Clinical trials: Kidney Damage
Surgery--Complications, Cardiac Valve Disease
Prevention of Acute Kidney Injury by N-Acetylcystein in Patients Undergone Cardiac Valve Replacement
This is a randomized clinical trial, double-blind, placebo-controlled study with the goal to assess the influence of using N-AcetylCysteyn (NAC) for prevention of AKI (Acute Kidney Injury) in post operatory of valve replacement…
- Conditions
- Surgery--Complications, Cardiac Valve Disease, Acute Kidney Injury, Oxygen Radical Damage
- Trial name
- NCT03440268
- Testing
- N Acetyl Cysteine
- Where
- Brazil
- Volunteers
- 154 people
- Sponsor
- University of Sao Paulo General Hospital
Urine Reflux, Kidney Damage
(ARFI) Shear Velocity Imaging of the Kidneys in Pediatric Patients
Urine reflux (urine backing up into the kidneys) is common in the pediatric population and may be complicated by renal abnormalities, such as infection and scarring.
- Trial name
- NCT01781819
- Testing
- ARFI SVI Ultrasound Imaging
- Where
- United States
- Sponsor
- University of Michigan
Advanced Malignant Solid Neoplasm, Ann Arbor Stage III Childhood Non-Hodgkin Lymphoma
Olaparib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Defects in DNA Damage Repair Genes (A Pediatric MATCH Treatment Trial)
This phase II Pediatric MATCH trial studies how well olaparib works in treating patients with solid tumors, non-Hodgkin lymphoma, or histiocytic disorders with defects in deoxyribonucleic acid (DNA) damage repair genes that have…
- Conditions
- Advanced Malignant Solid Neoplasm, Ann Arbor Stage III Childhood Non-Hodgkin Lymphoma, Ann Arbor Stage IV Childhood Non-Hodgkin Lymphoma, Low Grade Glioma
- Trial name
- NCT03233204
- Testing
- Olaparib
- Where
- 113 sites in United States, Puerto Rico
- Volunteers
- 6 people
- Sponsor
- National Cancer Institute (NCI)
Acute Kidney Injury, Multi Organ Failure
Long Term Renal Function After CRRT in the Paediatric Intensive Care Unit, a Follow-up Study.
In this study the investigators will evaluate the long-term renal function in children treated with continuous renal replacement therapy (CRRT) due to acute kidney injury (AKI) and multiple organ failure (MOF) in the pediatric…
- Conditions
- Acute Kidney Injury, Multi Organ Failure, Children, Only
- Trial name
- NCT05629273
- Where
- Sweden
- Volunteers
- 156 people
- Sponsor
- Region Stockholm
Purpura, Schoenlein-Henoch
Research on the Blood- Cooling - Toxin - Removing - Stasis - Dispersing Protocol Evaluation of Hench-schonlein Purpura
Due to high incidence of renal damage by Hench-schonlein Purpura(HSP) is the key to affect prognosis, this project moves the research emphasis forward in line with the idea of "prevention of progress of disease", Which concerns…
- Trial name
- NCT01104428
- Testing
- "ziying" granules
- Where
- China
- Volunteers
- 256 people
- Sponsor
- Liaoning University of Traditional Chinese Medicine
Acute Kidney Injury, HIE
Theophylline Prophylaxis During Hypothermia to Limit Neonatal Nephron Damage
Acute kidney injury is a significant complication for infants who experience hypoxic ischemic encephalopathy, being associated with increased rates of death and prolonged hospitalization.
- Trial name
- TheoPHyLNNe (NCT05853601)
- Testing
- Single Dose Theophylline, Repeat Dose Theophylline
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Medical College of Wisconsin
Nephrotic Syndrome
From Immune System Damage to Podocyte Cell Damage: Prospective Database and Biological Collection of Patients (Children and Adults) With MGLS and HSFP
Idiopathic Nephrotic Syndrome (INS) is a kidney disease characterized by massive proteinuria and hypoalbuminemia. It includes two anatomopathological entities: nephrotic syndrome with minimal glomerular lesions (SNLGM) and…
- Trial name
- BiobankSNI (NCT04174066)
- Testing
- blood sample, tissue sample, excreta
- Where
- 2 sites in France
- Volunteers
- 144 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Chemotherapeutic Agent Toxicity, Sarcoma
CYP3A5 Gene as a Risk Factor for Kidney Damage in Young Patients With Cancer Treated With Ifosfamide
RATIONALE: Studying the genes expressed in samples of blood from young patients with cancer treated with ifosfamide may help doctors identify risk factors for kidney damage.
- Conditions
- Chemotherapeutic Agent Toxicity, Sarcoma, Unspecified Childhood Solid Tumor, Protocol Specific
- Trial name
- NCT00514345
- Testing
- gene expression analysis, polymorphism analysis, management of therapy complications
- Where
- 21 sites in Ireland, United Kingdom
- Volunteers
- 300 people
- Sponsor
- Children's Cancer and Leukaemia Group
Obstructive Uropathy
Ultrasonic Visualization of Obstructive Uropathies in Children
The purpose of this study was to develop proposals and recommendations for improving the safety of urological examination of children with obstructive uropathy by using Doppler ultrasound.
