Clinical trials: Intestinal Helminthiasis
Soil-transmitted Helminth Infections
Monitoring Drug Efficacy and Anthelmintic Resistance in Soil-transmitted Helminth Programs
Soil-transmitted helminths (STHs) are a group of parasitic worms that infect millions of children in sub-tropical and tropical countries, resulting in malnutrition, growth stunting, intellectual retardation and cognitive…
- Trial name
- StarwormsWP2 (NCT04177654)
- Testing
- Benzimidazoles
- Where
- 8 sites in Bangladesh, Cambodia and 6 more
- Volunteers
- 9,457 people
- Sponsor
- University Ghent
Schistosomiasis Haematobia
Effect of Artemisinin-based Combination Therapies on Schistosomiasis on Malaria Co-infection
Open labelled, non randomized study to evaluate the effects of Artemisinin based Combined Therapies(ACTs) on schistosomiasis since Praziquantel (PZQ) which is presently the drug of choice for treating Schistosomiasis (STS), is…
- Trial name
- SACT (NCT04264130)
- Testing
- Artesunate-Pyronaridine, Artemether-Lumefantrine, Artefenomel-Ferroquine
- Where
- Gabon
- Volunteers
- 54 people
- Sponsor
- Centre de Recherche Médicale de Lambaréné
Onchocerciasis, Epilepsy
Impact of a Bi-annual CDTI on the Incidence of Epilepsy in an Onchocerciasis-endemic Area
Onchocerciasis is a neglected tropical disease associated with epilepsy, particularly in areas of high Onchocerciasis volvulus transmission.
- Trial name
- OAETanzania (NCT05749653)
- Testing
- Bi-annual CDTI
- Where
- Tanzania
- Volunteers
- 6,500 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen
Malaria, Lymphatic Filariasis
Repeat Ivermectin Mass Drug Administrations for Control of Malaria: a Pilot Safety and Efficacy Study
The purpose of this study is to determine whether repeated ivermectin mass drug administrations to Burkinabé villagers, performed in three week intervals over the rainy-season, is well-tolerated and safe, and also effective in…
- Trial name
- RIMDAMAL (NCT02509481)
- Testing
- Ivermectin, Albendazole
- Where
- 2 sites in United States, Burkina Faso
- Volunteers
- 2,712 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Hematuria, Hydronephrosis
Influence of Transmission Season on Outcome of Treatment of Schistosoma Haematobium Infection in Mozambique
To assess the influence of seasonal variations in Schistosoma haematobium transmission on treatment outcome (morbidity and re-infection)
- Trial name
- NCT00231322
- Testing
- praziquantel
- Where
- Mozambique
- Volunteers
- 520 people
- Sponsor
- DBL -Institute for Health Research and Development
Mansonella Perstans Infection, Buruli Ulcer
Concomitant Infections of Mansonella Perstans in Tuberculosis and Buruli Ulcer Disease Patients From Ghana
This study will determine the influence of doxycycline treatment against Wolbachia/M. perstans on immunity against concomitant mycobacterial infections in healthy M. perstans infected individuals.
- Conditions
- Mansonella Perstans Infection, Buruli Ulcer, Tuberculosis, Co-infection
- Trial name
- Map2Co (NCT02281643)
- Testing
- Doxycycline
- Where
- Ghana
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Kwame Nkrumah University of Science and Technology
Schistosoma Haematobium
Performance of Tests for Schistosoma Haematobium Diagnosis
Urogenital schistosomiasis caused by infection with the blood fluke Schistosoma haematobium is a debilitating disease. The World Health Organization (WHO) has set the goal to eliminate schistosomiasis as a public health problem…
- Trial name
- SchistoBreak-D (NCT06808750)
- Testing
- S. haematobium egg detection by single urine filtration, S. haematobium egg detection by quintuple urine filtration, S. haematobium egg detection by artificial intelligence (AI) microscopy
- Where
- Tanzania
- Volunteers
- 801 people, healthy volunteers welcome
- Sponsor
- Stefanie Knopp
Soil Transmitted Helminths, Schistosomiasis Mansoni
Evaluation of an AI-DP for STH Deworming Programs: a Study Protocol
The goal of this observational study is to test a new AI diagnostic tool for detection, specification and quantification of parasitic infections (Ascaris, Trichuris, hookworm and S.
