Clinical trials: Internal Disorders
Esophageal Atresia With Tracheo-esophageal Fistula, Congenital Diaphragmatic Hernia
Open or Keyhole Surgery Through the Chest for Newborn Babies: Effect on Blood Gases
This is a pilot randomised controlled trial comparing open versus thoracoscopic surgery for repair of oesophageal atresia with tracheo-oesophageal fistula or congenital diaphragmatic hernia in neonates.
- Trial name
- CO2 (NCT01467245)
- Testing
- Hypercapnia during thoracoscopy, Open surgery
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Obesity, Obstructive Sleep Apnea
Does Treating Obstructive Sleep Apnea in Obese Canadian Youth Improve Blood Sugar Control?
To determine whether, in obese children with moderate-severe Obstructive Sleep Apnea who are prescribed Positive Airway Pressure(PAP) therapy, increased hours of PAP usage per night over a one-year period is associated with a…
- Trial name
- IMPACT Obesity (NCT01116375)
- Where
- 4 sites in Canada
- Volunteers
- 27 people
- Sponsor
- Katz, Sherri Lynne, M.D.
Congenital Diaphragmatic Hernia, Tracheoesophageal Fistula
Prospective Data Collection of Patients < 6 Months of Age Undergoing Thoracoscopic Surgery
The study is primarily a descriptive study examining the physiological, ventilatory, surgical, and recovery effects of patients ≤ 6 months of age who undergo thoracoscopic surgery and to determine the accuracy of transcutaneous…
- Conditions
- Congenital Diaphragmatic Hernia, Tracheoesophageal Fistula, Esophageal Atresia
- Trial name
- NCT02033772
- Testing
- Thoracoscopic surgery
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Arlyne Thung
Cerebral Palsy, Sleep Disorders in Children
Sleep Quality and Caregiver Burden in Children With Cerebral Palsy
Cerebral palsy (CP) is a lifelong condition affecting movement and posture, often requiring substantial care from family members.
- Conditions
- Cerebral Palsy, Sleep Disorders in Children, Caregiver Burden, Sleep Quality
- Trial name
- CP-SLEEP (NCT07168577)
- Where
- Turkey (Türkiye)
- Volunteers
- 61 people
- Sponsor
- Selim Sezikli
Insomnia
Clown Doctors and a Sedative Premedicant for Children Undergoing Surgery
The purpose of the present investigation will be to determine whether a combination of clown doctor and parental presence is more effective than a combination of sedative premedication and parental presence for reducing anxiety…
- Trial name
- NCT00886314
- Testing
- midazolam, clown doctor
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- Shaare Zedek Medical Center
Obesity, Obstructive Sleep Apnea Syndrome
Pilot Study to Assess the Effectiveness of Tonsil and Adenoidectomy (T+A) in Overweight Children and Adolescents
Obesity has reached epidemic proportions in the United States with roughly 20% of American children being overweight and has serious consequences such as sleep apnea.Additionally, obesity is known to result in the earlier onset…
- Trial name
- NCT00222963
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Rochester
Childhood Cerebral Anaplastic Astrocytoma, Childhood Oligodendroglioma
Bevacizumab and Irinotecan in Treating Young Patients With Recurrent, Progressive, or Refractory Glioma, Medulloblastoma, Ependymoma, or Low Grade Glioma
This phase II trial is studying how well giving bevacizumab together with irinotecan works in treating young patients with recurrent, progressive, or refractory glioma, medulloblastoma, ependymoma, or low grade glioma.
- Conditions
- Childhood Cerebral Anaplastic Astrocytoma, Childhood Oligodendroglioma, Childhood Spinal Cord Neoplasm, Recurrent Childhood Brain Stem Glioma
- Trial name
- NCT00381797
- Testing
- Bevacizumab, Fludeoxyglucose F-18, Irinotecan Hydrochloride
- Where
- 11 sites in United States
- Volunteers
- 97 people
- Sponsor
- National Cancer Institute (NCI)
Adenoid Hypertrophy
Conventional Curettage Versus Endoscopic Microdebrider-Assisted Adenoidectomy in Children
The purpose of this randomized clinical trial is to compare two surgical methods for removing enlarged adenoids in children: conventional curettage adenoidectomy and endoscopic microdebrider-assisted adenoidectomy.
- Trial name
- NCT07856771
- Testing
- Conventional Curretage Adenoidectomy, Endoscopic Microdebrider-Assisted Adenoidectomy
- Where
- Pakistan
- Volunteers
- 88 people
- Sponsor
- Allama Iqbal Teaching Hospital
Narcolepsy, Obstructive Sleep Apnea
SUNOSI® (Solriamfetol) Pregnancy Registry
The SUNOSI (solriamfetol) Pregnancy Registry is a US- and Canada-based prospective, observational study to evaluate the safety of solriamfetol exposure during pregnancy in women with a diagnosis of narcolepsy or obstructive sleep…
- Conditions
- Narcolepsy, Obstructive Sleep Apnea, Pregnant Women and Their Offspring
- Trial name
- NCT06413420
- Testing
- Sunosi (solriamfetol), Other prescription wake-promoting medications or stimulants, No treatment
- Where
- 2 sites in United States
- Volunteers
- 1,731 people
- Sponsor
- Axsome Therapeutics, Inc.
