Clinical trials: Intestinal Transit
Constipation
Colonic Transit Time Validation Study
The protocol described herein is designed to provide clinical evidence of the substantial equivalence of SmartPill GI Monitoring System (SP) to the Sitzmarks (Konsyl Pharmaceuticals, Easton, MD) radio-opaque markers (ROM).
- Trial name
- CTT (NCT00857363)
- Where
- 13 sites in United States, United Kingdom
- Volunteers
- 210 people
- Sponsor
- The SmartPill Corporation
Irritable Bowel Syndrome (IBS)
Probiotics and Biomarkers in Irritable Bowel Syndrome
The goal of this double-blind parallel-arm randomized controlled trial is to learn if a probiotic supplement (containing a new strain derived from L.
- Trial name
- BIO-IBS (NCT07584278)
- Testing
- Probiotic Supplementation (Lactobacillus Reuteri)
- Where
- Sweden
- Volunteers
- 252 people
- Sponsor
- Sahlgrenska University Hospital
Ulcerative Colitis
Gastrointestinal Transit Times and Motility in Severe Ulcerative Colitis Obtained by Motilis-3D-transit
The purpose of this study is to describe gastrointestinal (GI) motility in patients suffering from severe Ulcerative Colitis (UC) and to compare these results with similar results from a study on healthy subjects.
- Trial name
- NCT01752361
- Testing
- Motilis-3D transit
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- University of Aarhus
Constipation, Slow Transit Constipation
YQD Combined With Plant Lactobacillus for Slow Transit Constipation
Slow transit constipation (STC) is a common and difficult-to-treat subtype of chronic constipation, characterized by reduced colonic motility and delayed stool passage.
- Trial name
- YQD-LAC-STC (NCT07757061)
- Testing
- YQD (Yìqì Jiànpí Decoction), Plant-derived Lactobacillus, Mosapride Citrate
- Where
- China
- Volunteers
- 120 people
- Sponsor
- First People's Hospital Of Lin'an District, Hangzhou
Constipation
Study of Effect of Tegaserod on Small and Large Bowel Transit by Scintigraphic Method
Functional constipation is a common problem in Hong Kong. In a recent telephone survey, the prevalence of constipation as defined by Rome II criteria was 14%.
- Trial name
- NCT00563615
- Testing
- Tegaserod
- Where
- 3 sites in China
- Volunteers
- 60 people
- Sponsor
- Hospital Authority, Hong Kong
Irritable Bowel Syndrome Constipation Predominant
Effects of ROSE-010 on GI Transit in Constipation Predominant Irritable Bowel Syndrome (C-IBS) Patients
This trial will study the effects of an investigational (not FDA approved) medication, ROSE-010, on the movement of food through the stomach, small intestine and colon in females with constipation predominant irritable bowel…
- Trial name
- NCT01056107
- Testing
- ROSE-010
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Mayo Clinic
IBS
Effects of Mexiletine on Colonic Transit in a Patient With Irritable Bowel Syndrome - Constipation (IBS-C)
To understand if Mexiletine will restores normal colonic motility in a patient with irritable bowel syndrome - constipation (IBS-C) and a genetic mutation in SCN5A.
- Trial name
- NCT01717404
- Testing
- Mexiletine
- Volunteers
- 1 people
- Sponsor
- Mayo Clinic
Constipation
Effectiveness of Non-invasive Neuromodulation for Intestinal Transit in Healthy Subjects
Objectives Main objective: Assess the effectiveness of non-invasive neuromodulation treatment (NESA) for the management of constipation in patients without diagnosed pathology in Spain Secondary objectives: Evaluate the…
- Trial name
- NCT06294457
- Testing
- Non-Invasive Neuromodulation NESA
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidad Europea de Madrid
Irritable Bowel Syndrome (IBS)
A Study To Investigate The Effect Of Solabegron (GW427353) On Gastrointestinal Transit In Healthy Volunteers
This study will test the hypothesis that GW427353, a beta-3 adrenergic agonist, retards the emptying of the colon and increases total colonic transit time.
- Trial name
- NCT00401479
- Testing
- Solabegron (GW427353)
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Gastrointestinal Symptoms
Effect of Bifidobacterium Lactis HN019 on Colonic Transit Time and Digestive Symptoms
The purpose of this study was to investigate the dose response effect of Bifidobacterium lactis HN019 supplementation on colonic transit time and gastrointestinal symptoms.
