Clinical trials: Infection Control
Pneumonia, Mycoplasma
Treatment of Macrolide-resistant Mycoplasma Pneumoniae
A randomized clinical trial comparing treatment effectiveness of azithromycin and doxycycline for pediatric Mycoplasma pneumonia.
- Trial name
- NCT03530319
- Testing
- Doxycycline, Azithromycin
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Intestinal Helminthiasis, Diarrhea
The Impact of Anthelmintic Treatment on the Incidence of Diarrheal Disease in Vietnamese School Children
Cheap and effective drugs called 'anthelmintics' are routinely administered to children in developing countries to eliminate infections by parasitic helminths.
- Trial name
- NCT02597556
- Testing
- Albendazole
- Where
- Vietnam
- Volunteers
- healthy volunteers welcome
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Cytomegalovirus (CMV) Infection
ValgaNciclovIR for CMV Viraemia in AdvaNced HIV diseAse
The goal of this clinical trial is to learn if valganciclovir works to treat cytomegalovirus (CMV) infection in people with advanced HIV disease.
- Trial name
- NIRVANA (NCT07379203)
- Testing
- Valganciclovir
- Volunteers
- 130 people
- Sponsor
- Wits Health Consortium (Pty) Ltd
Malaria, Anemia
Uganda Housing Modification Study
To explore housing modification as a malaria control intervention, and to assess the degree to which it may offer protection in moderate to high malaria endemicity settings, we propose a two-phase study evaluating epidemiological…
- Trial name
- UHMS (NCT04622241)
- Testing
- Eave Tubes, Eave Ribbons, Full House Screening
- Where
- Uganda
- Volunteers
- 2,422 people, healthy volunteers welcome
- Sponsor
- Infectious Diseases Research Collaboration, Uganda
Seizure, Epilepsy
A Safety and Feasibility Study of Enteral LVT vs. Standard of Care for Seizure Control in Pediatric CM
Pediatric cerebral malaria (CM) affects more than 3 million children each year killing ~20% and leaving one third of survivors with long term neurologic and psychiatric sequelae.
- Conditions
- Seizure, Epilepsy, Cerebral Malaria
- Trial name
- LVT2 (NCT01982812)
- Testing
- Oral Levetiracetam, Standard AED
- Where
- Malawi
- Volunteers
- 44 people
- Sponsor
- University of Rochester
Plasmodium Falciparum Infection
Optimising Operational Use of Artemether-lumefantrine Comparing 3 Day Versus 5 Day
This is a randomised two arm study, comparing artemether-lumefantrine 3 days and 5 days treatment. Patients will be randomised in blocks of ten to one of the two treatment arms.
- Trial name
- AL3vs5 (NCT02020330)
- Testing
- Artemether-lumefantrine 3 days, Artemether-lumefantrine 5 days
- Where
- Burma
- Volunteers
- 150 people
- Sponsor
- University of Oxford
Otitis Media, Suppurative
Amoxicillin-clavulanate in Treating Acute Otitis Media Evaluated by Daily Tympanometry
The purpose of the study is to assess the efficacy of amoxicillin-clavulanate in treating acute otitis media in children. The primary end point is time to disappearance of middle ear effusion which monitored by daily tympanometry…
- Trial name
- NCT01244581
- Testing
- Amoxicillin-clavulanate
- Where
- 2 sites in Finland
- Volunteers
- 84 people
- Sponsor
- University of Oulu
HIV Infections
Comparison of Efficacy and Safety of Infant Peri-exposure Prophylaxis With Lopinavir/Ritonavir Versus Lamivudine to Prevent HIV-1 Transmission by Breastfeeding
The ANRS 12174 study is a clinical trial that will compare the efficacy and safety of prolonged infant peri-exposure prophylaxis (PEP) with Lopinavir/Ritonavir (LPV/r) versus Lamivudine to prevent HIV-1 transmission through…
- Trial name
- NCT00640263
- Testing
- lopinavir/ritonavir (LPV/r), Lamivudine (3TC)
- Where
- 4 sites in Burkina Faso, South Africa and 2 more
- Volunteers
- 1,500 people
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis
Ureaplasma Infections
Trial of Intravenous Azithromycin to Eradicate Ureaplasma Respiratory Tract Infection in Preterm Infants
The purpose of this study is to determine whether intravenous azithromycin is effective in eradicating Ureaplasma respiratory tract infection in preterm infants born at 24 to 28 weeks gestation.
