Clinical trials: Infectious Diarrhea
Diarrhea
Shigella WRSS1 Vaccine Trial in Bangladesh
This is a research study of an experimental (investigational) live attenuated Shigella sonnei vaccine (WRSS1) to find a dose of the vaccine that is safe, tolerable, and develops an immune response.
- Trial name
- NCT02934178
- Testing
- Shigella sonnei Strain WRSS1 Vaccine
- Where
- Bangladesh
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- PATH
Cryptosporidium; Diarrhea, Cryptosporidiosis
Trial of Ceramic Water Filters to Reduce Cryptosporidium Infection in Kenya
The aim of the study is to examine the efficacy of ceramic water filters to reduce the burden of waterborne diarrheal illness among infants in selected villages in Kenya.
- Conditions
- Cryptosporidium; Diarrhea, Cryptosporidiosis, Communicable Diseases, Diarrheal Disease
- Trial name
- NCT01695304
- Testing
- Ceramic water filter
- Where
- Kenya
- Volunteers
- 227 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Acute Diarrhea
Fecal Calprotectin: Cheap Marker for Diagnosing Acute Infectious Diarrhea
Every year more than 4 billion cases of diarrhea occur worldwide culminating in about 2.5 million deaths, almost all in the developing nations.
- Trial name
- NCT00429325
- Where
- 2 sites in Germany
- Volunteers
- 400 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
HIV Infections, Cryptosporidiosis
Nitazoxanide for the Treatment of Chronic Diarrhea in HIV Infected Children
Cryptosporidium parvum (C. parvum) is a parasite that can cause chronic diarrhea and is a significant problem for HIV infected children in developing countries. C. parvum infection can be treated with the drug nitazoxanide (NTZ).
- Trial name
- NCT00055107
- Testing
- Nitazoxanide
- Where
- 2 sites in South Africa, Thailand
- Volunteers
- 6 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Shigella Infection
Safety and Immunogenicity Study of IP-QSV Vaccine in Healthy Adults/Adolescents, Children and Infants
The goal of this phase 1/2a, randomized, observer-blind, age-descending, dose-finding trial is to evaluate the safety and immunogenicity of a quadrivalent synthetic oligosaccharide-based Shigella vaccine (adjuvanted IP-QSV) in…
- Trial name
- NCT07666750
- Testing
- 30μg IP-QSV, 10μg IP-QSV, 2μg IP-QSV
- Volunteers
- 370 people, healthy volunteers welcome
- Sponsor
- International Vaccine Institute
Respiratory Tract Infections, Diarrhea
Effect of L. Rhamnosus Yoba on RTI and Other Health Outcomes Among Children (3-6 Years) in Uganda
This is a nutritional trial with two arms: 1) Intervention arm of Probiotic Yoghurt containing Lactobacillus rhamnosus yoba 2012 and 2) Control arm of custard-like dairy product.
- Conditions
- Respiratory Tract Infections, Diarrhea, Skin Diseases, Tinea Capitis
- Trial name
- NCT04144491
- Testing
- Probiotic
- Where
- Uganda
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- VU University of Amsterdam
Breastfeeding, Breastfeeding Education
Improved Child Nutrition and Development Through Social Transfers
The goal of this clinical trial is to learn if a conditional social transfer works to improve rates of complementary breastfeeding.
- Conditions
- Breastfeeding, Breastfeeding Education, Breastfeeding Duration, Breastfeeding Continuation
- Trial name
- TENDER (NCT07569172)
- Testing
- Social Transfer
- Where
- Côte d’Ivoire
- Volunteers
- 1,040 people
- Sponsor
- Swiss Tropical & Public Health Institute
Influenza-like Illness, Upper Respiratory Disease
Non-specific Effects of Rabies Vaccine
Vaccines work by stimulating the body to produce a high-quality, rapid and specific immune response upon exposure to infection by a particular disease-causing microorganism - the microorganism targeted by the vaccine.
- Conditions
- Influenza-like Illness, Upper Respiratory Disease, Diarrhea, Fever
- Trial name
- NCT03656198
- Testing
- Rabivax-S, Sterile Water Injection
- Where
- Saint Kitts and Nevis
- Volunteers
- 546 people, healthy volunteers welcome
- Sponsor
- Ross University School of Veterinary Medicine
Antibiotic Associated Diarrhea, Upper Respiratory Tract Infection
Effectiveness of Saccharomyces Boulardii in Prevention of Antibiotic Associated Diarrhea
Antibiotic-associated diarrhea (AAD) is a common adverse effect in pediatric patients receiving broad-spectrum antibiotics such as co-amoxiclav for upper respiratory tract infections (URTI).
- Trial name
- NCT07785206
- Testing
- Co-amoxiclav, Saccharomyces boulardii
- Where
- Pakistan
- Volunteers
- 88 people
- Sponsor
- University of Child Health Sciences and Children's Hospital, Lahore
Diarrhea, Infantile, Infection Gastrointestinal
PAthogen Transmission and Health Outcome Models of Enteric Disease
The objective of the PATHOME study is to (1) develop statistical and computational methods for examining a complex disease system of interactions between and amongst children, animals, the environment, and enteric pathogens and…
- Conditions
- Diarrhea, Infantile, Infection Gastrointestinal, Stunting, Wasting
- Trial name
- PATHOME (NCT05322655)
- Where
- Kenya
- Volunteers
- 286 people
- Sponsor
- State University of New York at Buffalo
Diarrhea, Acute Respiratory Infection
Zinc Sulphate vs. Zinc Amino Acid Chelate
Acute respiratory infection and acute diarrhea are among the most prevalent diseases of childhood increase the burden of morbidity and mortality in children under 5 years.
