Clinical trials: Internal Disorders
CNS Embryonal Tumor, Not Otherwise Specified, Malignant Glioma
Ribociclib and Everolimus in Treating Children With Recurrent or Refractory Malignant Brain Tumors
This phase I trial studies the side effects and best dose of ribociclib and everolimus and to see how well they work in treating patients with malignant brain tumors that have come back or do not respond to treatment.
- Conditions
- CNS Embryonal Tumor, Not Otherwise Specified, Malignant Glioma, Recurrent Atypical Teratoid/Rhabdoid Tumor, Recurrent Childhood Ependymoma
- Trial name
- NCT03387020
- Testing
- Everolimus, Laboratory Biomarker Analysis, Pharmacological Study
- Where
- 12 sites in United States
- Volunteers
- 22 people
- Sponsor
- Pediatric Brain Tumor Consortium
Sleep Apnea, Obstructive, Insomnia
The IPAD Cohort Study: Insomnia and Positive Airway Pressure Adherence in Children and Adolescents
Positive Airway Pressure (PAP) is a treatment used to help people with sleep-disordered breathing, particularly those with obstructive sleep apnea (OSA).
- Trial name
- IPAD (NCT07176767)
- Testing
- Positive airway pressure therapy
- Where
- Canada
- Volunteers
- 82 people
- Sponsor
- Lena Xiao
Digital Screen Addiction and Sleep Quality in Adolescents
The Impact of Digital Detox Training on Screen Use, Sleep Quality, and Healthy Lifestyle Behaviors in Adolescents
This study evaluates the effects of a digital detox program on screen time, sleep quality, and healthy lifestyle behaviors among adolescents aged 10-19 years.
- Trial name
- DIGIDETOX-RCT (NCT07555834)
- Testing
- Digital Detox Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Şırnak Üniversitesi
Primary Insomnia, Secondary Insomnia
Two Contrasting Interventions for Sleep Management
This study will determine whether Mind-Body Bridging (MBB), a mindfulness training program is more effective than a common sleep medication, Zolpidem, in treating insomnia.
- Trial name
- NCT01804036
- Testing
- Zolpidem, Mind-Body Bridging
- Where
- 2 sites in United States
- Volunteers
- 72 people
- Sponsor
- University of Utah
Obstructive Sleep Apnea
Long-term Impact of Maxillomandibular Advancement Osteotomy on Sleep Apnea Patients
Background Maxillomandibular advancement surgery (MMA) has demonstrated high success rates, improving both the apnea-hypopnea index and associated patient' quality of life (QOL), in patients diagnosed with obstructive sleep apnea…
- Trial name
- MIMOSA (NCT03246477)
- Volunteers
- 12 people
- Sponsor
- AZ Sint-Jan AV
Lung Diseases, Sleep
Pharmacological and Behavioral Treatment of Insomnia
to develop the maximally effective treatment strategy for chronic sleep-onset insomnia and to reduce its impact on psychological functioning, health, and economic sequelae.
- Conditions
- Lung Diseases, Sleep, Sleep Initiation and Maintenance Disorders
- Trial name
- NCT00005753
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Medulloblastoma, Glioblastoma Multiforme
A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade Glioma, Ependymoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma
Patients will receive a vaccine called SurVaxM on this study. While vaccines are usually thought of as ways to prevent diseases, vaccines can also be used to treat cancer.
- Conditions
- Medulloblastoma, Glioblastoma Multiforme, Anaplastic Astrocytoma, High-grade Astrocytoma NOS
- Trial name
- NCT04978727
- Testing
- SurVaxM for patients with relapsed or progressive MB, HGG or ependymoma ages ≥10 and ≤21 years, SurVaxM for patients with relapsed or progressive MB, HGG or ependymoma ages ≥1 and <10 years, SurVaxM for patients with non-relapsed DIPG post radiation-therapy ages ≥1 and ≤21 years
- Where
- 14 sites in United States, Canada
- Volunteers
- 35 people
- Sponsor
- Children's Oncology Group
Blood Pressure, Sleep-Disordered Breathing
High Blood Pressure in Paediatric Patients With Sleep Disorder Breathing.
There are data supporting a possible increase in the prevalence of High Blood Pressure (HBP) in pediatric patients with Sleep Disorder Breathing (SDB).
- Trial name
- NCT03696654
- Testing
- adenotonsillar surgery
- Where
- Spain
- Volunteers
- 286 people
- Sponsor
- Fundacion del Hospital Nacional de Paraplejicos para la Investigacion y la Integracion
Congenital Diaphragmatic Hernia
Management of Late Presenting Congenital Diaphragmatic Hernia .
Diagnosis and different ways of surgical repair of Congenital diaphragmatic hernia
- Trial name
- NCT07397793
- Testing
- MIS and open surgery repair
- Where
- Egypt
- Volunteers
- 10 people
- Sponsor
- Jehad Emam Abdelrahman
Multiple Sclerosis, Caregiver Burden
Multiple Sclerosis Severity and Caregiver Health Outcomes
This cross-sectional observational study aims to investigate the associations between multiple sclerosis (MS) severity and caregivers' sleep quality, physical activity, body awareness, perceived stress, and caregiver burden.
