Clinical trials: Insulin Therapy
Diabetes, Diabetes Mellitus, Type 1
Observational Study of Patients Using NovoMix® 30 or Levemir® for Treatment of Type 1 or Type 2 Diabetes
This trial is conducted in Europe. The aim of this observational study is to evaluate the glycaemic control in patients with type 1 or 2 diabetes using NovoMix® 30 or Levemir® under normal clinical practice conditions.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT00671008
- Testing
- biphasic insulin aspart 30, insulin detemir
- Where
- Bosnia and Herzegovina
- Volunteers
- 400 people
- Sponsor
- Novo Nordisk A/S
Hyperglycemia, Cardiovascular Diseases
REsearching Coronary REduction by Appropriately Targeting Euglycemia (RECREATE Pilot Study)
Insulin will safely reduce glucose levels in patients with acute ST-elevation myocardial infarction and admission hyperglycemia.
- Conditions
- Hyperglycemia, Cardiovascular Diseases, Myocardial Infarction
- Trial name
- RECREATE Pilot (NCT00640991)
- Testing
- glulisine insulin, glargine insulin
- Where
- 13 sites in Argentina, Canada and 1 more
- Volunteers
- 500 people
- Sponsor
- Population Health Research Institute
Polycystic Ovary Syndrome, Periodontitis
Non-surgical Periodontal Therapy and Myo-inositol in Polycystic Ovary Syndrome Women Having Chronic Periodontitis
The Purpose of this study is to assess the correlation between the inflammatory periodontal status and the medical treatment status in Polycystic Ovary Syndrome(PCOS) women with systemic inflammation and to evaluate the effect of…
- Conditions
- Polycystic Ovary Syndrome, Periodontitis, Insulin Resistance
- Trial name
- NCT02633462
- Testing
- scaling and root planing , Myo-inositol, Myo-inositol
- Volunteers
- 56 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Diabetes, Diabetes Mellitus, Type 2
Physiological Concept of Insulin Therapy in Subjects With Type 2 Diabetes
This study is conducted in Europe. The aim of the study was to evaluate the safety and efficacy of biphasic insulin aspart 30 (NovoMix® 30) when switching to a modern premix insulin analogue treatment compared to previous insulin…
- Trial name
- NCT01536639
- Testing
- biphasic insulin aspart 30
- Where
- Slovakia
- Volunteers
- 454 people
- Sponsor
- Novo Nordisk A/S
Childhood Obesity, Dyslipidemia
Nutritional Treatment of Overweight Adolescents With Cardiovascular Risk Factors (PowerUp)
This study is designed to evaluate the efficacy of two diets, a low glycemic load diet and a low saturated fat diet, in the treatment of adolescents with some heart disease risk factors associated with being overweight, such as…
- Conditions
- Childhood Obesity, Dyslipidemia, Insulin Resistance, Hypertension
- Trial name
- NCT00477477
- Testing
- Diet
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Boston Children's Hospital
Diabetes Mellitus, Type 1
PINIT Study: Primary Intranasal Insulin Trial
Type 1 diabetes (T1D) results from an autoimmune destruction of the insulin-producing beta cells. Administration of mucosal insulin in islet autoantibody-negative children who are genetically predisposed for T1D offers the…
- Trial name
- NCT03182322
- Testing
- intranasal insulin
- Where
- 2 sites in Germany
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Type 1 Diabetes Mellitus
Reducing Risks and Improving Glucose Control During Extended Exercise in Youth With T1DM: The AP Ski Camp
The biggest challenges for glycemic control during the day time involve meals and exercise variations, which are impacted by age, fitness level, duration, intensity and history of exercise.
- Trial name
- NCT02604524
- Testing
- Closed-Loop Control, Sensor Augmented Pump Therapy
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- Daniel Chernavvsky, MD, CRC
Type 1 Diabetes
Incretin-based Therapy in Late Preclinical Type 1 Diabetes
The objective of the trial is to study whether daily treatment with liraglutide improves endogenous insulin secretion, postpones progression to overt Type 1 diabetes, and is tolerable and safe in subjects aged 10-30 years, who…
- Trial name
- NCT02898506
- Testing
- Victoza®
- Where
- 4 sites in Finland, Sweden
- Volunteers
- 13 people
- Sponsor
- University of Oulu
Heart Failure, Hyperuricemia
Treatment of Hyperuricemia in Patients With Heart Failure
The study aims to assess (I) the contribution of UA itself to the CHF pathophysiology and (II) to test the effect of lowering UA by uricosuric treatment in CHF.
- Trial name
- NCT00422318
- Testing
- Benzbromarone (drug)
- Where
- Japan
- Sponsor
- Tottori University Hospital
Diabetes Mellitus, Type 1
Safety And Efficacy Of Exubera Compared With Subcutaneous Human Insulin Therapy In Children And Adolescents
To assess the safety and efficacy of Exubera on pulmonary function and glycemic control in subjects ages 6-17 over a 1 year period.
