Clinical trials: Infections, Nosocomial
Influenza, Influenza Prophylaxis
Oseltamivir and Baloxavir Marboxil for Prophylaxis Against Influenza Under a Hospital-based Setting
This study aims to randomly assign close contacts of hospitalized influenza virus patients to receive baloxavir marboxil prophylaxis, oseltamivir prophylaxis or no antiviral prophylaxis and monitor the incidence of clinical…
- Conditions
- Influenza, Influenza Prophylaxis, Nosocomial Infection
- Trial name
- NCT06762587
- Testing
- Baloxavir Marboxil, Oseltamivir
- Where
- China
- Volunteers
- 372 people, healthy volunteers welcome
- Sponsor
- Capital Medical University
MRSA Infection
Two Strategies for Methicillin-resistant Staphylococcus Aureus (MRSA) Infection Prevention in Surgical Patients
The study is a two-arm controlled multi-centre trial of two strategies to reduce nosocomial MRSA transmission and infection among surgical patients. Enrolment and primary analyses will be performed at the hospital level.
- Trial name
- MOSAR-04 (NCT00685867)
- Testing
- Rapid molecular MRSA test, Hand hygiene promotion
- Where
- Switzerland
- Volunteers
- 126,750 people
- Sponsor
- University Hospital, Geneva
Oncology [See Also, Affected System], Hematological Disease
Assessing the Effect of Contact Isolation on Nosocomial Colonization With ESBL-EC in German Hematology/Oncology Wards
This study aims to evaluate the impact of contact isolation on the rate of hospital-acquired transmissions of ESBL-producing Escherichia coli (ESBL-EC) and the rate of colonization and infection.
- Conditions
- Oncology [See Also, Affected System], Hematological Disease, Infection Due to ESBL Escherichia Coli
- Trial name
- CONTAIN (NCT02456818)
- Volunteers
- 2,264 people
- Sponsor
- University of Cologne
Clostridium Difficile
C Difficile Near-patient Diagnostics
The investigators will conduct a two-period, two-intervention, cluster randomized crossover (CRXO) designed study at Foothills Hospital in Calgary, Alberta.
- Trial name
- NCT03857464
- Testing
- Near Patient Testing, SOP for C. difficile diagnostics
- Where
- 2 sites in Canada
- Volunteers
- 3,816 people
- Sponsor
- University of Calgary
Hospital Infections, Environment, Controlled
CLEAN Frontline: A Stepped Wedge Cluster Trial
Environmental hygiene is a key component of infection prevention in healthcare, and a driver of healthcare associated infections.
- Conditions
- Hospital Infections, Environment, Controlled, Infection Control
- Trial name
- NCT05540886
- Testing
- TEACH CLEAN
- Where
- Cambodia
- Volunteers
- 390 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Blood Stream Infection
Topical Emollient Therapy
Almost all (99%) of the neonatal deaths occur in lower and middle income countries. Most of these deaths are attributable to prematurity and infection.
- Trial name
- NCT01396642
- Testing
- Topical Emollient
- Where
- 2 sites in Pakistan
- Volunteers
- 258 people
- Sponsor
- Aga Khan University
Nosocomial Infection in Neonatal Intensive Care Unit
Bacteriological Profile and Antibiotic Sensitivity in Neonatal Intensive Care Unit at Assuit University Children Hospital
The study aims to assess the bacteriological profile and antibiotic sensitivity in NICU of pediatric hospital of assuit university.
- Trial name
- NCT06891768
- Testing
- Blood culture
- Volunteers
- 134 people
- Sponsor
- Assiut University
Infection, Bacterial, Infection Prevention
Optimising Kangaroo Care to Reduce Neonatal Severe Infection/Sepsis and Resistant Bacterial Colonisation Among High-risk Infants in NICU.
NeoDeco is a pragmatic, multicenter, parallel-group, cluster-randomised hybrid effectiveness-implementation trial designed to evaluate the impact of implementing optimised Kangaroo Care (KC) at the unit level compared to standard…
- Trial name
- NeoDeco (NCT05993442)
- Testing
- Optimised kangaroo care
- Where
- 24 sites in Greece, Italy and 3 more
- Volunteers
- 3,080 people
- Sponsor
- PENTA Foundation
Healthcare Associated Infection, Hand Hygiene
Effect of Video Camera Monitoring Feedback on Hand Hygiene Compliance and Infections in NICU
The purpose of this study is to determine if use of the video camera surveillance system for HH observation and performance feedback about HH compliance rates can improve the HH compliance of HCWs and reduce healthcare-associated…
- Conditions
- Healthcare Associated Infection, Hand Hygiene, Neonatal Infection
- Trial name
- CaM-HAI (NCT04053257)
- Testing
- Hand hygiene compliance observation with video camera surveillance system and performance feedback of the HH rates to HCWs
- Where
- Turkey (Türkiye)
- Volunteers
- 8,335 people, healthy volunteers welcome
- Sponsor
- Marmara University
Pneumonia, Bacterial, Community-Acquired Infections
A Safety and Tolerability Study of Doripenem Compared With Cefepime in Hospitalized Children With Bacterial Pneumonia
The purpose of this study is to evaluate the safety and tolerability of doripenem compared to cefepime in children hospitalized with pneumonia.
