Clinical trials: Light
Myopia
Sustained Effect of Red-light Therapy for Myopia Control: A 2-Year Post-Trial Follow-up Study
To evaluate the long-term efficacy and safety of red-light therapy for myopia control over 2 years, and the potential rebound effect after treatment cessation.
- Trial name
- NCT06232161
- Testing
- Red-light therapy device, Spectacles
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Beijing Airdoc Technology Co., Ltd.
AL Amyloidosis
Open-label Extension Study of NEOD001 in Subjects With Light Chain (AL) Amyloidosis
The rationale for this study is to provide additional treatment with NEOD001 for subjects who complete Study NEOD001-001, and to continue to evaluate long term safety and tolerability.
- Trial name
- OLE (NCT02613182)
- Testing
- NEOD001
- Where
- 5 sites in United States
- Volunteers
- 34 people
- Sponsor
- Prothena Biosciences Ltd.
Burn Wound
Safety Study of a Novel Wearable Phototherapy System for the Management of Acute Burn Wounds
The primary purpose of this first-in-human, early feasibility study is to assess safety and feasibility of the Low-Irradiance Monochromatic Biostimulation (LIMB) System as a phototherapeutic intervention for the management of…
- Trial name
- NCT03948360
- Testing
- Low-Irradiance Monochromatic Biostimulation (LIMB) Device, Standard of Care
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Rogers Sciences Inc.
Asthma
Validation of Structured Light Plethysmography: Asthma
Validation of Structured Light Plethysmography (SLP) in patients with asthma, in patients with acute asthma; an observational study in healthy participants and during patients' clinical investigation of broncho-reversibility in…
- Trial name
- SLPBD (NCT02543333)
- Where
- 2 sites in United Kingdom
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- Pneumacare Ltd
Myopia, Amblyopia
Real Word Study on Myopia Control With Repeated Red Light Therapy for Ages of 3~6 Years Old
Repeated Red Light Therapy had been used as an amblyopia therapy for children as well as the myopia control in primary schools. However, ultra low lever of red light therapy with irradiance of 0.37mW and 0.60mW effectiveness and…
- Trial name
- RMC (NCT05811598)
- Testing
- repeated ultra low lever red light
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing Airdoc Technology Co., Ltd.
Chronic Obstructive Pulmonary Disease (COPD)
Validation of Structured Light Plethysmography - Health and Disease
Validation of Structured Light Plethysmography (SLP) in patients with conditions such as Chronic Obstructive Pulmonary Disease (COPD) that effect breathing and in healthy participants.
- Trial name
- SLP-RespDis (NCT02626468)
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Pneumacare Ltd
Pulmonary Disease
Validation of Structured Light Plethysmography
Measurements of Structured Light Plethysmography (SLP) using a chest wall movement based method will be compared to those obtained by spirometry using a flow based pneumotachograph method.
- Trial name
- SLPvsPNT (NCT02598336)
- Testing
- Structured Light Plethysmography, Pneumotachograph Spirometry
- Where
- United Kingdom
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Pneumacare Ltd
Hyperbilirubinemia
Comparative Study of Phototherapy for Hyperbilirubinemia
Hyperbilirubinemia is a common problem for term and preterm newborns in intensive care nurseries around the world. It is a condition in which there is too much bilirubin in the blood.
- Trial name
- NCT00635375
- Testing
- LED fiberoptic blanket phototherapy (BiliSoft blue LED fiberoptic blanket phototherapy), Metal halide phototherapy (Spot PT metal halide phototherapy), LED bank phototherapy (Natus neoBlue LED bank phototherapy)
- Where
- 2 sites in United States
- Volunteers
- 82 people
- Sponsor
- GE Healthcare
Fetal Growth Retardation
Study Aimed At Improving Height With Genotonorm In Children Born Little And/Or Light With Growth Retardation At The Age
To estimate the percentage of children with serum IGF-1 > 2 standard deviation (compared to a child of the same gender and age and without growth hormone (GH) deficiency) 9 months and 12 months after initiation of GH treatment.
- Trial name
- NCT00174252
- Testing
- Genotonorm (Somatropin)
- Where
- 22 sites in France
- Volunteers
- 57 people
- Sponsor
- Pfizer
Myopia
Influence of Rodenstock Spectacle Lenses on Myopia Progression.
The prevalence of myopia in Singapore is among the highest in the world, with 65 percent of our children being myopic by Primary 6, and 83 percent of young adults being myopic.
- Trial name
- NCT06816446
- Testing
- Myopia control spectacle lens, Single-vision lens
- Where
- Singapore
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- Rodenstock GmbH
Autistic Disorder
An Evaluation of Low Level Laser Light Therapy for Autistic Disorder
The purpose of this study is to determine whether the Erchonia HLS Laser is effective in the treatment of irritability associated with autistic disorder in children and adolescents aged five (5) to seventeen (17) years.
