Clinical trials: Interventional Study
Spinal Deformity
Spinal Deformity Intraoperative Monitoring.
A multicenter, international prospectively collected patient cohort undergoing high-risk spinal cord level surgery or spinal osteotomy procedures will be enrolled to establish the incidence of intraoperative alerts in high-risk…
- Trial name
- NCT03880292
- Testing
- Document intraoperative Maneuvers
- Where
- 24 sites in United States, Australia and 12 more
- Volunteers
- 592 people
- Sponsor
- AO Foundation, AO Spine
Malnutrition
Non Randomized Controlled Intervention Study Comparing Two Interventions of Nutritional Supplement on Malnutrition, Health and Mortality
The hypothesis for the study is that 12 months of a Ready-To-Use Supplementary Food (RUSF) distributions have a greater impact on children's health than the standard RUSF distributions during the hunger gap period (june to…
- Trial name
- NRCI-ASPE (NCT02085044)
- Testing
- Ready-to-Used Supplement Food administration
- Where
- Chad
- Volunteers
- 5,700 people, healthy volunteers welcome
- Sponsor
- France Broillet
Heart Failure
Real-world Dapagliflozin Experience in Patients With Heart Failure in United Kingdom.
Heart failure (HF) is a global, public health issue that affects more than 63 million people worldwide; this burden is expected to increase substantially as the population ages.
- Trial name
- EVOLUTION-HF (NCT05188144)
- Where
- 10 sites in United Kingdom
- Volunteers
- 237 people
- Sponsor
- AstraZeneca
Reproductive Health, Sexual Health
Using a Theory-based SMS/VM Intervention to Improve Sexual and Reproductive Health of Female Entertainment Workers in Cambodia
In Cambodia, HIV is prevalent in several high-risk groups including among female entertainment workers (FEWs) who work at entertainment venues such as karaoke bars and massage parlors and may engage in direct or indirect sex…
- Trial name
- NCT03117842
- Testing
- Automated text and voice messages
- Where
- Cambodia
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Touro University, California
Mood Disorders, Anxiety Disorders
Clinical Study Evaluating Pharmacogenomics-informed Pharmacotherapy Versus Dosing as Usual in Psychiatric Disorders
A 24-week, patient- and rater-blinded, two-arm, parallel-group controlled, and multi-centre randomized clinical trial (RCT) to establish the benefits of pharmacogenetics-informed pharmacotherapy versus dosing as usual (DAU) in…
- Conditions
- Mood Disorders, Anxiety Disorders, Psychotic Disorders
- Trial name
- PSY-PGx (NCT05656469)
- Testing
- Personalised medication advice based on pharmacogenetic testing
- Where
- 9 sites in United States, Germany and 5 more
- Volunteers
- 2,500 people
- Sponsor
- Parnassia Groep
Frequent Attenders
Effectiveness of the "7H" Intervention to Reduce Frequent Attendance in Primary Care
The main objective is to measure the effectiveness of a new intervention to decrease use of services of primary care frequent attenders (FA).Among the secondary objectives are to evaluate the cost-effectiveness and cost utility…
- Trial name
- "7H" (NCT01151969)
- Testing
- New multicomponent "7H" intervention
- Where
- Spain
- Volunteers
- 527 people
- Sponsor
- The Mediterranean Institute for the Advance of Biotechnology and Health Research
Rupture of Anterior Cruciate Ligament
Study of the Anatomical Direct Insertion Anterior Cruciate Ligament Reconstruction
The purpose of the study is to study the effect of anatomical direct insertion ACL reconstruction compared with conventional anatomical ACL reconstruction.
- Trial name
- NCT02833454
- Testing
- direct insertion anterior cruciate ligament reconstruction, single bundle anterior cruciate ligament reconstruction, double bundle anterior cruciate ligament reconstruction
- Volunteers
- 320 people
- Sponsor
- Peking University Third Hospital
Colorectal Neoplasms, Colorectal Surgery
Attitudes and Technical Maneuvers Regarding Enterostomy Management and Stoma Creation Among Surgeons
This study was aiming to investigate Chinese surgeons' attitudes toward and technical preferences for stoma creation.
- Trial name
- NCT06735729
- Where
- China
- Volunteers
- 401 people
- Sponsor
- Peking University Cancer Hospital & Institute
Health Knowledge, Attitudes, Practice
Operations Research to Address Unmet Need for Contraception in the Postpartum Period in Sylhet District, Bangladesh
The proposed operations research study is designed to evaluate a package of family planning services and related behavior change interventions aimed at addressing the unmet need for family planning in postpartum women, integrated…
- Trial name
- NCT01702402
- Testing
- Educational and Behavior Change intervention, Comparison Group
- Volunteers
- 6,916 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Ovarian Cancer
Intervention of Ovarian Cancer With Antigen-specific Engineered Immune Effectors
This is a single-arm, open-label, phase I/II trial to evaluate the safety and efficacy of ovarian cancer-specific, engineered immune effectors (OC-EIEs) in women.
