Clinical trials: Ischemic
Coronary Heart Disease
A Single Center Prospective Randomized Controlled Clinical Study of JANUS Stent in Patients With Coronary Artery Disease
Janus stent is the only marketed drug-eluting stent (DES) without polymer coating as yet in China. The goal of this study is to evaluate the efficacy of JANUS (Tacrolimus eluted stent) in inhibiting of restenosis in percutaneous…
- Trial name
- NCT00406523
- Testing
- JANUS Stent
- Sponsor
- Shenyang Northern Hospital
Cardiovascular Diseases, Hypertrophic Cardiomyopathy (HCM)
AI-enabled Screening and Diagnosis of Cardiomyopathies Using Coronary CTA
The goal of this observational and diagnostic study is to develop and validate an artificial intelligence assisted approach for coronary computer tomography angiography-(CCTA)-based screening and diagnosis of cardiomyopathies in…
- Conditions
- Cardiovascular Diseases, Hypertrophic Cardiomyopathy (HCM), Dilated Cardiomyopathy (DCM), Restrictive Cardiomyopathy
- Trial name
- Atlantis (NCT06748261)
- Testing
- CCTAI model
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Shanghai Zhongshan Hospital
Myocardial Infarction, Stroke
The Brain Heart Interaction in Acute Stroke
Many studies have shown that acute cerebral dysfunction can impair cardiac function and autonomic control of blood pressure, heart rate and vascular tone, however, the size of the stroke is rarely reported.
- Trial name
- NCT02734082
- Where
- Switzerland
- Volunteers
- 204 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Angina Pectoris, Coronary Artery Disease
Chronic Total Coronary Occlusion Treatment Results 6 Years After Bioresorbable Scaffold Implantation
Aim of the study is to evaluate chronic total coronary occlusion treatment results 6 years after bioresorbable scaffold implantation by quantitative coronary analysis, intravascular ultrasound and optical coherence tomography.
- Conditions
- Angina Pectoris, Coronary Artery Disease, Occlusion, Coronary
- Trial name
- CTO_BVS (NCT06164977)
- Testing
- Percutaneous coronary intervention.
- Where
- Latvia
- Volunteers
- 34 people
- Sponsor
- Pauls Stradins Clinical University Hospital
Acute Coronary Syndrome (ACS)
PROSPECT II & PROSPECT ABSORB - an Integrated Natural History Study and Randomized Trial.
The present study has two components, an overall prospective observational study using multimodality imaging (PROSPECT II) that will examine the natural history of patients with unstable atherosclerotic coronary artery disease…
- Trial name
- P2 (NCT02171065)
- Testing
- ABSORB BVS
- Where
- Sweden
- Volunteers
- 902 people
- Sponsor
- Uppsala University
Non-ischemic Cardiomyopathy
Non-ischemic Cardiomyopathy Registry, Biobank and Imaging Data Repository
The main goal of CaNICM is to create a central database that includes a biobank and an imaging data repository for patients with non-ischemic cardiomyopathy (NICM), as well as for at-risk family members.
- Trial name
- CaNICM (NCT07110818)
- Where
- Canada
- Volunteers
- 2,000 people
- Sponsor
- Montreal Heart Institute
Hyperhomocysteinemia, Thrombotic, Cbs-Related, Ischemic Stroke
Methylenetetrahydrofolate Reductase Deficiency in Ischemic Stroke
Adult onset epileptic seizures is rare and often associated with metabolic disorders, drugs and intracranial pathologies such as ischemia, hemorrhage or space-occupying lesions.
- Conditions
- Hyperhomocysteinemia, Thrombotic, Cbs-Related, Ischemic Stroke, Epilepsy
- Trial name
- NCT04287881
- Testing
- Methylenetetrahydrofolate reductase (MTHFR) deficiency
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Istanbul Medeniyet University
Coronary Stenosis, Angina Pectoris
Evaluation of the Correlation Between the Coronary Stenosis Degree With FFRCT and the Grade of Stable Angina Pectoris
Angina pectoris is the most common clinical manifestation of coronary heart disease（CHD）, which is the main feature of chest pain caused by transient myocardial ischemia.
- Trial name
- NCT02802046
- Testing
- Computed tomographic angiography of coronary artery
- Volunteers
- 20 people
- Sponsor
- Guiyang No.4 People's Hospital
Cardiovascular Diseases, Heart Diseases
Speech Characteristics in Coronary Heart Disease
To improve the predictive validity of Structured Interview assessments of Type A behavior by comparing interviewer techniques in the Multiple Risk Factor Intervention Trial (MRFIT) and the Western Collaborative Group Study…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease
- Trial name
- NCT00005157
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Ischemia/Reperfusion Injury After Neonatal Cardiac Surgery, Inflammatory Reaction After Neonatal Cardiac Surgery
Efficacy of Nitric Oxide Administration in Attenuating Ischemia/Reperfusion Injury During Neonatal Cardiopulmonary Bypass
Around 7500 neonates born yearly in the United States have complex congenital heart disease that require surgical repair in the first few days of life.
