Clinical trials: Internal Disorders
Sleep Disorders
Evaluation of WP200 With the Unified Probe (WP200U)
The prevalence of OSAS is estimated at 2% and 4% for adult women and men respectively, most of whom are undiagnosed and untreated.
- Trial name
- NCT01929447
- Where
- Israel
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Itamar-Medical, Israel
Heart Failure
LV Dysfunction Following Pacemaker Placement
Several studies have confirmed the link between chronic RV apical pacing and the development of heart failure and LV systolic dysfunction in some patients 1,2.
- Trial name
- NCT03850808
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Oregon Health and Science University
Hypoplastic Left Heart Syndrome, Obstructive Sleep Apnea Syndrome
Sleep Disordered Breathing in Children With Single Ventricle Physiology
This is an exploratory study designed to evaluate the incidence of, and to quantify sleep disordered breathing following stage I Norwood reconstructive surgery. Sleep disordered breathing will be correlated with: 1.
- Conditions
- Hypoplastic Left Heart Syndrome, Obstructive Sleep Apnea Syndrome, Single Ventricle Physiology
- Trial name
- NCT00156455
- Where
- United States
- Sponsor
- University of Rochester
Insulin Resistance, Glucose Intolerance
Endothelial Function in Obese Adolescents
Childhood obesity is perhaps the most significant public health problem in the most developed countries and is rapidly becoming so in developing countries.
- Conditions
- Insulin Resistance, Glucose Intolerance, Obesity, Atherosclerosis
- Trial name
- NCT01879033
- Testing
- Reactive hyperemia peripheral artery tonometry (Rh-PAT), Blood levels for glucose, insulin, lipids and adipocytokines
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Ondine Syndrome (Congenital Central Hypoventilation Syndrome)
Locus Coeruleus and CCHS (Congenital Central Hypoventilation Syndrome)
This study investigates whether cognitive dysfunction in young patients with congenital central hypoventilation syndrome (Ondine Syndrome) is related to the severity of the disease and dysfunction of the locus coeruleus (a…
- Trial name
- ONDINE-LC (NCT07081464)
- Testing
- MRI, EEG, Pupillometry
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Umbilical Cord Clamping, Congenital Diaphragmatic Hernia
Physiological Umbilical Cord Clamping in Patients With Congenital Diaphragmatic Hernia. Clinical Trial
Congenital diaphragmatic hernia (CDH) is a malformation that affects 1 in every 3000 newborns. The diaphragm does not complete its closure during embryogenesis, which allows the abdominal organs to herniate into the thoracic…
- Conditions
- Umbilical Cord Clamping, Congenital Diaphragmatic Hernia, Delayed Umbilical Cord Separation
- Trial name
- NCT06408376
- Testing
- Physiological cord clamping
- Where
- Argentina
- Volunteers
- 80 people
- Sponsor
- Hospital JP Garrahan
Psychological Distress, Insomnia
Clinical Trial for Acupuncture in Adolescents With Psychological Distress and Insomnia
This is an assessor-blinded, randomized, MAS-controlled trial. A total of 148 adolescents aged 15-22 years experiencing mild to moderate anxiety or depressive symptoms will be recruited.
- Trial name
- NCT06638450
- Testing
- Dense Cranial Electroacupuncture Stimulation plus Body Acupuncture (DCEAS+BA), Minimal Acupuncture Stimulation (MAS)
- Where
- Hong Kong
- Volunteers
- 148 people
- Sponsor
- The University of Hong Kong
Pierre Robin Sequence (PRS), Difficult Laryngoscopy
3D-CT-Based Prediction of Difficult Laryngoscopy in Infants With Pierre Robin Sequence
This study aims to develop and validate a quantitative prediction model using three-dimensional computed tomography (3D-CT) imaging for identifying infants with Pierre Robin sequence (PRS) at risk of difficult laryngoscopy.
- Conditions
- Pierre Robin Sequence (PRS), Difficult Laryngoscopy, Airway Management
- Trial name
- PRS-3DCT (NCT07257276)
- Where
- China
- Volunteers
- 294 people
- Sponsor
- Nanjing Children's Hospital
Narcolepsy Type 1
Clinical and Neurophysiological Characteristics of Narcolepsy
The study is the first attempt in post-Soviet Russian history to collect and analyze the existing available data of narcolepsy cohort in order to get prove characteristics of narcolepsy in Russia according to known data.
- Trial name
- NCT05375890
- Testing
- no intervention
- Where
- 11 sites in Russia
- Volunteers
- 89 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Sleep Initiation and Maintenance Disorders
Cognitive Behavioral Therapy for Trauma-Related Insomnia in Veterans
Understanding the effectiveness of Cognitive Behavioral Therapy for trauma-related insomnia (CBT-I) is important because sleep difficulties often persist after traditional post-trauma treatments are completed and other…
- Trial name
- CBT-I Telemed (NCT01176123)
- Testing
- Cognitive Behavioral Therapy for Insomnia
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Southeast Louisiana Veterans Health Care System
Pathology of the Thoracic Aorta, Aneurysm Thoracic
French Assessment of the Relay Plus and Relay NBS Plus Thoracic Stent-Graft
Stent treatment of thoracic aortic pathologies, including aneurysms, pseudo-aneurysms, dissections, intramural hematomas, penetrating ulcers and ruptures of the isthmus, seems to provide a likely benefit compared to surgery in…
- Conditions
- Pathology of the Thoracic Aorta, Aneurysm Thoracic, Pseudo-aneurysm, Thoracic, Dissection of Thoracic Aorta
- Trial name
- NCT05030740
- Where
- 10 sites in France
- Volunteers
- 170 people
- Sponsor
- Vascutek Ltd.
Obstructive Sleep Apnea, Down Syndrome
Validation of Sleep Questionnaires in the Down Syndrome Population
This will be a prospective validation study of a sample of consecutive pediatric Down syndrome patients who are seen through the weekly Down syndrome clinic at OHSU/Doernbecher's.
- Trial name
- NCT03771469
- Testing
- Sleep study
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Obstructive Apnea
Comparison of a Demand Oxygen Delivery
Conducting a randomized control trial of oxygen in children with Down syndrome to treat moderate to severe obstructive sleep apnea.
- Trial name
- DOSA (NCT06609694)
- Testing
- Portable oxygen concentrator Inogen G5 model
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Burnout Syndrome, Depression Disorder
The COMET Study: a Prospective COhort of MEdical residenTs to Assess Professional, Personal and Psychological Trajectories of Residents in General Internal Medicine
Introduction. Switzerland, like most Western countries, faces a paradox: an ageing, multimorbid population needs general internal medicine (GIM) physicians more than ever, yet fewer young doctors choose - and stay in - the…
- Conditions
- Burnout Syndrome, Depression Disorder, Insomnia, Perceived Stress
- Trial name
- COMET (NCT07707453)
- Where
- 3 sites in Switzerland
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- University of Fribourg
Stroke, Transient Ischemic Attack
Prospective Evaluation of Carotid Free-floating Thrombus
Hardened plaque located in the carotid arteries can cause stroke or transient ischemic attack (TIA). This type of plaque is linked to unstable free-floating thrombi (FFT).
- Trial name
- NCT02405845
- Testing
- Computed Tomographic Angiogram
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Ottawa Hospital Research Institute
Patent Foramen Ovale
Internal Microstructure of Patent Foramen Ovale Related to Stroke
This study aims to (1) investigate the internal microstructure of patent foramen ovale related to cryptogenic stroke, transient ischemic attack or migraine and determine the effectiveness of transcatheter closure in these…
- Trial name
- IMPORT (NCT04686253)
- Testing
- not appliable
- Where
- 2 sites in China
- Volunteers
- 1,200 people
- Sponsor
- China National Center for Cardiovascular Diseases
Obstructive Sleep Disordered Breathing
Prediction of Tongue Base Obstruction During Sleep
This study investigates the hypothesis that, in children, tongue motor functions can predict both the anatomical site and the degree of upper airway obstruction contributing to obstructive sleep-disordered breathing.
- Trial name
- PTOS (NCT06792045)
- Testing
- Physiotherapist assessment, ENT assessment, Drug-Induced Sleep Endoscopy
- Where
- Belgium
- Volunteers
- 48 people
- Sponsor
- Université Catholique de Louvain
Adolescent Behaviour Disorder, Stress Reduction
Mindfulness-Based Stress Reduction for Adolescents: Effects on Game Addiction, Stress, and Sleep
This randomized controlled trial investigated the impact of a Mindfulness-Based Stress Reduction (MBSR) program on digital game addiction, perceived stress, and sleep quality among adolescents.
- Conditions
- Adolescent Behaviour Disorder, Stress Reduction, Sleep Quality, Digital Addiction
- Trial name
- MBSR (NCT07274553)
- Testing
- Mindfulness-Based Stress Reduction Program (MBSR)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Muş Alparslan University
Epiretinal Membrane, Internal Limiting Membrane Wrinkling
Fovea ERM After Fovea-sparing ILM Peeling
To report cases who had received previous fovea-sparing internal limiting peeling membrane and developed secondary fovea epiretinal membrane contraction
- Trial name
- NCT04445142
- Testing
- fovea-sparing internal limiting membrane peeling
- Where
- Taiwan
- Volunteers
- 3 people
- Sponsor
- Changhua Christian Hospital
Congenital Diaphragmatic Hernia
Children With Congenital Diaphragmatic Hernia and the Quality of Their Daily Lives
Background: Congenital diaphragmatic hernia is a rare disease, resulting from a developmental malformation of the diaphragm. Over the last years, management of the affected children has improved significantly.
- Trial name
- NCT07432672
- Where
- Austria
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
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