Clinical trials: Intraocular Inflammation, open to volunteers
Behçet Disease
Apremilast Pediatric Study in Children With Active Oral Ulcers Associated With Behçet's Disease
The aim of this study is to estimate the efficacy of apremilast compared to placebo in the treatment of oral ulcers in pediatric participants from 2 to < 18 years of age with oral ulcers associated with Behçet's disease (BD)…
- Trial name
- BEAN (NCT04528082)
- Testing
- Apremilast
- Where
- 27 sites in France, Greece and 6 more
- Volunteers
- 60 people
- Sponsor
- Amgen
Uveitis, Aqueous Humor
Metagenomics for Ocular Inflammation
The aim of this study is to apply a diagnostic test called 'metagenomic sequencing' to identify the involvement of potential infections in patients with ocular inflammation, where this hasn't been detected by currently available…
- Conditions
- Uveitis, Aqueous Humor, Infection
- Trial name
- NCT06974162
- Testing
- Metagenomic sequencing of aqueous humor, Ocular Imaging
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- Moorfields Eye Hospital NHS Foundation Trust
Uveitis
Analysis of Anterior Chamber Inflammation by Optical Coherence Tomography
A prospective, observational, case series investigating the feasibility of utilizing OCT scans of the anterior chamber of eyes with uveitis.
- Trial name
- ATAC (NCT01746537)
- Where
- United States
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Juvenile Idiopathic Arthritis Associated Uveitis, Uveitis, Anterior
Adalimumab Dose Adjustment for Pediatric Uveitis Treatment Trial
The goal of this clinical trial is to learn whether children and young adults with well-controlled juvenile idiopathic arthritis (JIA)-associated uveitis or chronic anterior uveitis can safely take adalimumab (or biosimilar)…
- Trial name
- ADAPT (NCT07699107)
- Testing
- Adalimumab/Biosimilar
- Where
- 18 sites in United States, Italy and 1 more
- Volunteers
- 160 people
- Sponsor
- Nisha Acharya
Uveitis, Infectious Uveitis
Genetics of Uveitis
In order to improve the investigators knowledge about uveitis and the underlying mechanism of disease, the investigators propose collecting blood from patients with uveitis, isolating DNA and sequencing the DNA to identify…
- Trial name
- NCT02357238
- Where
- United States
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Non-infectious Anterior Uveitis, Non-infectious Intermediate Uveitis
Efficacy and Safety of Adalimumab for the Treatment of Ocular Inflammation
This study aims to evaluate the clinical efficacy and safety of adalimumab in pediatric non-infectious uveitis and to generate domestic real-world evidence (RWE), thereby establishing a clinical foundation for label expansion and…
- Conditions
- Non-infectious Anterior Uveitis, Non-infectious Intermediate Uveitis, Non-infectious Posterior Uveitis, Panuveitis
- Trial name
- PANDA-U (NCT07913750)
- Testing
- Adalimumab PFS and Pen
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Samsung Medical Center
Hereditary Autoinflammatory Diseases, Schnitzler Syndrome
AutoInflammatory Disease Alliance Registry (AIDA)
Autoinflammatory diseases (AID) are clinical entities characterized by recurrent inflammatory attacks in absence of infection, neoplasm or deregulation of the adaptive immune system.
- Conditions
- Hereditary Autoinflammatory Diseases, Schnitzler Syndrome, Behcet Syndrome, PFAPA Syndrome
- Trial name
- AIDA (NCT05200715)
- Testing
- No intervention is foreseen by the protocol.
- Where
- 112 sites in Algeria, Australia and 20 more
- Volunteers
- 3,500 people
- Sponsor
- University of Siena
Uveitis
A Study of Uveitis in Children <18 Years of Age
The goal of this observational study is to collect data regarding clinical features and current/past treatments in children under 18 with uveitis.
- Trial name
- UV1 (NCT07518134)
- Where
- 4 sites in United States
- Volunteers
- 300 people
- Sponsor
- Jaeb Center for Health Research
Vogt Koyanagi Harada Disease
Early Immunosuppressive Therapy on the Course of Vogt-Koyanagi-Harada Disease
This prospective study will include patients with Vogt-Koyanagi-Harada disease from disease onset, treated with early systemic high-dose corticosteroid and immunosuppressive therapy.
- Trial name
- NCT03399175
- Testing
- Early high-dose corticosteroid and immunosuppressive therapy
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo
Infectious Panuveitis, Infectious Iridocyclitis
Pathogen Detection in Infectious Uveitis
Infectious uveitis is a very important blinding disease. Some people who have been diagnosed with idiopathic uveitis may also have the activity of pathogens in the eye.
