Clinical trials: Internal Disorders
Obstructive Sleep Apnea of Child
The Effect of Self-care Emphasizing on Balloon-Blowing Exercise Program on Severity of Sleep Apnea and Respiratory Muscle Strength Among School Age Children With Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) is a common condition in school-age children, often leading to sleep disturbances and associated health issues.
- Trial name
- "SEES" (NCT06780982)
- Testing
- Balloon-Blowing exercise program, Standard nursing care
- Where
- Thailand
- Volunteers
- 30 people
- Sponsor
- Chulalongkorn University
ADHD, Iron-deficiency
Impact of Iron Supplementation Treatment on Brain Iron Concentrations
The goal of the present study is to provide novel data to evaluate brain iron concentration as a mediator of the association between iron supplementation treatment and improvement in symptoms of ADHD and RLS in children…
- Conditions
- ADHD, Iron-deficiency, Restless Legs Syndrome, Periodic Limb Movement Sleep Disorder
- Trial name
- NCT04144790
- Testing
- ferrous sulfate
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Insomnia
Cognitive-behavioral Therapy for Insomnia in School-aged Children
This randomized controlled trial will test the efficacy of CBT-I intervention for school-aged children (7-11 years old) with insomnia. The trial will focus on the role of sleep restriction therapy in treatment.
- Trial name
- NCT07048340
- Testing
- Cognitive Behavioral Therapy for Insomnia, Cognitive Behavioral Therapy for Insomnia without SRT
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Tel Aviv University
Autism Spectrum Disorder, Insomnia
Iron Treatment of Sleep Disorders in Children With Autism Spectrum Disorder
Autism Spectrum Disorders (ASD) are characterized by difficulties in language, social communication, and repetitive and restricted behaviors. ASD affects as many as 1 in 90-150 children.
- Trial name
- NCT01745497
- Testing
- Ferrous sulfate
- Where
- 4 sites in United States, Canada
- Volunteers
- 24 people
- Sponsor
- University of Colorado, Denver
Autism Spectrum Disorder, Sleep Initiation and Maintenance Disorders
Sensory-Friendly Physical Activity for Sleep in Autistic Children
Sleep problems are very common in children on the autism spectrum and can worsen daytime behaviour, learning, and family stress. Many families have limited access to specialist sleep services.
- Trial name
- SFPAS (NCT07277101)
- Testing
- Sensory-Friendly Physical Activity Program (PAP), Conventional control group
- Where
- China
- Volunteers
- 106 people
- Sponsor
- Xili Wen
Obstructive Sleep Apnea, Malocclusion
Premolar Extractions for Obstructive Sleep Apnea in Children With Overjet
This research aims to provide pediatric patients with polysomnography (a sleep study) before and after orthodontic treatment to determine if the extraction of upper premolars for treating excessive overjet results in an increase…
- Trial name
- NCT04946201
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mohamed Bazina
Insomnia, Sleep Disturbance
Improving Sleep to Prevent Depression & Anxiety in Adolescents at High Risk
Emerging evidence has shown that sleep interventions such as Cognitive Behavioral Therapy for Insomnia (CBT-I) improve depressive and anxiety symptoms in adults, even when the intervention is brief, such as four to six sessions.
- Conditions
- Insomnia, Sleep Disturbance, Depressive Symptoms, Anxiety Symptoms
- Trial name
- NCT06358495
- Testing
- Cognitive Behavioral Therapy for Insomnia, Active Control
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Calgary
Sleep Apnea, Obstructive
Is Change in Mouth Opening Related to Change in Quality of Life in Children With Type 1 Obstructive Sleep Apnea After Adenotonsillectomy?
The goal of this clinical trial is to learn if changes in quality of life are linked to changes in mouth opening after adenotonsillectomy in a group of children who were diagnosed with Type 1 Obstructive Sleep Apnea (OSA1).
- Trial name
- JawChild (NCT06973928)
- Testing
- Measures of jaw activity using the Jawac
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Groupe Adène
Yoga
Yoga for Adolescents
Purpose: Specific effects of high-density Hatha Yoga(HY) training in adolescents have not yet been clarified. Aim of our study is to investigate the effects of high-density HY education on physical fitness, pulmonary function and…
- Trial name
- NCT04658563
- Testing
- High Density Exercise Training Program - Yoga
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Baskent University
Obstructive Sleep Apnea
Adherence and Outcome of Upper Airway Stimulation (UAS) for OSA International Registry
Inspire intends to conduct this registry to: 1) collect Inspire therapy clinical evidence in the clinical practice setting; 2) collect additional information on the effectiveness, use and safety in the commercial setting; and 3)…
- Trial name
- NCT02907398
- Testing
- Inspire therapy, No intervention
- Where
- 64 sites in United States, Belgium and 3 more
- Volunteers
- 5,000 people
- Sponsor
- Inspire Medical Systems, Inc.
