Clinical trials: Infection Control
Malaria
Phase Ib Trial of MSP3 LSP in Children in Tanzania
This study will evaluate the safety of candidate malaria vaccine MSP3 in children aged 12-24 months in Tanzania in a highland area with low malaria transmission.
- Trial name
- MSP3TN (NCT00469651)
- Testing
- MSP 3 Long Synthetic Peptide, MSP3 vaccine, Hepatitis B vaccine
- Where
- Tanzania
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- African Malaria Network Trust
Brain Injuries, Malaria
An MRI Ancillary Study of a Malaria Fever Investigation
This study will seek consent from parents of children enrolled in the Malaria FEVER study to obtain neuroimaging and 12-month neuropsychiatric outcomes data and kidney function on their child.
- Conditions
- Brain Injuries, Malaria, MRI Imaging, Neurocognitive Deficits
- Trial name
- MRIA (NCT05746819)
- Testing
- Aggressive antipyretics therapy of fever vs usual care in the Malaria RCT study
- Where
- 2 sites in Malawi, Zambia
- Volunteers
- 181 people
- Sponsor
- University of Rochester
Acute Appendicitis
Laparoscopic Assisted or Total Laparoscopic Appendectomy
Acute appendicitis (AA), is a common intra-abdominal surgical pathology with the overall incidence of approximately 7% and mortality of 0.2-0.8%.
- Trial name
- NCT02673528
- Testing
- Laparoscopic appendectomy
- Volunteers
- 451 people
- Sponsor
- Medical Park Gaziantep Hospital
Healthcare-associated Infections
Trial of Positive Deviance in Inpatient Wards to Reduce Hospital Infections
Healthcare-associated infections (HAI) are a significant public health burden. Even with existence of recommendations on technical strategies to prevent these infections, there is a need for strategies to increase staff…
- Trial name
- NCT02244905
- Testing
- Positive Deviance, Standard-of-Care Infection Control approach
- Volunteers
- 16,876 people
- Sponsor
- University of Texas Southwestern Medical Center
Relapsed Adult ALL, B-cell Acute Lymphoblastic Leukemia
Bridging Allogeneic Hematopoietic Stem Cell Transplantation or Not After CD19 CAR - T (S1904) Cell Therapy for r/r B-cell Acute Lymphoblastic Leukemia
Traditional salvage chemotherapy has low efficacy and poor long-term prognosis for relapsed or refractory (R/R) B-cell acute lymphoblastic leukemia (B-ALL).
- Conditions
- Relapsed Adult ALL, B-cell Acute Lymphoblastic Leukemia, Refractory Acute Lymphoblastic Leukemia, Relapsed Pediatric ALL
- Trial name
- NCT06581081
- Testing
- Senl_B19 autologous CAR-T (S1904) treatment
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Peking University People's Hospital
Sexually Transmitted Diseases
The "Notijoves" Randomised Controlled
Background: Increase of sexually transmitted infections (STIs) as well as increased use of new information and communication technologies (ICTs) among young people in Catalonia triggers the idea of designing a mobile phone…
- Trial name
- notijoves (NCT03986567)
- Testing
- gamification for partner notification among youngsters
- Where
- Spain
- Volunteers
- 416 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Rhinosinusitis
Efficacy and Safety of Acetylcysteine for the Treatment of Acute Uncomplicated Rhinosinusitis
The trial was conducted as a prospective, randomized, multinational, multicenter, double-blind study in 4 parallel groups of patients.
- Trial name
- NCT04123405
- Testing
- acetylcysteine
- Where
- 37 sites in Bulgaria, Germany and 2 more
- Volunteers
- 944 people
- Sponsor
- Sandoz
Necrotizing Enterocolitis, Sepsis
Human Milk Fortification in Extremely Preterm Infants
This is a randomised controlled multi-centre trial comparing the effect of diet supplementation of a human breast milk-based nutrient fortifier (H2MF®) with standard bovine protein-based nutrient fortifier in 222 extremely…
- Conditions
- Necrotizing Enterocolitis, Sepsis, Mortality
- Trial name
- N-forte (NCT03797157)
- Testing
- H2MF, Bovine milk-based fortifier
- Where
- 5 sites in Sweden
- Volunteers
- 229 people
- Sponsor
- Thomas Abrahamsson, MD, PhD
Appendicitis, Surgery
Sugammadex vs Neostigmine Reversal in Pediatric Appendectomy
This study is designed as a randomized controlled trial with patients assigned to neuromuscular reversal with either sugammadex or neostigmine/glycopyrrolate reversal.
- Trial name
- NCT05256901
- Testing
- Sugammadex, Neostigmine/Glycopyrrolate
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Emory University
Dengue
Citizen Action for Sustainable Dengue Control in Sub-Saharan Africa
This project focuses on addressing arboviral outbreaks in Ivory Coast by involving local communities in the sustainable control of Aedes mosquitoes, utilizing scientific advice and environmental interventions.
