Clinical trials: Insulin Therapy
Closed Loop, Diabetes Mellitus, Type 1
Diabeloop WP6.2 : Crossover Evaluation of Glycemic Control
The study will be conducted in crossover trial, with two 72-hour hospitalization separated by a period Wash-out of at least one week. Each hospitalization is a period of treatment.
- Trial name
- WP6-2 (NCT02627911)
- Testing
- Diabeloop System, Continuous Glucose Monitoring, Accelerometer and heart rate monitor
- Where
- 9 sites in France
- Volunteers
- 36 people
- Sponsor
- Centre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète
Hypertriglyceridemia, Metabolic Syndrome
Study to Assess Tricor Therapy Effectiveness in Patients With Metabolic Syndrome (TRISTAN)
This study is a prospective observational program within the frames of which Tricor (fenofibrate) is prescribed to patients with hypertriglyceridemia within a routine procedure as a part of the combination therapy with statins.
- Trial name
- TRISTAN (NCT04650152)
- Testing
- Tricor (fenofibrate), 145 mg, film-coated tablet
- Where
- 63 sites in Russia
- Volunteers
- 1,000 people
- Sponsor
- Abbott
Type 2 Diabetes
Short-term Effect of Intensive Insulin Therapy on Incretin Secretion
In type 2 diabetic patients, abnormality in secretion or action of incretin(GLP-1, GIP) is observed. Although controversy still exists, the secretion of GLP-1 is thought to be reduced by 20-30% while GIP secretion is normal or…
- Trial name
- NCT00776243
- Where
- 2 sites in South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Catholic University of Korea
Growth Disorders
Treatment of Children and Adolescents With Growth Failure Associated With Primary IGF-1 Deficiency
This is an extension study to Tercica study MS301 (NCT00125164) and is intended to collect long term safety and efficacy data on the continued use of recombinant human insulin-like growth factor-1 (rh IGF-1) in children and…
- Trial name
- NCT00330668
- Testing
- rh IGF-1 (mecasermin)
- Where
- France
- Volunteers
- 114 people
- Sponsor
- Ipsen
Diabetes Mellitus Type 2
Effect of Momordica Charantia Administration on Type 2 Diabetes Mellitus, Insulin Sensitivity and Insulin Secretion
The hypoglycemic effect of Momordica Charantia has been evaluated in clinical trials in patients with type 2 diabetes mellitus. Important reductions in fasting plasma glucose, glycated hemoglobin (A1C), and fructosamine were…
- Trial name
- NCT02397447
- Testing
- Momordica charantia
- Where
- Mexico
- Volunteers
- 24 people
- Sponsor
- University of Guadalajara
Intensified Insulin Therapy, Diabetes
Intensified Insulin Therapy With Telemedicine
Investigation of the effect of a 3-month telemedicine-led lifestyle intervention in individuals requiring intensified insulin therapy.
- Trial name
- NCT05100576
- Testing
- Telemedicine system users
- Where
- Hungary
- Volunteers
- 60 people
- Sponsor
- Szeged University
Cancer, Advanced Solid Malignancies
Dose-escalation Study to Assess Safety, Tolerability and Pharmacokinetics of MEDI-573 in Japanese Subjects
The primary purpose of this study is to explore the safety and tolerability of MEDI-573 in Japanese subjects with advanced solid tumours refractory to standard therapy or for which no standard therapy exists.
- Trial name
- NCT01340040
- Testing
- MEDI-573
- Where
- Japan
- Volunteers
- 10 people
- Sponsor
- AstraZeneca
Diabetes Type 1
Transition of T1DM Patients Aged Over 65 Years Into AHCL (780G) Insulin Pump
Older people with diabetes have a higher risk for cognitive impairment and for physical disability whether this may be effected by an improvement in glucose indices is unknown.
- Trial name
- 780G65+ (NCT06207838)
- Testing
- MiniMed 780G system
- Where
- Poland
- Volunteers
- 30 people
- Sponsor
- Jagiellonian University
Type 1 Diabetes Mellitus
Reinforcement of the Impact of a Functional Insulin Therapy Training Course by Telemonotoring With a PDA-phone in Type 1 Diabetic Patients. The TELFIT Study Patients
TELFIT is a monocenter, controlled, randomised trial. It focuses on type 1 diabetes patients that have attended a functional insulin therapy training course.
- Trial name
- TELFIT (NCT00758082)
- Testing
- paper support, PDA-phone + telemonitoring
- Where
- France
- Volunteers
- 62 people
- Sponsor
- University Hospital, Grenoble
Type 2 Diabetes Mellitus
Stepping-down Approach in Patients With Chronic Poorly-controlled Diabetes on Advanced Insulin Therapy?
In traditional step-up approach, the patients with poorly-controlled type 2 diabetes are instructed to take up to 4 insulin injections daily or multiple daily injections (MDI) as the most advanced therapy.
- Trial name
- NCT02846233
- Testing
- GLP1 receptor agonist, basal insulin, SGLT2 inhibitor
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of California, San Francisco
Obesity, Metabolic Syndrome X
Drug Therapy Induced Weight Loss to Improve Blood Vessel Function in Subjects With Obesity
Obesity is common (>30% of US adults), contributes to substantial morbidity and mortality, but is difficult to treat. Partly this is due to the transient, arduous and modest nature of lifestyle interventions.
- Trial name
- REVIVE (NCT01351753)
- Testing
- Metformin, Orlistat, Topiramate
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- University of Iowa
Type 2 Diabetes Mellitus, Peritoneal Dialysis
A Study of Adding Linagliptin to Control Glycemic Variability and HbA1c in Peritoneal Dialysis Patients With Type 2 Diabetes(PDPD) With Premixed Insulin Therapy
In china, there are the most population of type 2 diabetes mellitus (DM) among the world and DM becomes currently the second cause for end-stage renal disease (ESRD).
- Trial name
- NCT03320031
- Testing
- Linagliptin, Humalog Mix 75/25
- Where
- China
- Volunteers
- 232 people
- Sponsor
- Yanbing Li
Hyperglycemia, Critically Ill Patients
Impact of 2 Blood Glucose Levels on Hospital Mortality in Patients Admitted in ICU
During hospitalization in the intensive care unit (ICU), the occurrence of a blood glucose imbalance is frequent and associated with increased mortality.
- Trial name
- INSUREA (NCT00591071)
- Testing
- Strict glycemic control, Conventional glycemic control
- Where
- 2 sites in France
- Volunteers
- 440 people
- Sponsor
- Poissy-Saint Germain Hospital
Metabolic Syndrome, Lipotoxicity
Regression of Fatty Heart by Valsartan Therapy
Traditionally, obesity is considered an indirect cause of heart disease. Obese individuals typically present with a number of traditional Framingham risk factors (hypertension, dyslipidemia, and type 2 diabetes), predisposing…
- Trial name
- NCT00745953
- Testing
- Valsartan, Hydrochlorothiazide
- Where
- United States
- Sponsor
- University of Texas Southwestern Medical Center
Diabetes, Medication Adherence
Insulin Dosing Practices in Persons With Diabetes on Multiple Daily Injections
In this cross-sectional study the investigators will examine two populations: young adults with (ages 18-35) and older adults (ages 65 and over) with diabetes who are on > 2 insulin injections per day.
- Conditions
- Diabetes, Medication Adherence, Technology, Insulin
- Trial name
- NCT02914730
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Joslin Diabetes Center
Type 1 Diabetes Mellitus, Type 1 Diabetes Mellitus With Hypoglycemia
Glycemic Excursions in Patients With Type 1 Diabetes Mellitus Using Closed-loop Systems
The study aims to compare glycemic excursions during several life situations (such as periods of driving, periods of night sleep, periods of occupation, periods of physical activity, and periods of stress) in patients with type 1…
- Conditions
- Type 1 Diabetes Mellitus, Type 1 Diabetes Mellitus With Hypoglycemia, Drive
- Trial name
- SAFEDRIVE (NCT06382350)
- Testing
- MiniMed 780 G
- Where
- Czechia
- Volunteers
- 120 people
- Sponsor
- University Hospital, Motol
Metabolic Syndrome, Bipolar Depression
Pioglitazone for the Treatment of Bipolar Disorder and Comorbid Metabolic Syndrome or Insulin Resistance
The study is an open-label 8-week adjunctive trial of pioglitazone for the acute relief of bipolar depression comorbid with metabolic syndrome/insulin resistance.
- Conditions
- Metabolic Syndrome, Bipolar Depression, Insulin Resistance
- Trial name
- NCT00835120
- Testing
- Pioglitazone
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University Hospitals Cleveland Medical Center
Diabetes Mellitus, Diabetes Mellitus, Type 2
Different Initial Insulin Dose Regimens on Time to Achieve Glycemic Targets and Treatment Safety in SIIT
To compare the effects of different initial insulin dose regimens during the short-term insulin intensive treatment on time to glycemic goal, hypoglycemia prevalence, glycemic variability and other safety problems in newly…
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 2, Glucose Metabolism Disorders, Metabolic Disease
- Trial name
- NCT05084079
- Testing
- CSII with formula-based initial insulin regimen, CSII with weight-based initial insulin regimen
- Where
- China
- Volunteers
- 56 people
- Sponsor
- Sun Yat-sen University
Bipolar Disorder, Insulin Resistance
Pioglitazone for the Treatment of Bipolar Depression
The primary objective is to test the hypothesis that adjunctive pioglitazone is more effective than placebo for the relief of acute depressive symptoms resulting from bipolar disorder.
- Trial name
- NCT01717040
- Testing
- Pioglitazone
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University Hospitals Cleveland Medical Center
Post-Transplant Glucocorticoid Induced Diabetes
Insulin Therapy for Post-transplant Glucocorticoid Induced Hyperglycemia
No consensus guidelines exist for management of post-transplant glucocorticoid induced hyperglycemia, but most published reviews recommend insulin as first line therapy.
- Trial name
- PTHG (NCT01648218)
- Testing
- Neutral protamine hagedorn (NPH) insulin, Regular human insulin or Insulin Aspart, Insulin glargine
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- Vancouver General Hospital
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