- Trial name
- NCT03393962
- Testing
- OC-EIEs
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shenzhen Geno-Immune Medical Institute
Cystic Fibrosis, Respiratory Tract Infections
Vitamin D for Enhancing the Immune System in Cystic Fibrosis (DISC Study)
The purpose of this study is determine if high-dose vitamin D supplementation improves clinical outcomes related to lung function and immunity in patients with Cystic Fibrosis who are admitted to the hospital with an acute lung…
- Trial name
- DISC (NCT01426256)
- Testing
- Cholecalciferol
- Where
- 5 sites in United States
- Volunteers
- 91 people
- Sponsor
- Emory University
Cartilage Disease
Non-interventional Study in Pediatric Patients Treated With NOVOCART Inject in the Knee
The study is a prospective, multicenter, single-arm non-interventional study to evaluate the efficacy, safety and health economics of NOVOCART® Inject in the treatment of cartilage defects of the knee in pediatric patients with…
- Trial name
- NINJA (NCT05391841)
- Testing
- NOVOCART Inject
- Where
- 6 sites in Germany
- Sponsor
- Tetec AG
Aortic Aneurysm, Abdominal
Enhanced Guidance for Endovascular Repair of Abdominal Aortic Aneurysm
An increasing incidence of abdominal aortic aneurysms (AAA) is observed in our ageing population. Since it is less invasive, endovascular repair (EVAR) by stent-graft (SG) insertion is frequently indicated in patients with…
- Trial name
- AAA 2D/3D II (NCT01824654)
- Testing
- Validation of the new rigid registration software, Validation of the new elastic registration software
- Where
- 2 sites in Canada
- Volunteers
- 25 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Neovascular Age-related Macular Degeneration
A 52-weeks Observational Study to Evaluate the Safety of Brolucizumab in Patients With nAMD
This study was a prospective, uncontrolled, central registration system, multicenter, domestic observational study (special drug-use surveillance) to evaluate the safety of 52-week clinical treatment with Beovu kit for…
- Trial name
- NCT04632056
- Testing
- Beovu
- Where
- 67 sites in Japan
- Volunteers
- 329 people
- Sponsor
- Novartis Pharmaceuticals
Myopia
Observational Survey Study on the Impact of Myopia and Its Complications on Quality of Life.
This study aims to assess the impact of myopia in childhood and its long-term complications in adulthood on health-related Quality of Life (HRQoL), providing valuable data for cost-effectiveness models.
- Trial name
- NCT06912802
- Testing
- Non-Intervention
- Where
- 10 sites in Denmark, France and 5 more
- Volunteers
- 344 people
- Sponsor
- Santen SAS
Electrophysiology Study, Ablation
Torque Device Evaluation
This study will evaluate the safety and efficacy of a novel catheter torque device after the completion of a clinically-indicated electrophysiology study and/or ablation procedure in a pediatric patient.
- Trial name
- NCT07094256
- Testing
- Peritorq
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- University of Minnesota
Obesity, Malignant Neoplasm
A Study to See if an iPhone Weight Management App Can Help Promote Weight Loss in Adolescents and Young Adults After a Stem Cell Transplant
This early phase I trial studies how well a behavioral weight loss intervention consisting of a smartphone application and coaching works for the promotion of weight loss in adolescents and young adults after a stem cell…
- Trial name
- NCT04453072
- Testing
- Interview, Media Intervention, Questionnaire Administration
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Jonsson Comprehensive Cancer Center
Gastrointestinal Disorders, Functional
Web-based Management of Pediatric Functional Abdominal Pain
Functional abdominal pain (FAP), a pediatric pain condition without significant organic pathology, is a precursor to chronic pain and high healthcare utilization in young adulthood.
- Trial name
- NCT02327377
- Testing
- Online Cognitive Behavior Therapy, Online Education
- Where
- United States
- Volunteers
- 344 people
- Sponsor
- Vanderbilt University Medical Center
Diabetes Mellitus, Diabetes Mellitus, Type 1
An International Non-interventional Cohort Study to Evaluate the Safety of Treatment With Insulin Detemir in Pregnant Women With Diabetes Mellitus. Diabetes Pregnancy Registry
This study is conducted in Europe and Asia. The purpose of the study (Diabetes Pregnancy Registry) is to evaluate the safety of treatment with insulin detemir in pregnant women with diabetes mellitus.
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT01892319
- Testing
- insulin detemir, other injectable antidiabetic treatment regimens
- Where
- 93 sites in Croatia, Finland and 14 more
- Volunteers
- 2,446 people
- Sponsor
- Novo Nordisk A/S
HIV Infections, Sexually Transmitted Diseases
Video-based Intervention Study to Prevent HIV/Sexually Transmitted Diseases (STDs) Among STD Clinic Patients
The purpose of this study is to assess the effectiveness of a brief 23-minute video-based educational waiting room intervention to reduce incident STD and high risk behavior among STD patients attending STD clinics in three…
- Trial name
- NCT00137670
- Testing
- Video-based HIV/STD prevention intervention
- Where
- 4 sites in United States
- Volunteers
- 45,000 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
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