- Trial name
- NCT03379662
- Testing
- Erchonia HLS Laser
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Erchonia Corporation
Vitiligo
A Study to Compare the Efficacy and Safety of SCENESSE and Narrow-Band Ultraviolet (NB-UVB) Light Versus NB-UVB Light Alone in Patients With Vitiligo
The CUV105 study will assess the efficacy and safety of afamelanotide and NB-UVB light in patients with vitiligo on the body and face versus NB-UVB light alone.
- Trial name
- NCT06109649
- Testing
- Afamelanotide and NB-UVB Light, NB-UVB Light
- Where
- 30 sites in United States, France and 2 more
- Volunteers
- 200 people
- Sponsor
- Clinuvel, Inc.
Neonatal Jaundice, Hyperbilirubinemia
Compassionate Use of Stanate (TM) [Stannsoporfin]
The purpose of this protocol is to make Stanate (TM) [stannsoporfin, tin-mesoporphyrin] available to infants who meet the following criteria: 1.
- Trial name
- NCT00076960
- Testing
- Stanate (TM) [stannsoporfin, tin-mesoporphyrin]
- Where
- United States
- Sponsor
- InfaCare Pharmaceuticals Corporation, a Mallinckrodt Company
Re-mineralization
Re-mineralization Effects of Sugar Free Chewing Gum Sweetened With Different Sugar-substitutes
The purpose of this study is to evaluate the clinical effect of chewing gum containing maltitol, on re-mineralization of early caries following daily chewing for 6 months by school children, compared to a xylitol gum, gum base…
- Trial name
- NCT02468388
- Testing
- maltitol, xylitol, gum base
- Where
- China
- Volunteers
- 482 people
- Sponsor
- Roquette Management (Shanghai) Co., Ltd.
Orthodontic Appliance Complication, Plaque, Dental
Regular Home Use of Dual-light Photodynamic Therapy on Oral Health in Adolescents Undergoing Fixed Orthodontic Treatment
This study is designed to determine the efficacy of the Lumoral method on oral health in adolescents undergoing fixed orthodontic treatment.
- Conditions
- Orthodontic Appliance Complication, Plaque, Dental, Gingival Inflammation
- Trial name
- NCT05825742
- Testing
- Lumoral Treatment, Standard oral health instructions
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Koite Health Oy
Nutritional and Metabolic Diseases
Efficacy and Safety of Stannsoporfin in Neonates
This is a multi-center, randomized, sham injection-controlled (placebo) masked trial of a single intramuscular injection of Stannsoporfin compared to "sham" (placebo) in healthy term and near-term newborns admitted to the…
- Trial name
- NCT02685137
- Testing
- stannsoporfin
- Where
- United States
- Volunteers
- 185 people
- Sponsor
- InfaCare Pharmaceuticals Corporation, a Mallinckrodt Company
Cutaneous Metastatic Melanoma
Intratumoral Targeted Hyperthermia Therapy (THT) for Cutaneous Metastatic Melanoma
This device phase I/II, first in human, early feasibility study (EFS), open-label, single-arm trial aims to evaluate the safety, tolerability, and preliminary efficacy of Gold Nanorod (GNR)-enabled sub-ablative targeted…
- Trial name
- NCT06870994
- Testing
- Targeted Hyperthermia Therapy
- Volunteers
- 10 people
- Sponsor
- Sona Nanotech Inc
Myopia, Progressive
Slow Myopia Progression With Different Irradiance Light
It is a prospective clinical control study on red light control myopia with specail design spectacles for 75 children in 3 groups. Study Groups with two different powers of 0.6 mW and 1.2 mW at wavelength of 650nm.
- Trial name
- NCT05881655
- Testing
- Airdoc Red Lighting Device, Special Spectacles to Control Myopia
- Where
- China
- Volunteers
- 75 people
- Sponsor
- Beijing Airdoc Technology Co., Ltd.
Dysfunctional Breathing
Structured Light Plethysmography Against Standard of Care in the Diagnosis and Monitoring of Dysfunctional Breathing
This is an observational, controlled, single-centre study to validate the Thora3Di™ against standard practice in patients who are undergoing investigation for disproportionate breathlessness.
- Trial name
- SLPDB (NCT04255446)
- Testing
- Thora3DiTM
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Pneumacare Ltd
Endometriosis, Infertility
Harnessing the Disease Signatures From Endometrium and Menstrual Blood to Identify Avenues for the Treatment of Chronic Conditions Such as Endometriosis and Related Pathologies: This is an Observational Study Aimed at Shedding Light on Women's Health
Many women's health conditions have limited treatments available and poor outcomes, in part due to the lack of understanding of disease processes and lack of data available.
- Conditions
- Endometriosis, Infertility, Endometrial Cancer, Adenomyosis, Endometriosis
- Trial name
- CYCLE_ENDO (NCT06990971)
- Testing
- No Intervention: Observational Cohort
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Cycle Therapeutics Ltd