- Trial name
- NCT00479258
- Testing
- Inhaled insulin (Exubera), Subcutaneous Insulin (subject's prescribed)
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Pfizer
Type 1 Diabetes
Insulin Clamp Ancillary Study for Assessment of Insulin Resistance
Insulin Clamp Ancillary study for Assessment of Insulin Resistance will be conducted as a sub-study to the main protocol, Metformin Therapy for Overweight Adolescents With Type 1 Diabetes (NCT01881828).
- Trial name
- NCT02045290
- Testing
- Metformin
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Jaeb Center for Health Research
Diabetes, Diabetes Mellitus, Type 2
Observational Study of Safety and Effectiveness of NovoMix® 30 for the Treatment of Diabetes
This study is conducted in Asia, Europe, Japan and North America. The aim of this observational study is to evaluate the safety and effectiveness while using NovoMix® 30 during 26 weeks under normal clinical practice, in the…
- Trial name
- IMPROVE™ (NCT00659282)
- Testing
- biphasic insulin aspart
- Where
- 11 sites in Canada, China and 9 more
- Volunteers
- 57,610 people
- Sponsor
- Novo Nordisk A/S
Diabetes, Diabetes Mellitus, Type 1
Observational Study on Levemir® in Obese Diabetic Patients
This study is conducted in Europe. The aim of this observational study is to investigate the effect of switch from other basal insulin treatments to Levemir® on body weight in obese diabetic patients.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- KILOS (NCT00849342)
- Testing
- insulin detemir
- Where
- 2 sites in Netherlands, Slovenia
- Volunteers
- 580 people
- Sponsor
- Novo Nordisk A/S
Cardiovascular Complications, Leukemia
Study of Metabolic Syndrome in Adolescent and Young Adult Survivors of Childhood Leukemia Who Have Undergone Stem Cell Transplant
RATIONALE: Gathering information about how often metabolic syndrome occurs in young survivors of childhood leukemia who have undergone stem cell transplant may help doctors learn more about the disease and the long-term effects…
- Conditions
- Cardiovascular Complications, Leukemia, Long-term Effects Secondary to Cancer Therapy in Children, Metabolic Syndrome
- Trial name
- NCT00920842
- Where
- United States
- Volunteers
- 244 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Severe Insulin Resistance
Effect of Metreleptin Therapy in the Treatment of Severe Insulin Resistance
Study Description: Patients with mutations of the insulin receptor have diabetes that is challenging to control with conventional therapies, leading to early morbidity and mortality.
- Trial name
- NCT00085982
- Testing
- Metreleptin
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type 1 Diabetes, Closed Loop
Semi-closed Loop Automated Insulin Therapy in the Pediatric Population Aged 2-6 Years With Type 1 Diabetes: Impact on Quality of Life and Glycemic Control
The incidence of type 1 diabetes is increasing, with an incidence of +4% per year in France today. The treatment for type 1 diabetes is insulin therapy.
- Conditions
- Type 1 Diabetes, Closed Loop, Insulin, Quality of Life
- Trial name
- Diablife (NCT06875167)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Fondation Lenval
Diabetes Mellitus
Evaluation of a Diabetes Treatment and Education Program for Insulin Pump Therapy (INPUT)
This study is a randomized, controlled, prospective trial with a 6-month follow-up. A newly developed treatment and education programme for diabetic patients with an insulin pump therapy (INPUT) will be tested compared to a…
- Trial name
- INPUT (NCT02868931)
- Testing
- INPUT
- Where
- Germany
- Volunteers
- 268 people
- Sponsor
- Norbert Hermanns
Diabetes, Diabetes Mellitus, Type 2
Observational Study to Assess the Quality of Life and Clinical Outcomes in Subjects Using NovoMix® 30 for the Treatment of Diabetes
This study is conducted in Asia. The aim of this observational study is to evaluate the quality of life and clinical outcomes in subjects using NovoMix® 30 (biphasic insulin aspart 30) for the treatment of diabetes mellitus under…
- Trial name
- IMPROVE Life (NCT00696163)
- Testing
- biphasic insulin aspart 30
- Where
- India
- Volunteers
- 24,975 people
- Sponsor
- Novo Nordisk A/S
Diabetes
Comparison Study of Insulin Glargine and NPH Insulin
This study will compare the safety, effectiveness, and cost of two different types of long-acting insulin.
- Trial name
- NCT01854723
- Testing
- Switching to NPH insulin, Continuation of insulin glargine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Providence Health & Services
HTLV-I Infection, T Cell Leukemia
Anti-Tac for Treatment of Leukemia
The purpose of the study was to determine: (1) the toxicity and maximum tolerated dose (MTD) of humanized anti-Tac (daclizumab), (Zenapax(Registered Trademark)) in patients with adult T-cell leukemia/lymphoma (ATL); (2) to define…
- Trial name
- NCT00001941
- Testing
- daclizumab
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- National Cancer Institute (NCI)