- Trial name
- NCT04521673
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Uveitis, Posterior
Role of OCT & OCT Angiography in Patients With Posterior at the Uveitis Clinic of Assiut University Hospital.
OCT angiography is a recent evaluation of OCT technology which combines the structural assessment of ocular tissues obtained by OCT image with visualization of blood flow within the vessels in imaged area.
- Trial name
- NCT06743906
- Volunteers
- 25 people
- Sponsor
- Assiut University
Non-infectious Uveitis Affecting the Posterior Segment of the Eye
Open Label Trial Studying the Safety and Effectiveness of ILUVIEN® (190μg) in Children and Adolescents, Who Have Recurrent Non-infectious Uveitis Affecting the Posterior Segment of the Eye.
The main aim is to test how safe and effective the medicine ILUVIEN® (190μg) is for children and adolescents, who have non-infectious uveitis that keeps coming back and affects the back of the eye.
- Trial name
- NCT06539481
- Testing
- fluocinolone acetonide 190 micrograms
- Where
- 6 sites in Germany, Spain and 1 more
- Volunteers
- 25 people
- Sponsor
- Alimera Sciences
Behcet Disease
Behcet Disease Patients With Pulmonary Endoarterectomy: Outcomes of Program of Inspiratory Msucle Trianing
physical complications are common in Behcet disease patients with pulmonary endoarterectomy, so outcomes of program of inspiratory msucle trianing must be investigated
- Trial name
- NCT07662603
- Testing
- inspiratory muscle trianing
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Noninfectious Uveitis
The Microbiome in Uveitis and Pediatric Inflammatory Diseases
Chronic, noninfectious uveitis in children, associated with various systemic inflammatory diseases, carries a high risk of vision loss.
- Trial name
- MUMIP (NCT07885501)
- Where
- France
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Behcet Disease, Antineutrophil Cytoplasmic Antibody (ANCA) Positive Vasculitis
Armenian NAtionwide REGistry of Systemic Autoimmune and Autoinflammatory Diseases
Longitudinal prospective multicenter Armenian registry of systemic autoimmune, autoinflammatory diseases with constitution of bio-banking.
- Conditions
- Behcet Disease, Antineutrophil Cytoplasmic Antibody (ANCA) Positive Vasculitis, Takayasu Arteritis, Giant Cell Arteritis
- Trial name
- NAREG (NCT05904301)
- Testing
- Usual medical management of patients, additional blood and stool samples for biobanking
- Where
- 6 sites in Armenia
- Volunteers
- 800 people
- Sponsor
- Santé Arménie French-Armenian Research Center
Behçet's Disease, Juvenile Psoriatic Arthritis
A Study of Apremilast in Children With Oral Ulcers Associated With Behçet's Disease or Juvenile Psoriatic Arthritis
The primary objective of this study is to evaluate the long-term safety of apremilast in subjects 2 years of age or older with oral ulcers associated with Behçets disease or 5 years of age or older with active juvenile psoriatic…
- Trial name
- NCT05767047
- Testing
- Apremilast
- Where
- 7 sites in Greece, Israel and 2 more
- Volunteers
- 48 people
- Sponsor
- Amgen
Presumed Trematode Induced Uveitis, Uveitis
Ocular Fluid Work-up in Presumed Trematode Induced Granulomatous Uveitis
Ocular Fluid Work-up in Presumed Trematode Induced Granulomatous Uveitis
- Trial name
- NCT07885137
- Testing
- AC fluid sample, Vitreous fluid sample
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Kasr El Aini Hospital
Pediatric Uveitis
Demographic Data and Clinical Presentation of Pediatric Uveitis
To describe and analyze the demographics, Clinical characteristics, etiology, and visual outcomes of pediatric uveitis cases attending the outpatient clinic of Ophthalmology department, Assiut University Hospital.
- Trial name
- NCT06920017
- Volunteers
- 40 people
- Sponsor
- Assiut University
Behcet Disease
Evaluation of Voice in Behcet's
Behçet's disease (BD) is a systemic inflammatory condition of unknown origin with no definite aetiopathogenetic pathways accepted worldwide.
- Trial name
- NCT06836817
- Testing
- 1-Laryngyscopic examination 2-Acoustic analysis
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Minia University
Anterior Uveitis (AU), Birdshot Chorioretinitis
Quantification & Classification of Inflammatory Cells in Uveitis Using OCT
The goal of this study is to determine if it's possible to use a high resolution imaging device called optical coherence tomography (OCT) to develop an unbiased, standard method of counting and categorizing the various types of…
- Conditions
- Anterior Uveitis (AU), Birdshot Chorioretinitis, Behcet Disease, Herpes Simplex Virus
- Trial name
- NCT07065747
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University