Clinical trials: Linear Growth
Metastatic Colorectal Cancer
Dual Targeting of Vascular Endothelial Growth Factor-A Together With Angiopoietins in Chemotherapy-naïve Metastatic Colorectal Cancer
This is a clinical trial investigating the effectiveness and safety of the combination of the study drugs bevacizumab and AMG386 in patients with advanced (metastatic) chemotherapy-naive bowel (colorectal) cancer.
- Trial name
- Vengeance (NCT01249521)
- Testing
- AMG386 and bevacizumab
- Where
- Australia
- Volunteers
- 40 people
- Sponsor
- Austin Health
Stunting
Food-based Approach Development to Fulfil Amino Acid Gap by Considering the Intestinal Permeability of Children
This study will be comprised of 2 phases. Phase 1 study is a comparative cross-sectional study which will be conducted among children aged 12-24 months living in agricultural area.
- Trial name
- NCT04157413
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Nia Novita Wirawan
Linear Growth, Neurodevelopment
The Effects of Early Complementary Feeding on Growth, Neurodevelopment, Sleep and Gut Health
The overall objective of this project is to understand how consuming a prescribed diet of different infant foods (which may contain cereals,fruits, vegetables, meats, dairy) during the time of early complementary feeding (~5 to…
- Conditions
- Linear Growth, Neurodevelopment, Gut Microbiome
- Trial name
- NCT04137445
- Testing
- Baby Foods, Foods from the home
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Asthma
Effects of Inhaled Ciclesonide Versus Fluticasone Propionate Versus Placebo on Lower Leg Growth in Prepubertal Children With Mild Persistent Asthma (6 to 12 y) (BY9010/M1-208)
The aim of the study is to compare the effects of ciclesonide inhaled at one dose level twice daily versus fluticasone propionate inhaled at one dose level twice daily versus placebo, on short-term lower leg growth in prepubertal…
- Trial name
- NCT00163371
- Testing
- Ciclesonide
- Where
- Denmark
- Volunteers
- 28 people
- Sponsor
- AstraZeneca
Small Intestine Bacterial Overgrowth
Comparative Efficacy of Antibiotics for Small Intestine Bacterial Overgrowth in Bangladeshi Children
The purpose of this Phase IIa study is to identify the most effective antibiotic regimen to treat small intestine bacterial overgrowth (SIBO) in impoverished Bangladeshi children.
- Trial name
- NCT07451171
- Testing
- Trimethoprim-sulfamethoxazole (TMP/SMX), Metronidazole, Amoxicillin-Clavulanate (4:1 formulation)
- Where
- Bangladesh
- Volunteers
- 60 people
- Sponsor
- University of Virginia
Osteogenesis Imperfecta, Osteogenesis Imperfecta Type III
Mesenchymal Cell Therapy in Osteogenesis Imperfecta (OI)
This is a Phase 1/2 study to determine the safety and efficacy of allogeneic (third party), bone-marrow derived mesenchymal stromal cells (MSCs) for the treatment of Osteogenesis Imperfecta (OI) Type 3.
- Trial name
- NCT05559801
- Testing
- Bone marrow-derived mesenchymal stromal cells (MSCs)
- Volunteers
- 12 people
- Sponsor
- Emory University
Infant, Low Birth Weight
Preventing Linear Growth Faltering Among Low Birth Weight Infants in Bangladesh
Low birth weight (LBW) infants are particularly vulnerable to frequent infections and consequent morbidity resulting in sub-optimal breastfeeding, limited ingestion of complementary foods and ultimately micronutrient deficiencies…
- Trial name
- NCT01455636
- Testing
- Hand Sanitizer, Improved Micronutrient Powder, No hand sanitizer
- Where
- 2 sites in Bangladesh, Canada
- Volunteers
- 467 people
- Sponsor
- The Hospital for Sick Children
Child Growth
Home-based Growth Charts in Indonesia
The investigators developed a home-based growth chart that offers a simple and inexpensive way for caregivers to have access to simple health and nutrition information guided by behavioural economics analysis as well as to track…
- Trial name
- NCT04222998
- Testing
- Home-based growth charts, Home visits for baseline surveys, Home visits for end line surveys
- Where
- Indonesia
- Volunteers
- 1,487 people
- Sponsor
- Boston University
Stunting, Anemia
Linear Programming Approach to Develop Local Specific Food-based Complementary Feeding Recommendation
Stunting and anemia amongst under-two children are attributable to poor nutrient intakes. The study evaluates the effectiveness of nutrition education on local specific food-based complementary feeding recommendation (CFR) to…
- Conditions
- Stunting, Anemia, Complementary Feeding Recommendation, Linear Programming
- Trial name
- NCT03895164
- Testing
- Enhanced NE, Standard NE
- Where
- 2 sites in Indonesia
- Volunteers
- 926 people, healthy volunteers welcome
- Sponsor
