Clinical trials: Infarction
Acute Myocardial Infarction
Metoprolol in Acute Myocardial Infarction. A PK/PD Study
The objective of the study was to compare treatment with two different oral formulations of metoprolol, metoprolol immediate release (IR) and metoprolol extended release (CR/XL) in patients with acute myocardial infarction…
- Trial name
- NCT01523054
- Testing
- Metoprolol- Toprol XL, Metoprolol- Lopressor
- Volunteers
- 27 people
- Sponsor
- AstraZeneca
Myocardial Infarction, Frailty
Management and Outcomes of Patients Admitted to Coronary Care Units, Depending on Degree of Frailty and Comorbidities
Background Patients less than 80 years of age, who suffer a myocardial infarction (MI) are usually (>90%) offered an early invasive strategy including coronary angiography possibly followed by intervention, preferably…
- Trial name
- NCT04488536
- Testing
- Clinical Frailty Scale
- Where
- 2 sites in Sweden
- Volunteers
- 10,000 people
- Sponsor
- Linkoeping University
Cerebrovascular Accident, Focal Infarct
Database for Stroke in Infants and Children: the International Pediatric Stroke Study
The International Pediatric Stroke Study (IPSS) was established in 2003 as a multi-center, multi-national clinical research registry.
- Trial name
- IPSS (NCT00084292)
- Where
- Canada
- Volunteers
- 12,000 people
- Sponsor
- The Hospital for Sick Children
Coronary Artery Disease, Myocardial Infarction
BRIEF-PCI: Brief Infusion of Eptifibatide Following Percutaneous Coronary Intervention
This trial was designed to examine the efficacy of a brief versus a standard prolonged (18 hours) infusion of eptifibatide in preventing troponin I release following successful coronary stenting.
- Trial name
- NCT00111566
- Testing
- eptifibatide
- Where
- Canada
- Volunteers
- 624 people
- Sponsor
- Cardiology Research UBC
Acute Myocardial Infarction
Acute Myocardial Infarction Study in Northeastern China
This is a real-world prospective cohort study aiming to generate knowledge about the characteristics, treatments, and outcomes of hospitalized AMI patients in Jilin Province.
- Trial name
- NCT04451967
- Testing
- thrombolysis
- Where
- China
- Volunteers
- 3,159 people
- Sponsor
- Second Hospital of Jilin University
Left Ventricular Thrombus
Relation of Laboratory Indices to Left Ventricular Thrombus Formation in Patients With Acute Anterior ST Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention or Thrombolytic Therapy
to find the relationship between the different hematological indices including platelet indices, and blood cell ratios, to the development of LV thrombus in acute anterior STEMI patients managed by primary percutaneous coronary…
- Trial name
- NCT06152939
- Testing
- Primary percutaneous coronary intervention or thrombolytic therapy
- Volunteers
- 400 people
- Sponsor
- Assiut University
Acute Coronary Syndrome, Acute Myocardial Infarction
ShorT and OPtimal Duration of Dual AntiPlatelet Therapy-2 Study for the Patients With ACS
The purpose of this study is to evaluate the safety of reducing dual antiplatelet therapy (DAPT) duration to 1 month after implantation of the everolimus-eluting cobalt-chromium stent (CoCr-EES) under the setting of acute…
- Conditions
- Acute Coronary Syndrome, Acute Myocardial Infarction, Coronary Artery Disease, Percutaneous Coronary Intervention
- Trial name
- STOPDAPT-2 ACS (NCT03462498)
- Testing
- 1-months DAPT, 12-month DAPT
- Where
- Japan
- Volunteers
- 3,008 people
- Sponsor
- Kyoto University, Graduate School of Medicine
Cerebral Amyloid Angiopathy, Small Vessel Cerebrovascular Disease
Prognosis of Cerebral Small Vessel Disease
Prognosis of small vessel disease (SVD) depends on the underlying type of SVD and index manifestation. The aim of this prospective, observational cohort study is to determine the risk of different outcome events among patients…
- Conditions
- Cerebral Amyloid Angiopathy, Small Vessel Cerebrovascular Disease, Cadasil, CAA - Cerebral Amyloid Angiopathy
- Trial name
- PRO-SVD (NCT05734378)
- Where
- Switzerland
- Volunteers
- 900 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Cerebral Infarction
Early Determinants of Multidimensional Outcome at School Age After Neonatal Arterial Ischemic Stroke
While perinatal ischemic stroke is the most frequent form of childhood stroke, early determinants of outcome remain poorly understood.
- Trial name
- NCT02511249
- Where
- 5 sites in France
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Acute Coronary Syndromes (ACS), NSTEMI - Non-ST-Segment Elevation Myocardial Infarction
The CORE - μFR Clinical Trial
Acute coronary syndromes (ACS) are frequently associated with multivessel coronary artery disease (CAD), and current guidelines recommend complete revascularization beyond the culprit lesion.
- Conditions
- Acute Coronary Syndromes (ACS), NSTEMI - Non-ST-Segment Elevation Myocardial Infarction, STEMI - ST Elevation Myocardial Infarction, Multivessel Coronary Artery Disease
- Trial name
- NCT07598565
- Testing
- Angiography-guided PCI, μFR based-PCI
- Where
- Italy
- Volunteers
- 350 people
- Sponsor
- University of Roma La Sapienza
LCx Occlusion STEMI, STEMI
Outcomes of Isolated LCx Occlusion
To assess procedural success and short term clinical outcomes of primary PCI to isolated LCx acute occlusion.
