Clinical trials: Keratitis
Acanthamoeba Keratitis
Retrospective Study of Acanthamoebic Keratitis During the Past 10 Years
Acanthamoebic keratitis is an important corneal disease which may cause severe complication. The difficulty in diagnosis, the difficulty in treatment, and the long treatment process are factors leading to the poor prognosis of…
- Trial name
- NCT02763605
- Testing
- no intervention
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Acanthamoeba Keratitis
Polihexanide (PHMB) Eye Drops in Patients Affected by Acanthamoeba Keratitis
Prospective randomized study to evaluate the efficacy, safety and tolerability of 0.08% polihexanide (PHMB) eye drops in patients affected by acanthamoeba keratitis.
- Trial name
- NCT03274895
- Testing
- PHMB 0.08%, Propamidine 0.1%, PHMB 0.02%
- Where
- 6 sites in Italy, Poland and 1 more
- Volunteers
- 135 people
- Sponsor
- SIFI SpA
Conjunctivitis, Iritis
Screening for NEI Clinical Studies
This screening protocol is designed to facilitate patient recruitment to National Eye Institute (NEI) clinical research studies.
- Conditions
- Conjunctivitis, Iritis, Keratitis, Retinitis
- Trial name
- NCT00001734
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- National Eye Institute (NEI)
Acute Bacterial Corneal Ulcers, Bacterial Keratitis
Safety and Efficacy Study of Gatifloxacin Compared With Ciprofloxacin in Patients With Acute Bacterial Corneal Ulcers
This study evaluates the safety and efficacy of gatifloxacin 0.3% ophthalmic solution compared with ciprofloxacin 0.3% ophthalmic solution in patients with acute bacterial corneal ulcers
- Trial name
- NCT00651586
- Testing
- Gatifloxacin 0.3% ophthalmic solution, Ciprofloxacin 0.3% ophthalmic solution
- Where
- 2 sites in United States, India
- Volunteers
- 129 people
- Sponsor
- Allergan
Keratitis, Automatic Judgement
Deep Learning for the Discrimination Among Different Types of Keratits: a Nationwide Study
Detecting the cause of keratitis fast is the premise of providing targeted therapy for reducing vision loss and preventing severe complications.
- Conditions
- Keratitis, Automatic Judgement, Image
- Trial name
- NCT05538793
- Where
- 2 sites in China
- Volunteers
- 10,369 people
- Sponsor
- Ningbo Eye Hospital
Uveitis, Conjunctivitis
Ocular Manifestations in Rheumatic Diseases
This is a search strategy for determining the prevalence of ocular complications in inflammatory rheumatic diseases for the purposes of a meta analysis.
- Conditions
- Uveitis, Conjunctivitis, Keratoconjunctivitis Sicca, Xerophthalmia
- Trial name
- NCT03753893
- Testing
- No intervention used
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Keratoconus, Unstable, Ectasia Corneal
Safety and Effectiveness of the PXL Platinum 330 System for Corneal Collagen Cross-Linking in Eyes With Corneal Thinning Position
To determine whether the Peschke PXL-330 is safe and effective in the treatment of corneal thinning conditions.
- Conditions
- Keratoconus, Unstable, Ectasia Corneal, Bacterial Keratitis
- Trial name
- NCT04213885
- Testing
- PXL 330 Platinum device/Riboflavin
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Eye Specialists of Indiana
Infective Keratitis
The Role of Adjuvant Corneal Crosslinking in the Management of Infective Keratitis
This was a prospective, single centre, randomised controlled study to evaluate the clinical effectiveness of corneal collagen crosslinking as an adjuvant to antimicrobial therapy.
- Trial name
- NCT06967376
- Testing
- Corneal Collagen Cross-Linking Solutions, Topical Antimicrobial/Antifungal Medications
- Where
- 2 sites in Egypt
- Volunteers
- 40 people
- Sponsor
- Research Institute of Ophthalmology, Egypt
Pterygium, Corneal Ulcer
The Application of Fibrin Glue in Ocular Surface Diseases
This clinical trial tries to use tissue fibrin glues (Tisseel) to treat various ocular surface diseases or surgeries, which includes pterygium surgery, corneal melting/perforation, Gunderson's flap, conjunctival laceration, and…
- Trial name
- NCT00155402
- Testing
- tissue fibrin glue application (Tisseel)
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Infectious Keratitis
Cross Linking for Treatment of Corneal Infection
This study is comparing 45 minute and 30 minute treatment durations with the UVX corneal cross linking system to treat corneal infections.