- Conditions
- Multiple Sclerosis, Caregiver Burden, Sleep Quality, Physical Activity
- Trial name
- NCT07842744
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Süleyman Korkusuz
Chronic Insomnia
REST: Restoring Effective Sleep Tranquility in College Veterans With Service-Related Injuries
The purpose of the project is to improve the sleep quality and sleep duration of post 9/11 veterans seeking college degrees. Preliminary research findings within CSU's New Start for Student Veterans program indicate veterans with…
- Trial name
- NCT02871414
- Testing
- REST - Early Group, REST - Late Group
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Colorado State University
Obstructive Sleep Apnea, Down Syndrome (Trisomy 21)
Effects of a Pacifier on Obstructive Sleep Apnea and Its Repercussions in Infants With Down Syndrome
Obstructive Sleep Apnea (OSA) is characterised by repetitive collapse of the upper airway during sleep, inducing breathing disturbances that can result in oxygen desaturation and frequent arousals.
- Trial name
- TET21 (NCT07658053)
- Testing
- CURAPROX pacifier use, Pacifier diary, Polysomnography (PSG) to explore OSA
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Hospices Civils de Lyon
Insomnia, Depression
Effects of Group Cognitive Behavioural Therapy on Comorbid Insomnia and Depression in Youth
Major depressive disorder (MDD) is among the most common psychiatric disorders among adolescents, and is associated with considerable psychosocial and functional impairments and an elevated risk of suicidal behaviour and…
- Trial name
- NCT03438331
- Testing
- Cognitive Behavioural Therapy for Insomnia (CBT-I), Cognitive Behavioural Therapy for Depression (CBT-D)
- Where
- Hong Kong
- Volunteers
- 133 people
- Sponsor
- The University of Hong Kong
Sleep Apnea, Obstructive, Craniofacial Abnormalities
3D-Printed CPAP Masks for Children With Obstructive Sleep Apnea
The purpose of this study is to determine whether patient-specific computer-aided design (CAD) and three-dimensional (3D) printing can be utilized to produce personalized, effective continuous positive airway pressure (CPAP)…
- Conditions
- Sleep Apnea, Obstructive, Craniofacial Abnormalities, Pediatric Disorder
- Trial name
- NCT02261857
- Testing
- Personalized continuous positive airway pressure (CPAP) mask
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Glenn Green
Sleep Hygiene, Habit, Good Sleep
Sleep Hygiene Training in Gymnasts: Sleep Behaviour, Quality and Sleepiness
Sleep is essential to human health and well-being. Lack of or poor sleep can negatively impact cognitive function, mood, and physical performance.
- Trial name
- NCT06418737
- Testing
- Sleep HygieneTraining
- Where
- Turkey (Türkiye)
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Brain Tumor, Pediatric, Medulloblastoma, Childhood
GD2-CAR T Cells for Pediatric Brain Tumours
The purpose of this study is to test the safety and efficacy of iC9-GD2-CAR T-cells, a third generation (4.1BB-CD28) CAR T cell treatment targeting GD2 in paediatric or young adult patients affected by relapsed/refractory…
- Conditions
- Brain Tumor, Pediatric, Medulloblastoma, Childhood, Embryonal Tumor, High Grade Glioma
- Trial name
- NCT05298995
- Testing
- GD2-CART01 (iC9-GD2-CAR T-cells)
- Where
- Italy
- Volunteers
- 54 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Pediatric Sleep Problems, Sleep Hygiene
Storybook App vs Cognitive Behavioral Therapy for Child Sleep and Attachment
This completed randomized controlled trial compared two caregiver-delivered interventions for sleep in young children: a multimodal mobile health intervention delivered through the Storybook mobile application and a face-to-face…
- Conditions
- Pediatric Sleep Problems, Sleep Hygiene, Parent-Child Attachment
- Trial name
- STORYBOOK-RCT (NCT07668609)
- Testing
- CBT-Based Psychoeducational Intervention, Storybook Mobile Application Intervention
- Where
- Ecuador
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidad Católica de Cuenca
Lung Diseases, Sleep Apnea Syndromes
SCOR in Neurobiology of Sleep--Intermediate Traits for Sleep Apnea
To determine intermediate traits for sleep apnea in a case-control study.
- Trial name
- NCT00005511
- Sponsor
- University of Pennsylvania
Obstructive Sleep Apnea
Rapid Maxillary Expansion for Residual Pediatric
Randomized Controlled Trial comparing Rapid Maxillary Expansion with Standard Clinical Practice in patients with residual pediatric Obstructive Sleep Apnea Syndrome after adenotonsillectomy.
- Trial name
- ERMES (NCT02947464)
- Testing
- Standard clinical practice, Standard clinical practice + Rapid Maxillary Expansion
- Where
- Spain
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Basque Health Service
Hypersomnia, Narcolepsy
Sleep Disorders of Patients With Diseases of the Nervous System
The purpose of this study is to assist training doctors about different diseases of the nervous system affecting sleep. Patients selected to participate in this study will have any of a variety of sleep disorders.
- Conditions
- Hypersomnia, Narcolepsy, Nervous System Disease, Sleep Disorder
- Trial name
- NCT00001664
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
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