Clinical trials: Larynx
Intubating Laryngeal Airway
Evaluation of the Intubating Laryngeal Airway in Children
The Air-Q® intubating laryngeal airway (Air-Q® ILA) is an extraglottic device specifically engineered for use both as a stand-alone laryngeal mask airway (LMA) and as a rescue device or "Plan B" device in the event of a difficult…
- Trial name
- NCT00885911
- Where
- Canada
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Dystonia, Drug Induced Dystonia
Clinical Validation of DystoniaNet Deep Learning Platform for Diagnosis of Isolated Dystonia
This research involves retrospective and prospective studies for clinical validation of a DystoniaNet deep learning platform for the diagnosis of isolated dystonia.
- Conditions
- Dystonia, Drug Induced Dystonia, Parkinson Disease, Essential Tremor
- Trial name
- NCT05317390
- Testing
- DystoniaNet-based diagnosis of isolated dystonia
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Methylene Blue, Recurrent Laryngeal Nerve Injuries
Methylene Blue Spray for Identification of Recurrent Laryngeal Nerve and Parathyroid Gland
Thyroidectomy is the procedure by which surgeons treat various thyroid diseases and is considered the commonest endocrinal surgery. Yet, it carries a risk for intraoperative complications.
- Conditions
- Methylene Blue, Recurrent Laryngeal Nerve Injuries, Parathyroid Gland
- Trial name
- NCT05113628
- Testing
- methylene blue identification
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Zagazig University
Voice Disorders, Gastroesophageal Reflux
Quantifying Effects of Treatment of Pediatric Dysphonia
The diagnosis and management of childhood dysphonia is a significant clinical problem; however, there have been few studies aimed at defining standard assessment methods for pediatric dysphonia.
- Trial name
- NCT00237679
- Testing
- Neuromuscular Electrical Stimulation, Unstimulated
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Wisconsin, Madison
Head and Neck Cancer
Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Previously Untreated Advanced Cancer of the Mouth, Pharynx, or Larynx
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00004094
- Testing
- carboplatin, fluorouracil, hydroxyurea
- Where
- 4 sites in United States
- Sponsor
- National Cancer Institute (NCI)
Dysphonia
Investigation of the Effectiveness of Group Voice Therapy in Children
This study aims to investigate whether there is a difference between groups receiving "group voice therapy" and "individual voice therapy" in pediatric populations diagnosed with dysphonia.
- Trial name
- NCT06124053
- Testing
- Group Voice Therapy, Individual Voice Therapy, Vocal Hygiene Education
- Where
- Turkey (Türkiye)
- Volunteers
- 18 people
- Sponsor
- Hacettepe University
Percent of Vocal Cords (Glottic) Opening
Vocal Cord Views With the Classical Miller, Wis-Hipple and C-MAC Size 1 Blades in Young Children
The purpose of this study is to compare straight blades in obtaining best vocal cord view in children. The investigators will compare size 1 Classical Miller, size 1 Wis-Hipple, and size 1 C-MAC straight blades in young children.
- Trial name
- POGO (NCT03053583)
- Testing
- Laryngoscope blade
- Volunteers
- 96 people
- Sponsor
- State University of New York at Buffalo
Recurrent Laryngeal Papillomatosis, Human Papilloma Virus
Human Papillomatosis Genotyping of Children in Thailand
The purpose of the present study was to identify risk factors for more severe juvenile Recurrent Respiratory Papillomatosis (RRP) through prospective evaluation of a pediatric population in Thailand by the employing a protocol…
- Trial name
- NCT01304966
- Testing
- biopsy
- Where
- 2 sites in Thailand
- Volunteers
- 15 people
- Sponsor
- Queen Sirikit National Institute of Child Health
Laryngospasm
Laryngeal Reflex Study Under Propofol Anesthesia: Effect of Intravenous Lidocaine
To describe respiratory and laryngeal responses to laryngeal stimulation during propofol anesthesia in children. To determine whether the co-administration of lidocaine blunts these reflex responses.
- Trial name
- LR6 (NCT01222169)
- Testing
- NaCl 0,9%
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- Thomas Erb
Recurrent Upper-Respiratory Tract Infections
CLEARI (Clinical Efficacy Assessment on Recurrent Upper-Respiratory Tract Infections) Study
The purpose of this study is to assess the efficacy and safety of J022X ST for prevention of Recurrent Upper-Respiratory Tract Infections (RURTI) compared to placebo in children of younger age who develop infectious diseases more…
- Trial name
- NCT01948856
- Testing
- J022X ST
- Where
- 24 sites in Italy, Lithuania and 3 more
- Volunteers
- 1,003 people
- Sponsor
- Pierre Fabre Medicament
Neonatal Resuscitation
Supreme-LMA for Neonatal Resuscitation: a Prospective, Randomized Single-center Study
Laryngeal mask airways (LMA) that fit over the laryngeal inlet have been shown to be effective for ventilating newborns at birth.
