Clinical trials: Intestinal Flora
Focus on Healthy Infant Growth.
Infant Formula Supplemented With Probiotic Microorganisms and/or Prebiotic.
Evaluation the nutritional suitability of a based milk infant formula supplemented with friendly bacteria (probiotic microorganisms) and or nutritional fibers (prebiotic) to healthy, full term infants compare with an otherwise…
- Trial name
- NCT00836771
- Testing
- Infant Formula
- Where
- Israel
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Materna Laboratories
Obesity
Hummus for Health: Dietary Quality and Health Outcomes in Toddlers
The goal of this study is to examine the effect of increasing children's intake of fiber and unsaturated fat, through daily servings of hummus and vegetables, on their microbiome profile.
- Trial name
- NCT02696278
- Testing
- Lesson about vegetables, Vegetables, Hummus
- Where
- United States
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Mixed Flora; Infection
Preterm Infant Gut (PINGU) - a Norwegian Multi Centre Study
Necrotizing enterocolitis (NEC) is a leading cause of morbidity and mortality among infants in the neonatal intensive care unit (NICU).
- Trial name
- PINGU (NCT02197468)
- Where
- 7 sites in Norway
- Volunteers
- 60 people
- Sponsor
- University Hospital of North Norway
Gut Microbiome
Neonatal Microbiome Validity Study
This is a validation study to compare proposed field collection methods with a gold standard collection technique for microbiome analysis of stool and breast milk samples.
- Trial name
- NCT02655250
- Testing
- Microbiome
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Celiac Disease
A Pilot Study to Explore the Role of Gut Flora in Celiac Disease
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records regarding Celiac Disease.
- Trial name
- NCT04148235
- Testing
- No Intervention
- Where
- United States
- Sponsor
- ProgenaBiome
Health Behavior, Disorder of Growth and Development
The Effects of Dietary Palmitic Acid Triacylglyceride Position on Intestinal Parameters in Infants (InFat_005)
The purpose of this study is to determine the effect of high sn-2 palmitic acid based infant formula on intestinal parameters in term formula fed infants.
- Trial name
- NCT01116115
- Testing
- InFat™ based infant formula, Standard vegetable oil based infant formula
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Enzymotec
Epilepsy
Epigenetics and Gut Microbiota in Children With Epilepsy
The ketogenic diet is a high-fat, low-carbohydrate diet used in the treatment of epilepsy. The diet can be an efficient treatment option in children with drug resistant epilepsy, with more than 50 % seizure reduction in about 40…
- Trial name
- EpiMICRO (NCT04063007)
- Testing
- Ketogenic diet
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Oslo University Hospital
Autism Spectrum Disorder, Gastro-Intestinal Disorder
MTT for Children With ASD Who Have Gastrointestinal Disorders
The investigators propose to investigate Microbiota Transfer Therapy (MTT) for treating children with Autism Spectrum Disorder (ASD) and gastrointestinal problems (primarily constipation and/or diarrhea).
- Conditions
- Autism Spectrum Disorder, Gastro-Intestinal Disorder, Constipation, Diarrhea
- Trial name
- NCT04182633
- Testing
- vancomycin, Miralax, intestinal microbiota
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Arizona State University
Irritable Bowel Syndrome
Effect of Curcumin on Gut Microbiota in IBS
To evaluate the effect of curcumin food supplement on gut microbiota of children with irritable bowel syndrome (IBS) and to review any correlation between the changes in the microbiota with symptoms.
- Trial name
- NCT03568513
- Testing
- Curcumin
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Medical College of Wisconsin
Neurodegenerative Diseases, Parkinson Disease
Neurodegenerative Diseases Progression Markers (MARKERS-NDD)
MARKERS-NDD is a prospective, observational, longitudinal study, which aims to collect data from patients affected by neurodegenerative diseases (NDD) followed longitudinally for routine examinations performed as part of normal…
- Conditions
- Neurodegenerative Diseases, Parkinson Disease, Synucleinopathies, Lewy Body Disease
- Trial name
- MARKERS-NDD (NCT06596746)
- Testing
- Observation
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- Casa di Cura San Raffaele Cassino
Drug Resistant Epilepsy
Role of the Gut Microbiota in Pediatric Epilepsy
Nearly a third of children with epilepsy are refractory to pharmacotherapy. The ketogenic diet (KD) is a highly effective alternative therapy reducing seizure frequency by 50% in more than half of treated children.
