Clinical trials: Isavuconazole
Cerebral Aspergillosis, Invasive Aspergillosis
European Study of Cerebral Aspergillosis Treated With Isavuconazole
Study clinical context Cerebral aspergillosis (CA) is a rare location of invasive aspergillosis (IA), associated with a high morbidity and mortality.
- Trial name
- ESCAI (NCT04486885)
- Where
- France
- Volunteers
- 41 people
- Sponsor
- Imagine Institute
Invasive Fungal Infections, Lung Transplantation
Isavuconazole Therapeutic Drug Monitoring in Transplant Recipients
Isavuconazole is an antifungal medicine used to prevent or treat serious fungal infections in people who have received a solid organ transplant (mainly lung, and also kidney or liver) or a hematopoietic stem cell (bone marrow)…
- Conditions
- Invasive Fungal Infections, Lung Transplantation, Hematopoietic Stem Cell Transplantation (HSCT), Kidney Transplantation
- Trial name
- TRIM-1 (NCT07716878)
- Testing
- Isavuconazole
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Zhibin Xu
Invasive Mucormycosis, Invasive Aspergillosis
A Study to Evaluate Isavuconazonium Sulfate for the Treatment of Invasive Aspergillosis (IA) or Invasive Mucormycosis (IM) in Pediatric Participants
The purpose of this study was to evaluate the safety, tolerability, and efficacy of isavuconazonium sulfate in pediatric participants.
- Trial name
- NCT03816176
- Testing
- Isavuconazonium sulfate
- Where
- 10 sites in United States, Belgium and 1 more
- Volunteers
- 31 people
- Sponsor
- Astellas Pharma Global Development, Inc.
Aspergillosis Invasive, Mucormycosis
Study on Theraputic Drug Monitoring and Phamacokinetics of Isavuconazole in Children
The goal of this clinical trial is to learn the plasma concentration of isavuconazole in pediatric patients. It will also learn about the relationship of isavuconazole plasma concentrations to efficacy and safety in pediatric…
- Trial name
- NCT06440915
- Testing
- Theraputic drug monitoring, Isavuconazole
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shanghai Children's Medical Center
Population Modeling of Anti-infective Drugs
Translational PKPD Modeling of Anti-infective Drugs Used in Pediatric Units.
Pharmacokinetic and pharmacodynamic modeling (PKPD) is becoming an essential tool for optimizing pharmacotherapy. Building mechanistic models allows determining the relationship between the dose, concentration, pharmacological…
- Trial name
- NCT05426499
- Testing
- Patients requiring cefotaxime treatment, Patients requiring meropenem treatment, Patients requiring fluconazole treatment
- Where
- 4 sites in Poland
- Volunteers
- 150 people
- Sponsor
- Poznan University of Medical Sciences
Mucormycosis
Amphotericin B Versus Isavuconazole for Mucormycosis: A Comparative Efficacy and Safety Study
Background: Mucormycosis is a serious but rare fungal infection that requires rapid and effective treatment. The two main antifungal medicines used are amphotericin B and isavuconazole.
- Trial name
- AIM (NCT07191756)
- Testing
- Amphotericin B, Isavuconazole
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Qiu Ye
Hematological Malignancy
A Study of Intravenous and Oral Isavuconazonium Sulfate in Pediatric Patients
The purpose of the study is to evaluate the pharmacokinetics (PK), safety and tolerability of multiple doses of intravenous (IV) and oral isavuconazonium sulfate administered daily in pediatric patients.
- Trial name
- NCT03241550
- Testing
- isavuconazonium sulfate - intravenous, isavuconazonium sulfate - oral
- Where
- 16 sites in United States
- Volunteers
- 49 people
- Sponsor
- Astellas Pharma Global Development, Inc.