- Trial name
- ZAZO (NCT01791608)
- Testing
- Zinc sulfate as dietary supplementation, Zinc amino acid chelate as dietary supplementation, Milk without fortification without zinc
- Where
- Colombia
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- CES University
Diarrhea Infectious, Algorithms
The Acceptability and Impact of Diarrheal Etiology Prediction (DEP) Algorithm
This is a randomized crossover study, where clinicians will be randomized to periods where they will use a rehydration calculator application with or without the Diarrheal Etiology Prediction (DEP) algorithm.
- Conditions
- Diarrhea Infectious, Algorithms, Decision Support Systems, Clinical, Clinical Decision-Making
- Trial name
- NCT04602676
- Testing
- Rehydration calculator application with DEP algorithm, Rehydration calculator application
- Where
- 2 sites in Bangladesh, Mali
- Volunteers
- 30 people
- Sponsor
- University of Utah
Antibiotic Resistant Infection, Antibiotic Resistant Strain
ESBL in Patients Returning to Sweden With Traveller's Diarrhoea
Patients with traveller's diarrhoea frequently harbour Extended Spectrum Betalactamase (ESBL)-producing Enterobacteriaceae (EPE) returning from EPE-endemic areas.
- Conditions
- Antibiotic Resistant Infection, Antibiotic Resistant Strain, Traveler's Diarrhea
- Trial name
- NCT03866291
- Testing
- No intervention, observational
- Where
- Sweden
- Volunteers
- 305 people
- Sponsor
- Lund University
Healthy Volunteers
ShigETEC Vaccine Study in Bangladesh
The goal of this clinical trial is to test ShigETEC vaccine, a combination vaccine against Shigella and ETEC diarrhoea in Bangladeshi adults (aged 18-45 years) and paediatric participants of three different age groups (aged 2-5…
- Trial name
- NCT05987488
- Testing
- ShigETEC live, attenuated, oral vaccine
- Where
- Bangladesh
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Eveliqure Biotechnologies GmbH
Pneumonia, Diarrhea
Vitamin A and Zinc: Prevention of Pneumonia (VAZPOP) Study
Children with malnutrition are often low in some nutrients, like zinc or vitamin A, that could help them fight off infections like pneumonia.
- Conditions
- Pneumonia, Diarrhea, Acute Upper Respiratory Tract Infections
- Trial name
- NCT00228254
- Testing
- Zinc (12.5 mg/day), vitamin A 10,000 IU per week
- Where
- 2 sites in United States, Ecuador
- Volunteers
- 2,582 people, healthy volunteers welcome
- Sponsor
- Tufts University
Cryptosporidiosis, HIV Infections
The Effectiveness of Cow's Milk Immune Globulin in the Treatment of AIDS-Related Diarrhea
To examine the efficacy of cow's milk immune globulin in the treatment of diarrhea due to chronic intestinal cryptosporidiosis in patients with AIDS.
- Trial name
- NCT00002264
- Testing
- Cryptosporidium Immune Whey Protein Concentrate (Bovine)
- Where
- United States
- Sponsor
- Stolle Milk Biologic International
Severe Illness, Septicaemia
Early Versus Late BCG Vaccination in HIV-1 Exposed Infants in Uganda in Uganda
BCG vaccination may have non-specific effects (NSE) i.e., additional benefits on childhood morbidity and mortality that are separate the vaccine's effect on the incidence of disseminated tuberculosis.
- Conditions
- Severe Illness, Septicaemia, Diarrhoea, Lower Respiratory Infection
- Trial name
- NCT02606526
- Testing
- BCG at birth, Control arm: Delayed BCG
- Where
- Uganda
- Volunteers
- 4,500 people, healthy volunteers welcome
- Sponsor
- Makerere University
Diarrhoea
A Study on the Safety and Immune Responses to the GVGH altSonflex1-2-3 Vaccine Against Shigellosis in Adults, Children, and Infants
The aim of the current clinical study was to evaluate, for the first time in humans (FTIH), the safety and immunogenicity of the altSonflex1-2-3 candidate vaccine against S. sonnei and S. flexneri serotypes 1b, 2a, and 3a.
- Trial name
- NCT05073003
- Testing
- AltSonflex1-2-3 High Dose, AltSonflex1-2-3 Medium Dose, AltSonflex1-2-3 Low Dose
- Where
- 2 sites in Belgium, Kenya
- Volunteers
- 551 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Diarrhea, Respiratory Infection
Micronutrient Sprinkles in a Daycare Center
Diarrheal diseases are a major cause of morbidity and mortality globally in children less than 5 years of age. Prolonged diarrhea, recurrent infections and growth failure in developing countries are usually a consequence of…
- Trial name
- NCT00967551
- Testing
- Micronutrient Sprinkles with zinc, Micronutrient sprinkles without zinc
- Where
- Brazil
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Emory University
Diarrhea, Dysentery
New Hypo-Osmolar ORS (Recommended by WHO) for Routine Use in the Diarrhea Management- Surveillance Study for Adverse Effects
For more than 25 years WHO and UNICEF have recommended a single formulation of glucose-based Oral Rehydration Salts (ORS) to prevent or treat dehydration from diarrhoea irrespective of the cause or age group affected.
- Trial name
- NCT00490932
- Testing
- Hypo-osmolar ORS
- Where
- India
- Volunteers
- 27,966 people
- Sponsor
- Society for Applied Studies