- SEAMEO Regional Centre for Food and Nutrition
Diarrhea, Stunting
Zinc-MNP Trial for Prevention of Diarrhea and Promotion of Linear Growth
This is a randomized, double-blind, community-based efficacy trial of different doses, forms, and frequencies of zinc supplementation for the prevention of diarrhea and promotion of linear growth among children 9-11 months of age…
- Trial name
- NCT03406793
- Testing
- Standard MNP, High zinc, low iron MNP, High zinc, low/no iron on alternating days
- Where
- Bangladesh
- Volunteers
- 2,886 people, healthy volunteers welcome
- Sponsor
- UCSF Benioff Children's Hospital Oakland
Growth Disorders, Infant Malnutrition
Effect of a Complementary Food Supplement on Growth and Morbidity of Ghanaian Infants
Prevention of malnutrition in infants and children requires access and intake of nutritious food starting at birth with exclusive breastfeeding for the first 6 months of life, breastfeeding in combination with complementary foods…
- Conditions
- Growth Disorders, Infant Malnutrition, Micronutrient Deficiency, Protein Malnutrition
- Trial name
- TRIUMF (NCT03181178)
- Testing
- Macro-micronutrient complementary food supplement, A micronutrient powder, Nutrition education
- Volunteers
- 1,204 people, healthy volunteers welcome
- Sponsor
- Nevin Scrimshaw International Nutrition Foundation
Glucose-Galactose Malabsorption, Enteropathy
Labelled Carbon Sucrose Breath Test (13C-SBT) as a Marker of Environmental Enteropathy
Linear growth failure, a manifestation of chronic undernutrition in early childhood, is a recalcitrant problem in resource constrained settings.
- Conditions
- Glucose-Galactose Malabsorption, Enteropathy, Malnutrition, Child, Intestinal Permeability
- Trial name
- SBT4EE (NCT04109352)
- Where
- 9 sites in Australia, Bangladesh and 6 more
- Volunteers
- 600 people
- Sponsor
- University of Virginia
Nutritional Stunting, Nutritional Anemia
Association Between Intakes of Protein, Calcium and Milk With Gene Expression and Linear Growth of School Aged Children
Protein is one type of nutrients known as the cause of stunting in developing countries since the mid-1970s (1) but then less attention on protein intake with the assumption that protein intake is sufficient.
- Conditions
- Nutritional Stunting, Nutritional Anemia, Nutritional Deficiency, Nutrigenetic
- Trial name
- NCT03895151
- Testing
- Milk supplementation, Food Based Recommendation (FBR) nutrition education
- Where
- Indonesia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- SEAMEO Regional Centre for Food and Nutrition
Malnutrition
Prevention of Linear Growth Failure in Infants and Young Children With Lipid-based Nutrient Supplements (iLiNS-DOSE)
The use of lipid-based nutrients (LNS), such as Nutributter or fortified spread (FS), have been associated with improved growth and development outcomes among infants in Ghana and Malawi.
- Trial name
- iLiNS-DOSE (NCT00945698)
- Testing
- Lipid-based nutrient supplement, 10gM, Lipid-based nutrient supplement, 20gM, Lipid-based Nutrient Supplement, 20gNoM
- Where
- Malawi
- Volunteers
- 1,920 people, healthy volunteers welcome
- Sponsor
- Tampere University
Severe Wasting, Severe Acute Malnutrition
High-protein Quantity and Quality RUTF in Improving Linear Growth Among Children With Severe Wasting
This is a proof-of-concept trial that aims to compare the efficacy of an 8-week treatment with higher-protein-Ready-to-Use Therapeutic Foods (RUTF) with standard RUTF in improving levels of markers of growths, height, nutritional…
- Trial name
- Protein+ (NCT05737472)
- Testing
- High-protein RUTF, Standard RUTF
- Where
- Malawi
- Volunteers
- 128 people
- Sponsor
- The Hospital for Sick Children
At Risk or Stunted Children
Nutrition Intervention of Complementary Milk Feeding to Improve Linear Growth of at Risk and Stunted Children
This is a non-randomized open label 6 months intervention study that aims to assess the effectiveness of consuming milk daily for 6 months will improve the linear growth rate of children aged 12-36 months.
- Trial name
- NCT05670002
- Testing
- Milk supplement
- Where
- Malaysia
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- FrieslandCampina
Asthma
Linear Growth Study (0476-097)(COMPLETED)
The purpose of this study is to compare the effect of montelukast with placebo and beclomethasone on the average rate of linear growth over a period of 56 weeks in children with mild asthma.
- Trial name
- NCT00395408
- Testing
- MK0476, montelukast sodium / Duration of Treatment : 56 Weeks, Comparator : beclomethasone dipropionate / Duration of Treatment : 56 Weeks
- Volunteers
- 360 people
- Sponsor
- Organon and Co