- Conditions
- Pneumonia, Bacterial, Community-Acquired Infections, Nosocomial Infection, Pneumonia, Ventilator-Associated
- Trial name
- NCT01110421
- Testing
- Cefepime, Doripenem, Amoxicillin/clavulanate potassium
- Where
- 25 sites in United States, Argentina and 8 more
- Volunteers
- 7 people
- Sponsor
- Janssen Research & Development, LLC
Covid-19, Nosocomial Infection
COG-UK Project Hospital-Onset COVID-19 Infections Study
Hospitals are recognised to be a major risk for the spread of infections despite the availability of protective measures. Under normal circumstances, staff may acquire and transmit infections, but the health impact of within…
- Conditions
- Covid-19, Nosocomial Infection, Coronavirus, Coronavirus Infection
- Trial name
- COG-UK HOCI (NCT04405934)
- Testing
- Use of virus (Covid-19) genome sequence report to inform infection prevention control procedures
- Where
- United Kingdom
- Volunteers
- 2,170 people
- Sponsor
- University College, London
Nontuberculous Mycobacterial Pulmonary Infection, Outbreak Investigation
Transmission and Acquisition of Nontuberculous Mycobacteria Outbreak Investigation (TrANsMIt)
The goal of this observational study is to support U.S. healthcare centers in determining if they may have an NTM outbreak among patients receiving care at the healthcare center.
- Conditions
- Nontuberculous Mycobacterial Pulmonary Infection, Outbreak Investigation, Healthcare Associated Infection, Mycobacterium Infections
- Trial name
- TrANsMIt (NCT06155747)
- Testing
- Epidemiologic investigation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of North Carolina, Chapel Hill
Candidemia
Prevalence and Epidemiology of Nosocomial Candidaemia and Antifungal Susceptibility Patterns in an Italian Tertiary-Care Hospital
During the past two decades, the frequency of invasive fungal infections has increased dramatically in hospitalised patients throughout the world, and Candida has now emerged as one of the leading causes of bloodstream infections…
- Trial name
- NCT00903526
- Volunteers
- 250 people
- Sponsor
- University of Modena and Reggio Emilia
Central Line-associated Bloodstream Infections
Impact of Disinfectant Caps on Nosocomial CLABSI
In a worldwide, one-day, prospective point-prevalence study, a prevalence of 15.1% for hospital-acquired central line-associated bloodstream infections (HA-CLABSI) was determined in 13,796 patients across 1,265 intensive care…
- Trial name
- NCT07430215
- Testing
- use of desinfection caps, sterile catheter cap
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- BDH-Klinik Hessisch Oldendorf
Severe Acute Malnutrition, Health Care Associated Infection
Prevention of Nosocomial Infections (CleanKids)
While the standardization of treatment protocols for Severe Acute Malnutrition (SAM) has helped to reduce historically high mortality, mortality in inpatient settings remains substantial, likely due to the severity of…
- Conditions
- Severe Acute Malnutrition, Health Care Associated Infection, Multi Drug Resistant Organisms
- Trial name
- CleanKids (NCT03360877)
- Testing
- Health-care associated infection (HCAI)
- Volunteers
- 4,944 people
- Sponsor
- Epicentre
Ventilator Associated Pneumonia, Staphylococcus Aureus
A Human Monoclonal Antibody Against Staphylococcus Aureus Alpha Toxin in Mechanically Ventilated Adult Subjects - 2
Clinical trial looking at safety and efficacy of suvratoxumab in prevention of pneumonia caused by Staphylococcus aureus in high-risk patients
- Trial name
- SAATELLITE-2 (NCT05331885)
- Testing
- Suvratoxumab
- Where
- 27 sites in Belgium, France and 4 more
- Volunteers
- 24 people
- Sponsor
- Aridis Pharmaceuticals, Inc.
Skin Colonization, Catheterization
Antiseptic Use and Dressing Application
The purposes of the study are: 1. To compare the local efficacy (skin colonization) of 2 commercialized antiseptics used for the disinfection of the dressing application for an epicutaneocavous catheter (EPI). 2.
- Conditions
- Skin Colonization, Catheterization, Bacterial Infection
- Trial name
- NCT00389558
- Testing
- disinfection efficacy using Biseptine, disinfection efficacy using Amukin
- Where
- France
- Volunteers
- 453 people
- Sponsor
- Maternite Regionale Universitaire
Nosocomial Infection, External Causes of Morbidity and Mortality
Tight Glycaemic Control During Cardiac Surgery
To determine whether intraoperative tight glycaemic control can reduce postoperative infection, morbidity and mortality
- Conditions
- Nosocomial Infection, External Causes of Morbidity and Mortality, Hypoglycemia
- Trial name
- TGC (NCT01225159)
- Testing
- TGC, Conventional glycaemic control
- Where
- Thailand
- Volunteers
- 200 people
- Sponsor
- Prince of Songkla University
Multidrug-resistant Colonization
Studies of the Human Microbiome in Clinical Center Patients
Background: The intestines, mouth, and skin all contain billions of bacteria and some fungi. Every person s body contains microorganisms like these. They normally do not make people sick.
- Trial name
- NCT01933620
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Nosocomial Infection
Nosocomial Bacterial and Fungal Chest Infections in Cirrhotic Patients
Hospital acquired chest Infections are common complications in hospitalized cirrhotic patients. Infectious complications are the most common cause of mortality in cirrhotic patients with bronchopneumonia early antibiotic…
- Trial name
- NCT03413293
- Testing
- Diagnosis of bacterial infections
- Volunteers
- 20 people
- Sponsor
- Assiut University