- Trial name
- NCT06750328
- Volunteers
- 50 people
- Sponsor
- Assiut University
Ulcerative Colitis, Myocardial Infarction
Estimation of Cardiovascular Risk in Patients With Crohn's Disease and Ulcerative Colitis (PROVACI)
Inflammatory bowel diseases (IBD) are progressively increasing their prevalence worldwide. Up to half of patients may also have extraintestinal manifestation and cardiovascular diseases (CVDs) is one of the most relevant, being…
- Conditions
- Ulcerative Colitis, Myocardial Infarction, Stroke, Ischemic Heart Disease
- Trial name
- PROVACI (NCT07095634)
- Where
- Italy
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Myocardial Infarction
CARESS in Acute Myocardial Infarction
The aim of this study conducted in patients with high risk ST-segment elevation AMI admitted to hospitals with no PTCA facilities is to compare the effects on clinical outcome and cost-effectiveness of two reperfusion strategies…
- Trial name
- NCT00220571
- Testing
- Coronary Angioplasty (PTCA)
- Where
- 85 sites in France, Italy and 1 more
- Volunteers
- 600 people
- Sponsor
- Società Italiana di Cardiologia Invasiva
Cardiovascular Disease, Coronary Heart Disease
Periodontitis and Cardiovascular Events or "PAVE"
The purpose of this study is to determine if treating periodontal infections (gum problems) will lead to fewer heart problems in patients at high risk for cardiovascular disease.
- Conditions
- Cardiovascular Disease, Coronary Heart Disease, Myocardial Infarction, Cerebrovascular Accident
- Trial name
- NCT00066053
- Testing
- Periodontal Treatment: SRP, Referral
- Where
- United States
- Volunteers
- 303 people
- Sponsor
- University at Buffalo
Cardiac Magnetic Resonance, Extracellular Volume Overload
Extracellular Volume Associated With New-Onset Atrial Fibrillation
Left ventricular fibrosis is strongly associated with atrial fibrillation (AF). However, the relationship between LV fibrosis and new-onset AF (NOAF) after ST-segment elevation myocardial infarction (STEMI) is currently unknown.
- Conditions
- Cardiac Magnetic Resonance, Extracellular Volume Overload, Myocardial Infarction, Atrial Fibrillation
- Trial name
- NCT06447857
- Testing
- Cardiac MRI
- Where
- China
- Volunteers
- 589 people
- Sponsor
- The Affiliated Hospital of Xuzhou Medical University
Cardiovascular Diseases, Coronary Disease
Observational Aspirin Use and CVD in the Physicians' Health Study
To analyze existing data from the Physicians Health Study (PHS), a randomized primary prevention trial of low-dose aspirin and beta carotene conducted among 22,071 U.S.
- Conditions
- Cardiovascular Diseases, Coronary Disease, Heart Diseases, Myocardial Infarction
- Trial name
- NCT00005493
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cardiovascular Diseases, Coronary Disease
Infection and Cardiovascular Disease
To investigate the role of chronic infection as a risk factor for vascular disease in a study of Native Americans. The primary focus is on the two most common agents Chlamydia pneumoniae and cytomegalovirus with a secondary…
- Conditions
- Cardiovascular Diseases, Coronary Disease, Cerebrovascular Accident, Heart Diseases
- Trial name
- NCT00005547
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Anterior MI, Colchicine
Effect of Colchicine On Left Ventricle Function After Anterior Myocardial Infarction Assessed By Speckle Tracking
Effect of colchicine use on Left ventricles systolic function in patients with anterior S-T elevation myocardial infarction undergoing primary Percutaneous coronary intervention by using speckle tracking Echocardiography…
- Trial name
- NCT05200052
- Testing
- Colchicine 0.5 mg Oral Tablet
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Myocardial Infarction
Safety And Feasibility of Early DischargE - a Prospective And Randomized Trial of Low-risk Primary Percutaneous Coronary Intervention (PCI) Patients
The purpose of this study is to determine if early hospital discharge (at 48-72 hours), is feasible, safe, cost-effective, and/or improves compliance with medications, positive lifestyle changes and quality-of-life, in low-risk…
- Trial name
- SAFE-DEPART (NCT00474214)
- Testing
- Early hospital discharge facilitated by close nurse practitioner follow-up
- Where
- Canada
- Volunteers
- 54 people
- Sponsor
- Hamilton Health Sciences Corporation
Ventricular Tachycardia, Myocardial Infarction
Cohort Study - SBRT for VT Radioablation
Ventricular tachycardia (VT) contributes to over 350,000 sudden deaths each year in the US. Malignant VTs involve an electrical "short circuit" in the heart, formed by narrow channels of surviving tissue inside myocardial scar.
- Conditions
- Ventricular Tachycardia, Myocardial Infarction, Heart Disease Structural Disorder
- Trial name
- NCT04162171
- Testing
- Stereotactic Body Radiotherapy (SBRT) ablation of VT
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- John Sapp