Clinical trials: Intestines Cancer
Colorectal Cancer
Genetic Study in Patients With Stage II or Stage III Colon Cancer
RATIONALE: Genetic studies may help in understanding the genetic processes that cause some types of cancer. PURPOSE: Genetic trial to study certain genes of patients who have stage II or stage III colon cancer.
- Trial name
- NCT00003833
- Testing
- DNA stability analysis, gene mapping
- Where
- 59 sites in United States, Canada
- Volunteers
- 598 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Ulcerative Colitis, Anti TNF Therapy
The Influence of Biologcal Treatment on the Short-Term Complications of Surgery in Patients With Inflematory Bowel Disease.
BACKGROUND: Previous studies of short-term surgical outcomes after preoperative exposure to anti-TNF therapy in ulcerative colitis (UC) patients who have undergone IPAA have been conflicting.
- Conditions
- Ulcerative Colitis, Anti TNF Therapy, Ileal Pouch Anal Anastomosis (IPAA)
- Trial name
- NCT03747068
- Testing
- Anti-TNF Drug
- Volunteers
- 130 people
- Sponsor
- HaEmek Medical Center, Israel
Colon Cancer
Definition of Surgical Technique of Lymphadenectomy and Complete Mesocolon Excision for Radical Right Colectomy: a Delphi Consensus
A Delphi consensus to define surgical steps of lymphadenectomy and complete mesocolic excision for radical right colectomy
- Trial name
- NCT05544474
- Testing
- Delphi questionnaire
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Rome Tor Vergata
Cancer
Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients
RATIONALE: Liposomal amphotericin B may be effective in controlling fever and granulocytopenia. It is not yet known which regimen of liposomal amphotericin B is more effective in treating cancer patients who have these…
- Trial name
- NCT00003938
- Testing
- liposomal amphotericin B
- Where
- 24 sites in Belgium, Czechia and 13 more
- Volunteers
- 115 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Acute Lymphoblastic Leukemia, Pediatric
Physical Exercise and Dairy Probiotics in Childhood Cancer Survivors
The goal of this clinical trial is to to compare the structure of the intestinal microbiome between children shortly after treatment for acute lymphoblastic leukemia (1-3 years after cancer treatment) and healthy controls.
- Trial name
- Exerbioall (NCT05939791)
- Testing
- Lacticaseibacillus paracasei subsp. Paracasei CNCMI-1518, Physical exercise
- Where
- Slovakia
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Comenius University
IBD (Inflammatory Bowel Disease), Colon Cancer
Microbiota: Its Role in Chronic Inflammation, IDB and Risk of Colorectal Cancer. Evaluation of a Predictive Prognostic Model With Therapeutic Implications
The gut microbiome is emerging as a crucial factor in several intestinal diseases, contributing to the etiopathogenesis of inflammatory disorders.
- Trial name
- NCT07106463
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Messina
Colorectal Cancer, Metastatic to the Liver
Utility of Intra-operative Image Guidance System for Missing Metastases
Intraoperatively, the surgeon will interrogate the liver with ultrasound. The time spent by the surgeon using the ultrasound is recorded.
- Trial name
- NCT02806037
- Volunteers
- 25 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
RECTAL CANCER
Prospective Randomised Study Comparing Laparoscopic Versus Open Surgery in Patients With Rectal Cancer
The aim of this study is to compare laparoscopic versus open approach on the surgical treatment of mid and low-lying rectal cancer, both performed by the same surgical team with experience in open colorectal surgery and advanced…
- Trial name
- NCT00782457
- Testing
- RECTAL CANCER RESECTION
- Volunteers
- 200 people
- Sponsor
- Hospital Universitario Virgen de la Arrixaca
Colorectal Cancer
Quality of Life in Colorectal Cancer Survivors
BACKGROUND: Colorectal cancer (CRC) and its treatment affect CRC survivors' quality of life (QoL), emotional distress and activities of daily living (ADL).
- Trial name
- NCT03521765
- Testing
- Cancer education
- Where
- Taiwan
- Volunteers
- 76 people
- Sponsor
- National Cheng Kung University
Gastric Adenocarcinoma or Gastroesophageal Junction Adenocarcinoma or Esophageal Carcinoma, Colon and Rectal Cancer
Concentrated Complex Plant Dietary Elements for Chemotherapy-Induced Diarrhea
Chemotherapy-induced diarrhea (CID) is common in patients with gastrointestinal cancer. We evaluated whether the concentrated phytodietary compound (hereafter referred to as CPC) as a nutritional adjuvant to routine…
- Trial name
- NCT07460596
- Testing
- Concentrated Phytodietary Compound
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum
Phase I-II Study of Fluorouracil in Combination With Phenylbutyrate in Advanced Colorectal Cancer
Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Interferon-gamma may interfere with the growth of tumor cells and slow the growth of the tumor.
