Clinical trials: Intestinal Transit
Constipation
Study of Effect of Tegaserod on Small and Large Bowel Transit by Scintigraphic Method
Functional constipation is a common problem in Hong Kong. In a recent telephone survey, the prevalence of constipation as defined by Rome II criteria was 14%.
- Trial name
- NCT00563615
- Testing
- Tegaserod
- Where
- 3 sites in China
- Volunteers
- 60 people
- Sponsor
- Hospital Authority, Hong Kong
Cystic Fibrosis
Gut Imaging for Function & Transit in Cystic Fibrosis Study 1
Many people with Cystic Fibrosis (CF) are troubled by symptoms from their stomach and bowels: their gastrointestinal (GI) tract.
- Trial name
- GIFT-CF1 (NCT03566550)
- Testing
- MRI scans
- Where
- United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Nottingham University Hospitals NHS Trust
Constipation
Magnetic Resonance Imaging in Paediatric Constipation
Constipation in children is a common problem. Managing these children is difficult, partly because they do not respond to laxatives and partly because their bowel problem cannot be defined.
- Trial name
- MAGIC (NCT03564249)
- Testing
- MiniCap
- Where
- United Kingdom
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Nottingham University Hospitals NHS Trust
Constipation - Functional
Effect of a Mixture of Fibers and Carbohydrates on Intestinal Transit in Children Diagnosed With Functional Constipation
Once the patients who are candidates to enter the study are identified, the patients will be randomly be assigned to two groups, according to the sequence: Group A: study product+wash out+control product Group B: control…
- Trial name
- VEGY-DOWN(A) (NCT04028258)
- Where
- 3 sites in Spain
- Volunteers
- 120 people
- Sponsor
- Laboratorios Ordesa
Lactose Intolerance
MSOT for Assessment of Intestinal Transit Time in Lactose Intolerance Patients
The study aims to investigate gastrointestinal transit using multispectral optoacoustic tomography (MSOT) in a prospective diagnostic study involving patients suspected of primary or secondary lactose intolerance.
- Trial name
- NCT06617364
- Testing
- gastrointestinal transit time measurement using MSOT and ICG contrast agent
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Cystic Fibrosis
Gut Imaging for Function & Transit in CF - GIFT-CF 3
An observational study of patients with cystic fibrosis (CF) starting treatment with Kaftrio (Elexacaftor / Tezacaftor / Ivacaftor) as part of routine clinical care, following EMA licensing (approved end of Aug 2020).
- Trial name
- GIFT-CF3 (NCT04618185)
- Testing
- Magnetic Resonance Imaging (MRI)
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Cystic Fibrosis
Gut Imaging for Function and Transit in Cystic Fibrosis 3 Junior
Recently trial data has shown that the medicine KaftrioTM (Elexacaftor/ Tezacaftor/ Ivacaftor) improves lung function in children aged 6 to 11 years who have cystic fibrosis (CF).
- Trial name
- GIFT-CFJunior (NCT05699148)
- Testing
- Elexacaftor / Ivacaftor / Tezacaftor
- Where
- United Kingdom
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Nottingham University Hospitals NHS Trust
Chronic Constipation, Slow Transit Constipation
MSOT and MRI for Non-invasive Assessment of Intestinal Transit Time in Children With Chronic Bowel Emptying Disorders
The project presented here is a monocentric clinical study conducted by the Pediatric Surgery and Pediatrics departments of the University Hospital Erlangen.