- Trial name
- EPBiome (NCT04705298)
- Testing
- Prebiotic
- Where
- 2 sites in Canada
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- British Columbia Children's Hospital
Prebiotics, Honey
Medically-Graded Honey Supplementation Formula To Preterm Infants
Honey is a natural product that contains multiple nutrients; it is composed of fructose, glucose and fructooligosaccharides that can potentially serve prebiotic functions.
- Conditions
- Prebiotics, Honey, Premature Infants, Intestinal Microbiota
- Trial name
- Honey (NCT02679183)
- Testing
- Medically-Graded Honey, Premature Milk Formula
- Volunteers
- 40 people
- Sponsor
- Cairo University
Food Intolerance
Washed Microbiota Transplantation for Food Intolerance
Food intolerance (FI) is an adverse reaction to food caused by non-immune mechanisms, mainly related to digestive enzyme deficiencies (e.g. lactase deficiency), metabolic abnormalities (e.g.
- Trial name
- NCT07190183
- Testing
- washed microbiota transplantation
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Autoimmune Diseases
Gut Microbiota In Children With Autoimmune Liver Disease and Its Effect on Treatment Response
Gut microbiota and liver disease are very closely linked. Microbiota influences the various liver diseases by Dysbiosis ratio .There is loss of tolerance targeting liver antigens which is thought to initiate disease in…
- Trial name
- NCT06183190
- Testing
- No intervention
- Where
- India
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Institute of Liver and Biliary Sciences, India
Beneficial Bacteria in Gut
Color Synbiotics Study
This study is initiated to investigate the effect of infant formula with added specific synbiotics mixture on proportion of beneficial bacteria.
- Trial name
- NCT01813175
- Testing
- Regular non-hydrolysed cow's milk I, Regular non-hydrolysed cow's milk II, Regular non-hydrolysed cow's milk - control
- Where
- 3 sites in Thailand
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- Danone Asia Pacific Holdings Pte, Ltd.
Anterior Crossbite
Evaluation of the Effect of Labio-Lingual Spring Hawley and Clear Aligners on Periodontal Health and Salivary Parameters
Objective: The aim of our study was to determine the effect of two different types of removable appliances on periodontal health, dental plaque colonization, as well as saliva, pH, flow rate, and buffering capacity of the…
- Trial name
- NCT06858033
- Testing
- Clear aligner, Labiolingual spring hawley
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Ozge Gungor
Type 1 Diabetes
Prebiotics in Patients With Type 1 Diabetes
Evidence suggests that prebiotic fibre can correct dysbiosis, reduce intestinal permeability and improve glycemic control. The investigators hypothesize that microbial changes induced by prebiotics contribute to gut and endocrine…
- Trial name
- NCT04963777
- Testing
- Prebiotic
- Where
- 3 sites in Canada
- Volunteers
- 144 people
- Sponsor
- University of Calgary
Constipation - Functional
Breath Gases, Gut Flora, and Immunity in Children With Constipation
Constipation is a common problem in children that can affect their daily life, school performance, and social activities. Researchers have found that the bacteria living in our intestines (called "gut microbiome") may play an…
- Trial name
- NCT07797491
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Crohn Disease
Mother-to-Infant Transfer of Bacteriome, Fungome, Virome, and Metabolome in Health and Crohn's Disease
Inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are caused by the loss of mucosal tolerance towards the commensal microbiota resulting in inflammatory responses.
- Trial name
- NCT05112497
- Testing
- No intervention procedure
- Where
- Hong Kong
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Myopia Progressing
Clinical Efficacy and Mechanism Exploration of MR-61 in Delaying the Progression of Myopia
To investigate whether probiotic MR-61 can assist in slowing down the progression rate of myopia (a prospective randomized controlled study).
- Trial name
- NCT07298824
- Testing
- Investigational Bifidobacterium Preparation MR-61
- Where
- China
- Volunteers
- 164 people
- Sponsor
- Second Affiliated Hospital of Nanchang University