Breast Cancer
A Prospective Observational Study of Clinical Outcomes for the NanoString® Technologies Prosigna Gene Signature Assay
The primary objective of this study is to assess the extent to which the Prosigna™ Breast Cancer Prognostic Gene Signature Assay affects the medical oncologist's treatment recommendations regarding adjuvant chemotherapy and…
- Trial name
- NCT01899079
- Where
- 7 sites in Spain
- Volunteers
- 217 people
- Sponsor
- NanoString Technologies, Inc.
Insomnia Chronic, Narcolepsy
The Impact of Light, Electrical, and Magnetic Neuroregulation Interventions on Sleep-wake Disorders
Carry out precise and effective neuromodulation interventions, and develop new neuromodulation technologies for sleep disorders.
- Conditions
- Insomnia Chronic, Narcolepsy, REM Sleep Behavior Disorder
- Trial name
- NCT06797284
- Testing
- Transcranial Magnetic Stimulation
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Second Affiliated Hospital of Soochow University
Intracranial Aneurysms
Treatment of Cranial Internal Carotid Artery Aneurysm With Willis Covered Stent and Coil Embolization
Intracranial aneurysm treatment with coil embolization is associated with relatively low complete occlusion and high recanalization rates.
- Trial name
- NCT01029938
- Testing
- Covered stent, Coil
- Where
- 2 sites in China
- Volunteers
- 85 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Headache Disorders, Migraine Disorders
Intervention for Sleep and Pain in Youth
This study tests the feasibility, acceptability, and preliminary efficacy of a seven-session cognitive-behavioral therapy intervention to treat sleep and pain problems in youth ages 11-17 with co-morbid headache and insomnia.
- Conditions
- Headache Disorders, Migraine Disorders, Insomnia
- Trial name
- I-SPY (NCT03137147)
- Testing
- Intervention for Sleep and Pain in Youth
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Seattle Children's Hospital
Therapy, Menopause
Menopause, Laughter Therapy, and Well-Being
The intervention will be conducted by Assist. Prof. Dr. Nurten ÖZÇALKAP. No invasive procedures will be performed; participants will engage in deep breathing, warm-up exercises, playful activities, and laughter exercises.
- Conditions
- Therapy, Menopause, Sleep, Psychological Well-being
- Trial name
- NCT07522840
- Testing
- grup 1 laughter yoga therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Agri Ibrahim Cecen University
Insomnia
Digital Cognitive Behavioral Treatment of Insomnia in Youth: An RCT Examining Feasibility, Acceptability, and Efficacy of NiteCAPP Jr
The proposed pilot will examine feasibility, acceptability, and preliminary efficacy of a digital CBT-I tailored for school-aged children.
- Trial name
- NiteCAPP JR (NCT07091149)
- Testing
- CBT-I
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of South Florida
Concussion (Diagnosis), Concussion, Mild Traumatic Brain Injury
Multidimensional Sleep Health Intervention to Optimize Concussion Recovery
Following adolescent concussion, poor sleep health is common and relates to the development of persisting post-concussion symptoms, and uninjured adolescents (independent of concussion) also commonly experience sleep…
- Conditions
- Concussion (Diagnosis), Concussion, Mild Traumatic Brain Injury, Treatment, Sleep Health
- Trial name
- SCORE (NCT07082218)
- Testing
- Sleep Intervention
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of Colorado, Denver
Narcolepsy, REM Sleep Behavior Disorder
Investigation of Clinical Feature and Brain Function in Narcoleptic Patients
This study evaluates the PSG and cerebral metabolism and functions in narcolepsy with/without RBD
- Trial name
- NCT03376568
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Obstructive Sleep Apnea
Improving Outcomes in Pediatric Obstructive Sleep Apnea With Computational Fluid Dynamics
To create a validated computational tool to predict surgical outcomes for pediatric patients with obstructive sleep apnea (OSA).
- Trial name
- OSA-MRI (NCT04991389)
- Testing
- 129-Xe
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Diffuse Intrinsic Pontine Glioma
Cilengitide in Combination With Irradiation in Children With Diffuse Intrinsic Pontine Glioma
The aim of the study is to determine the safety of Cilengitide in combination with radiation therapy.
- Trial name
- CILENT (NCT01165333)
- Testing
- Cilengitide dose escalation, Cilengitide, Concomitant radiotherapy
- Where
- 9 sites in France
- Volunteers
- 32 people
- Sponsor
- Centre Oscar Lambret
Insomnia Related to Another Mental Condition
Association Between the Quality of the Therapeutic Alliance and the Response to ChronoS Therapy
PREDI-CHRONOS is an ancillary study of the CHRONOS project (NCT07180290) The goal of this study is to measure the association between therapeutic alliance and the clinical response to the CHRONOS therapy.
- Trial name
- PREDI-CHRONOS (NCT07202338)
- Testing
- CHRONOS therapy
- Where
- France
- Volunteers
- 48 people
- Sponsor
- Centre Hospitalier St Anne
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