- Conditions
- Chronic Constipation, Slow Transit Constipation, Intestinal Transit Disorder, Hirschsprungs Disease
- Trial name
- NCT06911749
- Testing
- MSOT with ICG, MRI
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Dr. med. Sonja Diez
Gastric Transit Time, Small-bowel Transit Time
The Effectiveness of Chewing Gum in Influencing Capsule Endoscopy Transit Time
The purpose of this study is to determine the effect of chewing gum, during the first one hour of examination in patients undergoing CE for GTT and SBTT time and the proportion of cases with complete small bowel examination and…
- Trial name
- CGCE (NCT03815136)
- Testing
- Chewing Gum, Control
- Where
- China
- Volunteers
- 250 people
- Sponsor
- The First Affiliated Hospital of Zhejiang Chinese Medical University
Inflammatory Bowel Disease
Tailored Transition for IBD Adolescents
Background: Smooth transition of adolescent patients diagnosed with inflammatory bowel diseases (IBD) to adult care is necessary in order to secure continues clinical management and to prevent possible deleterious clinical and…
- Trial name
- TRANSIT (NCT02893670)
- Testing
- Radiologic (MRE) or endoscopic (sigmoidoscopy) evaluation
- Where
- Israel
- Volunteers
- 70 people
- Sponsor
- Schneider Children's Medical Center, Israel
Cystic Fibrosis, Gastrointestinal Dysfunction
Understanding Gut Symptoms in People With Cystic Fibrosis
Although chest infections affect wellbeing and survival in cystic fibrosis (CF), most people with CF also have difficulty digesting food and must take medication for this.
- Trial name
- GRAMPUS-CF SRC (NCT05934656)
- Testing
- Latent class analysis
- Where
- United Kingdom
- Volunteers
- 350 people
- Sponsor
- University of Nottingham
Cystic Fibrosis
Gut Imaging for Function & Transit in Cystic Fibrosis Study 2
People with Cystic Fibrosis (CF) have problems digesting their food properly. More than 8 in 10 people with CF must take medication to assist their digestion. In spite of this, complications such as bowel blockage occur.
- Trial name
- GIFT-CF2 (NCT04006873)
- Testing
- Tezacaftor/Ivacaftor + Ivacaftor
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Anastomotic Complication, Anastomotic Leak Small Intestine
Open Abdomen and Delayed Anastomosis After Anastomotic Dehiscences to Avoid Stomas
Phase III clinical trial to evaluate the efficacy of the open abdomen as bridging therapy to perform transit reconstruction in patients with anastomotic dehiscence.
- Conditions
- Anastomotic Complication, Anastomotic Leak Small Intestine, Anastomotic Leak Large Intestine
- Trial name
- STOP-STOMA (NCT05233995)
- Testing
- Damage Control Surgery
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Very Low Birth Weight Preterms
Effects of Recto-colic Enemas of Butyrate on the Digestive Disorders of Very Low Birth Weight Preterms <1250 Grams
Clinical management of very low birth weight newborns (VLBW <1250g) consists in several challenges to adapt immature physiological systems to extrauterine life.
- Trial name
- NEOTRANS (NCT01536483)
- Testing
- Butyrate enemas
- Where
- France
- Volunteers
- 61 people
- Sponsor
- Nantes University Hospital
Intestinal Diseases
Squatting on the Toilet and Capsule Endoscopy
This study evaluates the effect of squatting on the toilet on gastric transit time and complete examination rate of capsule endoscopy.In the observation group, the patients could go to squatting on the toilet at any time as they…
- Trial name
- SC (NCT04340089)
- Testing
- squatting on the toilet
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Colon Disease, Functional Constipation
Non-invasive Assessment of Colonic Motility
The current diagnostic process of colonic motility disorders often takes a long time and involves multiple invasive, painful and/or unnecessary diagnostic procedures.
- Conditions
- Colon Disease, Functional Constipation, Electroenterography, Slow Transit
- Trial name
- non-CoMoti (NCT04624334)
- Testing
- Elektro-Entero-Graphy procedure, EEnG Questionnaire, Gold Standard Questionnaire
- Where
- Netherlands
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Inflammatory Bowel Disease, Crohn Disease
Retrospective Collection of PillCam SB Movies
Up to two hundred un-identified PillCam SB movies will be collected from 2 clinical sites, during up to 3 years and transferred to Given Imaging. Demographical data and medical history will be collected.
- Trial name
- OCEAN (NCT02707289)
- Where
- 2 sites in Israel
- Volunteers
- 20 people
- Sponsor
- Medtronic - MITG