Clinical trials: Infection Control
Mycobacterium Avium-intracellulare Infection, HIV Infections
A Study to Evaluate the Effects of Azithromycin on MAC Disease Prevention in HIV-Positive Patients
This study is designed to find out whether HIV-positive patients whose immune systems have improved after receiving anti-HIV treatment should take azithromycin to prevent Mycobacterium avium complex (MAC) disease.
- Trial name
- NCT00000947
- Testing
- Azithromycin
- Where
- 19 sites in United States
- Volunteers
- 850 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Pneumonia Caused by Human Coronavirus (Disorder)
Treatment and Prevention of Traditional Chinese Medicines (TCMs) on COVID-19 Infection
The aim of this study is to test whether Traditional Chinese Medicines (TCMs) are effective and safe for treating COVID-19 infection.
- Trial name
- NCT04251871
- Testing
- Conventional medicines (Oxygen therapy, alfa interferon via aerosol inhalation, and lopinavir/ritonavir) and Traditional Chinese Medicines (TCMs) granules, Conventional medicines (Oxygen therapy, alfa interferon via aerosol inhalation, and lopinavir/ritonavir)
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Beijing 302 Hospital
HIV Infections
A Study of Retrovir in the Prevention of HIV Infection in Health Care Workers Accidentally Exposed to the Virus
To evaluate the safety and effectiveness of Retrovir (AZT) when used as prophylaxis for health care workers at risk for HIV infection from exposure to HIV-contaminated blood or blood components.
- Trial name
- NCT00002287
- Testing
- Zidovudine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Glaxo Wellcome
Cysticercosis
EFECAB: Improving Pig Management to Prevent Epilepsy in Burkina Faso
This is a pre-post randomized community-based controlled trial aimed at estimating the effectiveness of an educational package developed using PRECEDE PROCEED to reduce the cumulative incidence of Taenia solium cysticercosis in…
- Trial name
- EFECAB (NCT03095339)
- Testing
- Educational package
- Where
- Burkina Faso
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Hidradenitis Suppurativa
An Investigation Into the Efficacy of Provodine Topical Cream as Compared to 10% Benzoyl Peroxide Wash for the Treatment of Hidradenitis Suppurativa.
The purpose of this study is to compare the efficacy of Provodine™ topical cream to 10% benzoyl peroxide topical body wash for the treatment of early stage hidradenitis suppurativa.
- Trial name
- NCT01818167
- Testing
- 10% Benzoyl Peroxide Topical Body Wash, Provodine Topical Cream
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Pneumonia, Respiration Disorders
Continuous Sedation vs Daily Sedation Interruption in Ventilated Children
Sedation is essential for mechanically ventilated pediatric patients to ensure comfort, ventilator synchrony, and prevention of self-extubation.
- Trial name
- NCT07438834
- Testing
- Continuous Sedation Infusion (CSI), Daily Sedation Interruption (DSI)
- Volunteers
- 96 people
- Sponsor
- University of Health Sciences Lahore
COVID-19
Immunogenicity And Safety of COVID-19 Vaccine , Inactivated Co -Administration With EV71 Vaccine (Vero Cell)
This study is a randomized and controlled phase Ⅳ clinical trial of the COVID-19 vaccine (Vero cell), Inactivated manufactured by Sinovac Research \& Development Co., Ltd.
- Trial name
- NCT04993365
- Testing
- Experimental Group, Control Group
- Where
- 2 sites in China
- Volunteers
- 520 people, healthy volunteers welcome
- Sponsor
- Sinovac Research and Development Co., Ltd.
Bacterial Conjunctivitis
Safety and Efficacy of Vancomycin Ophthalmic Ointment in Patients With Moderate to Severe Bacterial Conjunctivitis
This is a Phase 3 study to evaluate the safety and efficacy of a vancomycin hydrochloride ophthalmic ointment dosed 4 times daily for 7 days compared to placebo (vehicle) in patients with moderate to severed Gram-positive…
- Trial name
- NCT02432807
- Testing
- Vancomycin 1.1%
- Where
- 16 sites in United States
- Volunteers
- 303 people
- Sponsor
- Kurobe LLC
Covid19
Effectiveness of Ivermectin and Doxycycline on COVID-19 Patients
A randomized controlled trial on using Ivermectin and doxycycline to treat mild-moderate outpatients, severe, and critical inpatients of Coronavirus disease 19 (COVID-19) along with standard of care.
- Trial name
- NCT04591600
- Testing
- Ivermectin and Doxycyline, Standard of care
- Where
- Iraq
- Volunteers
- 140 people
- Sponsor
- Alkarkh Health Directorate-Baghdad
Bacterial Vaginosis
BASIC (Boric Acid, Alternate Solution for Intravaginal Colonization) Study
Bacterial vaginosis (BV), the world's most common vaginal infection, continues to cost patients time, energy, comfort and money.