- Trial name
- NCT00912509
- Testing
- riboflavin, UVX Light
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Price Vision Group
Autoimmune Polyglandular Syndrome Type I, Autoimmune Keratitis
Tyrosine Hydroxylase Antibody Levels in Autoimmune Polyglandular Syndrome Type 1 Associated Keratitis
Tyrosine hydroxylase autoantibodies impair sympathetic innervation leading to keratitis. In this study, the investigators have shown the significant association between severity of keratitis and presence of tyrosine hydroxylase…
- Trial name
- NCT04375852
- Testing
- Detection of autoantibodies
- Volunteers
- 16 people
- Sponsor
- The Eye Center and The Eye Foundation for Research in Ophthalmology
Keratoconjunctivitis Sicca
Efficacy Study of Cyclosporine Ophthalmic Emulsion in Patients With Dry Eye Disease
This study will evaluate the efficacy of cyclosporine ophthalmic solution vs. other non-prescription treatments in patients with dry eye disease.
- Trial name
- NCT00717418
- Testing
- cyclosporine ophthalmic emulsion 0.05%, artificial tears
- Where
- United States
- Volunteers
- 781 people
- Sponsor
- Allergan
Keratoconjunctivitis Due to Adenovirus, Viral Shedding
A Placebo Controlled Comparison of Topical Zirgan Versus Genteal Gel for the Treatment of Adenovirus Conjunctivitis
The investigators are conducting this study because the patient have an eye infection which is called adenoviral conjunctivitis, and is the most common cause of "pink eye". There is currently no treatment for this condition.
- Trial name
- NCT01533480
- Testing
- Zirgan, genteal gel
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Lifelong Vision Foundation
Corneal Ulcer, Eye Infections, Fungal
Mycotic Ulcer Treatment Trial I
The purpose of this study is to determine if natamycin or voriconazole results in better visual outcomes in fungal corneal ulcers, especially visual acuity.
- Trial name
- MUTT I (NCT00996736)
- Testing
- Natamycin, Voriconazole
- Where
- 3 sites in United States, India
- Volunteers
- 323 people
- Sponsor
- University of California, San Francisco
Microbial Keratitis
Microbial Keratitis Sampling for Biomarker Discovery
The goal of this observational study is to identify prognostic and/or diagnostic signatures (biomarkers) related to microbial keratitis outcomes.
- Trial name
- NCT05888883
- Where
- United Kingdom
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Keratitis, Herpetic, Ocular Herpes Simplex
Herpetic Eye Disease Study (HEDS) I
To evaluate the efficacy of topical corticosteroids in treating herpes simplex stromal keratitis in conjunction with topical trifluridine.
- Trial name
- NCT00000138
- Testing
- Prednisolone Phosphate, Acyclovir
- Sponsor
- National Eye Institute (NEI)
Keratitis
Automated Quantitative Ulcer Analysis Study
This is a multiple site observational study that will review patient features (clinical and morphologic) over a 90 day period during care of participants with microbial keratitis with presence of clinically significant ≥2mm…
- Trial name
- AQUA (NCT04420962)
- Testing
- Visual Acuity
- Where
- 2 sites in United States, India
- Volunteers
- 124 people
- Sponsor
- University of Michigan
Keratoconjunctivitis
Corneal Topography in Vernal Keratoconjunctivitis
To evaluate the corneal topographic changes in VKC patients using Pentacam and prevalence of KC development in VKC.
- Trial name
- NCT06746467
- Testing
- pentacam
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Assiut University
Corneal Ulcer, Corneal Perforation
Topical Insulin - Utility and Results in Neurotrophic Keratopathy in Stages 2 and 3
Purpose: To evaluate the clinical outcome of patients with refractory Neurotrophic Keratopathy (NK) in stages 2 and 3 treated with topical insulin.
- Conditions
- Corneal Ulcer, Corneal Perforation, Corneal Epithelium Defect, Neurotrophic Keratitis
- Trial name
- NCT04820010
- Testing
- Topical Insulin
- Where
- Portugal
- Volunteers
- 20 people
- Sponsor
- Centro Hospitalar de Vila Nova de Gaia/Espinho, E.P.E.
Dry Eye Syndromes
Effects of RP101 in Post-menopausal Women With Dry Eye Syndrome
The main purpose of this study is to establish whether RP101 can reduce symptoms of dry eye syndrome in post-menopausal women.
- Trial name
- NCT03821415
- Testing
- RP101
- Where
- 8 sites in Austria, Germany and 1 more
- Volunteers
- 104 people
- Sponsor
- Redwood Pharma AB