Clinical trials: Intensive Care Medicine
Tongue Edema, Tongue Enlarged
Tongue Edema Caused by Intubation Tube in Intensive Care Unit Patients
Tongue edema (TE) is an enlargement of the tongue that can be noticed with the naked eye and protrudes from the mouth. Endotracheal intubation tube, which can exert high pressure on the tongue for a long time, may cause TE.
- Conditions
- Tongue Edema, Tongue Enlarged, Mechanical Ventilation Complication, Intubation Complication
- Trial name
- NCT05249738
- Testing
- Measuring tongue cross-sectional area by submental ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Selcuk University
Sleep Quality, Pain
Comparing the Efficacy of Earplugs and Eye Masks on Pain and Sleep Quality
Objective: To determine the superiority of earplugs and eye masks to each other and their efficacy in pain and sleep quality. Methods: The study was a three-arm randomised controlled trial.
- Conditions
- Sleep Quality, Pain, Intensive Care Medicine, Cardiac Surgery
- Trial name
- NCT07100002
- Testing
- Control Group, Earplug Group, Eye mask Group
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Giresun University
COVID-19
Effect of CytoSorb Adsorber on Hemodynamic and Immunological Parameters in Critical Ill Patients With COVID-19
This prospective randomized single Center study investigates to what extent the physical elimination of the inflammatory mediators using the CytoSorb adsorber reduces the morbidity of severely and critically ill patients with…
- Trial name
- CYTOCOV-19 (NCT04344080)
- Testing
- CytoSorb-Therapy
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Sleep Deprivation, Depression
Work Hour Reductions, Medical Errors, and Intern Well-Being at Providence St. Vincent Medical Center Intensive Care Unit
The purpose of this study is to determine whether reducing intern work hours and eliminating extended shifts in the intensive care unit will reduce prescribing errors and improve intern well-being.
- Trial name
- NCT00996320
- Testing
- Reduced work hour schedule
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Providence Health & Services
High-risk Surgery
Association of Intraoperative Hemodynamic Characteristics to Postoperative Complications and Mortality
Worldwide, about 400 million major surgeries are performed annually. The scarce data available in the literature still suggest high postoperative morbidity and mortality, even in Europe.
- Trial name
- HeCoMo (NCT06355362)
- Volunteers
- 1,000 people
- Sponsor
- Kliniken Essen-Mitte
Fatigue, Sleep Deprivation
Effect and Utilization of Protected Time Among Interns on Extended Duty-Hour Call Shifts
This study will test the feasibility and effectiveness of protected time for physicians in training during 30 hour shifts in a medical intensive care unit. The primary outcome will be fatigue.
- Conditions
- Fatigue, Sleep Deprivation, Depression
- Trial name
- NCT00983008
- Testing
- Protected time and Dedicated time
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Providence Health & Services
Drug Therapy
Safety Analysis of Antimicrobial Pharmacotherapy in Intensive Care Unit at Pediatric Hospital
Changes in the metabolic ability of cytochrome P-450 during child development can affect both bioavailability and elimination depending on the involvement of intestinal and hepatic metabolic processes.
- Trial name
- NCT04141657
- Testing
- Pharmacogenetic test
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- Anna Vlasova
Invasive Fungal Infection
Pharmacokinetics and Pharmacodynamics of Caspofungin (Cancidas ®) and Drug Tolerance of Fungi to Patients With an Invasive Fungal Infection in the Intensive Care Unit
To investigate pharmacokinetics(PK) and pharmacodynamics(PD) of Caspofungin in ICU patients after received a loading dose of 70mg followed by 50mg (35mg if Child-Pugh score is 7-9), 40 patients will be recruited.
- Trial name
- NCT02510053
- Testing
- Caspofungin
- Volunteers
- 40 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Sepsis, Septic
Evaluation of the Clinical Relationship Between Procalcitonin Level and Bacteremia Agent in Intensive Care Unit Patients
In intensive care units, sepsis, which can be defined as bacteremia and the irregular and uncontrolled inflammatory response to it, is one of the most important causes of mortality.
- Conditions
- Sepsis, Septic, Bacteremia and Sepsis, Intensive Care Medicine
- Trial name
- NCT06958354
- Where
- Turkey (Türkiye)
- Volunteers
- 1,529 people
- Sponsor
- Gulhane Training and Research Hospital
Value of Virtual Autopsy for Quality Control in Icu
Virtual Autopsy for Quality Control on Intensive Care Medicine
The study aimed to compare CT-based virtual autopsy with classic autopsy as a tool for quality control in intensive care medicine.
