) placement times of pit and fissure sealants using the DryShield system differ from those when using the cotton roll isolation technique; and 2) there is a significant difference in…
- Trial name
- NCT02995369
- Testing
- DryShield, Cotton rolls
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Montefiore Medical Center
Congenital Sensorineural Deafness
Effectiveness of Therapy Via Telemedicine Following Cochlear Implants
This study will assess the effectiveness of post-cochlear implant or hearing aid fitting Aural Rehabilitative Therapy (ART) delivered by means of telemedicine technology.
- Trial name
- TACIT (NCT02497690)
- Testing
- Telemedicine, In-person ART
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- University of Colorado, Denver
Obstructive Sleep Apnea of Adult
An Extension Study to Assess the Long-term Safety of the Genio® System
The objective of this study is to assess the long-term safety of the Genio® system in adult OSA patients with and without complete concentric collapse of the soft palate who have successfully been implanted with the Genio IS in a…
- Trial name
- OLE (NCT05939141)
- Testing
- Genio System
- Where
- 7 sites in Australia
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Nyxoah S.A.
Peri-implant Mucositis, Peri-Implantitis
Chitosan Brushes vs Air-Abrasive Devices on Peri-implant Mucositis Treatment: A Randomized Clinical
Bleeding on probing (0,1,2,3), plaque index (+,-) and pocket probing depth will be recorded for each visit. Before the procedure, the patient will be randomly assigned to one of four groups and records will be kept.
- Conditions
- Peri-implant Mucositis, Peri-Implantitis, Bleeding on Probing, Periodontal Pocket
- Trial name
- NCT06287957
- Testing
- Labrida BioClean, EMS Handy 3.0 Perio Premium
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Bleeding, Implants
Use of Curcumin to Treat Unfavorable Bleeding Patterns in Contraceptive Implant Users
The investigators plan to study the effects of curcumin, the active ingredient in the spice turmeric, on the irregular bleeding experienced by women who use the contraceptive implant.
- Conditions
- Bleeding, Implants, Breakthrough Bleeding
- Trial name
- NCT04205929
- Testing
- Curcumin
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University