- Trial name
- NCT04605835
- Testing
- ULTRASONIC VISUALIZATION OF OBSTRUCTIVE UROPATHIES IN CHILDREN.
- Where
- Uzbekistan
- Volunteers
- 655 people
- Sponsor
- Samarkand State Medical Institute
Congenital Heart Disease, Congenital Heart Defect
Nitric Oxide Effect on Brain and Kidney in Pediatric Patients Undergoing Cardiopulmonary Bypass
The goals of this study are: 1. To evaluate the neuroprotective effect of nitric oxide by measuring glial fibrillary acid protein (GFAP) before and after surgery.
- Conditions
- Congenital Heart Disease, Congenital Heart Defect, Congenital Heart Malformations
- Trial name
- NCT05101746
- Testing
- Nitric Oxide (NO) 20 part per million (ppm), Standard of care cardiopulmonary bypass
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Vanderbilt University Medical Center
CAKUT
Prediction of Renal Parenchymal Damage of CAKUT
To establish the prediction of the renal damage and renal development deficiency in congenital anomalies of kidney and urinary tract (CAKUT), a diagnostic accuracy study on MRI-DWI combined with urinary microprotein detection is…
- Trial name
- NCT04537364
- Testing
- combined diagnosis of renal parenchymal damage
- Where
- China
- Volunteers
- 234 people
- Sponsor
- Children's Hospital of Fudan University
Acute Pyelonephritis
Dexamethasone Administration in 1st Episode of Febrile Urinary Tract Infection
Hypothesis: Administration of corticoids (dexamethasone) together with the conventional antibiotherapy in the acute phase of a febrile urinary tract infection could reduce the risk of renal scarring after 6 months of the…
- Trial name
- DEXCAR-0212 (NCT02034851)
- Where
- 7 sites in Spain
- Volunteers
- 183 people
- Sponsor
- Institut Investigacio Sanitaria Pere Virgili
Nephronophthisis
Nephronophthisis : Clinical and Genetic Study
to describe evolution of Nephronophthisis
- Trial name
- NEPHAER (NCT01022957)
- Testing
- genetic diagnosis
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Kidney Cancer, Leukemia
Glutamic Acid in Reducing Nerve Damage Caused by Vincristine in Young Patients With Cancer
RATIONALE: Glutamic acid may help lessen or prevent nerve damage caused by vincristine. It is not yet known whether glutamic acid is more effective than a placebo in preventing nerve damage in patients receiving vincristine for…
- Conditions
- Kidney Cancer, Leukemia, Lymphoma, Neurotoxicity
- Trial name
- NCT00369564
- Testing
- glutamic acid
- Where
- 6 sites in United States
- Volunteers
- 250 people
- Sponsor
- University of South Florida
Vesicoureteral Reflux, Renal Hypodysplasia, Nonsyndromic, 1
Antibiotic Prophylaxis and Renal Damage In Congenital Abnormalities of the Kidney and Urinary Tract
The exact role of urinary tract infection in the appearance of chronic kidney disease is unclear. Children with congenital malformations of kidney and urinary tract have the higher risk of impairment of renal function.
- Conditions
- Vesicoureteral Reflux, Renal Hypodysplasia, Nonsyndromic, 1, Chronic Kidney Disease
- Trial name
- PREDICT (NCT02021006)
- Testing
- nitrofurantoin, No prophylaxis, Amoxicillin-Potassium Clavulanate Combination
- Where
- Italy
- Volunteers
- 292 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Hypertension, Left Ventricular Hypertrophy
Pediatric Hypertension and the Renin-Angiotensin SystEm (PHRASE)
Studying the causal roles of components of the renin-angiotensin-aldosterone system (including angiotensin-(1-7) (Ang-(1-7)), angiotensin-converting enzyme 2 (ACE2), Ang II, and ACE), uric acid, and klotho in pediatric…
- Conditions
- Hypertension, Left Ventricular Hypertrophy, Left Ventricular Dysfunction, Left Atrial Dilatation
- Trial name
- PHRASE (NCT04752293)
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Congenital Solitary Kidney
Long Term Outcome of Congenital Solitary Kidney
Congenital solitary kidney (CSK) is a disorder caused by an abnormal development of one of the two kidneys. The reported incidence ranges between 1:450-3200. It is debated whether CSK is a benign condition or not.
- Trial name
- CSKP (NCT01831141)
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Sickle Cell Disease
Screening Patients With Sickle Cell Disease for Kidney Damage
This study aims to study the temporal course of sickle nephropathy and assess novel biomarkers that can predict patients prone to nephropathy.
- Trial name
- NCT02239016
- Where
- 4 sites in United States
- Volunteers
- 320 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati