Clinical trials: Inhibitory Control
Primary Ciliary Dyskinesia
Clearing Lungs With ENaC Inhibition in Primary Ciliary Dyskinesia
To evaluate the safety and efficacy of treatment with VX-371 with and without ivacaftor, and the effect of VX-371 with and without ivacaftor on quality of life (QOL) in subjects with primary ciliary dyskinesia (PCD).
- Trial name
- CLEAN-PCD (NCT02871778)
- Testing
- VX-371, Hypertonic Saline, VX-371 + HS
- Where
- 34 sites in United States, Canada and 6 more
- Volunteers
- 123 people
- Sponsor
- Parion Sciences
Obesity, Overweight
Avoid and Resist Strategies for Weight Management
The proposed randomized controlled trial tests two self-regulatory approaches to improve intentional weight loss and diet quality in individuals with overweight or obesity: (1) an environmental control strategy (AVOID) and (2) an…
- Trial name
- NCT05143931
- Testing
- Home food environment and grocery delivery (AVOID), Inhibitory control training (RESIST), WW
- Where
- United States
- Volunteers
- 503 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
RESPIRATORY SYNCYTIAL VIRUS INFECTIONS
Viral Inhibition in Children for Treatment of RSV
VICTOR is a randomized, double-blind, placebo-controlled, multicenter, 2-part study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and antiviral effect of single and multiple dosing of AK0529 in infants…
- Trial name
- VICTOR (NCT02654171)
- Testing
- AK0529
- Where
- 28 sites in Australia, Hong Kong and 6 more
- Volunteers
- 72 people
- Sponsor
- Shanghai Ark Biopharmaceutical Co., Ltd.
Binge-Eating Disorder, Obesity
Precursors of Binge Eating Disorder in a Clinical Sample of Adolescents With Obesity
BACKGROUND: Binge eating disorder (BED) is the worldwide most-prevalent eating disorder. It is associated with psychiatric comorbidities and obesity, a high impact in life functioning, and high morbidity and mortality.
- Conditions
- Binge-Eating Disorder, Obesity, Eating Disorders, BED
- Trial name
- PREC-BED (NCT06387719)
- Testing
- Magnetic resonance imaging
- Where
- Spain
- Volunteers
- 102 people
- Sponsor
- Fundació Sant Joan de Déu
Trichotillomania
Response Inhibition Training for Individuals With Trichotillomania
This study tests a computerized cognitive training program designed for young individuals with compulsive hair pulling (also known as trichotillomania;TTM).
- Trial name
- NCT01638975
- Testing
- Response Inhibition Training Program
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Wisconsin, Milwaukee
Melanoma
A Study of Adjuvant Pembrolizumab/Vibostolimab (MK-7684A) Versus Pembrolizumab for Resected High-Risk Melanoma in Participants With High-Risk Stage II-IV Melanoma (MK-7684A-010/KEYVIBE-010)
The primary purpose of this study is to compare pembrolizumab/vibostolimab to pembrolizumab with respect to recurrence-free survival (RFS).
- Trial name
- NCT05665595
- Testing
- Pembrolizumab/Vibostolimab, Pembrolizumab
- Where
- 205 sites in United States, Argentina and 24 more
- Volunteers
- 1,594 people
- Sponsor
- Merck Sharp & Dohme LLC
Perennial Allergic Rhinitis, PAR
Safety Study of the Potential Inhibitory Effects of Ciclesonide Nasal Aerosol on the Hypothalamic-Pituitary-Adrenal Axis in Subjects 6-11 Years With Perennial Allergic Rhinitis
This is a multicenter, randomized, double-blind, placebo-controlled, parallel group, safety study of the effects of ciclesonide nasal aerosol (74 mcg) on the HPA axis when administered once daily to male and premenarchal female…
- Trial name
- NCT01378429
- Testing
- ciclesonide nasal aerosol
- Where
- 7 sites in United States
- Volunteers
- 89 people
- Sponsor
- Sumitomo Pharma America, Inc.
Overweight and/or Obesity
Brief Inhibitory Training for Eating - Intervention
The purpose of this study is to conduct a proof-of-concept intervention of daily inhibitory control (IC) training. Aim 1 is to examine the feasibility, acceptability, and barriers of an IC training EMI in adolescents' daily life.
- Trial name
- BITE-I (NCT07592728)
- Testing
- Daily inhibitory control training
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- George Mason University
Executive Function
Comparison Between Plyometrics and Calisthenics on Executive Function in School Going Children
The goal of this clinical trial is to compare the effects of calisthenics and plyometric exercises on executive functions in school-going children.
- Trial name
- NCT06770192
- Testing
- Calisthenics, Plyometric, Control
- Where
- Pakistan
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Leukoplakia, Periodontal Disease
Randomized, Double Blind, Placebo-Controlled, Phase IIB Trial of Ketorolac Mouth Rinse Evaluating the Effect of Cyclooxygenase Inhibition on Oropharyngeal Leukoplakia: Collaborative Study of the NCI, NIDCD and the NIDCR
In Phase II trials, treatment with ketorolac tromethamine oral rinse has been shown to block periodontal disease progression even in the absence of standard clinical intervention such as scaling and root planing which is…
- Trial name
- NCT00001698
- Testing
- Ketorolac Rinse
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- National Cancer Institute (NCI)
Obesity
Promoting Child Inhibitory Control Skills Around Food
Today's environment provides many hedonic stimuli that promote consumption of unhealthy energy-dense snack foods. It is widely recognized that a systems approach is required to deal with this complex problem.
- Trial name
- CHIC Play (NCT02077387)
- Testing
- CHild Inhibitory Control (CHIC) Play, Attention control
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Motor Development, Balance
Balance-Cognitive-Strength Training for Balance, Inhibitory Control, and Gait in Preschool Children
This randomized controlled study evaluated whether an 8-week balance-cognitive-strength training program improved balance ability, inhibitory control, and gait performance in preschool children aged 3 to 6 years.
- Conditions
- Motor Development, Balance, Healthy Children, Gait
- Trial name
- BCS-Preschool (NCT07689474)
- Testing
- Balance-Cognitive-Strength Training
- Where
- China
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Aiyoudong Children and Youth Sports Health Research Institute
Atopic Dermatitis
A Study of Lebrikizumab in Adults and Adolescents With Face and Neck Atopic Dermatitis
The main aim of the study is to evaluate the efficacy and safety of lebrikizumab treatment for up to 32 weeks in participants with moderate-to-severe face and neck atopic dermatitis (FNAD) who also have moderate-to-severe AD…
- Trial name
- ADface (NCT07873801)
- Testing
- Lebrikizumab
- Volunteers
- 230 people
- Sponsor
- Almirall, S.A.
Healthy
Nerve Stimulation to Modify a Spinal Reflex
This study will determine whether stimulating the nerves or the brain can modify the spinal reflex that controls the muscles that flex and extend the ankle.
- Trial name
- NCT00039819
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Trichotillomania
Online Response Inhibition Training for Trichotillomania
Trichotillomania (TTM) remains one of the most poorly-understood and inadequately-treated conditions. Research has shown poor response inhibition (RI; the ability to inhibit inappropriate but potent response) as an important…
- Trial name
- OTTM (NCT01984333)
- Testing
- Online cognitive training
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of Wisconsin, Milwaukee
Asthma
Zileuton CR vs Placebo in Poorly Controlled Asthma Patients on Moderate Dose ICS
Asthma is a chronic inflammatory disorder of the airways with a variety of inflammatory processes contributing to the pathogenesis.
- Trial name
- NCT00486343
- Testing
- Zileuton CR
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Critical Therapeutics
Osgood-Schlatter Disease
Rate of Torque Development in Adolescents With Osgood-Schlatter
Osgood-Schlatter is a growth-related condition involving multiple different types of tissue in the tendon-bone interface at the tibial tubercle.
- Trial name
- NCT05789095
- Testing
- Rate of torque development testing of knee flexors and knee extensors using a fixated handheld dynamometer (MicroFet 2, Hoggan, Scientific L.L.C., Salt Lake City, USA), sampling rate of 100hz)
- Where
- Denmark
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Chronic Plaque Psoriasis
Trial of PDE4 Inhibition With Roflumilast for the Management of Plaque Psoriasis
This is a double-blind, parallel group, vehicle-controlled study to assess the safety and efficacy of roflumilast (ARQ-151) 0.3% cream vs vehicle (placebo) cream for treatment of chronic plaque psoriasis (CPP) in adult…
- Trial name
- DERMIS-1 (NCT04211363)
- Testing
- Roflumilast 0.3% cream, Vehicle Cream
- Where
- 40 sites in United States, Canada
- Volunteers
- 439 people
- Sponsor
- Arcutis Biotherapeutics, Inc.
Social Anxiety
Virtual Reality Exposure for Socially Anxious Adolescents
Overall in this project, the primary goal is to evaluate the efficacy of virtual reality exposure (VRE) for adolescents with elevated social anxiety using a three-arm randomized controlled trial: (1) virtual reality exposure…
- Trial name
- VIRTUS (NCT06379633)
- Testing
- In vivo exposure, (Virtual reality) exposure
- Where
- Belgium
- Volunteers
- 120 people
- Sponsor
- KU Leuven
Down Syndrome
Drumming Lessons' Influence on Children With Down Syndrome
The goal of this clinical trial is to learn if drumming lessons can increase self-control in children with Down syndrome. The main question it aims to answer is whether 2 months of drumming lessons can improve the behavioral…
- Trial name
- NCT07156318
- Testing
- 2 months of drumming lessons given by a professional drummer with extensive experience working with children with Down syndrome, Lessons after measurement
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Vanderbilt University