Clinical trials: Infertility
Female Infertility
The Embryologist's Impact on Blastocyst Vitrification and Thawing
The goal of this monocentric retrospective observational study is to analyse, for the first time in literature, the role of the embryologist who freezes and thaws the embryos.
- Trial name
- NCT06220227
- Testing
- vitrification and thawing procedures
- Where
- Italy
- Volunteers
- 6,800 people, healthy volunteers welcome
- Sponsor
- Istituto Clinico Humanitas
Infertility
Geneexpression as a Marker of Embryo Viability
The aim of the post doc project is investigate which genes regulate implantation in order to analyze specific proteins and microRNA in the spent culture media with the long-term goal of developing a non-invasive method of embryo…
- Trial name
- NCT02399787
- Testing
- blastocyst biopsy
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- University of Aarhus
Male Infertility, Unexplained Infertility
Impact of Sperm DNA Integrity on In Vitro Cycles
Sperm DNA integrity will be measured via the Toluidine Blue Assay (TBA) for patients undergoing In Vitro Fertilization (IVF); the study will determine correlations, if any, between IVF success and sperm DNA integrity.
- Conditions
- Male Infertility, Unexplained Infertility, Abortion, Habitual
- Trial name
- TBA on IVF (NCT01232465)
- Where
- United States
- Volunteers
- 420 people
- Sponsor
- Northwell Health
Abnormal Fertilization, Infertility
Outcomes of Embryos Created From Abnormally Fertilized Oocytes
The purpose of this study is to retrospectively analyze data from multiple clinics in a fertility network on embryos that were created from abnormally fertilized oocytes (AFO) including the rate of transfers and any clinical…
- Trial name
- NCT07666243
- Volunteers
- 92 people
- Sponsor
- Inception Fertility Research Institute, LLC
IVF, Frozen Embryo Transfer
Lipiodol Prior to FET (LIFE)
Lipiodol® flushing is an effective fertility treatment for women with unexplained infertility. It is speculated that the treatment effect could work through a direct effect of Lipiodol® on the endometrium.
- Conditions
- IVF, Frozen Embryo Transfer, Hysterosalpingography
- Trial name
- LIFE (NCT06563908)
- Testing
- Lipiodol® uterine treatment prior to IVF/ICSI
- Volunteers
- 784 people
- Sponsor
- Mỹ Đức Hospital
Infertility
Hyaluronic Acid-enriched Transfer Medium in Single Blastocyst Transfer
The purpose of this study is to compare the live birth rates of high concentration of Hyaluronic Acid (0.5 mg/ml) transfer medium (EmbryoGlue®) to those containing low Hyaluronic Acid concentrations (0.125 mg/ml) (G2 medium) in…
- Trial name
- NCT06492785
- Testing
- High Hyaluronic Acid concentrations (0.5 mg/ml), Low Hyaluronic Acid concentrations (0.125 mg/ml)
- Where
- China
- Volunteers
- 858 people
- Sponsor
- Northwest Women's and Children's Hospital, Xi'an, Shaanxi
Infertility
Programming by Estrogen Treatment in Gonadotropin Releasing Hormone Antagonist Protocol
The purpose of this study is to determine if pretreatment with Estrogen can assist in the planning and programming of In Vitro Fertilization treatments.
- Trial name
- NCT01419353
- Testing
- estradiol valerate
- Where
- Israel
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Hyperprolactinemia, Subfertility
Hyperprolactinaemia Management in Reproductive Services at University Hospital of Coventry and Warwickshire
Hyperprolactinaemia and thyroid disorders can significantly reduce fertility by causing ovulatory dysfunction. There is no evidence to suggest treatment of hyperprolactinaemia in the presence of regular ovulatory menstruation…
- Conditions
- Hyperprolactinemia, Subfertility, Subclinical hypothyroïdism
- Trial name
- NCT03569787
- Testing
- MRI Pituitary
- Where
- United Kingdom
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
Polycystic Ovary Syndrome, Infertility
New Application of Sequential in Vitro Muturation System for Infertility Patients With Polycystic Ovary Syndrome
Oocyte in vitro maturation (IVM) is an artificial reproductive technologies (ART) in which cumulus-oocyte complex (COC) are collected at the immature germinal vesicle (GV) stage from unstimulated or FSH-primed ovaries and matured…
- Trial name
- NCT03773263
- Testing
- sequential IVM system, intracytoplasmic sperm injection (ICSI), Thawed embryo transfer (TET)
- Where
- 5 sites in China
- Volunteers
- 300 people
- Sponsor
- Sun Yat-sen University
Fertility Issues, Vaccine Adverse Reaction
COVID-19 Vaccine and Ovarian Reserve
As Israel is the first country to widely vaccinate its population using the mRNA vaccine against COVID-19, evaluating its influence on ovarian reserve is essential .