- Trial name
- NCT01171014
- Testing
- Bifidobacterium lactis HN019
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Fonterra Research Centre
Irritable Bowel Syndrome
Phase 2 Study of MD-1100 Acetate on Gastrointestinal Transit in Patients With C-IBS
The primary objective of this trial is to compare the dose-ranging pharmacodynamic effects of orally administered placebo, and 100 and 1000 ug qd of MD-1100 Acetate on gastrointestinal transit in patients with C-IBS.
- Trial name
- NCT00258193
- Testing
- MD-1100 Acetate
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Ironwood Pharmaceuticals, Inc.
Cystic Fibrosis
Gut Imaging for Function & Transit in Cystic Fibrosis Study 1
Many people with Cystic Fibrosis (CF) are troubled by symptoms from their stomach and bowels: their gastrointestinal (GI) tract.
- Trial name
- GIFT-CF1 (NCT03566550)
- Testing
- MRI scans
- Where
- United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Nottingham University Hospitals NHS Trust
Digestion Rate
Food DNA Digestion
This pilot study investigates the digestion rate of naturally occurring food DNA through the human digestive tract by detecting residual food DNA in stool samples.
- Trial name
- Anna Bauer (NCT06687226)
- Testing
- Reconstitutable food powder
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Duke University
Clostridium Difficile Colitis
Small Bowel Transit Time in Clostridium Difficile Colitis
Clostridium difficile is a bacteria that can infect the colon and cause severe diarrhea in patients after recent antibiotic use. The current standard of care treatment for severe C. diff.
- Trial name
- NCT01309750
- Testing
- Small Bowel Transit Study
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Corewell Health East
Constipation
B. Lactis HN019 for Functional Constipation
This study will investigate the effects of 4-week probiotic supplementation on whole gut transit time and gastrointestinal symptoms in adults with functional constipation.
- Trial name
- CTT (NCT01463293)
- Testing
- B. lactis HN019
- Where
- 12 sites in United States
- Volunteers
- 224 people
- Sponsor
- Fonterra Research Centre
Ulcerative Colitis
TP0502-B-Pharmaco-Scintigraphic-Study
This is a Phase I, open-label, single-site trial to evaluate the drug release, using scintigraphic images and mesalazine plasma levels (PK) in healthy subjects. Overall, nine [9] subjects will be evaluated.
- Trial name
- NCT02306798
- Testing
- TP05
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Tillotts Pharma AG
Electric Stimulation Therapy, Bowel Dysfunction
The Effect of NMES on Bowel Management in People With Chronic SCI
It has been reported that 62% of all people with Spinal Cord Injury (SCI) have experienced faecal incontinence and that neurogenic bowel dysfunction (NBD) is a major sequela.
- Conditions
- Electric Stimulation Therapy, Bowel Dysfunction, Spinal Cord Injuries, Defecation Disorder
- Trial name
- FES_Bowel (NCT04914975)
- Testing
- Neuromuscular electrical stimulation
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Swiss Paraplegic Research, Nottwil
Small Bowel Disease
Impact of Diet on Capsule Endoscopy
Capsule endoscopy studies are used for the diagnosis of small bowel mucosal lesions. Since capsule endoscopy depends on the small intestinal peristaltism, the food intake - especially the amount of fat ingested - after the…
- Trial name
- NCT03321669
- Testing
- Capsule endoscopy
- Where
- Argentina
- Volunteers
- 20 people
- Sponsor
- Hospital Britanico
Irritable Bowel Syndrome
A Study of BMS-562086 in Patients With Irritable Bowel Syndrome
The primary purpose of this study is to evaluate the effects of BMS-562086 on small bowel and colonic transits in female subjects with diarrhea-predominant irritable bowel syndrome (D-IBS)
- Trial name
- NCT00399438
- Testing
- BMS-562086
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Bristol-Myers Squibb
Constipation
Magnetic Resonance Imaging in Paediatric Constipation
Constipation in children is a common problem. Managing these children is difficult, partly because they do not respond to laxatives and partly because their bowel problem cannot be defined.
- Trial name
- MAGIC (NCT03564249)
- Testing
- MiniCap
- Where
- United Kingdom
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Nottingham University Hospitals NHS Trust