- Trial name
- NCT01963936
- Testing
- Supreme LMA, Facial mask
- Where
- Vietnam
- Volunteers
- 142 people
- Sponsor
- University of Padova
Exercise Induced Laryngeal Obstruction (EILO)
Managing Dysfunctional Breathing and Exercise-induced Laryngeal Obstruction in Adolescent Athletes
This study aimed to assess if a multidimensional individually tailored intervention, including Norwegian Psychomotor Physiotherapy (NPMP), elements of cognitive behavioural therapy and a rehabilitation plan, helped reduce…
- Trial name
- NCT06033755
- Testing
- Norwegian psychomotor physiotherapy
- Where
- Norway
- Volunteers
- 18 people
- Sponsor
- VID Specialized University
Airway Management
Compare the Efficacy of Different Laryngeal Mask Size Selection Methods in General Anesthesia in Children
The laryngeal mask is widely used in general anesthesia in children. Selection of an appropriately sized laryngeal mask airway (LMA) is critical to ensure safe and effective use of the device.
- Trial name
- NCT03845998
- Testing
- use the three-finger method, use the weight-related method
- Where
- China
- Volunteers
- 392 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Anesthesia
A Randomized Comparison of Pediatric I-gel, Air-Q With Classic Laryngeal Mask Airway
The aim of this randomized trial will be to evaluate the clinical performance of the I-gel, air- Q ILA compared with the LMA classic in pediatric patients undergoing peripheral surgery under general anesthesia.
- Trial name
- I-gelvsAir-q (NCT02757820)
- Testing
- LMA Classic, i- gel, Air-Q
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Assiut University
Airway Management, Anesthesia, General
Video Laryngeal Mask SaCoVLM Versus LMA Supreme and Ambu AuraGain in Children
This randomised controlled trial compares three supraglottic airway devices (laryngeal masks) in children with a body weight of 3-30 kg undergoing elective surgery under general anaesthesia: the SaCoVLM video laryngeal mask (UE…
- Conditions
- Airway Management, Anesthesia, General, Pediatric Anesthesia
- Trial name
- SACOVLM-PEDI (NCT07891832)
- Testing
- SaCoVLM video laryngeal mask, LMA Supreme, Ambu AuraGain
- Where
- Czechia
- Volunteers
- 135 people
- Sponsor
- Masarykova Nemocnice v Usti nad Labem, Krajska Zdravotni a.s.
Pediatric Anesthesia, Airway Management
Effective Dose of Alfentanil Combined With Propofol for Laryngeal Mask Airway Insertion in Children
This study uses a prospective, up-and-down sequential allocation method to determine the median effective dose (ED50) and 95% effective dose (ED95) of alfentanil combined with propofol for successful laryngeal mask airway (LMA)…
- Conditions
- Pediatric Anesthesia, Airway Management, General Anesthesia, LMA
- Trial name
- NCT07581665
- Testing
- Alfentanil
- Where
- China
- Volunteers
- 23 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Recurrent Laryngeal Nerve Injuries, Aortic Arch Hypoplasia
Recurrent Nerve Monitoring During Aortic Arch Repair
Almost half of newborns undergoing surgery to repair narrowing or interruption of the aortic arch will suffer injury to the recurrent laryngeal nerve.
- Trial name
- PREMAR (NCT04994964)
- Testing
- Electromyography
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Birmingham Women's and Children's NHS Foundation Trust
Laryngeal Dystonia, Spasmodic Dysphonia
Transcranial Magnetic Stimulation in Laryngeal Dystonia
This randomized clinical trial with a crossover design aims to investigate the effects of neuromodulation through repetitive transcranial magnetic stimulation (rTMS) applied to patients diagnosed with laryngeal dystonia.
- Trial name
- NCT07683767
- Testing
- Active rTMS, Speech-Language Therapy
- Volunteers
- 20 people
- Sponsor
- Universidade Federal de Pernambuco
Parathyroid Disease
Lidocaine Supplement for Minimal Invasive Parathyroid Surgery
Primary Objective: 1. To determine if the application of lidocaine to the airway will obtund or abolish the laryngeal reflexes. This in turn will lead to a quiescent controlled surgical field.
- Trial name
- NCT00528502
- Testing
- Lidocaine, Saline
- Sponsor
- M.D. Anderson Cancer Center