- Trial name
- NCT04748172
- Testing
- SARS-CoV-2 virus vaccines, AMH sampling, anti Covid-19 antibody levels (Serology)
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Infertility
Is it Safe to do Endometrial Injury in the Same ICSI Cycle: A Randomized Controlled Trial
Endometrial injury is one of the interventions suggested to improve the endometrial receptivity by enhancing the decidualization process, and so increasing the pregnancy rate
- Trial name
- NCT05987995
- Testing
- Endometrial injury
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Infertility, Intellectual Disability
Prospective Study to Assess Medical Performance of Optical Mapping and Long Read Sequencing in Detecting Numerical and Structural Chromosome Abnormalities
Chromosomal aberrations are major causes of developmental disorders (Intellectual disability (ID), multiple congenital anomalies (MCA), autism spectrum disorders (ASD)) as well as reproductive disorders (RD) in particular…
- Conditions
- Infertility, Intellectual Disability, Malformation, Miscarriage
- Trial name
- CHROMAPS (NCT05290051)
- Testing
- Optical Genome Mapping (Bionano®), Longread sequencing (Nanopore®)
- Where
- France
- Volunteers
- 350 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Sperm Count, Low, Reproductive Sterility
A Retrospective Study on the Effect of Male Progressive Sperm Count After Semen Pretreatment on ICSI Fertilization Outcome
The investigators plan to retrospectively analyze clinical data from 14,189 fresh ICSI cycles in Reproductive and Genetic Hospital of CITIC-Xiangya from January 2016 to December 2017.The investigators will regard total…
- Trial name
- NCT03594201
- Testing
- semen pretreatment
- Where
- China
- Volunteers
- 12,215 people
- Sponsor
- Reproductive & Genetic Hospital of CITIC-Xiangya
Insemination
Total Motile Sperm Count and Pregnancy Rate From Intrauterine Insemination
Intrauterine insemination (IUI) is one of the most important infertility treatments. Infertility is failure to establish pregnancy (>12 months) with regularly unprotected sexual intercourse.
- Trial name
- NCT05999591
- Testing
- Intrauterine insemination
- Where
- Indonesia
- Volunteers
- 330 people
- Sponsor
- Universitas Padjadjaran
Cancer in Pregnancy, Fertility Preservation
Advisory Board on Cancer, Infertility and Pregnancy
The Advisory Board on Cancer, Infertility and Pregnancy provides a platform where physicians from all over the world can request recommendations regarding the medical care of pregnant women diagnosed with cancer or regarding…
- Conditions
- Cancer in Pregnancy, Fertility Preservation, Cancer, Pregnancy
- Trial name
- ABCIP (NCT04904263)
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- University Hospital, Gasthuisberg
Infertility
Efficacy and Safety of Fertility Treatments and Fertility Preservation
This study analyses clinical data prospectively collected for over a decade in several clinical databases. Electronic medical records are available since 1998.
- Trial name
- NCT04602962
- Testing
- fertility preservation, several methods
- Where
- Sweden
- Volunteers
- 50,000 people
- Sponsor
- Karolinska Institutet
Infertility
Influence of Ethnical Differences on the Egg Cell Collected in Patients Undergoing Fertility Treatment
Investigators wants to analyze the differences considering the country of origin, ethnicity, characteristics, reproductive history and habits of participants undergoing in vitro fertilization (IVF) / intracytoplasmic sperm…
- Trial name
- NCT03927417
- Where
- United Arab Emirates
- Volunteers
- 1,117 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Infertility and at High Risk of OHSS
Dual Trigger to Reduce Ovarian Hyperstimulation Syndrome
Gonadotropin releasing hormone (GnRH) agonist is sufficient for triggering final oocyte maturation in GnRH antagonist protocol and can significantly reduce incidence of ovarian hyperstimulation syndrome (OHSS) in high-risk…
- Trial name
- NCT02022228
- Testing
- triptorelin, hCG
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Chenshiling
Male Infertility, Male Subfertility
Assessing the Correlation Between Phospholipase C Zeta Measurements and Semen Parameters
With declining fertility rates Worldwide, Assisted Reproductive Technology is seen as a viable solution for infertility, however, individual success rates following ART remain relatively low, rarely exceeding ~50%.
- Trial name
- PLCZeta (NCT07684339)
- Testing
- No Intervention: Observational Cohort
- Where
- 2 sites in United Arab Emirates
- Volunteers
- 200 people
- Sponsor
- Fakih IVF Fertility Center
Gender Dysphoria, Transgender
Testicular Tissue Cryopreservation in the Setting of Gender-Affirming Therapy
The goal of this study is to learn about fertility preservation in the gender-diverse community. The main objectives it aims to understand are to: 1. Optimize techniques for processing and cryopreserving testicular tissue. 2.
- Trial name
- NCT05829928
- Testing
- Infectious Disease Testing, Gonadal Tissue Removal
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Pittsburgh