- Trial name
- NCT00799214
- Testing
- Boric acid, Metronidazole
- Where
- Canada
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
HIV Infections
Optimizing Pediatric HIV-1 Treatment, Nairobi, Kenya
Given the high mortality associated with infant HIV-1 and the fact that surrogate markers are poorly predictive of mortality risk,empiric highly active antiretroviral therapy (HAART) initiation is started in infants younger than…
- Trial name
- NCT00428116
- Testing
- HAART
- Volunteers
- 140 people
- Sponsor
- University of Washington
MRSA, Cystic Fibrosis
AeroVanc in the Treatment of Methicillin-resistant Staphylococcus Aureus Infection in Patients With Cystic Fibrosis
This is a multi-center, randomized phase III study to evaluate the clinical effectiveness of AeroVanc in persistent methicillin-resistant Staphylococcus aureus (MRSA) infection in patients with cystic fibrosis (CF).
- Trial name
- NCT03181932
- Testing
- Vancomycin inhalation powder
- Where
- 71 sites in United States, Canada
- Volunteers
- 188 people
- Sponsor
- Savara Inc.
Chickenpox
A Study on the Immune Response and Safety of an Investigational Chickenpox Vaccine When Given to Healthy Children 12 to 15 Months of Age
The purpose of this study is to assess the consistency of immune response to three different lots of GSK's investigational varicella vaccine (VNS Vaccine), and to compare the safety and immune response of VNS vaccine to an…
- Trial name
- NCT06740630
- Testing
- Investigational varicella vaccine_Lot 1, Investigational varicella vaccine_Lot 2, Investigational varicella vaccine_Lot 3
- Where
- 97 sites in United States, Belgium and 9 more
- Volunteers
- 1,840 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Cystic Fibrosis, Rhinosinusitis
Tobramycin Delivered by Nebulized Sonic Aerosol for Chronic Rhinosinusitis Treatment of Cystic Fibrosis Patients
Patients with cystic fibrosis frequently develop chronic rhinosinusitis. Bacterial colonization is facilitated by a reduced mucociliary function and some previous studies suggest that the microbiology of the upper airways might…
- Conditions
- Cystic Fibrosis, Rhinosinusitis, Lung Diseases
- Trial name
- AVASMUC (NCT02888730)
- Testing
- Tobramycin nebulized nasally, Physiologic serum nebulized nasally
- Where
- 6 sites in France
- Volunteers
- 86 people
- Sponsor
- Virginie ESCABASSE
Tonsillitis, Tonsillectomy
Gabapentin Premedication to Reduce Postoperative Pain for Pediatric Tonsillectomy
The purpose of this pilot study: 1) to examine the use of gabapentin in reducing pain in the first 48 hours postoperatively including the total amount of narcotics mg/kg given 2) to record the time to first analgesic…
- Trial name
- NCT03625011
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Children's Healthcare of Atlanta
Sepsis, Shock, Septic
Medical Education for Sepsis Source Control and Antibiotics
Patients with severe sepsis or septic shock suffer from life-threatening infections. Fast and adequate therapy with antibiotics is crucial for survival.
- Trial name
- MEDUSA (NCT01187134)
- Testing
- Change Management
- Where
- 42 sites in Germany
- Volunteers
- 4,138 people
- Sponsor
- Center for Sepsis Control and Care, Germany
Sleeping Sickness, Trypanosomiasis, African
Screen and Treat Implementation for HAT Control
Human African Trypanosomiasis (HAT), or sleeping sickness, is one of the parasitic diseases targeted for interruption of transmission by 2030 by the WHO.
- Trial name
- NCT05645822
- Testing
- Screen&treat
- Sponsor
- Institute of Tropical Medicine, Belgium
Tuberculosis, Tubercular Meningitis
Cyclophosphamide in the Treatment of Refractory Proliferative Arachnoiditis in CNS Tuberculosis
Tubercular meningitis occurs in around 10% of those with extrapulmonary tuberculosis and is a major cause of mortality and morbidity.
- Conditions
- Tuberculosis, Tubercular Meningitis, Arachnoiditis; Tuberculous (Etiology)
- Trial name
- NCT04620772
- Testing
- Cyclophosphamide injection
- Volunteers
- 40 people
- Sponsor
- All India Institute of Medical Sciences
Soft Tissue Inflammation
Prevention of Hypergranulation Tissue After Gastrostomy Tube Placement
The primary objective of this study is to compare the incidence of postoperative hypergranulation tissue formation after gastrostomy tube placement among children randomized to one of three treatments, in addition to measuring…
- Trial name
- NCT01501539
- Testing
- Standard Hydrocolloid Dressing, Silver Hydrocolloid Dressing
- Where
- United States
- Volunteers
- 171 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Carbapenem Resistant Bacterial Infection, Acinetobacter Bacteremia
Cefiderocol and Ampicillin-sulbactam vs. Colistin +/- Meropenem for Carbapenem Resistant A. Baumannii
Patients with bloodstream infections, hospital acquired pneumonia or ventilator-associated pneumonia caused by carbapenem-resistant Acinetobacter baumannii (CRAB) treated with cefiderocol combined with ampicillin sulbactam will…
- Conditions
- Carbapenem Resistant Bacterial Infection, Acinetobacter Bacteremia, Acinetobacter Pneumonia
- Trial name
- CASCADE (NCT05922124)
- Testing
- Cefiderocol, Ampicillin-sulbactam, Colistin
- Where
- 3 sites in Israel
- Volunteers
- 734 people
- Sponsor
- Rambam Health Care Campus
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