- Trial name
- NCT06648603
- Testing
- Community-based larval source management, Enhanced Aedes adults trapping (BG-GAT), Community-based larval source management with Enhanced Aedes adults trapping (BG-GAT)
- Where
- Côte d’Ivoire
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Swiss Tropical & Public Health Institute
Myelitis, Transverse, Neuromyelitis Optica
A Multicentre randomiSed Controlled TRial of IntraVEnous Immunoglobulin Versus Standard Therapy for Transverse Myelitis
This multi-center randomized controlled trial evaluates if the addition of intravenous immunoglobulin to standard treatment of corticosteroids improves outcome in children and adults with first episode of Transverse Myelitis of…
- Trial name
- STRIVE (NCT02398994)
- Testing
- Intravenous Methylprednisolone, Intravenous Immunoglobulin
- Where
- 18 sites in United Kingdom
- Volunteers
- 2 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
COVID-19, SARS-CoV Infection
Glycine Supplement for Severe COVID-19
This study will explore whether a daily supplement of glycine, a substance that has antiinflammatory, cytoprotective, and endothelium-protecting effects, can improve mortality, as well as clinical and biochemical parameters, in…
- Conditions
- COVID-19, SARS-CoV Infection, SARS (Severe Acute Respiratory Syndrome), SARS Pneumonia
- Trial name
- NCT04443673
- Testing
- Glycine
- Where
- Mexico
- Volunteers
- 59 people
- Sponsor
- Instituto Nacional de Enfermedades Respiratorias
Surgical Site Infection (SSI)
Effect of Early vs Late Water Exposure After Cutaneous Surgery
This randomized controlled trial aims to compare the effect of early versus delayed water exposure after cutaneous surgeries on the incidence of surgical site infections.
- Trial name
- NCT07580274
- Testing
- Care as usual
- Volunteers
- 82 people
- Sponsor
- Pak Emirates Military Hospital
Influenza
Study to Assess the Safety, Pharmacokinetics, and Efficacy of Baloxavir Marboxil in Chinese Pediatric Participants 1 to <12 Years of Age With Influenza Symptoms
The purpose of this study is to evaluate the safety of a single dose baloxavir marboxil compared with 5 days of oseltamivir administered twice a day (BID) in Chinese pediatric participants aged 1 to < 12 years with influenza…
- Trial name
- NCT06774859
- Testing
- Baloxavir Marboxil, Oseltamivir
- Where
- 16 sites in China
- Volunteers
- 100 people
- Sponsor
- Hoffmann-La Roche
Chlamydia
Home-sampling in Partner Notification of Chlamydia
Though partner notification is mandatory to perform of Chlamydia trachomatis infected individuals in Sweden, there was a 10-15% annually increase of reported cases between 1997 and 2007 indicating that partner notification may…
- Trial name
- NCT01596946
- Testing
- Contact tracing mode test at clinic, Self-sampling at home - Sent Test Kit
- Where
- Sweden
- Volunteers
- 633 people, healthy volunteers welcome
- Sponsor
- Ostergotland County Council, Sweden
Chronic Obstructive Pulmonary Disease, COPD
The Effect of Breathing Helium-Hyperoxia During Pulmonary Rehabilitation in Patients With COPD
The purpose of this study is to examine whether breathing helium-hyperoxia during exercise in a pulmonary rehabilitation program can improve the exercise tolerance and health related quality of life of patients with Chronic…
- Conditions
- Chronic Obstructive Pulmonary Disease, COPD, Emphysema, Lung Diseases
- Trial name
- NCT00406705
- Testing
- Helium-Hyperoxia
- Where
- Canada
- Volunteers
- 38 people
- Sponsor
- University of Alberta
Sepsis, Septic Shock
Lipopolysaccharide Adsorption (Efferon LPS NEO) in Children With Sepsis
One of the major health problems in the world is sepsis, the number of cases of which, according to WHO, annually reaches 20-30 million.
- Trial name
- LASSONEO (NCT05707494)
- Testing
- Efferon LPS NEO
- Where
- 7 sites in Russia
- Volunteers
- 78 people
- Sponsor
- Efferon JSC
Cholestasis in Newborn
Parenteral Nutrition Cycling for Prevention of Cholestatic Syndrome in Newborn
Background: Despite the use of parenteral nutrition cycling (PNC) in neonatal intensive care units (NICU), there is limited evidence regarding the benefits in relation to the nutrición parenteral total (NPT) in term and late…
- Trial name
- NCT06366880
- Testing
- Parenteral nutrition cycling
- Where
- Mexico
- Volunteers
- 66 people
- Sponsor
- Hospital Pediátrico de Sinaloa
Mpox (Monkeypox)
Epidemiological and Clinical Characteristics of Human Mpox Outbreak in Equateur Province in the Democratic Republic of Congo (Part3)
The goal of this study is to evaluate the effectiveness of smallpox vaccination administered before the global eradication of smallpox against currently circulating mpox in the Democratic Republic of the Congo.
- Trial name
- NCT06984705
- Where
- Democratic Republic of the Congo
- Volunteers
- 144 people
- Sponsor
- Osaka Metropolitan University
Urinary Tract Infections
Cranberry Juice in the Prevention of Urinary Tract Infections in Children
The objective of the study is to determine whether recurrences of urinary tract infection in children can be prevented with cranberry juice.
- Trial name
- NCT00638170
- Testing
- Cranberry juice
- Where
- Finland
- Volunteers
- 262 people
- Sponsor
- University of Oulu
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