- Trial name
- KAKADU (NCT06055530)
- Testing
- Artificial Intelligence Digital Pathology
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Enaiblers AB
Intestinal Helminthiasis
Impact of Health Education on School Children
There is a sever lack in application of health education intervention for Soil Transmitted Disease (STH) in rural communities and in school children among Orang Asli in Pahang in Malaysia, and also there is a lack of information…
- Trial name
- NCT01640626
- Testing
- Health Education package
- Where
- Malaysia
- Volunteers
- 317 people
- Sponsor
- University of Malaya
Malaria
Clinical Performance Evaluation of Fyodor Urine Malaria Test (UMT)
The purpose of this study is to evaluate the clinical performance of the one-step Fyodor Urine Malaria Test (UMT), to determine its accuracy (sensitivity and specificity) for the diagnosis of Plasmodium falciparum malaria in…
- Trial name
- NCT01921413
- Testing
- Urine Malaria Test
- Where
- Nigeria
- Volunteers
- 1,893 people, healthy volunteers welcome
- Sponsor
- Fyodor Biotechnologies Inc
Hydatid Cyst, Hepatic
Epidemiological Study of Hydatid Cyst in Najaf City, Iraq
Background Cystic echinococcosis (hydatid cyst) is a significant zoonotic disease endemic to Iraq. Understanding the localized clinical and epidemiological trends is vital for improving surgical outcomes and public health…
- Trial name
- Hydatid cyst (NCT07369674)
- Where
- Iraq
- Volunteers
- 350 people
- Sponsor
- Al-Kafeel University
Helminthiasis
Study of the Efficacy of Oxfendazole Compared to Albendazole in the Treatment of Trichuris Trichiura Infection in Adults
The aim of this study is to provide data on the efficacy of oxfendazole against Trichuris trichiura at different doses in comparison to the standard single 400 mg dose of albendazole.
- Trial name
- NCT02636803
- Testing
- oxfendazole, albendazole
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Schistosomiasis Haematobia
The Chinese-made Praziquantel for Treatment of Schistosoma Haematobium
Schistosomiasis remains an important parasitic disease in the tropics, special in Africa including Zanzibar. The WHO-recommended strategy to eliminate schistosomiasis involves large-scale treatment of affected populations through…
- Trial name
- NCT03133832
- Testing
- Companion Tablet
- Where
- Tanzania
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Jiangsu Institute of Parasitic Diseases
Schistosomiasis
Schistosoma Haematobium Infections and Praziquantel
The purpose of this study is to evaluate the impact of praziquantel for the treatment of Schistosoma haematobium infection among schoolchildren in Al Salamania in Central Sudan.
- Trial name
- NCT01558336
- Testing
- praziquantel
- Where
- Sudan
- Volunteers
- 520 people
- Sponsor
- University of Khartoum
Schistosomiasis
Evaluation of Strategies for Improved Uptake of Preventive Treatment for Intestinal Schistosomiasis
Previous research undertaken among adults in high endemic districts of Busia, Adjumani, Moyo and Nebbi reported unwillingness to take preventive treatment.
- Trial name
- ESIUPT (NCT01869465)
- Testing
- Pre-treatment snack, Education arm
- Where
- Uganda
- Volunteers
- 1,277 people
- Sponsor
- Makerere University
Hookworm Infections
Efficacy and Safety of Emodepside in Adolescents and Adults Infected With Hookworm
To compare the efficacy and safety of emodepside to that of albendazole (Zentel®) in participants aged 12-60, inclusive, infected with hookworm.
- Trial name
- NCT05538767
- Testing
- Emodepside, Albendazole 400mg
- Where
- Tanzania
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Jennifer Keiser
Onchocerciasis
Safety of a Single Dose of Moxidectin Compared With Ivermectin in Individuals Living in Onchocerciasis Endemic Areas and in Individuals Living in Onchocerciasis Endemic Areas With High Levels of Lymphatic Filariasis Co-endemicity Receiving Concomitant Albendazole
The purpose of this phase 3b study is to determine the safety of a single dose of moxidectin, compared to a single dose of ivermectin, in individuals living in onchocerciasis endemic areas and in individuals living in…
- Trial name
- NCT04311671
- Testing
- Moxidectin, Ivermectin, Albendazole
- Where
- 2 sites in Côte d’Ivoire, Democratic Republic of the Congo
- Volunteers
- 12,979 people, healthy volunteers welcome
- Sponsor
- Medicines Development for Global Health
Latent Tuberculosis, Diabete Mellitus
Comorbidities and Coinfections in Latent TB
Approximately 2 billion people worldwide are infected with Mycobacterium tuberculosis (TB), with 90% of individuals having latent infection (LTBI).
- Conditions
- Latent Tuberculosis, Diabete Mellitus, Malnutrition, Helminth Infection
- Trial name
- COMBINE-TB (NCT04642755)
- Where
- India
- Volunteers
- 300 people
- Sponsor
- Tuberculosis Research Centre, India
Helminthiasis, Diarrhea
Spillover Effects of Water, Sanitation, and Hygiene Interventions on Child Health
The purpose of this study is to measure whether a combined water, sanitation, and hygiene intervention leads to improved health of children who did not receive the intervention themselves and who live within a close vicinity of…
- Conditions
- Helminthiasis, Diarrhea, Respiratory Infection
- Trial name
- NCT02396407
- Testing
- Combined water, sanitation, and hygiene
- Where
- Bangladesh
- Volunteers
- 1,789 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
Mansonelliasis, Pruritus
Epidemiology and Control of Mansonella Perstans Infection in Uganda
Mansonella perstans (M. perstans) infection is widespread in Uganda. Knowledge about the epidemiology of this infection, and of the morbidity it induces is poor, and no effective treatment is available.
- Conditions
- Mansonelliasis, Pruritus, Lymphoedema, Abdominal Pains
- Trial name
- NCT00215280
- Testing
- ivermectin and albendazole
- Where
- Uganda
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- DBL -Institute for Health Research and Development