Restless Legs Syndrome
A Study of Rotigotine Patch in Adolescent Subjects With Restless Legs Syndrome of Unknown Cause
The purpose of this study is to demonstrate the efficacy of rotigotine against placebo in adolescent subjects with idiopathic Restless Legs Syndrome (RLS) over a 12-week maintenance period and to investigate the safety and…
- Trial name
- NCT03728933
- Testing
- Rotigotine 1 milligram/24 hours, Rotigotine 2 milligram/24 hours
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- UCB Biopharma SRL
Obstructive Sleep Apnea (Mild, Moderate, Severe) as Per Polysomnography
Intranasal Mometasone in Children With Obstructive Sleep Apnea Due to Adenotonsillar Hypertrophy
Obstructive sleep apnea (OSA) in children is a disorder of breathing during sleep characterized by prolonged partial upper airway obstruction and/or intermittent complete obstruction (obstructive apnea) that disrupts normal…
- Trial name
- Nasonex OSA (NCT01671852)
- Testing
- Mometasone furoate nasal spray
- Where
- Canada
- Sponsor
- Children's & Women's Health Centre of British Columbia
Sport, Muscle Fatigue
Effect of KA-EX Supplementation on Recovery Parameters in High-Level Young Football Players
The purpose of this study is to evaluate the effects of KA-EX supplementation on recovery parameters in elite young football players.
- Conditions
- Sport, Muscle Fatigue, Recovery of Function (G11.427.698.620), Athletic Performance
- Trial name
- Effect of KA-E (NCT07824752)
- Testing
- KA-EX, Experimental: KA-EX Supplement
- Where
- Italy
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Antonio Molina Lopez
Glioma, Diffuse Intrinsic Pontine Glioma
A Study of Panobinostat in Combination With Everolimus for Children and Young Adults With Gliomas
This phase 2 trial will evaluate the activity of Panobinostat in combination with Everolimus for children with gliomas harboring H3.1 or H3.3K27M mutation, including newly diagnosed high-grade glioma or DIPG (diffuse intrinsic…
- Trial name
- NCT03632317
- Testing
- Panobinostat, Everolimus
- Where
- United States
- Sponsor
- University of Michigan Rogel Cancer Center
Cerebral Palsy, Gait, Hemiplegic
Effects of Different Focuses of Attention on Walking and Balance in Children With Cerebral Palsy
This study was planned to examine the effects of different focuses (external and internal focus)of attention on functional walking and balance in children with cerebral palsy.
- Conditions
- Cerebral Palsy, Gait, Hemiplegic, Balance
- Trial name
- NCT06170814
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Gazi University
Cystic Fibrosis, Hirschprung's Disease
Evaluating the Alimentary and Respiratory Tracts in Health and Disease (EARTH) Research Program.
The investigators have established the "Evaluating the Alimentary and Respiratory Tracts in Health and disease" (EARTH) research program.
- Conditions
- Cystic Fibrosis, Hirschprung's Disease, Obstructive Sleep Apnea, Healthy
- Trial name
- EARTH (NCT04071314)
- Where
- Australia
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- The University of New South Wales
Apnea, Sleep
Controlled Exercises Effectiveness in Patients With Sleep Apnea
The aim is to compare a programme of controlled exercises therapy vs a programme of non controlled exercises therapy in patients with sleep apnea
- Trial name
- NCT04326634
- Testing
- controlled exercises, non controlled exercises group
- Volunteers
- 30 people
- Sponsor
- Universidad Complutense de Madrid
Apnea, Obstructive
Validation of the French Version of the OSA-18 Questionnaire
Obstructive sleep apnea (OSA) is characterized by repetitive partial and/or total closure of the upper airway during sleep, inducing oxygen desaturation and sleep disturbance. Its prevalence in the pediatric population is 1-5%.
- Trial name
- French OSA18 (NCT07136909)
- Testing
- Completion of the OSA-18 questionnaire by parents, during hospitalization planned as part of routine care.
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Hospices Civils de Lyon
Recurrent Diffuse Intrinsic Pontine Glioma, Recurrent Malignant Glioma
Savolitinib in Treating Patients With Recurrent or Refractory Primary CNS Tumors
This phase I trial studies the side effects and best dose of savolitinib in treating patients with primary central nervous system (CNS) tumors that have come back (recurrent) or does not respond to treatment (refractory).
- Conditions
- Recurrent Diffuse Intrinsic Pontine Glioma, Recurrent Malignant Glioma, Recurrent Medulloblastoma, Recurrent Primary Central Nervous System Neoplasm
- Trial name
- NCT03598244
- Testing
- Biospecimen Collection, Magnetic Resonance Imaging, Savolitinib
- Where
- 12 sites in United States, Canada
- Volunteers
- 41 people
- Sponsor
- National Cancer Institute (NCI)
Obstructive Sleep Apnea, Hypoventilation
The IPAd Study: Exploring the Association Between Insomnia and Positive Airway Pressure Adherence in Children
Sleep-disordered breathing (SDB) is prevalent in children and adolescents and untreated SDB impacts key indicators of physical and psychosocial health.
- Conditions
- Obstructive Sleep Apnea, Hypoventilation, Central Sleep Apnea
- Trial name
- IPAd (NCT05949164)
- Testing
- Insomnia
- Where
- Canada
- Volunteers
- 216 people
- Sponsor
- The Hospital for Sick Children
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