- Trial name
- AZIPIII (NCT01778634)
- Testing
- Azithromycin
- Where
- 7 sites in United States
- Volunteers
- 121 people
- Sponsor
- University of Maryland, Baltimore
Bacterial Vaginosis
Role of Oral Lactobacilli on Vaginal Flora of Pregnant Women
Bacterial vaginosis (BV) occurs in about 20% of pregnancies and responsible for up to 25% of visits to gynecological clinics. BV is characterized by a shift in vaginal bacterial flora from lactobacilli to pathogenic bacterial…
- Trial name
- NCT04638257
- Testing
- Lactobacilli rhamnosus GR-1 and Lactobacilli fermentum RC-14
- Volunteers
- 49 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Cross Infection, Infection Control
A Randomized Trial Comparing Matt and Antimicrobial Cellomed Laminates
Sepsis contributes to nearly 20% of all hospital deaths and is the leading cause of death on non-coronary intensive care units. Contamination of the patient environment is common with organisms such as MRSA, VRE and C.difficile…
- Trial name
- NCT01245829
- Testing
- Swabbing of observation chart
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- County Durham and Darlington NHS Foundation Trust
Human Immunodeficiency Virus, HIV
Europe-Africa Research Network for Evaluation of Second-line Therapy
The trial aim is to ascertain what, if anything, needs to be combined with a boosted protease inhibitor (bPI) backbone in second-line therapy in order to maximize the chance of a good clinical outcome following WHO-defined…
- Trial name
- EARNEST (NCT00988039)
- Testing
- Aluvia + 2NRTIs, Aluvia + raltegravir, Aluvia monotherapy
- Where
- 14 sites in Kenya, Malawi and 3 more
- Volunteers
- 1,277 people
- Sponsor
- Justine Boles
Laparoscopic Appendectomy
Comparison Between Metallic Clip Ligation and Suture Ligation of Appendicular Stump in Laparoscopic Appendectomy
Laparoscopic appendectomy is the standard procedure for acute appendicitis. Among the various steps of the procedure one of the rate limiting step is the ligation of the appendicular stump which can be done using suture material…
- Trial name
- NCT07129746
- Testing
- Metallic clip ligation of the appendicular stump, Suture ligation of appendicular stump
- Where
- Pakistan
- Volunteers
- 10 people
- Sponsor
- Jinnah Hospital
Recurrent Urinary Tract Infection, Genitourinary Syndrome of Menopause
RCT Comparing Intravaginal Laser Therapy to Sham in Post-menopausal Women with Recurrent Urinary Tract Infections
Recurrent urinary tract infection (rUTI) is a common and difficult to treat problem with limited treatment option; postmenopausal women are disproportionately affected.
- Trial name
- UTIEXTERMINATE (NCT06124820)
- Testing
- Deka SmartXide Touch C60 (MonaLisa Touch)
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- King's College Hospital NHS Trust
HIV Infections, Alcoholism
Brief Therapy Intervention for Heavy/Hazardous Drinking in HIV-Positive Women
The purpose of this study is to determine whether two brief counseling sessions reduce drinking and improve health outcomes in HIV-positive women who drink at heavy/hazardous levels.
- Trial name
- NCT00127231
- Testing
- Brief alcohol intervention based on Project Treat, Standard care
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- Johns Hopkins University
Pyelonephritis
Short-term Antibiotic Therapy for Pyelonephritis in Childhood
The purpose of this study is to evaluate the efficacy of oral ceftibuten for 7 days versus 10 days in acute pyelonephritis in children.
- Trial name
- STUTI (NCT00724256)
- Testing
- ceftibuten
- Where
- Italy
- Volunteers
- 36 people
- Sponsor
- IRCCS Burlo Garofolo
Dysentery, Shigella, Shigellosis
Ciprofloxacin Versus Azithromycin for Children Hospitalised With Dysentery
The purpose of this study is to assess the efficacy of 3 days of azithromycin (AZI) compared to 3 days of ciprofloxacin (CIP) (standard-of-care) for the treatment of children hospitalised with dysentery in Ho Chi Minh City.
- Conditions
- Dysentery, Shigella, Shigellosis, Diarrhea
- Trial name
- CIPAZ (NCT03854929)
- Testing
- Ciprofloxacin, Azithromycin
- Where
- Vietnam
- Volunteers
- 364 people
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Meningococcal Disease
Safety and Immunogenicity of One Dose of Novartis' Meningococcal ACWY-CRM Vaccine and GlaxoSmithKline Biologicals' Meningococcal ACWY-TT Vaccine in Healthy Toddlers
Evaluate the immune response and reactogenicity of one dose of Meningococcal ACWY-cross reactive material (CRM) and Meningococcal ACWY-tetanus toxoid (TT) in 12-15 months old healthy toddlers.
- Trial name
- NCT01994629
- Testing
- MenACWY-CRM, MenACWY-TT
- Where
- 4 sites in Italy
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- Novartis Vaccines
Diarrhea
A Post-marketing Observational Study of Oral Cholera Vaccine
Chinese survey data indicate that the incidence rate of diarrhea in the general population ranges from 0.17 to 0.70 episodes per person-year, whereas among children under five years of age, the rate is significantly higher…
- Trial name
- NCT07300462
- Testing
- Recombinant subunit B/bacterial cholera vaccine (enteric-coated capsules)
- Where
- 5 sites in China
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Shanghai United Cell Biotechnology Co., Ltd
Pneumococcal Infections, Streptococcal Infections
Phase III Clinical Trial of a Candidate PCV13 in Healthy People Aged 6 Weeks and Above (PICTPCV13i)
Streptococcus pneumoniae is a major cause of morbidity and mortality in children worldwide, resulting in up to 1 million pediatric deaths every year.Since the licensure of PCV7 and PCV13,the reported overall decline in invasive…
- Conditions
- Pneumococcal Infections, Streptococcal Infections, Bacterial Infections
- Trial name
- NCT04841369
- Testing
- 13-Valent Pneumococcal Polysaccharide Conjugate Vaccine（CRM197,TT）, 13-Valent Pneumococcal Polysaccharide Conjugate Vaccine
- Where
- China
- Volunteers
- 3,420 people, healthy volunteers welcome
- Sponsor
- CanSino Biologics Inc.
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