- Conditions
- Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum, Recurrent Colon Cancer, Recurrent Rectal Cancer
- Trial name
- NCT00002796
- Testing
- fluorouracil, sodium phenylbutyrate, indomethacin
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- National Cancer Institute (NCI)
Breast Carcinoma, Colorectal Carcinoma
Assessment of Current Biomarker Testing Practices for Common Solid Cancers in Precision Oncology in the Community Setting
This trial assesses current biomarker testing practices for common solid cancers in precision oncology in the community setting.
- Conditions
- Breast Carcinoma, Colorectal Carcinoma, Community Practice, Lung Carcinoma
- Trial name
- NCT03804255
- Testing
- Survey Administration
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- ECOG-ACRIN Cancer Research Group
Lynch Syndrome
Diagnosis of Lynch Syndrome Based on Next-generation Sequencing in Patients Meeting Chinese Lynch Syndrome Criteria
The purpose of this study is to find out the proportion of patients diagnosed with Lynch syndrome in colorectal cacner patients meeting Chinese Lynch syndrome criteria.
- Trial name
- NCT03046849
- Testing
- next-generation sequencing
- Where
- 3 sites in China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Non-Small Cell Lung Cancer, Medullary Thyroid Cancer
A Study of Selpercatinib (LOXO-292) in Participants With Advanced Solid Tumors, RET Fusion-Positive Solid Tumors, and Medullary Thyroid Cancer (LIBRETTO-001)
This is an open-label, first-in-human study designed to evaluate the safety, tolerability, pharmacokinetics (PK) and preliminary anti-tumor activity of selpercatinib (also known as LOXO-292) administered orally to participants…
- Conditions
- Non-Small Cell Lung Cancer, Medullary Thyroid Cancer, Colon Cancer, Any Solid Tumor
- Trial name
- LIBRETTO-001 (NCT03157128)
- Testing
- LOXO-292
- Where
- 85 sites in United States, Australia and 14 more
- Volunteers
- 857 people
- Sponsor
- Eli Lilly and Company
Islet Cell Adenoma, Neoplasm Metastasis
Combination Chemotherapy in Patients With Zollinger-Ellison Syndrome and Tumors of the Pancreas
Patients with Zollinger-Ellison Syndrome suffer from ulcers of the upper gastrointestinal tract, higher than normal levels of gastric acid, and tumors of the pancreas known as non-beta islet cell tumors.
- Conditions
- Islet Cell Adenoma, Neoplasm Metastasis, Zollinger Ellison Syndrome
- Trial name
- NCT00001165
- Testing
- combined chemotherapy with streptozotocin, 5-fluorouracil, and doxorubicin
- Where
- United States
- Volunteers
- 999 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Colorectal Cancer
Monoclonal Antibody Plus Chemotherapy in Treating Patients With Advanced Colorectal Cancer That Overexpresses HER2
Phase II trial to study the effectiveness of the monoclonal antibody trastuzumab and chemotherapy with irinotecan in treating patients who have stage IV colorectal cancer that overexpresses HER2.
- Trial name
- NCT00003995
- Testing
- trastuzumab, irinotecan hydrochloride
- Where
- 5 sites in United States
- Volunteers
- 32 people
- Sponsor
- National Cancer Institute (NCI)
Colorectal Cancer, Quality of Life
Cetuximab + Best Supportive Care Compared With Best Supportive Care Alone in Metastatic Epidermal Growth Factor Receptor-Positive Colorectal Cancer
RATIONALE: Monoclonal antibodies, such as cetuximab, can target tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells.
- Trial name
- NCT00079066
- Testing
- cetuximab, quality-of-life assessment
- Where
- 33 sites in Australia, Canada
- Volunteers
- 572 people
- Sponsor
- NCIC Clinical Trials Group
Colorectal Cancer, Appendicitis
Appendectomy and Colorectal Cancer
Colorectal cancer (CRC) is one of the most common cancer worldwide. Initiation and progression of CRC involve complex interactions among genetic, epigenetic and environmental factors.
- Trial name
- NCT06091137
- Where
- Hong Kong
- Volunteers
- 180,000 people
- Sponsor
- Chinese University of Hong Kong
Colorectal Cancer, Lynch Syndrome
Molecular Screening for Lynch Syndrome in Southern Denmark
A clinically applicably strategy for molecular screening for Lynch Syndrome has been implemented in the Region of Southern Denmark.
- Conditions
- Colorectal Cancer, Lynch Syndrome, HNPCC
- Trial name
- NCT01216930
- Testing
- Observation
- Where
- 7 sites in Denmark
- Volunteers
- 2,000 people
- Sponsor
- Vejle Hospital
Colon Cancer Screening
An Interactive Video Educational Tool Improves the Quality of Bowel Preparation for Colonoscopy
The investigators aimed to determine whether an interactive, online educational platform could improve procedure show rates and bowel preparation scores in an outpatient population presenting for routine colonoscopy.
- Trial name
- NCT04491565
- Testing
- educational video
- Where
- United States
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine