Clinical trials: Intraocular Inflammation
Ocular Toxoplasmosis
Spectral Optical Coherence Tomography Findings in Patients With Ocular Toxoplasmosis
Ocular toxoplasmosis is the most common cause of infectious uveitis worldwide. The diagnosis of ocular toxoplasmosis is primarily clinical when it is a typical presentation .With an atypical presentation in the fundus…
- Trial name
- NCT04219176
- Testing
- Spectral optical coherence tomography
- Volunteers
- 9 people
- Sponsor
- Université de Sousse
Behçet
Assessment of Endocan Serum Levels in Patients With Behcet Disease
The aim of our study was to assess serum endocan levels in patients with Behcet disease and to correlate it with various disease clinical and laboratory parameters of disease activity as well as carotid intima media thickness.
- Trial name
- NCT03853135
- Testing
- measurement of serum endocan
- Where
- Egypt
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Benha University
Behcet Disease
Behcet Disease Patients With Pulmonary Endoarterectomy: Outcomes of Program of Inspiratory Msucle Trianing
physical complications are common in Behcet disease patients with pulmonary endoarterectomy, so outcomes of program of inspiratory msucle trianing must be investigated
- Trial name
- NCT07662603
- Testing
- inspiratory muscle trianing
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Uveitis, JIA
Adalimumab in JIA-associated Uveitis Stopping Trial
The proposed study is a stratified, block-randomized, double-masked, controlled trial to determine the feasibility of discontinuing adalimumab treatment in patients with quiescent uveitis associated with juvenile idiopathic…
- Trial name
- ADJUST (NCT03816397)
- Testing
- Adalimumab
- Where
- 21 sites in United States, Australia and 1 more
- Volunteers
- 87 people
- Sponsor
- Nisha Acharya
Capsular Contracture, Implant, Pediatric Cataract
Capsular Outcomes of Pediatric Cataract Surgery With Primary Intraocular Lens Implantation
Lens capsular often changes after pediatric cataract surgery，causing complications such as anterior capsulerhexis shrinkage, visual axis opacification (VAO), zonular dehiscence and so on.
- Trial name
- capsular (NCT04803097)
- Where
- China
- Volunteers
- 62 people
- Sponsor
- Yune Zhao
Behcet's Syndrome
Colchicine Randomized Double-Blind Controlled Crossover Study in Behcet's Disease
Colchicine was first used in Behcet's Disease (BD), in 1977. There are controversial reports of the efficacy of Colchicine in BD.
- Trial name
- NCT00700297
- Testing
- Colchicine
- Where
- Iran
- Volunteers
- 169 people
- Sponsor
- Tehran University of Medical Sciences
Autoimmune Uveitis
Treatment Outcome of Uveitis in Autoimmune Diseases
reviewing the outcomes of patients with uveitis caused by autoimmune diseases treated at Assiut University Hospital at the Ophthalmology and Rheumatology and Rehabilitation Departments.
- Trial name
- NCT03886233
- Testing
- Corticosteroid Series
- Volunteers
- 1 people
- Sponsor
- Assiut University
Uveitis
Adalimumab Plus Methotrexate for the Treatment of Pediatric Uveitis
The aim of this study is to determine the efficacy and safety of ADA plus MTX for the treatment in non-infectious pediatric panuveitis.
- Trial name
- NCT04588818
- Testing
- Adalimumab plus Methotrexate
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Sun Yat-sen University
Uveitis
Objective Choroidal Thickness Measurements in Uveitis
Optical Coherence Tomography (OCT) machines are non-contact instruments that can provide micrometer scale imaging of biological tissue.
- Trial name
- NCT03889860
- Where
- Poland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
Uveitis
HUMIRA® Long-term Treatment in Patients With Non-infectious Intermediate-, Posterior-, or Pan-uveitis
This study evaluates the long- term safety and effectiveness of adalimumab in participants with non-infectious intermediate-, posterior-, or pan-uveitis in daily practice in Japan.
- Trial name
- NCT02916017
- Where
- 39 sites in Japan
- Volunteers
- 259 people
- Sponsor
- AbbVie
Juvenile Rheumatoid Arthritis, Uveitis
TNRF:Fc to Treat Eye Inflammation in Juvenile Rheumatoid Arthritis
This study will investigate the safety and effectiveness of the drug TNFR:Fc to treat uveitis (eye inflammation) in patients with juvenile rheumatoid arthritis.
- Trial name
- NCT00001862
- Testing
- Enbrel
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Eye Institute (NEI)
Behçet Disease
Apremilast Pediatric Study in Children With Active Oral Ulcers Associated With Behçet's Disease
The aim of this study is to estimate the efficacy of apremilast compared to placebo in the treatment of oral ulcers in pediatric participants from 2 to < 18 years of age with oral ulcers associated with Behçet's disease (BD)…
- Trial name
- BEAN (NCT04528082)
- Testing
- Apremilast
- Where
- 27 sites in France, Greece and 6 more
- Volunteers
- 60 people
- Sponsor
- Amgen
Uveitis
Clinical Outcome in Uveitis
This study is aimed at investigating the long term clinical outcome of patients with uveitis.
- Trial name
- NCT01983488
- Where
- United Kingdom
- Volunteers
- 231 people
- Sponsor
- Moorfields Eye Hospital NHS Foundation Trust
Non-infectious Uveitis
Safety and Efficacy of Fluocinolone Acetonide Intravitreal Implant vs Standardized Therapy
This is a 3 year,superiority, multicenter, open-label, randomised controlled safety and efficacy study. The aim of this study is to evaluate the effect of an intravitreal fluocinolone acetonide (0.59 mg) implant compared to…
- Trial name
- NCT00468871
- Testing
- fluocinolone acetonide intravitreal implant, corticosteroids and immunosuppressants
- Volunteers
- 140 people
- Sponsor
- Bausch & Lomb Incorporated
Uveitis
PANDA-ASOCT: Paediatric Anterior Uveitis Detection With Automated Image Analysis Using ASOCT
Uveitis is an inflammation inside the eye. Although rare, it is an important auto-inflammatory eye condition that affect children and young people (CYP).
- Trial name
- PANDA (NCT07813598)
- Testing
- Slit Lamp Examination, Anterior segment ocular coherence tomography (ASOCT)
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- Sheffield Children's NHS Foundation Trust
Vogt Koyanagi Harada Disease (VKH)
Corticosteroid Combining Noncorticosteroid Systemic Immunomodulatory Therapy in VKH
The aim of this study is to evaluate the efficacy and safety of corticosteroidcombining noncorticosteroid systemic immunomodulatory therapy (NCSIT) for the treatment of Vogt Koyanagi Harada disease (VKH).
- Trial name
- NCT05120687
- Testing
- noncorticosteroid systemic immunomodulatory therapy (NCSIT)
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Behcet's Disease, Vasculitis
Induction Therapy With Anti-TNFα vs Cyclophosphamide in Severe Behçet Disease
Behçet's disease (BD) is a systemic vasculitis of arterial and venous vessels of any size, involving young patients (from 15 to 45 years). BD significantly increases morbidity and mortality.
- Trial name
- ITAC (NCT03371095)
- Testing
- Infliximab, Cyclophosphamide
- Where
- 27 sites in France
- Volunteers
- 53 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Uveitis
Adalimumab vs. Conventional Immunosuppression for Uveitis Trial
Non-infectious intermediate, posterior, and panuveitides are chronic, potentially-blinding diseases. Vision-threatening cases require long-term therapy with oral corticosteroids and immunosuppression.
- Trial name
- ADVISE (NCT03828019)
- Testing
- Adalimumab (ADA), Conventional immunosuppression (CON)
- Where
- 26 sites in United States, Australia and 1 more
- Volunteers
- 227 people
- Sponsor
- JHSPH Center for Clinical Trials
Uveitis
Analysis of Anterior Chamber Inflammation by Optical Coherence Tomography
A prospective, observational, case series investigating the feasibility of utilizing OCT scans of the anterior chamber of eyes with uveitis.
- Trial name
- ATAC (NCT01746537)
- Where
- United States
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Uveitis, Panuveitis
Study of Difluprednate Ophthalmic Emulsion in the Treatment of Severe Uveitis
The purpose of this phase 3 open-labeled study is to determine if difluprednate ophthalmic emulsion is effective in the treatment of severe uveitis.
- Trial name
- NCT00407056
- Testing
- Difluprednate Ophthalmic Emulsion
- Volunteers
- 20 people
- Sponsor
- Sirion Therapeutics, Inc.