Clinical trials: Intensive Care Medicine
Venous Thromboembolism (VTE), Intensive Care Medicine
Pulsed Electromagnetic Field Therapy or Pneumatic Compression VTE Prophylaxis
Venous thromboembolism (VTE) is frequent in patients in the intensive care unit (ICU). Pharmacologic prophylaxis is sometimes contraindicated, and mechanical prophylaxis is used.
- Conditions
- Venous Thromboembolism (VTE), Intensive Care Medicine, Venous Thromboembolism
- Trial name
- SOPHIE (NCT06958588)
- Testing
- Experimental: Hyperslim, Active Comparator #1
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Science Valley Research Institute
Competency-Based Education
Effect of a Competence Based Medical Education Programme on Training Quality in Intensive Care Medicine.
This study evaluates whether the implementation of a competency-based medical education program called CoBaTrICE (Competency Based Training program in Intensive Care in Europe) provides higher levels of competency in comparison…
- Trial name
- COBALIDATION (NCT04278976)
- Testing
- Implementation of CoBaTrICE
- Where
- 14 sites in Spain
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Alvaro Castellanos Ortega
PICU, Nurses
Smart Mind Maps in Promoting Safe Administration of High-Alert Medications
In PICU setting, drug administration, monitoring, and prescribing errors made up most cases (54%) of MEs . Emphasizes these issues requires a multifaceted approach, including staff training, creation of innovative cognitive…
- Trial name
- HAMs- PICU (NCT07320196)
- Testing
- smart mind mapsde
- Volunteers
- 70 people
- Sponsor
- Mansoura University
Death
Advance Directives and End-of-life Decision Making in Intensive Care Medicine in Germany
Description of the decision making process as well as the practices of end of life care in an ICU of a German university hospital during the period when changes of German legislation occurred.
- Trial name
- NCT01294189
- Where
- Germany
- Volunteers
- 224 people
- Sponsor
- Charite University, Berlin, Germany
Shock, Septic
COMPACT 2 - COMbining Plasma-filtration and Adsorption Clinical Trial 2
The study objective is to clarify whether the application of high doses CPFA (coupled plasma-filtration adsorption) in addition to the current clinical practice is able to reduce hospital mortality in septic shock patients in…
- Trial name
- COMPACT-2 (NCT01639664)
- Testing
- High doses CPFA
- Where
- 13 sites in Italy
- Volunteers
- 115 people
- Sponsor
- Gruppo Italiano per la Valutazione degli Interventi in Terapia Intensiva
Extracorporeal Membrane Oxygenation Complication, ARDS (Acute Respiratory Distress Syndrome)
RECOMMEND Platform Trial
The goal of this platform trial is to determine the efficacy, safety and cost-effectiveness of various interventions in patients with acute cardiorespiratory failure requiring extracorporeal membrane oxygenation (ECMO) The main…
- Conditions
- Extracorporeal Membrane Oxygenation Complication, ARDS (Acute Respiratory Distress Syndrome), Intensive Care Medicine, Cardiac Arrest (CA)
- Trial name
- RECOMMEND (NCT06526533)
- Testing
- Liberal RBC Transfusion, Restrictive RBC Transfusion
- Where
- 3 sites in Australia
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Multi-Drug Resistant Organisms, Late-Onset Sepsis, Neonatal
Using Antibiotics Wisely - An Antimicrobial Stewardship Program
There are significant variations in antimicrobial consumption across Canadian Neonatal Intensive Care Units (NICUs). Inappropriate and overuse of antibiotics can result in antimicrobial resistance and adverse outcomes among…
- Conditions
- Multi-Drug Resistant Organisms, Late-Onset Sepsis, Neonatal, Antimicrobial Resistance
- Trial name
- NCT04388293
- Testing
- Exposure of interest
- Where
- Canada
- Volunteers
- 2,000 people
- Sponsor
- University of British Columbia
Procedural Pain
Intranasal Fentanyl in Preterm Infants Undergoing Peripherally Inserted Central Catheter Placement
The purpose of this feasibility clinical trial is to explore the role of intranasal fentanyl for pain associated with PICC placement in preterm infants.
- Trial name
- INFENT PICC (NCT06590870)
- Testing
- Fentanyl, Normal saline
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- Mount Sinai Hospital, Canada
Stress
Efficacy of Healing Touch in Stressed Neonates
The purpose of this project is to evaluate whether or not Healing Touch therapy (HT) helps to treat the stress of babies in the Neonatal Intensive Care Unit (NICU).
- Trial name
- NCT00034008
- Testing
- Healing Touch
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Infant, Newborn, Pharmacoepidemiology
Commonly Used Medicines On Neonatal Units in the UK
This retrospective analysis of drug utilisation data aims to study the patterns of use of medicines in neonatal units in the UK from 2010 to 2017.
- Conditions
- Infant, Newborn, Pharmacoepidemiology, Intensive Care Units, Neonatal
- Trial name
- COMMON (NCT03773289)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 642,729 people
- Sponsor
- University of Nottingham
Education, Health
Simulation Training as a Tool for Teamwork Improvement in Multidisciplinary Intensive Care Team
The purpose of the study is to check whether training mixed teams of physicians and nurses from intensive care units on patient simulators improves teamwork within the teams.
- Trial name
- NCT00229411
- Testing
- simulation training
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Intensive Care Units, Neonatal, Misadventures to Patients During Surgical and Medical Care
SEPREVEN: a Stepped-wedge Randomised Controlled Trial
Adverse events are frequent in Neonatal Intensive Care Units' (NICU) patients and account for a high morbidity and mortality. Possible severe adverse events are central line associated bloodstream infections (CLABSI), ventilator…
- Conditions
- Intensive Care Units, Neonatal, Misadventures to Patients During Surgical and Medical Care, Catheter-related Bloodstream Infection (CRBSI) Nos, Quality of Healthcare
- Trial name
- SEPREVEN (NCT02598609)
- Testing
- Education program for NICU caregivers
- Where
- 12 sites in France
- Volunteers
- 8,000 people
- Sponsor
- Dr Caeymaex Laurence
Patient Satisfaction
Patient Survey as a Tool to Quality Assurance and Quality Improvement 2024
One goal of the investigators of the Department of Anesthesiology and Intensive Care Medicine CCM/CVK, Charité - Universitätsmedizin Berlin is a continuous improvement in the quality of care to the patients.
- Trial name
- NCT06224231
- Where
- 2 sites in Germany
- Volunteers
- 624 people
- Sponsor
- Charite University, Berlin, Germany
Extreme Prematurity, Neurodevelopmental Abnormality
Osteopathic Manipulative Medicine to Reduce Developmental Delays
This randomized clinical trial seeks to determine if osteopathic manipulative medicine (OMM) increases the likelihood of improved neurodevelopmental outcomes as estimated by the Test of Infant Motor Performance (TIMP).
- Trial name
- NCT04652063
- Testing
- Osteopathic Manipulative Medicine
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Red Blood Cell Transfusions
Implementation of Red Blood Cell Transfusion Recommendations in the Pediatric Intensive Care Unit
Evidence demonstrates that the risks of red blood cell transfusions outweigh benefits in many patients who are hospitalized in the pediatric intensive care unit with increased risk of organ dysfunction, infection, delirium, and…
- Trial name
- TRIP (NCT07108374)
- Testing
- Implementation strategies to increase use of transfusion recommendations
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Stanford University
Bacteremia, Infant, Very Low Birth Weight
Preventing Catheter-related Bacteremia When Administering Injectable Medications in Premature Infants.
This study evaluates the potential interest of a new multi-lumen infusion access device (Edelvaiss® Multiline NEO) in the prevention of catheter-related bacteremia when administering injectable drugs in premature infants.
- Trial name
- MultilineNEO (NCT02633124)
- Testing
- Edelvaiss Multiline NEO, Standard Infusion Set
- Where
- 4 sites in France
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Brain Injuries, Traumatic
CREACTIVE - Collaborative REsearch on ACute Traumatic Brain Injury in intensiVe Care Medicine in Europe
CREACTIVE is a large-scale observational cohort study concerning Traumatic Brain Injury (TBI) care in the ICU setting
- Trial name
- CREACTIVE (NCT02004080)
- Testing
- Intensive Care treatment
- Where
- 20 sites in Italy
- Volunteers
- 8,000 people
- Sponsor
- Gruppo Italiano per la Valutazione degli Interventi in Terapia Intensiva
Drug Therapy
Safety Analysis of Antimicrobial Pharmacotherapy in Intensive Care Unit at Pediatric Hospital
Changes in the metabolic ability of cytochrome P-450 during child development can affect both bioavailability and elimination depending on the involvement of intestinal and hepatic metabolic processes.
- Trial name
- NCT04141657
- Testing
- Pharmacogenetic test
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- Anna Vlasova
Waiting-time in the Anaesthesia Admissions Ambulance
Optimizing of Waiting - Time in the Anesthesia Admissions Ambulance of the Charité - University Medicine Berlin by Support of a Mobile Application - a Pilot Study
In this study the investigators measure and optimize the patients waiting time in the preanesthetic assessment by integrating an interactive mobile device.
- Trial name
- NCT02457767
- Sponsor
- Charite University, Berlin, Germany
Drug Interaction
Risk Factors for Potential Drug -Drug Interactions: Study in Surgical Intensive Care Unit -Zagazig University Hospitals.
Drug drug interactions is frequent in critically ill patients due to polypharmacy, different drug groups and prolonged ICU or hospital stay
- Trial name
- NCT04078620
- Testing
- Survey for drug drug interactions on medscape and lexicomp applications
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Zagazig University