- Trial name
- NCT01541982
- Where
- 2 sites in Germany
- Volunteers
- 160 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
PICU, Nurses
Smart Mind Maps in Promoting Safe Administration of High-Alert Medications
In PICU setting, drug administration, monitoring, and prescribing errors made up most cases (54%) of MEs . Emphasizes these issues requires a multifaceted approach, including staff training, creation of innovative cognitive…
- Trial name
- HAMs- PICU (NCT07320196)
- Testing
- smart mind mapsde
- Volunteers
- 70 people
- Sponsor
- Mansoura University
Bacterial Transmission Surveillance, Neonatal Intensive Care Unit
Bacterial Transmission Dynamics Study
Infections with multiply antibiotic-resistant bacteria represent a major cause of preventable morbidity and mortality amongst hospitalized neonates worldwide.
- Conditions
- Bacterial Transmission Surveillance, Neonatal Intensive Care Unit, Drug Resistance
- Trial name
- BTS (NCT02401204)
- Testing
- Longitudinal surveillance study
- Where
- Thailand
- Volunteers
- 97 people
- Sponsor
- University of Oxford
Metabolic Acidosis
ADVOS® Versus CVVHD in Metabolic or Mixed Acidosis
The aim of the study is to investigate the effects of ADVOS® therapy in critically ill patients with acute kidney injury, necessity of renal replacement therapy and acidosis.
- Trial name
- NCT05842369
- Testing
- ADVOS, CVVHD
- Where
- Germany
- Volunteers
- 52 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Ventilator-Associated Pneumonia (VAP)
Immediate Versus Substantiated Antibiotic Therapy in Suspected Non-Severe Ventilator-Associated Pneumonia
Ventilator-associated pneumonia is the leading nosocomial infection in the intensive care units, and is associated with prolonged mechanical ventilation and overuse of antibiotics.
- Trial name
- POSTPONE (NCT06743529)
- Testing
- control group, Conservative strategy
- Where
- 42 sites in France, Guadeloupe
- Volunteers
- 686 people
- Sponsor
- Nantes University Hospital
Venous Thromboembolism (VTE), Intensive Care Medicine
Pulsed Electromagnetic Field Therapy or Pneumatic Compression VTE Prophylaxis
Venous thromboembolism (VTE) is frequent in patients in the intensive care unit (ICU). Pharmacologic prophylaxis is sometimes contraindicated, and mechanical prophylaxis is used.
- Conditions
- Venous Thromboembolism (VTE), Intensive Care Medicine, Venous Thromboembolism
- Trial name
- SOPHIE (NCT06958588)
- Testing
- Experimental: Hyperslim, Active Comparator #1
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Science Valley Research Institute
ARDS, Sepsis
Drug Monitoring of Antibiotics in Critical Care Patients
Infections are critical factors for the survival of critically ill patients. A broad, high-dose and early initial therapy of antibiotics is of particular relevance.
- Trial name
- DRAK (NCT01793012)
- Where
- Germany
- Volunteers
- 186 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Sepsis
The Distribution of Plasma Drug Concentrations of Beta-lactam Antibiotics in Intensive Care Unit Patients
In this project, intensive care unit (ICU) patients treated with beta-lactam antibiotics are included with the aim to investigate the potential underdosing in this patient group.
- Trial name
- TDM-ICU (NCT02446392)
- Testing
- No intervention.
- Where
- 4 sites in Sweden
- Volunteers
- 120 people
- Sponsor
- Linkoeping University
Intensive Care Unit, Antibiotic Therapy
Therapeutic Monitoring of Antibiotics in Intensive Care Patients: a Cohort Study PopTDM-ICU
Intensive care patients are exposed to serious infections. Mortality linked to these infections remains high and antibiotic therapy treatment optimization is one of the key points of therapeutic success .
- Conditions
- Intensive Care Unit, Antibiotic Therapy, Pharmacokinetic
- Trial name
- NCT05367011
- Volunteers
- 2,500 people
- Sponsor
- Poitiers University Hospital
Covid19, Severe Acute Respiratory Syndrome
Ivermectin in Adults With Severe COVID-19.
Since the onset of the disease, more than 40.5 million people have been diagnosed with COVID-19 and nearly 1.2 million people have died (October 21, 2020).
- Trial name
- NCT04602507
- Testing
- Ivermectin
- Where
- Colombia
- Volunteers
- 75 people
- Sponsor
- CES University
Severe Sepsis, Septic Shock
(1,3)-β-D-glucan Based Diagnosis of Invasive Candida Infection in Sepsis
This prospective randomized multicenter study evaluates whether the decision to prescribe antifungals guided by (1,3)-β-D-glucan in comparison to standard of care shortens time to antifungal therapy and reduces mortality in…
- Trial name
- CandiSep (NCT02734550)
- Testing
- Standard of care, (1,3)-β-D-glucan guided therapy
- Where
- 18 sites in Germany
- Volunteers
- 342 people
- Sponsor
- Center for Sepsis Control and Care, Germany