- Trial name
- NCT02151877
- Testing
- Inhaled Nitric Oxide
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Wake Forest University Health Sciences
Smoking Status, Genetic Risk Factors
Effect of Smoking Status and Genetic Risk Factors on Restenosis and Efficacy of Clopidogrel After de Novo Percutaneous Coronary Intervention
Restenosis occurs for many different reasons. Over the years, many predictive clinical, biological, genetic, epigenetic, lesion-related, and procedural risk factors for restenosis have been identified.
- Conditions
- Smoking Status, Genetic Risk Factors, Restenosis, Clopidogrel
- Trial name
- NCT03613337
- Testing
- clinical restenosis
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Cui Yimin
Cardiovascular Diseases, Coronary Disease
Hostility and Coronary Risk--Role of Weak Vagal Function
To determine whether deficient vagal antagonism of sympathetic nervous system (SNS) actions on the heart contributed to increased coronary heart disease risk in hostile persons.
- Conditions
- Cardiovascular Diseases, Coronary Disease, Heart Diseases, Myocardial Ischemia
- Trial name
- NCT00005337
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Ischemic Heart Disease, Coronary Artery Disease
Impact of Acute Normovolemic Hemodilution on Blood Viscosity
Acute normovolemic hemodilution (ANH) has long been employed for reducing allogenic blood transfusion for cardiac surgery, and hydroxyethyl starch has been used as an intravenous replacement fluid during ANH procedure.
- Trial name
- NCT03366753
- Testing
- acute normovolemic hemodilution, In-vitro hemodilution
- Where
- South Korea
- Volunteers
- 21 people
- Sponsor
- Konkuk University Medical Center
Hypoxic-ischemic Encephalopathy
Hyperbaric Oxygen Therapy Improves Outcome of Hypoxic-Ischemic Encephalopathy
The purpose of this study is to to evaluate the safety and efficacy of hyperbaric oxygen in term gestation newborn infants with hypoxic-ischemic encephalopathy..
- Trial name
- NCT02894866
- Testing
- hyperbaric oxygen
- Where
- 10 sites in China
- Volunteers
- 250 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Coronary Heart Disease, Angina Pectoris
Safety Study of DanshenDuofensuanyan(a Chinese Medicine Injection)Used in Hospitals in China
This study was advocated by Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences in January 2013.
- Trial name
- NCT01814566
- Volunteers
- 30,000 people
- Sponsor
- China Academy of Chinese Medical Sciences
Cardiovascular Diseases, Heart Diseases
Cardiovascular Disease Trends 1980-91--A Gender Specific Perspective
To test hypotheses related to gender differences in cardiovascular mortality trends between 1980 and 1991 in two southeastern New England communities which were part of the Pawtucket Heart Health Program.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease, Cerebrovascular Accident
- Trial name
- NCT00005473
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Death, Carotid Artery Disease
NOR-SYS: The Norwegian Stroke in the Young Study
NOR-SYS is a clinical research program about young ischemic stroke patients from 15 to 60 years. Patients, partners and the couple´s adult children who are at least 18 years old, are all invited to ultrasound examinations due to…
- Conditions
- Death, Carotid Artery Disease, Cardiovascular Disease, Peripheral Artery Disease
- Trial name
- NOR-SYS (NCT01597453)
- Testing
- Lifestyle counseling
- Where
- Norway
- Volunteers
- 1,062 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Myocardial Infarction, Compliance Behavior
The Music Activity INTervention for Adherence Improvement Through Neurological Entrainment
Auditory motor-coupling has been shown to induce neural-entrainment that can synchronize walking-pace with sonic tempo. The extent to which acoustical-motor entrainment can induce longer-term changes to physical activity…
- Conditions
- Myocardial Infarction, Compliance Behavior, Patient Compliance
- Trial name
- MAINTAIN (NCT01752595)
- Testing
- Preference Based Rhythmic Auditory Stimulation Music, Preference Based Music Intervention
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- Toronto Rehabilitation Institute
Heart Arrest
Impact if Desflurane Preconditioning on the Content of the Phospho-GSK-3b in the Rat's Neurons in the Model of I/R
Endpoint implementation of reactions initiated by ischemia is the mitochondrial transition pore permeability. Mitochondria pores opening results in a release of factors triggering apoptosis primarily the cytochrome С Inhibition…
- Trial name
- NCT04287842
- Testing
- Desflurane, Sevoflurane, Cardiac arrest
- Sponsor
- Negovsky Reanimatology Research Institute
Coronary Artery Disease
Deutsches Dual Therapy Stent Register
The DTS.DE registry is an initiative for the collection of high quality process and historical data of implantations with the COMBO Dual Therapy Stent in Germany.
- Trial name
- DTS Register (NCT02102997)
- Where
- Germany
- Volunteers
- 130 people
- Sponsor
- OrbusNeich
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